Keith Cross

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Christine A Seers, A Sayeed M Mahmud, N Laila Huq, Keith J Cross, Eric C Reynolds

Journal article  |  2021  |  JOURNAL OF ORAL MICROBIOLOGY

Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors ..

Molecular Interactions of Peptide Encapsulated Calcium Phosphate Delivery Vehicle at Enamel Surfaces

NL Huq, KJ Cross, H Myroforidis, DP Stanton, YY Chen, BR Ward, EC Reynolds

Book Chapter  |  2018

Phosphorylated peptides derived from milk caseins, known as casein phosphopeptides (CPP) self-assemble and encapsulate the calcium..

Porphyromonas gingivalis Gingipains Display Transpeptidation Activity

Lianyi Zhang, Paul D Veith, N Laila Huq, Yu-Yen Chen, Christine A Seers, Keith J Cross, Dhana G Gorasia, Eric C Reynolds

Journal article  |  2018  |  JOURNAL OF PROTEOME RESEARCH

Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface p..

Physico-chemical Characterisation of the Processes Involved in Enamel Remineralisation by CPP-ACP

Keith J Cross, N Laila Huq, Boon Loh, Li-Ming Bhutta, Bill Madytianos, Sarah Peterson, David P Stanton, Yi Yuan, Coralie Reynolds, Glen Walker, Peiyan Shen, Eric C Reynolds

Book Chapter  |  2018

Molecular Interactions of Peptide Encapsulated Calcium Phosphate Delivery Vehicle at Enamel Surfaces

Noorjahan Laila Huq, Keith John Cross, Helen Myroforidis, David Phillip Stanton, Yu-Yen Chen, Brent Robert Ward, Eric Charles Reynolds

Book Chapter  |  2018

Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors

Stuart G Dashper, Helen L Mitchell, Christine A Seers, Simon L Gladman, Torsten Seemann, Dieter M Bulach, P Scott Chandry, Keith J Cross, Steven M Cleal, Ericc Reynolds

Journal article  |  2017  |  FRONTIERS IN MICROBIOLOGY

Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of P. gingivalis is reported to be strain ..

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.

Journal article  |  2016  |  NPJ VACCINES

Porphyromonas gingivalis infected mice with an established P. gingivalis-specific inflammatory immune response were protected from..

PG1058 Is a Novel Multidomain Protein Component of the Bacterial Type IX Secretion System

Jacqueline E Heath, Christine A Seers, Paul D Veith, Catherine A Butler, Nor A Nor Muhammad, Yu-Yen Chen, Nada Slakeski, Benjamin Peng, Lianyi Zhang, Stuart G Dashper, Keith J Cross, Steven M Cleal, Caroline Moore, Eric C Reynolds

Journal article  |  2016  |  PLOS ONE

Porphyromonas gingivalis utilises the Bacteroidetes-specific type IX secretion system (T9SS) to export proteins across the outer m..

Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes: A Structural Model

Keith J Cross, N Laila Huq, Eric C Reynolds

Journal article  |  2016  |  BIOCHEMISTRY

Tryptic digestion of the calcium-sensitive caseins yields casein phosphopeptides (CPP) that contain clusters of phosphorylated ser..

The Interactions of CPP-ACP with Saliva

Noorjahan Laila Huq, Helen Myroforidis, Keith J Cross, David P Stanton, Paul D Veith, Brent R Ward, Eric C Reynolds

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on cas..