Assoc/Prof. Salvatore Pepe is a clinical scientist who leads the Molecular & Cellular Cardiology Laboratory in the Heart Research Group (Clinical Sciences Theme) at the Murdoch Children's Research Institute (MCRI) and is a clinical research manager in the Department of Cardiology, Royal Children's Hospital.
After initially training in clinical pharmacology and completing a doctorate in cardiovascular physiology he undertook four years post-doctoral training (NIH Fogarty Postdoctoral Fellow) at Johns Hopkins Hospital, Bayview Campus, Baltimore, USA, in the NIH, National Institute on Aging Intramural Research Program (Cardiovascular Science).
Previous to working at Melbourne Children's Campus he was Head of the Cardiothoracic Surgical Research Laboratory, (Dept of Cardiothoracic Surgery), at the Alfred Hospital, and Adjunct Senior Lecturer, Department of Surgery (Alfred), Monash University, Melbourne, involved in clinical trial and laboratory research focused on cellular and mitochondrial processes in heart failure, transplantation, and cardiopulmonary bypass surgery.
Working with cardiac surgery, cardiology and intensive care clinicians, Dr Pepe's work is focused on cardiovascular complications arising from congenital and acquired heart and lung disorders, premature birth and surgical interventions.
The emphasis of the research effort is to translate new understanding of disease mechanisms and novel therapeutic agents to clinical use. Currently he is investigating the safety and efficacy of cord blood stem cell therapy as an adjunct to cardiopulmonary bypass surgery in children with severe heart malformations (i.e. hypoplastic left heart syndrome) or with cardiomyopathy. The research program over the past decade spans from in vitro and in vivo laboratory studies to clinical trials.
A/Prof Pepe has served NHMRC, NHF and ARC as a panel member and external reviewer, and is an invited reviewer for numerous medical and scientific journals. Currently he is an Associate Editor of Heart Lung and Circulation (Elsevier) and Clinical and Experimental Pharmacology and Physiology (Wiley), and also an editorial board member of the Journal of Molecular and Cellular Cardiology (Elsevier) and Heliyon (Elsevier). He is Past-President of the International Society for Heart Research and in 2016 was awarded the ISHR Distinguished Leader Award.
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Enhancing The Cardioprotective Effect Of Diadenosine Tetraphosphate: Designing Inhibitors ..
Postnatal inflammation following intrauterine inflammation exacerbates the development of ..
Raising the Dead: Mitochondrial Cardiolipin as a Key Target for Post-Cardiac Arrest Resusc..
Adaptations in Protein Expression and Regulated Activity Pyruvate Dehydrogenase Multienzym..
Shifts in ovine cardiopulmonary microRNA expression in late gestation and the perinatal pe..
Displaying the most recent project by Salvatore Pepe.
Displaying the 39 most recent scholarly works by Salvatore Pepe.
Remote ischaemic preconditioning modifies serum apolipoprotein D, met-enkephalin, adenosine, and nitric oxide in healthy young adults
Michelle W Ng, Julie Angerosa, Igor E Konstantinov, Michael M Cheung, Salvatore Pepe
Journal article | 2019 | Clinical and Experimental Pharmacology and Physiology
Remote ischemic preconditioning (RIPC) has been employed as a non-invasive protective intervention against myocardial ischemia-rep..
Postnatal inflammation following intrauterine inflammation exacerbates the development of atherosclerosis in ApoE(-/-) mice
Siroon Bekkering, Albert P Limawan, Maria U Nguyen, Lisa K Widiasmoko, Hui Lu, Salvatore Pepe, Michael M Cheung, Trevelyan R Menheniott, Megan J Wallace, David P Burgner, Timothy J Moss
Journal article | 2019 | Clinical Science
Pericardial adipose and aromatase: A new translational target for aging, obesity and arrhythmogenesis?
