Mark Hew

Addressing the impact of ethnicity on asthma care.

Tunn Ren Tay, Jonathan Pham, Mark Hew

Journal article  |  2020  |  Current Opinion in Allergy and Clinical Immunology

PURPOSE OF REVIEW: In asthma, there is an increasing focus on personalizing treatment by targeting treatable traits. Ethnicity has..

Trajectory Analyses of Adherence Patterns in a Real-Life Moderate to Severe Asthma Population.

Job FM van Boven, Marjaana Koponen, Samanta Lalic, Johnson George, J Simon Bell, Mark Hew, Jenni Ilomaki

Journal article  |  2020  |  The Journal of Allergy and Clinical Immunology: In Practice

BACKGROUND: Global Initiative for Asthma step 5 therapies (GINA-5), other than inhaled corticosteroids and long-acting β-agonists ..

Is diet partly responsible for differences in COVID-19 death rates between and within countries?

J Bousquet, JM Anto, G Iaccarino, W Czarlewski, T Haahtela, A Anto, CA Akdis, H Blain, GW Canonica, V Cardona, AA Cruz, M Illario, JC Ivancevich, M Jutel, L Klimek, P Kuna, D Laune, D Larenas-Linnemann, J Mullol, NG Papadopoulos, et al.

Journal article  |  2020  |  Clinical and Translational Allergy

Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5

Mark Hew, Joy Lee, Nirupama Varese, Pei M Aui, Craig I McKenzie, Bruce D Wines, Heather Aumann, Jennifer M Rolland, Phillip Mark Hogarth, Menno C van Zelm, Robyn E O'Hehir

Journal article  |  2020  |  Allergy

Systematic Assessment for Difficult and Severe Asthma Improves Outcomes and Halves Oral Corticosteroid Burden Independent of Monoclonal Biologic Use.

Eve Denton, Joy Lee, TunnRen Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Anna Mackay, Ryan Hoy, Eli Dabscheck, Robyn E O'Hehir, Mark Hew

Journal article  |  2020  |  The Journal of Allergy and Clinical Immunology: In Practice

BACKGROUND: Guidelines endorse systematic assessment for severe asthma, with data indicating benefit across multiple outcome domai..

Induction of IgG2 and IgG4 B-cell memory following sublingual immunotherapy for ryegrass pollen allergy.

Jorn J Heeringa, Craig I McKenzie, Nirupama Varese, Mark Hew, Amy TCM Bakx, Pei M Aui, Jennifer M Rolland, Robyn E O'Hehir, Menno C van Zelm

Journal article  |  2020  |  Allergy

BACKGROUND: While treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen-specific immunotherapy (AIT) is..

Mepolizumab effectiveness and identification of super-responders in severe asthma

Erin S Harvey, David Langton, Constance Katelaris, Sean Stevens, Claude S Farah, Andrew Gillman, John Harrington, Mark Hew, Vicky Kritikos, Naghmeh Radhakrishna, Philip Bardin, Matthew Peters, Paul N Reynolds, John W Upham, Melissa Baraket, Simon Bowler, Jeffrey Bowden, Jimmy Chien, Li Ping Chung, Christopher Grainge, et al.

Journal article  |  2020  |  European Respiratory Journal

Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to as..

Characterization of Severe Asthma Worldwide: Data From the International Severe Asthma Registry.

Eileen Wang, Michael E Wechsler, Trung N Tran, Liam G Heaney, Rupert C Jones, Andrew N Menzies-Gow, John Busby, David J Jackson, Paul E Pfeffer, Chin Kook Rhee, You Sook Cho, G Walter Canonica, Enrico Heffler, Peter G Gibson, Mark Hew, Matthew Peters, Erin S Harvey, Marianna Alacqua, James Zangrilli, Lakmini Bulathsinhala, et al.

Journal article  |  2020  |  Chest

BACKGROUND: Clinical characteristics of the international population with severe asthma are unknown. Intercountry comparisons are ..

International Severe Asthma Registry: Mission Statement.

undefined ISAR Study Group

Journal article  |  2020  |  Chest

Regional and/or national severe asthma registries provide valuable country-specific information. However, they are often limited i..

