Keith Cross

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Christine A Seers, A Sayeed M Mahmud, N Laila Huq, Keith J Cross, Eric C Reynolds

Journal article  |  2021  |  JOURNAL OF ORAL MICROBIOLOGY

Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors ..

Molecular Interactions of Peptide Encapsulated Calcium Phosphate Delivery Vehicle at Enamel Surfaces

NL Huq, KJ Cross, H Myroforidis, DP Stanton, YY Chen, BR Ward, EC Reynolds

Book Chapter  |  2018

Phosphorylated peptides derived from milk caseins, known as casein phosphopeptides (CPP) self-assemble and encapsulate the calcium..

Porphyromonas gingivalis Gingipains Display Transpeptidation Activity

Lianyi Zhang, Paul D Veith, N Laila Huq, Yu-Yen Chen, Christine A Seers, Keith J Cross, Dhana G Gorasia, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF PROTEOME RESEARCH

Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface p..

Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors

Stuart G Dashper, Helen L Mitchell, Christine A Seers, Simon L Gladman, Torsten Seemann, Dieter M Bulach, P Scott Chandry, Keith J Cross, Steven M Cleal, Ericc Reynolds

Journal article  |  2017  |  FRONTIERS IN MICROBIOLOGY

Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of P. gingivalis is reported to be strain ..

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.

Journal article  |  2016  |  NPJ VACCINES

Porphyromonas gingivalis infected mice with an established P. gingivalis-specific inflammatory immune response were protected from..

PG1058 Is a Novel Multidomain Protein Component of the Bacterial Type IX Secretion System

Jacqueline E Heath, Christine A Seers, Paul D Veith, Catherine A Butler, Nor A Nor Muhammad, Yu-Yen Chen, Nada Slakeski, Benjamin Peng, Lianyi Zhang, Stuart G Dashper, Keith J Cross, Steven M Cleal, Caroline Moore, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Porphyromonas gingivalis utilises the Bacteroidetes-specific type IX secretion system (T9SS) to export proteins across the outer m..

Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes: A Structural Model

Keith J Cross, N Laila Huq, Eric C Reynolds

Journal article  |  2016  |  BIOCHEMISTRY

Tryptic digestion of the calcium-sensitive caseins yields casein phosphopeptides (CPP) that contain clusters of phosphorylated ser..

The Interactions of CPP-ACP with Saliva

Noorjahan Laila Huq, Helen Myroforidis, Keith J Cross, David P Stanton, Paul D Veith, Brent R Ward, Eric C Reynolds

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on cas..

Bioinformatic investigation of the cost management strategies of five oral microbes

KJ Cross, NL Huq, SH Park, JS Park, P Pham, M Quah, M Ranjan, EC Reynolds

Journal article  |  2015  |  MOLECULAR ORAL MICROBIOLOGY

Some amino acids are more energetically costly to synthesize de novo, therefore many microbes have evolved to regulate the metabol..

Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health

Michael A Gorman, Christine A Seers, Belinda J Michell, Susanne C Feil, N Laila Huq, Keith J Cross, Eric C Reynolds, Michael W Parker

Journal article  |  2015  |  PROTEIN SCIENCE

The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the pri..