Barbara Fam

Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Yann W Yap, Patricia M Rusu, Andrea Y Chan, Barbara C Fam, Andreas Jungmann, Samantha M Solon-Biet, Christopher K Barlow, Darren J Creek, Cheng Huang, Ralf B Schittenhelm, Bruce Morgan, Dieter Schmoll, Bente Kiens, Matthew DW Piper, Mathias Heikenwaelder, Stephen J Simpson, Stefan Broer, Sofianos Andrikopoulos, Oliver J Mueller, Adam J Rose

Journal article  |  2020  |  Nature Communications

Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this resp..

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass

Patricia K Russell, Salvatore Mangiafico, Barbara C Fam, Michele V Clarke, Evelyn S Marin, Sofianos Andrikopoulos, Kristine M Wiren, Jeffrey D Zajac, Rachel A Davey

Journal article  |  2018  |  Journal of Endocrinology

Androgens act via the Androgen Receptor (AR) in progenitor cells residing within the bone marrow to reduce fat mass in male mice

Rachel A Davey, Patricia K Russell, Barbara C Fam, Salvatore Mangiafico, Michele V Clarke, Sof Andrikopoulos, Kristine M Wiren, Jeffrey D Zajac

Conference Proceedings  |  2017  |  CLINICAL ENDOCRINOLOGY

Muscle-specific androgen receptor deletion shows limited actions in myoblasts but not in myofibers in different muscles in vivo

Kesha Rana, Maria WS Chiu, Patricia K Russell, Jarrod P Skinner, Nicole KL Lee, Barbara C Fam, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2016  |  Journal of Molecular Endocrinology

Identification of ABCC8 as a contributory gene to impaired early-phase insulin secretion in NZO mice

Sofianos Andrikopoulos, Barbara C Fam, Anita Holdsworth, Sherley Visinoni, Zheng Ruan, Maria Stathopoulos, Anne W Thorburn, Christos N Joannides, Michael Cancilla, Lois Balmer, Joseph Proietto, Grant Morahan

Journal article  |  2016  |  Journal of Endocrinology

Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice

Barbara C Fam, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2015  |  JOURNAL OF ENDOCRINOLOGY

High-Fat-Fed Obese Glutathione Peroxidase 1-Deficient Mice Exhibit Defective Insulin Secretion but Protection from Hepatic Steatosis and Liver Damage

Troy L Merry, Melanie Tran, Maria Stathopoulos, Florian Wiede, Barbara Christianne Fam, Garron T Dodd, Iain Clarke, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2014  |  Antioxidants & Redox Signaling

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

CE Hagberg, A Mehlem, A Falkevall, L Muhl, BC Fam, H Ortsäter, P Scotney, D Nyqvist, E Samén, L Lu, S Stone-Elander, J Proietto, S Andrikopoulos, A Sjöholm, A Nash, U Eriksson

Journal article  |  2014  |  Diabetes Technology & Therapeutics

DICARBA MODIFICATION OF INSULIN PROVIDES GREATER GLUCOSE LOWERING EFFECT UNDER NORMAL AND INSULIN RESISTANT STATES, WHILE AVOIDING THE MITOGENIC ACTIVITY OF UNMODIFIED INSULIN

S Andrikopoulos, B van Lierop, BC Fam, B Forbes, A Robinson

Journal article  |  2013  |  DIABETES TECHNOLOGY & THERAPEUTICS

Response to comment on: Visinoni et al. The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity. Diabetes 2012;61:1122-1132

BC Fam, CN Joannides, S Andrikopoulos

Journal article  |  2012  |  Diabetes

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

Carolina E Hagberg, Annika Mehlem, Annelie Falkevall, Lars Muhl, Barbara C Fam, Henrik Ortsater, Pierre Scotney, Daniel Nyqvist, Erik Samen, Li Lu, Sharon Stone-Elander, Joseph Proietto, Sofianos Andrikopoulos, Ake Sjoholm, Andrew Nash, Ulf Eriksson

Journal article  |  2012  |  Nature

The liver: Key in regulating appetite and body weight.

Barbara C Fam, Christos N Joannides, Sofianos Andrikopoulos

Journal article  |  2012  |  Adipocyte

Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat i..

