Lyudmila Kostenko

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

Huimeng Wang, Lars Kjer-Nielsen, Mai Shi, Criselle D'Souza, Troi J Pediongco, Hanwei Cao, Lyudmila Kostenko, Xin Yi Lim, Sidonia BG Eckle, Bronwyn S Meehan, Tianyuan Zhu, Bingjie Wang, Zhe Zhao, Jeffrey YW Mak, David P Fairlie, Michele WL Teng, Jamie Rossjohn, Di Yu, Barbara Fazekas de St Groth, George Lovrecz, et al.

Journal article  |  2019  |  Science Immunology

Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthe..

IL-23 co-stimulation drives antigen-specific MAIT cell activation and enables vaccination against bacterial infection

H Wang, L Kjer-Nielsen, M Shi, DC Souza, T Pediongco, H Cao, L Kostenko, X Lim, S Eckle, B Meeha, B Wang, T Zhu, J Mak, D Fairlie, M Teng, J Rossjohn, D Yu, B Groth, J McCluskey, R Strugnell, et al.

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality

Timothy SC Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J Pediongco, Bronwyn S Meehan, Lyudmila Kostenko, Stephen J Turner, Alexandra J Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey

Journal article  |  2019  |  Cell Reports

Rapid Detection of HLA-B*57:01-Expressing Cells Using a Label-Free Interdigitated Electrode Biosensor Platform for Prevention of Abacavir Hypersensitivity in HIV Treatment

Jianxiong Chan, Gita V Soraya, Lauren Craig, Shah M Uddin, Marian Todaro, Duc H Huynh, Chathurika D Abeyrathne, Lyudmila Kostenko, James McCluskey, Efstratios Skafidas, Patrick Kwan

Journal article  |  2019  |  Sensors

Pre-treatment screening of individuals for human leukocyte antigens (HLA) HLA-B*57:01 is recommended for the prevention of life-th..

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Xiaoxiao Jia, Catarina F Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn S Meehan, Axel Kallies, Dale I Godfrey, Patrick C Reading, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

MAIT cells protect against pulmonary Legionella longbeachae infection

Huimeng Wang, Criselle D'Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J Pediongco, Sidonia BG Eckle, Bronwyn S Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Yoichiro Iwakura, Jennifer M Gunnersen, Andrew W Stent, Dale I Godfrey, Jamie Rossjohn, Glen P Westall, Lars Kjer-Nielsen, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nussing, Sneha Sant, Zhongfang Wang, Criselle D'Souza, Catarina Almeida, Lyudmila Kostenko, Sidonia BG Eckle, Bronwyn Meehan, Dale Godfrey, Patrick Reading, Alexandra Corbett, James McCluskey, et al.

Journal article  |  2018  |  Nature Communications

Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lung..

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

Criselle D'Souza, Troi Pediongco, Huimeng Wang, Jean-Pierre Y Scheerlinck, Lyudmila Kostenko, Robyn Esterbauer, Andrew W Stent, Sidonia BG Eckle, Bronwyn S Meehan, Richard A Strugnell, Hanwei Cao, Ligong Liu, Jeffrey YW Mak, George Lovrecz, Louis Lu, David P Fairlie, Jamie Rossjohn, James McCluskey, Alison L Every, Zhenjun Chen, et al.

Journal article  |  2018  |  The Journal of Immunology

The frequency of mucosal-associated invariant T cells is selectively increased in dermatitis herpetiformis

Jane Li, Rangsima Reantragoon, Lyudmila Kostenko, Alexandra Jane Corbett, George Varigos, Francis Robert Carbone

Journal article  |  2017  |  Australasian Journal of Dermatology

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

Andrew N Keller, Sidonia BG Eckle, Weijun Xu, Ligong Liu, Victoria A Hughes, Jeffrey YW Mak, Bronwyn S Meehan, Troi Pediongco, Richard W Birkinshaw, Zhenjun Chen, Huimeng Wang, Criselle D'Souza, Lars Kjer-Nielsen, Nicholas A Gherardin, Dale I Godfrey, Lyudmila Kostenko, Alexandra J Corbett, Anthony W Purcell, David P Fairlie, James McCluskey, et al.

