Brendan Ansell

Spatial distribution of metabolites in the retina and its relevance to studies of metabolic retinal disorders.

Roberto Bonelli, Sasha M Woods, Sarah Lockwood, Paul N Bishop, Kamron N Khan, Melanie Bahlo, Brendan RE Ansell, Marcus Fruttiger

Journal article  |  2023  |  Metabolomics

INTRODUCTION: The primate retina has evolved regional specialisations for specific visual functions. The macula is specialised tow..

VIVID A Web Application for Variant Interpretation and Visualization in Multi-dimensional Analyses

Swapnil Tichkule, Yoochan Myung, Myo T Naung, Brendan RE Ansell, Andrew J Guy, Namrata Srivastava, Somya Mehra, Simone M Caccio, Ivo Mueller, Alyssa E Barry, Cock van Oosterhout, Bernard Pope, David B Ascher, Aaron R Jex

Journal article  |  2022  |  MOLECULAR BIOLOGY AND EVOLUTION

Large-scale comparative genomics- and population genetic studies generate enormous amounts of polymorphism data in the form of DNA..

Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

Samantha Bannister, Bowon Kim, Jorge Dominguez-Andres, Gizem Kilic, Brendan RE Ansell, Melanie R Neeland, Simone JCFM Moorlag, Vasiliki Matzaraki, Amanda Vlahos, Rebecca Shepherd, Susie Germano, Melanie Bahlo, Nicole L Messina, Richard Saffery, Mihai G Netea, Nigel Curtis, Boris Novakovic

Journal article  |  2022  |  SCIENCE ADVANCES

Trained immunity describes the capacity of innate immune cells to develop heterologous memory in response to certain exogenous exp..

Heterozygous PNPT1 Variants Cause Spinocerebellar Ataxia Type 25

Mathieu Barbier, Melanie Bahlo, Alessandra Pennisi, Maxime Jacoupy, Rick M Tankard, Claire Ewenczyk, Kayli C Davies, Patricia Lino-Coulon, Claire Colace, Haloom Rafehi, Nicolas Auger, Brendan RE Ansell, Ivo van der Stelt, Katherine B Howell, Marie Coutelier, David J Amor, Emeline Mundwiller, Lena Guillot-Noel, Elsdon Storey, RJ McKinlay Gardner, et al.

Journal article  |  2022  |  ANNALS OF NEUROLOGY

OBJECTIVE: Dominant spinocerebellar ataxias (SCA) are characterized by genetic heterogeneity. Some mapped and named loci remain wi..

Genetics of reticular pseudodrusen in age-related macular degeneration

Samaneh Farashi, Zhichao Wu, Carla J Abbott, Alice Pebay, Erica L Fletcher, Robyn H Guymer, Melanie Bahlo, Brendan RE Ansell

Journal article  |  2022  |  TRENDS IN GENETICS

Reticular pseudodrusen (RPD) are subretinal deposits that, when observed with age-related macular degeneration (AMD), form a disti..

Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal expanded transporter repertoire and duplication of entire chromosome ends including subtelomeric regions

Rodrigo P Baptista, Yiran Li, Adam Sateriale, Mandy J Sanders, Karen L Brooks, Alan Tracey, Brendan RE Ansell, Aaron R Jex, Garrett W Cooper, Ethan D Smith, Rui Xiao, Jennifer E Dumaine, Peter Georgeson, Bernard J Pope, Matthew Berriman, Boris Striepen, James A Cotton, Jessica C Kissinger

Journal article  |  2022  |  GENOME RESEARCH

Cryptosporidiosis is a leading cause of waterborne diarrheal disease globally and an important contributor to mortality in infants..

A survey of RNA editing at single-cell resolution links interneurons to schizophrenia and autism

Brendan Robert E Ansell, Simon N Thomas, Roberto Bonelli, Jacob E Munro, Saskia Freytag, Melanie Bahlo

Journal article  |  2021  |  RNA

Conversion of adenosine to inosine in RNA by ADAR enzymes, termed "RNA editing," is essential for healthy brain development. Editi..

Multimodal regulation of encystation in Giardia duodenalis revealed by deep proteomics

Balu Balan, Samantha J Emery-Corbin, Jarrod J Sandow, Brendan Robert E Ansell, Swapnil Tichkule, Andrew Webb, Staffan G Svard, Aaron R Jex

Journal article  |  2021  |  INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cyst formation in the parasitic protist Giardia duodenalis is critical to its transmission. Existing proteomic data quantifies onl..

Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder (vol 4, 274, 2021)

Roberto Bonelli, Victoria E Jackson, Aravind Prasad, Jacob E Munro, Samaneh Farashi, Tjebo FC Heeren, Nikolas Pontikos, Lea Scheppke, Martin Friedlander, Catherine A Egan, Rando Allikmets, Brendan RE Ansell, Melanie Bahlo

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01972-y

Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression

Roberto Bonelli, Brendan RE Ansell, Luca Lotta, Thomas Scerri, Traci E Clemons, Irene Leung, Tunde Peto, Alan C Bird, Ferenc B Sallo, Claudia Langenberg, Melanie Bahlo

Journal article  |  2021  |  GENOME MEDICINE

BACKGROUND: Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid w..