After completing my clinical training and Chicago post-doctoral position, my research focus has been on improving dementia diagnosis through understanding neurodegenerative mechanisms. For the last decade I have been examining the links between vascular risk, stroke and dementia, and running a cognitive disorders clinic specialising in young and focal onset dementia.
My research is regarded as changing the field: a recent editorial from the Mayo Clinic stated that this work is “endorsing a model of cerebrovascular pathophysiology that represents a major departure from the approach that has dominated the field for the last 40 years”. I have had continuous NHMRC funding for work in Australia since I received my NHMRC Postgraduate Scholarship, including project lead, PI and CIA on large projects. Since 2015 I have led the Vascular mechanisms of neurodegeneration Dementia Research Team Grant.
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The Neglected Prescription: A Phase 2b Exercise Study To Prevent Vascular Neurodegeneratio..
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an..
The heterogeneous functional architecture of the posteromedial cortex is associated with s..
Displaying the 2 most recent projects by Amy Brodtmann.
Displaying the 98 most recent scholarly works by Amy Brodtmann.
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
Katrina M Moore, Jennifer Nicholas, Murray Grossman, Corey T McMillan, David J Irwin, Lauren Massimo, Vivianna M Van Deerlin, Jason D Warren, Nick C Fox, Martin N Rossor, Simon Mead, Martina Bocchetta, Bradley F Boeve, David S Knopman, Neill R Graff-Radford, Leah K Forsberg, Rosa Rademakers, Zbigniew K Wszolek, John C van Swieten, Lize C Jiskoot, et al.
Journal article | 2020 | The Lancet Neurology
BACKGROUND: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most ..
The heterogeneous functional architecture of the posteromedial cortex is associated with selective functional connectivity differences in Alzheimer's disease
Wasim Khan, Ali Amad, Vincent Giampietro, Emilio Werden, Sara De Simoni, Jonathan O'Muircheartaigh, Eric Westman, Owen O'Daly, Steve CR Williams, Amy Brodtmann
Journal article | 2019 | Human Brain Mapping
Choroid plexus volume after stroke
Natalia Egorova, Elie Gottlieb, Mohamed Salah Khlif, Neil J Spratt, Amy Brodtmann
Journal article | 2019 | International Journal of Stroke
BACKGROUND: Cerebrospinal fluid circulation is crucial for the functioning of the brain. Aging and brain pathologies such as Alzhe..
A Human Depression Circuit Derived From Focal Brain Lesions
Jaya L Padmanabhan, Danielle Cooke, Juho Joutsa, Shan H Siddiqi, Michael Ferguson, R Ryan Darby, Louis Soussand, Andreas Horn, Na Young Kim, Joel L Voss, Andrew M Naidech, Amy Brodtmann, Natalia Egorova, Sophia Gozzi, Thanh G Phan, Maurizio Corbetta, Jordan Grafman, Michael D Fox
Journal article | 2019 | Biological Psychiatry
BACKGROUND: Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. Howev..
Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing
Sharna D Jamadar, Francesco Sforazzini, Parnesh Raniga, Nicholas J Ferris, Bryan Paton, Michael J Bailey, Amy Brodtmann, Paul A Yates, Geoffrey A Donnan, Stephanie A Ward, Robyn L Woods, Elsdon Storey, John J McNeil, Gary F Egan
Journal article | 2019 | The Journals of Gerontology: Series B
OBJECTIVES: The onset of many illnesses is confounded with age and sex. Increasing age is a risk factor for the development of man..
Evolution of brain volume and hippocampal neurogenesis over 12 months after focal ischemia in adult rats
Charlotte Ermine, Warda Syeda, David Wright, Jessica Kauhausen, Stefano Frausin, Vanessa Brait, Katrina O'Brien, Jessica Nithianantharajah, Emilio Werden, Leigh Johnston, Amy Brodtmann, Lachlan Thompson
Conference Proceedings | 2019 | INTERNATIONAL JOURNAL OF STROKE
A systematic review protocol of timing, efficacy and cost effectiveness of upper limb therapy for motor recovery post-stroke
Kathryn S Hayward, Sharon F Kramer, Vincent Thijs, Julie Ratcliffe, Nick S Ward, Leonid Churilov, Laura Jolliffe, Dale Corbett, Geoffrey Cloud, Tina Kaffenberger, Amy Brodtmann, Julie Bernhardt, Natasha A Lannin
Journal article | 2019 | Systematic Reviews
BACKGROUND: Improving upper limb (UL) motor recovery after stroke represents a major clinical and scientific goal. We aim to compl..
Extending thrombolysis to 4.5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data
Bruce C Campbell, Henry Ma, Peter A Ringleb, Mark W Parsons, Leonid Churilov, Martin Bendszus, Christopher R Levi, Chung Hsu, Timothy J Kleinig, Marc Fatar, Didier Leys, Carlos Molina, Tissa Wijeratne, Sami Curtze, Helen M Dewey, P Alan Barber, Kenneth S Butcher, Deidre A De Silva, Christopher F Bladin, Nawaf Yassi, et al.