Severe Asthma Toolkit: an online resource for multidisciplinary health professionals-needs assessment, development process and user analytics with survey feedback.

Steven Maltby, Peter G Gibson, Helen K Reddel, Lorraine Smith, Peter AB Wark, Gregory G King, John W Upham, Vanessa L Clark, Mark Hew, Louisa Owens, Stephen Oo, Alan L James, Bruce Thompson, Guy B Marks, Vanessa M McDonald

Journal article  |  2020  |  BMJ Open

OBJECTIVES: Severe asthma imposes a significant burden on individuals, families and the healthcare system. New treatment and manag..

Systematic Assessment of Difficult-to-Treat Asthma: Principles and Perspectives.

Mark Hew, Andrew Menzies-Gow, James H Hull, Louise Fleming, Celeste Porsbjerg, Anneke Ten Brinke, David Allen, Robin Gore, Tunn Ren Tay

Journal article  |  2020  |  The Journal of Allergy and Clinical Immunology: In Practice

Difficult-to-treat asthma affects a minority of adults and children with asthma but represents a challenging mix of misdiagnosis, ..

Paradoxical Vocal Fold Motion in Difficult Asthma Is Associated with Dysfunctional Breathing and Preserved Lung Function.

Joy Lee, Eve Denton, Ryan Hoy, Tunn Ren Tay, Janet Bondarenko, Fiona Hore-Lacy, Naghmeh Radhakrishna, Robyn E O'Hehir, Eli Dabscheck, Michael J Abramson, Mark Hew

Journal article  |  2020  |  The Journal of Allergy and Clinical Immunology: In Practice

BACKGROUND: Many patients with difficult asthma also have coexisting vocal cord dysfunction (VCD), evident by paradoxical vocal fo..

Rational oral corticosteroid use in adult severe asthma: A narrative review.

Li Ping Chung, John W Upham, Philip G Bardin, Mark Hew

Journal article  |  2020  |  Respirology

OCS play an important role in the management of asthma. However, steroid-related AE are common and represent a leading cause of mo..

Prevalence and Clinical Implications of Chronic Rhinosinusitis in People with Bronchiectasis: A Systematic Review.

Emma Handley, Caroline H Nicolson, Mark Hew, Annemarie L Lee

Journal article  |  2019  |  The Journal of Allergy and Clinical Immunology: In Practice

BACKGROUND: Chronic rhinosinusitis (CRS) is an extrapulmonary manifestation in some individuals with bronchiectasis, but the preva..

Factors Associated with Dysfunctional Breathing in Patients with Difficult to Treat Asthma.

Eve Denton, Janet Bondarenko, TunnRen Tay, Joy Lee, Naghmeh Radhakrishna, Fiona Hore-Lacy, Catherine Martin, Ryan Hoy, Robyn O'Hehir, Eli Dabscheck, Mark Hew

Journal article  |  2019  |  The Journal of Allergy and Clinical Immunology: In Practice

BACKGROUND: Understanding of dysfunctional breathing in patients with difficult asthma who remain symptomatic despite maximal inha..

Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma.

Eve Denton, Fiona Hore-Lacy, Naghmeh Radhakrishna, Annie Gilbert, TunnRen Tay, Joy Lee, Eli Dabscheck, Erin S Harvey, Lakmini Bulathsinhala, James Fingleton, David Price, Peter G Gibson, Robyn O'Hehir, Mark Hew

Journal article  |  2019  |  The Journal of Allergy and Clinical Immunology: In Practice

Severe asthma is complex and heterogeneous; ad hoc outpatient assessment can be suboptimal. Systematic evaluation improves outcome..

Integrated Adherence Monitoring for Inhaler Medications.

Mark Hew, Helen K Reddel

Journal article  |  2019  |  JAMA

Development of the International Severe Asthma Registry (ISAR): A Modified Delphi Study.

Lakmini Bulathsinhala, Nevaashni Eleangovan, Liam G Heaney, Andrew Menzies-Gow, Peter G Gibson, Matthew Peters, Mark Hew, Job FM van Boven, Lauri Lehtimäki, Eric van Ganse, Manon Belhassen, Erin S Harvey, Luis Perez de Llano, Anke H Maitland-van der Zee, Nikolaos G Papadopoulos, J Mark FitzGerald, Celeste Porsbjerg, G Walter Canonica, Vibeke Backer, Chin Kook Rhee, et al.