Normal muscle glucose uptake in mice deficient in muscle GLUT4

Barbara C Fam, Laura J Rose, Rebecca Sgambellone, Zheng Ruan, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2012  |  Journal of Endocrinology

The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity

Sherley Visinoni, Nurul Fathiah Izzati Khalid, Christos N Joannides, Arthur Shulkes, Mildred Yim, Jon Whitehead, Tony Tiganis, Benjamin J Lamont, Jenny M Favaloro, Joseph Proietto, Sofianos Andrikopoulos, Barbara C Fam

Journal article  |  2012  |  DIABETES

Response to comment on: Visinoni et al. the role of liver fuctose-1,6-Bisphosphatase in regulating appetite and adiposity. diabetes 2012;61:1122-1132

BC Fam, C JOANNIDES, S Andrikopoulos

Journal article  |  2012  |  Diabetes

Increased adiposity in DNA binding-dependent androgen receptor knockout male mice associated with decreased voluntary activity and not insulin resistance

Kesha Rana, Barbara C Fam, Michele V Clarke, Tammy PS Pang, Jeffrey D Zajac, Helen E MacLean

Journal article  |  2011  |  American Journal of Physiology - Endocrinology and Metabolism

Deficiency in Interferon-gamma Results in Reduced Body Weight and Better Glucose Tolerance in Mice

Nicole Wong, Barbara C Fam, Gitta R Cempako, Gregory R Steinberg, Ken Walder, Thomas W Kay, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2011  |  Endocrinology

A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion

Salvatore P Mangiafico, Shueh H Lim, Sandra Neoh, Helene Massinet, Christos N Joannides, Joseph Proietto, Sofianos Andrikopoulos, Barbara C Fam

Journal article  |  2011  |  Journal of Endocrinology

ALTERED SYMPATHOINHIBITORY RESPONSES TO GASTRIC HORMONES IN OBESITY: POTENTIAL ROLE IN OBESITY-RELATED HYPERTENSION

Daniela M Sartor, Jackie M-Y How, Talia Pumpa, Barbara C Fam, Anthony JM Verberne

Conference Proceedings  |  2011  |  HYPERTENSION

High-fat diet is associated with blunted splanchnic sympathoinhibitory responses to gastric leptin and cholecystokinin: implications for circulatory control

Jackie MY How, Barbara C Fam, Anthony JM Verberne, Daniela M Sartor

Journal article  |  2011  |  American Journal of Physiology - Heart and Circulatory Physiology

Liver-Specific Suppressor of Cytokine Signaling-3 Deletion in Mice Enhances Hepatic Insulin Sensitivity and Lipogenesis Resulting in Fatty Liver and Obesity

Nirupa Sachithanandan, Barbara C Fam, Stacey Fynch, Nicolas Dzamko, Matthew J Watt, Sam Wormald, Jane Honeyman, Sandra Galic, Joseph Proietto, Sofianos Andrikopoulos, Andrea L Hevener, Thomas WH Kay, Gregory R Steinberg

Journal article  |  2010  |  Hepatology

T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis

Atsushi Fukushima, Kim Loh, Sandra Galic, Barbara Fam, Ben Shields, Florian Wiede, Michel L Tremblay, Matthew J Watt, Sofianos Andrikopoulos, Tony Tiganis

Journal article  |  2010  |  Diabetes

Evaluating the glucose tolerance test in mice

Sofianos Andrikopoulos, Amy R Blair, Nadia Deluca, Barbara C Fam, Joseph Proietto

Journal article  |  2008  |  American Journal of Physiology - Endocrinology and Metabolism

Increased glucose production in mice overexpressing human fructose-1,6-bisphosphatase in the liver

Sherley Visinoni, Barbara C Fam, Amy Blair, Christian Rantzau, Benjamin J Lamont, Russell Bouwman, Matthew J Watt, Joseph Proietto, Jenny M Favaloro, Sofianos Andrikopoulos

Journal article  |  2008  |  American Journal of Physiology - Endocrinology and Metabolism

Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion - A new mechanism for fat-induced impairment of beta-cell function

Melkam Kebede, Jenny Favaloro, Jenny E Gunton, D Ross Laybutt, Margaret Shaw, Nicole Wong, Barbara C Fam, Kathryn Aston-Mourney, Christian Rantzau, Anthony Zulli, Joseph Proietto, Sofianos Andrikopoulos

Journal article  |  2008  |  Diabetes

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

BE Needham, ME Wlodek, GD Ciccotosto, BC Fam, CL Masters, J Proietto, S Andrikopoulos, R Cappai

Journal article  |  2008  |  Journal of Pathology

Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion

M KEBEDE, J FAVALORO, JEG GUNTON, DRL LAYBUTT, M SHAW, N WONG, B FAM, K ASTON-MOURNEY, C RANTZAU, A ZULLI, J PROIETTO, S ANDRIKOPOULOS