Journal article | 2019 | The Lancet
Pioglitazone Therapy in Patients With Stroke and Prediabetes A Post Hoc Analysis of the IRIS Randomized Clinical Trial
J David Spence, Catherine M Viscoli, Silvio E Inzucchi, Jennifer Dearborn-Tomazos, Gary A Ford, Mark Gorman, Karen L Furie, Anne M Lovejoy, Lawrence H Young, Walter N Kernan, Christopher Bladin, Stephen Davis, Tissa Wijeratne, Christopher Levi, Mark Parsons, Amy Brodtmann, Steven Ng, John Archer, Candice Delcourt, Toni R Winder, et al.
Journal article | 2019 | JAMA Neurology
A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants
Mohamed Salah Khlif, Natalia Egorova, Emilio Werden, Alberto Redolfi, Marina Boccardi, Charles S DeCarli, Evan Fletcher, Baljeet Singh, Qi Li, Laura Bird, Amy Brodtmann
Journal article | 2019 | NeuroImage: Clinical
Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease
Barbara R Cardoso, Blaine R Roberts, Charles B Malpas, Lucy Vivash, Sila Genc, Michael M Saling, Patricia Desmond, Christopher Steward, Rodney J Hicks, Jason Callahan, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Niall M Corcoran, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brien, Dominic J Hare, Ashley I Bush
Journal article | 2019 | Neurotherapeutics
Assessment of longitudinal hippocampal atrophy in the first year after ischemic stroke using automatic segmentation techniques
Mohamed Salah Khlif, Emilio Werden, Natalia Egorova, Marina Boccardi, Alberto Redolfi, Laura Bird, Amy Brodtmann
Journal article | 2019 | NeuroImage: Clinical
We assessed first-year hippocampal atrophy in stroke patients and healthy controls using manual and automated segmentations: AdaBo..
APOE epsilon 4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke
Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Toby Cumming, Jennifer Bradshaw, Wasim Khan, Matthew Pase, Carolina Restrepo, Michele Veldsman, Natalia Egorova, Sheila K Patel, Elie Gottlieb, Amy Brodtmann
Journal article | 2019 | Journal of Alzheimer's Disease
The Post Ischaemic Stroke Cardiovascular Exercise Study: Protocol for a randomised controlled trial of fitness training for brain health
Liam Johnson, Emilio Werden, Chris Shirbin, Laura Bird, Elizabeth Landau, Toby Cumming, Leonid Churilov, Julie A Bernhardt, Vincent Thijs, Amy Brodtmann
Journal article | 2018 | European Stroke Journal
Understanding the potential for yoga and tai chi interventions to moderate risk factors for stroke - a scoping review
Tharshanah Thayabaranathan, Maarten A Immink, Philip Stevens, Susan Hillier, Amanda G Thrift, Amy Brodtmann, Leeanne Carey, Monique F Kilkenny, Dominique A Cadilhac
Journal article | 2018 | Future Neurology
CEREBRAL ATROPHY IN PATIENTS WITH TYPE 2 DIABETES AND LEFT VENTRICULAR HYPERTROPHY: PRELIMINARY DATA FROM THE DIABETES AND DEMENTIA (D2) STUDY
Sheila Patel, Sheila K Patel, Mohamed S Khlif, Jay Ramchand, Carolina Restrepo, Elise Harrison, Amanda Shanks, Emilio Werden, Piyush M Srivastava, Elif I Ekinci, Louise M Burrell, Amy Brodtmann
Conference Proceedings | 2018 | Journal of Hypertension
Movement-based mindfulness interventions and potential pathophysiological pathways for moderating stroke risk - a scoping review
Tharshanah Thayabaranathan, Maarten A Immink, Philip Stevens, Susan Hillier, Amanda G Thrift, Amy Brodtmann, Leeanne Carey, Monique F Kilkenny, Dominique Cadilhac
Conference Proceedings | 2018 | INTERNATIONAL JOURNAL OF STROKE
Reply: Cortical tau pathology: a major player in fibre-specific white matter reductions in Alzheimer's disease?