Journal article  |  2017  |  Nature Immunology

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals

Z Chen, H Wang, C D'Souza, S Sun, L Kostenko, SBG Eckle, BS Meehan, DC Jackson, RA Strugnell, H Cao, N Wang, DP Fairlie, L Liu, DI Godfrey, J Rossjohn, J McCluskey, AJ Corbett

Journal article  |  2017  |  Mucosal Immunology

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

Sidonia BG Eckle, Richard W Birkinshaw, Lyudmila Kostenko, Alexandra J Corbett, Hamish EG McWilliam, Rangsima Reantragoon, Zhenjun Chen, Nicholas A Gherardin, Travis Beddoe, Ligong Liu, Onisha Patel, Bronwyn Meehan, David P Fairlie, Jose A Villadangos, Dale I Godfrey, Lars Kjer-Nielsen, James McCluskey, Jamie Rossjohn

Journal article  |  2014  |  JOURNAL OF EXPERIMENTAL MEDICINE

TCR Bias and Affinity Define Two Compartments of the CD1b-Glycolipid-Specific T Cell Repertoire

Ildiko Van Rhijn, Nicholas A Gherardin, Anne Kasmar, Wilco de Jager, Daniel G Pellicci, Lyudmila Kostenko, Li Lynn Tan, Mugdha Bhati, Stephanie Gras, Dale I Godfrey, Jamie Rossjohn, D Branch Moody

Journal article  |  2014  |  Journal of Immunology

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Rangsima Reantragoon, Alexandra J Corbett, Isaac G Sakala, Nicholas A Gherardin, John B Furness, Zhenjun Chen, Sidonia BG Eckle, Adam P Uldrich, Richard W Birkinshaw, Onisha Patel, Lyudmila Kostenko, Bronwyn Meehan, Katherine Kedzierska, Ligong Liu, David P Fairlie, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey, Lars Kjer-Nielsen

Journal article  |  2013  |  Journal of Experimental Medicine

MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen, Onisha Patel, Alexandra J Corbett, Jerome Le Nours, Bronwyn Meehan, Ligong Liu, Mugdha Bhati, Zhenjun Chen, Lyudmila Kostenko, Rangsima Reantragoon, Nicholas A Williamson, Anthony W Purcell, Nadine L Dudek, Malcolm J McConville, Richard AJ O'Hair, George N Khairallah, Dale I Godfrey, David P Fairlie, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Patricia T Illing, Julian P Vivian, Nadine L Dudek, Lyudmila Kostenko, Zhenjun Chen, Mandvi Bharadwaj, John J Miles, Lars Kjer-Nielsen, Stephanie Gras, Nicholas A Williamson, Scott R Burrows, Anthony W Purcell, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Nature

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Rangsima Reantragoon, Lars Kjer-Nielsen, Onisha Patel, Zhenjun Chen, Patricia T Illing, Mugdha Bhati, Lyudmila Kostenko, Mandvi Bharadwaj, Bronwyn Meehan, Ted H Hansen, Dale I Godfrey, Jamie Rossjohn, James McCluskey

Journal article  |  2012  |  Journal of Experimental Medicine

Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity

L Kostenko, L Kjer-Nielsen, I Nicholson, F Hudson, A Lucas, B Foley, K Chen, K Lynch, J Nguyen, AHB Wu, BD Tait, R Holdsworth, S Mallal, J Rossjohn, M Bharadwaj, J McCluskey

Journal article  |  2011  |  Tissue Antigens

Personalized medicine for HLA-associated drug-hypersensitivity reactions

Mandvi Bharadwaj, Patricia Illing, Lyudmila Kostenko

Journal article  |  2010  |  Personalized Medicine

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Scott R Burrows, Zhenjun Chen, Julia K Archbold, Fleur E Tynan, Travis Beddoe, Lars Kjer-Nielsen, John J Miles, Rajiv Khanna, Denis J Moss, Yu Chih Liu, Stephanie Gras, Lyudmila Kostenko, Rebekah M Brennan, Craig S Clements, Andrew G Brooks, Anthony W Purcell, James McCluskey, Jamie Rossjohn

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide

Nicholas G Walpole, Lars Kjer-Nielsen, Lyudmila Kostenko, James McCluskey, Andrew G Brooks, Jamie Rossjohn, Craig S Clements

Journal article  |  2010  |  Journal of Molecular Biology

Simple, rapid, cost effective screening assay for Abacavir Hypersensitivity Reaction (ABC HSR) by Flow Cytometry

KH Chen, JW Nguyen, DA Kane, DA Kane, HP Wang, L Kostenko, S Mallal, AH Wu

Conference Proceedings  |  2009  |  CLINICAL CHEMISTRY

Human leukocyte antigen class I-restricted activation of CD8( ) T cells provides the immunogenetic basis of a systemic drug hypersensitivity (vol 28, pg 822, 2008)

Diana Chessman, Lyudmila Kostenko, Tessa Lethborg, Anthony W Purcell, Nicholas A Williamson, Zhenjun Chen, Lars Kjer-Nielsen, Nicole A Mifsud, Brian D Tait, Rhonda Holdsworth, Coral Ann Almeida, David Nolan, Whitney A Macdonald, Julia K Archbold, Anthony D Kellerher, Debbie Marriott, Simon Mallal, Mandvi Bharadwaj, Jamie Rossjohn, James McCluskey