Journal article  |  2019  |  The Journal of Allergy and Clinical Immunology: In Practice

BACKGROUND: The lack of centralized data on severe asthma has resulted in a scarcity of information about the disease and its mana..

Anaphylaxis presentations to the emergency department: impending Victorian reporting legislation.

Celia Zubrinich, Jo Douglass, James Bartlett, Mittal Patel, Mark Hew

Journal article  |  2019  |  Internal Medicine Journal

Asthma and chronic obstructive pulmonary disease in the intensive care unit

D Tuxen, M Hew

Journal article  |  2019  |  Anaesthesia & Intensive Care Medicine

The 2016 Melbourne thunderstorm asthma epidemic: Risk factors for severe attacks requiring hospital admission

Mark Hew, Joy Lee, Nugroho H Susanto, Shivonne Prasad, Philip G Bardin, Sara Barnes, Laurence Ruane, Anne M Southcott, Andrew Gillman, Alan Young, Kanishka Rangamuwa, Robyn E O'Hehir, Christine McDonald, Michael Sutherland, Matthew Conron, Sarah Matthews, Nur-Shirin Harun, Philippe Lachapelle, Jo A Douglass, Louis Irving, et al.

Journal article  |  2019  |  Allergy

Strongyloides infection as a reversible cause of chronic urticaria

CM Zubrinich, RM Puy, RE O’Hehir, M Hew

Journal article  |  2019  |  Journal of Asthma and Allergy

Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial.

William W Busse, Eugene R Bleecker, J Mark FitzGerald, Gary T Ferguson, Peter Barker, Stephanie Sproule, Richard F Olsson, Ubaldo J Martin, Mitchell Goldman, undefined BORA study investigators

Journal article  |  2019  |  The Lancet Respiratory Medicine

BACKGROUND: Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal antibody that has been shown to safely reduc..

Breathing pattern disorder in difficult asthma: Characteristics and improvement in asthma control and quality of life after breathing re-training.

Eve Denton, Janet Bondarenko, Robyn E O'Hehir, Mark Hew

Journal article  |  2019  |  Allergy

Recent developments and highlights in biomarkers in allergic diseases and asthma.

Ibon Eguiluz-Gracia, Tunn Ren Tay, Mark Hew, Maria M Escribese, Domingo Barber, Robyn E O'Hehir, Maria J Torres

Journal article  |  2018  |  Allergy

The potential of precision medicine in allergy and asthma has only started to be explored. A significant clarification in the path..

Diagnosis of concomitant inducible laryngeal obstruction and asthma.

Joy W Lee, Tunn Ren Tay, Paul Paddle, Amanda L Richards, Lisa Pointon, Miriam Voortman, Michael J Abramson, Ryan Hoy, Mark Hew

Journal article  |  2018  |  Clinical & Experimental Allergy

BACKGROUND: Inducible laryngeal obstruction, an induced, inappropriate narrowing of the larynx, leading to symptomatic upper airwa..

Managing patients with severe asthma in Australia: Current challenges with the existing models of care.

Li Ping Chung, Mark Hew, Philip Bardin, Vanessa M McDonald, John W Upham

Journal article  |  2018  |  Internal Medicine Journal

Severe asthma leads to debilitating symptoms for patients and excessive socioeconomic burden for the community. Comprehensive mode..

Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity

Peter Wallbridge, Selina M Parry, Sourav Das, Candice Law, Gary Hammerschlag, Louis Irving, Mark Hew, Daniel Steinfort

Journal article  |  2018  |  Scientific Reports

Diagnostic chest ultrasound for acute respiratory failure

Peter Wallbridge, Daniel Steinfort, Tunn Ren Tay, Louis Irving, Mark Hew

Journal article  |  2018  |  Respiratory Medicine

Diagnosis of severe asthma.

Tunn Ren Tay, Joy W-Y Lee, Mark Hew

Journal article  |  2018  |  The Medical journal of Australia

Patients with asthma that is uncontrolled despite high intensity medication can present in both primary and specialist care. An in..