Remika Mito, David Raffelt, Thijs Dhollander, David N Vaughan, J-Donald Tournier, Olivier Salvado, Amy Brodtmann, Christopher C Rowe, Victor L Villemagne, Alan Connelly
Journal article | 2018 | Brain
Noncontrast Hybrid Arterial Spin-Labeled Imaging of the Intracranial Arteries
Ruth P Lim, Elena Trajcevska, Farah Al Rawi, Dinesh Gooneratne, Windell Ang, Yuliya Perchyonok, Gregory Fitt, Andrew Kemp, Shivraman Giri, Davide Piccini, Amy Brodtmann, Helen Dewey, Ioannis Koktzoglou
Journal article | 2017 | Journal of Computer Assisted Tomography
Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study
Sheila K Patel, Carolina Restrepo, Emilio Werden, Leonid Churilov, Elif I Ekinci, Piyush M Srivastava, Jay Ramchand, Bryan Wai, Brian Chambers, Christopher J O'Callaghan, David Darby, Vladimir Hachinski, Toby Cumming, Geoff Donnan, Louise M Burrell, Amy Brodtmann
Journal article | 2017 | BMC Endocrine Disorders
ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly
Stephanie A Ward, Parnesh Raniga, Nicholas J Ferris, Robyn L Woods, Elsdon Storey, Michael J Bailey, Amy Brodtmann, Paul A Yates, Geoffrey A Donnan, Ruth E Trevaks, Rory Wolfe, Gary F Egan, John J McNeil
Journal article | 2017 | International Journal of Stroke
STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease.
Perminder S Sachdev, Jessica W Lo, John D Crawford, Lisa Mellon, Anne Hickey, David Williams, Régis Bordet, Anne-Marie Mendyk, Patrick Gelé, Dominique Deplanque, Hee-Joon Bae, Jae-Sung Lim, Amy Brodtmann, Emilio Werden, Toby Cumming, Sebastian Köhler, Frans RJ Verhey, Yan-Hong Dong, Hui Hui Tan, Christopher Chen, et al.
Journal article | 2017 | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascu..
Quantification of motor speech in primary progressive aphasia and frontotemporal dementia
M Poole, A Brodtmann, D Darby, A Vogel
Conference Proceedings | 2016 | JOURNAL OF NEUROCHEMISTRY
Frontotemporal dementia (FTD) and primary progressive aphasia (PPA) are two groups of related disorders which are classified into ..
A Phase IIa Randomized Control Trial of VEL015 ( Sodium Selenate) in Mild-Moderate Alzheimer's Disease
Charles B Malpas, Lucy Vivash, Sila Genc, Michael M Saling, Patricia Desmond, Christopher Steward, Rodney J Hicks, Jason Callahan, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Niall M Corcoran, Christopher M Hovens, Dennis Velakoulis, Terence J O'Brien
Journal article | 2016 | Journal of Alzheimer's Disease
Acoustic monitoring of speech impairment in motor neuron disease associated with frontotemporal dementia: a case series
A VOGEL, M Poole, D Darby, A Brodtmann
Conference Proceedings | 2016 | EUROPEAN JOURNAL OF NEUROLOGY
Frontotemporal dementia is the second most common form of younger onset dementia. A subset of people with this disorder develop mo..
Charting cognitive and volumetric trajectories after stroke: protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study
Amy Brodtmann, Emilio Werden, Heath Pardoe, Qi Li, Graeme Jackson, Geoffrey Donnan, Tiffany Cowie, Jennifer Bradshaw, David Darby, Toby Cumming
Journal article | 2014 | International Journal of Stroke
Phenocopy or variant: a longitudinal study of very slowly progressive frontotemporal dementia.
Amy Brodtmann, Tiffany Cowie, Catriona McLean, David Darby
Journal article | 2013 | BMJ case reports
Frontal variant frontotemporal dementia (fvFTD) can present with a range of social and cognitive impairments. Complicating this cl..
Episodic Memory Decline Predicts Cortical Amyloid Status in Community-Dwelling Older Adults
David G Darby, Amy Brodtmann, Robert H Pietrzak, Julia Fredrickson, Michael Woodward, Victor L Villemagne, Amy Fredrickson, Paul Maruff, Christopher Rowe
Journal article | 2011 | Journal of Alzheimer's Disease
Action myoclonus-renal failure syndrome: characterization of a unique cerebro-renal disorder
A Badhwar, SF Berkovic, JP Dowling, M Gonzales, S Narayanan, A Brodtmann, L Berzen, J Caviness, C Trenkwalder, J Winkelmann, J Rivest, M Lambert, O Hernandez-Cossio, S Carpenter, F Andermann, E Andermann
Journal article | 2004 | Brain
Action myoclonus-renal failure syndrome: Characterization of a novel autosomal recessive disease.
A Badhwar, F Andermann, S Berkovic, S Carpenter, M Gonzales, J Dowling, A Brodtmann, J Caviness, L Berzen, A Rothdach, O HernandezCossio, E Andermann
Conference Proceedings | 2002 | AMERICAN JOURNAL OF HUMAN GENETICS
Honours, Awards and Fellowships
FRACP - Fellow of the Royal Australasian College of Physicians
Medicine - Austin Health
Florey Department Of Neuroscience And Mental Health
American Heart Association/American Stroke Association
Member, Stroke Neurologist
Stroke Society of Australasia
Inaugural Chair, Australian Chapter
Organization for Human Brain Mapping
Royal Australian College of Physicians
Australian and New Zealand Association of Neurologists
University of Melbourne
Royal College of Physicians
Medical Bachelor Bachelor of Surgery
University of Melbourne