Suzanne Cory

Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis

Vu Nguyen Hai, Cassandra J Vandenberg, Ashley P Ng, Mikara R Robati, Natasha S Anstee, Joel Rimes, Edwin D Hawkins, Suzanne Cory

Journal article  |  2020  |  BLOOD

Deregulated overexpression of MYC is implicated in the development and malignant progression of most (∼70%) human tumors. MYC driv..

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

Natasha S Anstee, Rebecca A Bilardi, Ashley P Ng, Zhen Xu, Mikara Robati, Cassandra J Vandenberg, Suzanne Cory

Journal article  |  2019  |  CELL DEATH AND DIFFERENTIATION

Many acute myeloid leukaemias (AMLs) express high levels of BCL-2 and MCL-1, especially after therapy. To test the impact of these..

A Joint Odyssey into Cancer Genetics

Suzanne Cory, Jerry M Adams

Journal article  |  2019  |  ANNUAL REVIEW OF CANCER BIOLOGY, VOL 3

The war on cancer that began some 40 years ago with the discovery of oncogenes is starting to be won. We feel fortunate to have co..

Phosphatidylserine hide-and-seek

Suzanne Cory

Journal article  |  2018  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis

Selma Tuzlak, Manuel D Haschka, Anna-Maria Mokina, Thomas Ruelicke, Suzanne Cory, Verena Labi, Andreas Villunger

Journal article  |  2018  |  FEBS JOURNAL

Overexpression of BCLX and BFL1/A1 has been reported in various human malignancies and is associated with poor prognosis and drug ..

Anti-apoptotic A1 is not essential for lymphoma development in E mu-Myc mice but helps sustain transplanted E mu-Myc tumour cells

Mark Mensink, Natasha S Anstee, Mikara Robati, Robyn L Schenk, Marco J Herold, Suzanne Cory, Cassandra J Vandenberg

Journal article  |  2018  |  CELL DEATH AND DIFFERENTIATION

The transcription factor c-MYC regulates a multiplicity of genes involved in cellular growth, proliferation, metabolism and DNA da..

The BCL-2 arbiters of apoptosis and their growing role as cancer targets

Jerry M Adams, Suzanne Cory

Journal article  |  2018  |  CELL DEATH AND DIFFERENTIATION

Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepeni..

Mnt modulates Myc-driven lymphomagenesis

Kirsteen J Campbell, Cassandra J Vandenberg, Natasha S Anstee, Peter J Hurlin, Suzanne Cory

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

The transcriptional represser Mnt is a functional antagonist of the proto-oncoprotein Myc. Both Mnt and Myc utilise Max as an obli..

Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo

Emma M Carrington, Yifan Zhan, Jamie L Brady, Jian-Guo Zhang, Robyn M Sutherland, Natasha S Anstee, Robyn L Schenk, Ingela B Vikstrom, Rebecca B Delconte, David Segal, Nicholas D Huntington, Philippe Bouillet, David M Tarlinton, David CS Huang, Andreas Strasser, Suzanne Cory, Marco J Herold, Andrew M Lew

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family m..

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice

Natasha S Anstee, Cassandra J Vandenberg, Kirsteen J Campbell, Peter D Hughes, Lorraine A O'Reilly, Suzanne Cory

Journal article  |  2017  |  CELL DEATH AND DIFFERENTIATION

Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there ..