Epidemic Thunderstorm Asthma Protection with Five-Grass Pollen Tablet Sublingual Immunotherapy: A Clinical Trial.

Robyn E O'Hehir, Nirupama P Varese, Kirsten Deckert, Celia M Zubrinich, Menno C van Zelm, Jennifer M Rolland, Mark Hew

Journal article  |  2018  |  American Journal of Respiratory and Critical Care Medicine

Comorbid "treatable traits" in difficult asthma: Current evidence and clinical evaluation.

TR Tay, M Hew

Journal article  |  2018  |  Allergy

The care of patients with difficult-to-control asthma ("difficult asthma") is challenging and costly. Despite high-intensity asthm..

Working while unwell: Workplace impairment in people with severe asthma

SA Hiles, ES Harvey, VM McDonald, M Peters, P Bardin, PN Reynolds, JW Upham, M Baraket, Z Bhikoo, J Bowden, B Brockway, LP Chung, B Cochrane, G Foxley, J Garrett, M Hew, L Jayaram, C Jenkins, C Katelaris, G Katsoulotos, et al.

Journal article  |  2018  |  Clinical & Experimental Allergy

The Melbourne epidemic thunderstorm asthma event 2016: an investigation of environmental triggers, effect on health services, and patient risk factors

Francis Thien, Paul J Beggs, Danny Csutoros, Jai Darvall, Mark Hew, Janet M Davies, Philip G Bardin, Tony Bannister, Sara Barnes, Rinaldo Bellomo, Timothy Byrne, Andrew Casamento, Matthew Conron, Anthony Cross, Ashley Crosswell, Jo A Douglass, Matthew Durie, John Dyett, Elizabeth Ebert, Bircan Erbas, et al.

Journal article  |  2018  |  The Lancet Planetary Health

BACKGROUND: A multidisciplinary collaboration investigated the world's largest, most catastrophic epidemic thunderstorm asthma eve..

Nonadherence in the era of severe asthma biologics and thermoplasty.

Joy Lee, Tunn Ren Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Anna Mackay, Ryan Hoy, Eli Dabscheck, Robyn O'Hehir, Mark Hew

Journal article  |  2018  |  Eur Respir J

Nonadherence to inhaled preventers impairs asthma control. Electronic monitoring devices (EMDs) can objectively measure adherence...

The Melbourne thunderstorm asthma event: can we avert another strike?

Mark Hew, Michael Sutherland, Francis Thien, Robyn O'Hehir

Journal article  |  2017  |  Internal Medicine Journal

Comorbidities in difficult asthma are independent risk factors for frequent exacerbations, poor control and diminished quality of life.

Tunn Ren Tay, Naghmeh Radhakrishna, Fiona Hore-Lacy, Catherine Smith, Ryan Hoy, Eli Dabscheck, Mark Hew

Journal article  |  2016  |  Respirology

BACKGROUND AND OBJECTIVE: Little is known about how comorbidities affect difficult asthma patients across different domains of ast..

Coexisting atopic conditions influence the likelihood of allergic bronchopulmonary aspergillosis in asthma.

Tunn Ren Tay, Julian Bosco, Andrew Gillman, Heather Aumann, Robert Stirling, Robyn O'Hehir, Mark Hew

Journal article  |  2016  |  Annals of Allergy, Asthma & Immunology

BACKGROUND: The diagnosis of allergic bronchopulmonary aspergillosis (ABPA) in asthma is often made in patients with total serum I..

Diagnosis and investigation in the severe asthma clinic.

Peter AB Wark, Mark Hew, Steven Maltby, Vanessa M McDonald, Peter G Gibson

Journal article  |  2016  |  Expert Review of Respiratory Medicine

Severe asthma is recognised as an important and emerging area of unmet need in asthma. The assessment of severe asthma should incl..

Addressing ethnic disparity in asthma trials.

Naghmeh Radhakrishna, Mark Hew

Journal article  |  2014  |  Respirology

Bronchoscopic evaluation of the mediastinum using endobronchial ultrasound: a description of the first 216 cases carried out at an Australian tertiary hospital

DP Steinfort, MJ Hew, LB Irving

Journal article  |  2011  |  Internal Medicine Journal