Gabriel B Bernasochi, Wah Chin Boon, Claire L Curl, Upasna Varma, Salvatore Pepe, Marianne Tare, Laura J Parry, Evdokia Dimitriadis, Stephen B Harrap, Chrishan J Nalliah, Jonathan M Kalman, Lea MD Delbridge, James R Bell
Journal article | 2017 | Journal of Molecular and Cellular Cardiology
Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats
Wendy TK Ip, Andrew McAlindon, Sarah E Miller, James R Bell, Claire L Curl, Catherine E Huggins, Kimberley M Mellor, Antonia JA Raaijmakers, Laura A Bienvenu, Peter L McLennan, Salvatore Pepe, Lea MD Delbridge
Journal article | 2016 | American Journal of Physiology-Heart and Circulatory Physiology
Posttranslational modifications and dysfunction of mitochondrial enzymes in human heart failure.
Freya L Sheeran, Salvatore Pepe
Journal article | 2016 | American Journal of Physiology-Endocrinology and Metabolism
Deficiency of energy supply is a major complication contributing to the syndrome of heart failure (HF). Because the concurrent act..
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, et al.
Journal article | 2016 | Autophagy
Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: A randomized controlled trial
Bryn O Jones, Salvatore Pepe, Freya L Sheeran, Susan Donath, Pollyanna Hardy, Lara Shekerdemian, Daniel J Penny, Ian McKenzie, Stephen Horton, Christian P Brizard, Yves d'Udekem, Igor E Konstantinov, Michael MH Cheung
Journal article | 2013 | Journal of Thoracic and Cardiovascular Surgery
Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium
Norman Y Liaw, Louise See Hoe, Freya L Sheeran, Jason N Peart, John P Headrick, Michael MH Cheung, Salvatore Pepe
Journal article | 2013 | American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Effect of Remote Ischemic Preconditioning on Phosphorylated Protein Signaling in Children Undergoing Tetralogy of Fallot Repair: A Randomized Controlled Trial
Salvatore Pepe, Norman Y Liaw, Michele Hepponstall, Freya L Sheeran, Matthew S Yong, Yves d'Udekem, Michael M Cheung, Igor E Konstantinov
Journal article | 2013 | Journal of the American Heart Association
Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A12-26
Chengxue Qin, Keith D Buxton, Salvatore Pepe, Anh H Cao, Kylie Venardos, Jane E Love, David M Kaye, Yuan H Yang, Eric F Morand, Rebecca H Ritchie
Journal article | 2013 | British Journal of Pharmacology
Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy
Bi-Xia Ke, Salvatore Pepe, David R Grubb, Jasper C Komen, Adrienne Laskowski, Felicity A Rodda, Belinda M Hardman, James J Pitt, Michael T Ryan, Michael Lazarou, Jane Koleff, Michael MH Cheung, Joseph J Smolich, David R Thorburn
Journal article | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Dietary fish oil is antihypertrophic but does not enhance postischemic myocardial function in female mice
Catherine E Huggins, Claire L Curl, Ruchi Patel, Peter L McLennan, Mandy L Theiss, Thierry Pedrazzini, Salvatore Pepe, Lea MD Delbridge
Journal article | 2009 | American Journal of Physiology - Heart and Circulatory Physiology
Letter to the Editor: H-1, C-13, and N-15 resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP
JD Swarbrick, S Buyya, D Gunawardana, JI Fletcher, K Branson, B Smith, S Pepe, A McLennan, KR Gayler, PR Gooley
Journal article | 2005 | Journal of Biomolecular NMR
Honours, Awards and Fellowships
International Society for Heart Research Distinguished Leader Award 2016
FCSANZ - Fellow of the Cardiac Society of Australia and New Zealand
FSGC - Fellow of the Society for Gerontological Cardiology
FAHA - Fellow of the American Heart Association
Paediatrics Royal Children'S Hospital
Membership Of The Perinatal Society Of Australia And New Zealand
Perinatal Society of Australia and New Zealand
American Physiological Society -Cardiovascular Section
American Physiological Society
Fellowship Of The Cardiac Society Of Australia And New Zealand
Cardiac Society of Australia and New Zealand
Fellowship Of American Heart Association
American Heart Association
International Society For Heart Research -Australasian Section
International Society for Heart Research
Flinders University of South Australia
University of South Australia
Doctor of Philosophy