Tobias D. Merson

High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS

YL Xing, J Poh, BHA Chuang, K Moradi, S Mitew, WD Richardson, TJ Kilpatrick, Y Osanai, TD Merson

Journal article  |  2023  |  Cell Reports Methods

Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) by targeted cell ablation in the rodent CNS have limitatio..

Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage

Jiawei Huang, Kin U Pong, Fuyuan Yang, Zeyuan Ji, Jiacheng Lin, Zhihui Weng, Lai Ling Tsang, Tobias D Merson, Ye Chun Ruan, Chao Wan, Gang Li, Xiaohua Jiang

Journal article  |  2022  |  THERANOSTICS

Aims: Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in neonates and infants. Mesenchymal stromal..

NogoA-expressing astrocytes limit peripheral macrophage infiltration after ischemic brain injury in primates

Anthony G Boghdadi, Joshua Spurrier, Leon Teo, Mingfeng Li, Mario Skarica, Benjamin Cao, William C Kwan, Tobias D Merson, Susan K Nilsson, Nenad Sestan, Stephen M Strittmatter, James A Bourne

Journal article  |  2021  |  NATURE COMMUNICATIONS

Astrocytes play critical roles after brain injury, but their precise function is poorly defined. Utilizing single-nuclei transcrip..

Primate-specific response of astrocytes to stroke limits peripheral macrophage infiltration

Anthony G Boghdadi, Joshua Spurrier, Leon Teo, Mingfeng Li, Mario Skarica, Benjamin Cao, William Kwan, Tobias D Merson, Susie K Nilsson, Nenad Sestan, Stephen M Strittmatter, James A Bourne

Journal article  |  2020

Reactive astrocytes play critical roles after brain injuries but their precise function in stroke is not well defined. Here, we ut..

Aging of the ventricular-subventricular zone neural stem cell niche

Tobias D Merson

Book Chapter  |  2020

Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling beta-Peptide Hydrogel

Sepideh Motamed, Mark P Del Borgo, Kun Zhou, Ketav Kulkarni, Peter J Crack, Tobias D Merson, Marie-Isabel Aguilar, David Finkelstein, John S Forsythe

Journal article  |  2019  |  FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

Neural stem cells, which are confined in localised niches are unable to repair large brain lesions because of an inability to migr..

EGF and HB-EGF infusion into the demyelinated adult mouse brain potentiates the regeneration of oligodendrocytes from neural precursor cells originating in the subventricular zone

K Moradi, S Mitew, YL Xing, TD Merson

Conference Proceedings  |  2019  |  GLIA

A tractable preclinical model of optic nerve demyelination

Peter van Wijngaarden, Joseph P Paul, Vickie Hoi Ying Wong, Bang V Bui, Tobias D Merson

Conference Proceedings  |  2019  |  Investigative Ophthalmology and Visual Science

Purpose : Progress in the development of therapies to enhance remyelination in demyelinating diseases has been hampered by a lack ..

Oligodendroglial responses to neuronal activity in the developing and adult CNS

B Emery, S Mitew, I Gobius, LR Fenlon, S McDougall, D Hawkes, Y Lulu Xing, H Bujalka, AL Gundlach, LJ Richards, TJ Kilpatrick, T Merson, A Foster

Conference Proceedings  |  2019  |  GLIA

Regeneration of oligodendrocyte progenitor cells following pharmogenetic ablation in the adult central nervous system

YL Xing, B Chuang, S Mitew, TD Merson

Conference Proceedings  |  2019  |  GLIA