Journal article  |  2008  |  Immunity

Human leukocyte antigen class I-restricted activation of CD8( ) T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Diana Chessman, Lyudmila Kostenko, Tessa Lethborg, Anthony W Purcell, Nicholas A Williamson, Zhenjun Chen, Lars Kjer-Nielsen, Nicole A Mifsud, Brian D Tait, Rhonda Holdsworth, Coral Ann Almeida, David Nolan, Whitney A Macdonalds, Julia K Archbold, Anthony D Kellerher, Debbie Marriott, Simon Mallal, Mandvi Bharadwaj, Jamie Rossjohn, James McCluskey

Journal article  |  2008  |  Immunity

Abacavir hypersensitivity in HLA-B57-positive individuals with HIV infection is dependent upon the conventional MHC-I Ag presentation pathway

D Chessman, T Lethborg, L Kostenko, AW Purcell, L Kjer-Nielsen, NA Mifsud, BD Tait, R Holdsworth, CA Almeida, D Nolan, S Mallal, M Bharadwaj, J Rossjohn, J McCluskey

Conference Proceedings  |  2007  |  TISSUE ANTIGENS

T-cell receptor deformation of a bulged antigenic peptide enables MHC restricted recognition

FE Tynan, HH Reid, L Kjer-Nielsen, JJ Miles, MCJ Wilce, L Kostenko, NA Borg, NA Williamson, AW Purcell, SR Burrows, J McCluskey, J Rossjohn

Conference Proceedings  |  2007  |  TISSUE ANTIGENS

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Fleur E Tynan, Hugh H Reid, Lars Kjer-Nielsen, John J Miles, Matthew CJ Wilce, Lyudmila Kostenko, Natalie A Borg, Nicholas A Williamson, Travis Beddoe, Anthony W Purcell, Scott R Burrows, James McCluskey, Jamie Rossjohn

Journal article  |  2007  |  Nature Immunology

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition

L Kjer-Nielsen, NA Borg, DG Pellicci, T Beddoe, L Kostenko, CS Clements, NA Williamson, MJ Smyth, GS Besra, HH Reid, M Bharadwaj, DI Godfrey, J Rossjohn, J McCluskey

Journal article  |  2006  |  JOURNAL OF EXPERIMENTAL MEDICINE

The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt

CS Clements, L Kjer-Nielsen, L Kostenko, J McCluskey, J Rossjohn

Journal article  |  2006  |  Acta Crystallographica Section F - Structural Biology and Crystallization Communications

A super-bulged epitope and single amino acid polymorphism identify critical features for T cell recognition

FE Tynan, SR Burrows, AM Buckle, CS Clements, NA Borg, JJ Miles, T Beddoe, JC Whisstock, MC Wilce, SL Silins, JM Burrows, L Kjer-Nielsen, L Kostenko, AW Purcell, J McCluskey, J Rossjohn

Conference Proceedings  |  2005  |  Tissue Antigens

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

FE Tynan, SR Burrows, AM Buckle, CS Clements, NA Borg, JJ Miles, T Beddoe, JC Whisstock, MC Wilce, SL Silins, JM Burrows, L Kjer-Nielsen, L Kostenko, AW Purcell, J McCluskey, J Rossjohn

Journal article  |  2005  |  NATURE IMMUNOLOGY

Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface

CS Clements, L Kjer-Nielsen, L Kostenko, HL Hoare, MA Dunstone, E Moses, K Freed, AG Brooks, J Rossjohn, J McCluskey

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

The production and purification of the human T-cell receptors, the CD3 epsilon gamma and CD3 epsilon delta heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

MA Dunstone, LB Kjer-Nielsen, L Kostenko, AW Purcell, AG Brooks, J Rossjohn, J McCluskey

Journal article  |  2004  |  Acta Crystallographica Section D - Biological Crystallography

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3

L Kjer-Nielsen, MA Dunstone, L Kostenko, LK Ely, T Beddoe, NA Mifsud, AW Purcell, AG Brooks, J McCluskey, J Rossjohn

Journal article  |  2004  |  Proceedings of the National Academy of Sciences of the United States of America

The 2.1 angstrom crystal structure of the human T cell receptor CD3E Gamma heterodimer complexed to the therapeutic MAB OKT3

L Kjer-Nielsen, MA Dunstone, L Kostenko, LK Ely, T Beddoe, N Mifsud, AW Purcell, AG Brooks, J Rossjohn, J McCluskey

Conference Proceedings  |  2004  |  GENES AND IMMUNITY