Matt Bird

Leigh Syndrome: Neuropathology and Pathogenesis

Nicole J Lake, Matthew J Bird, Pirjo Isohanni, Anders Paetau

Journal article  |  2015  |  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Leigh syndrome (LS) is the most common pediatric presentation of a defined mitochondrial disease. This progressive encephalopathy ..

Functional Characterization of Friedreich Ataxia iPS-Derived Neuronal Progenitors and Their Integration in the Adult Brain

Matthew J Bird, Karina Needham, Ann E Frazier, Jorien van Rooijen, Jessie Leung, Shelley Hough, Mark Denham, Matthew E Thornton, Clare L Parish, Bryony A Nayagam, Martin Pera, David R Thorburn, Lachlan H Thompson, Mirella Dottori

Journal article  |  2014  |  PLOS ONE

Friedreich ataxia (FRDA) is an autosomal recessive disease characterised by neurodegeneration and cardiomyopathy that is caused by..

Modelling biochemical features of mitochondrial neuropathology

Matthew J Bird, David R Thorburn, Ann E Frazier

Journal article  |  2014  |  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

BACKGROUND: The neuropathology of mitochondrial disease is well characterised. However, pathophysiological mechanisms at the level..

Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4 fky fky mouse

Matthew J Bird, Xiaonan W Wijeyeratne, Jasper C Komen, Adrienne Laskowski, Michael T Ryan, David R Thorburn, Ann E Frazier

Journal article  |  2014  |  BIOSCIENCE REPORTS

Mitochondrial dysfunction causes a range of early-onset neurological diseases and contributes to neurodegenerative conditions. The..