Journal article  |  2008  |  Diabetes

Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes

K Aston-Mourney, N Wong, M Kebede, S Zraika, L Balmer, JM McMahon, BC Fam, J Favaloro, J Proietto, G Morahan, S Andrikopoulos

Journal article  |  2007  |  Diabetologia

Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes

K Aston-Mourney, N Wong, M Kebede, S Zraika, L Balmer, JM McMahon, BC Fam, J Favaloro, J Proietto, G Morahan, S Andrikopoulos

Journal article  |  2007  |  Diabetologia

Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity

BC Fam, MJ Morris, MJ Hansen, M Kebede, S Andrikopoulos, J Proietto, AW Thorburn

Journal article  |  2007  |  Diabetes, Obesity and Metabolism

Modulation of central leptin sensitivity and energy balance in a rat model of diet-induced obesity

BC Fam, MJ Morris, MJ Hansen, M Kebede, S Andrikopoulos, J Proietto, AW Thorburn

Journal article  |  2007  |  Diabetes Obesity & Metabolism

Transgenic mice overexpressing human fructose-1,6-bisphosphatase in the liver develop glucose intolerance in response to a high fat diet

S Visinoni, BC Fam, A Blair, C Rantzau, BJ Lamont, R Bouwman, J Favaloro, J Proietto, S Andrikopoulos

Conference Proceedings  |  2007  |  DIABETOLOGIA

The New Zealand Obese Mouse: Polygenic model of obesity, glucose intolerance, and the metabolic syndrome

BC Fam, S Andrikopoulos

Book Chapter  |  2007

Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

Gregory R Steinberg, Belinda J Michell, Bryce JW van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Gorgun, David Carling, Gokhan S Hotamisligil, Mark A Febbraio, Thomas W Kay, Bruce E Kemp

Journal article  |  2006  |  Cell Metabolism

Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice

Gregory R Steinberg, Matthew J Watt, Barbara C Fam, Joseph Proietto, Sofianos Andrikopoulos, Andrew M Allen, Mark A Febbraio, Bruce E Kemp

Journal article  |  2006  |  Endocrinology

Expression of Human Fructose-1,6-Bisphosphatase in the Liver of Transgenic Mice Results in Increased Glycerol Gluconeogenesis

Benjamin J Lamont, Sherley Visinoni, Barbara C Fam, Melkam Kebede, Blaise Weinrich, Stavroula Papapostolou, Helene Massinet, Joseph Proietto, Jenny Favaloro, Sofianos Andrikopoulos

Journal article  |  2006  |  Endocrinology

Expression of human fructose-1,6-bisphosphatase in the liver of transgenic mice results in increased glycerol gluconeogenesis

Benjamin J Lamont, Sherley Visinoni, Barbara C Fam, Melkam Kebede, Blaise Weinrich, Stavroula Papapostolou, Helene Massinet, Joseph Proietto, Jenny Favaloro, Sofianos Andrikopoulos

Journal article  |  2006  |  Endocrinology

Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet

S Andrikopoulos, CM Massa, K Aston-Mourney, A Funkat, BC Fam, RL Hull, SE Kahn, J Proietto

Journal article  |  2005  |  Journal of Endocrinology

Socs1 deficiency enhances hepatic insulin signaling

E Jamieson, MMW Chong, GR Steinberg, V Jovanovska, BC Fam, DVR Bullen, Y Chen, BE Kemp, J Proietto, TWH Kay, S Andrikopoulos

Journal article  |  2005  |  Journal of Biological Chemistry

Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment

MA Heffernan, AW Thorburn, B Fam, R Summers, B Conway-Campbell, MJ Waters, FM Ng

Journal article  |  2001  |  International Journal of Obesity

Novel anti-obesity drugs.

J Proietto, BC Fam, DA Ainslie, AW Thorburn

Journal article  |  2000  |  Expert Opinion on Investigational Drugs

There is increasing evidence that body weight is homeostatically regulated and that in obesity this regulation maintains weight at..

Short-term, high-fat diets lower circulating leptin concentrations in rats.

DA Ainslie, J Proietto, BC Fam, AW Thorburn

Journal article  |  2000  |  The American Journal of Clinical Nutrition

BACKGROUND: Leptin is produced in proportion to body fat mass and can act on the brain to induce satiety and regulate adipose tiss..

Leptin in the pathophysiology of human obesity and the clinical potential of leptin-based therapy

AW Thorburn, DA Ainslie, B Fam, J Proietto

Journal article  |  2000  |  BioDrugs