Shane Liddelow

THE CHOROID PLEXUS: A MISSING LINK IN OUR UNDERSTANDING OF BRAIN DEVELOPMENT AND FUNCTION

Norman R Saunders, Katarzyna M Dziegielewska, Ryann M Fame, Maria K Lehtinen, Shane A Liddelow

Journal article  |  2023  |  PHYSIOLOGICAL REVIEWS

Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier, despite a much longer history. This r..

Multi-modal sequencing analysis of astrocytes in human and mouse reveals strategically positioned novel reactive sub-states

P Hasel, M O'Dea, JS Sadick, SA Liddelow

Journal article  |  2022  |  Alzheimer's and Dementia

Background: Astrocytes can have helpful or harmful effects on neuron health and brain function in disease. While they normally pro..

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease

Emilie L Castranio, Philip Hasel, Jean-Vianney Haure-Mirande, Angie V Ramirez Jimenez, B Wade Hamilton, Rachel D Kim, Charles G Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A Liddelow, Michelle E Ehrlich

Journal article  |  2022  |  ALZHEIMERS & DEMENTIA

INTRODUCTION: The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphory..

Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis

Haley E Titus, Huan Xu, Andrew P Robinson, Priyam A Patel, Yanan Chen, Damiano Fantini, Valerie Eaton, Molly Karl, Eric D Garrison, Indigo VL Rose, Ming Yi Chiang, Joseph R Podojil, Roumen Balabanov, Shane A Liddelow, Robert H Miller, Brian Popko, Stephen D Miller

Journal article  |  2022  |  GLIA

Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neu..

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.

Anthony Fernández-Castañeda, Peiwen Lu, Anna C Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Michael R O'Dea, Selena Dutton, Kiarash Shamardani, Kamsi Nwangwu, Rebecca Mancusi, Belgin Yalçın, Kathryn R Taylor, Lehi Acosta-Alvarez, Karen Malacon, Michael B Keough, Lijun Ni, Pamelyn J Woo, Daniel Contreras-Esquivel, Angus Martin Shaw Toland, et al.

Journal article  |  2022  |  Cell

COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a..

Abstract LB052: Melanoma-secreted amyloid beta suppresses neuroinflammation and promotes brain metastasis

Kevin Kleffman, Grace Levinson, Indigo V Rose, Lili Blumenberg, Sorin A Shadaloey, Avantika Dhabaria, Eitan Wong, Francisco Galán-Echevarría, Alcida Karz, Diana Argibay, Richard Von-Itter, Alfredo Floristán, Gillian Baptiste, Nicole Eskow, James Tranos, Jenny Chen, Eleazar C Vega Saenz de Miera, Melissa Call, Robert Rogers, George Jour, et al.

Journal article  |  2022  |  Cancer Research

Abstract Brain metastasis is a significant cause of morbidity and mortality in multiple cancer types and represents..

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease.

Jessica S Sadick, Michael R O'Dea, Philip Hasel, Taitea Dykstra, Arline Faustin, Shane A Liddelow

Journal article  |  2022  |  Neuron

Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in neuronal function, such as reduced synap..

Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.

Kevin Kleffman, Grace Levinson, Indigo VL Rose, Lili M Blumenberg, Sorin AA Shadaloey, Avantika Dhabaria, Eitan Wong, Francisco Galán-Echevarría, Alcida Karz, Diana Argibay, Richard Von Itter, Alfredo Floristán, Gillian Baptiste, Nicole M Eskow, James A Tranos, Jenny Chen, Eleazar C Vega Y Saenz de Miera, Melissa Call, Robert Rogers, George Jour, et al.

Journal article  |  2022  |  Cancer Discov

UNLABELLED: Brain metastasis is a significant cause of morbidity and mortality in multiple cancer types and represents an unmet cl..

Solving neurodegeneration: common mechanisms and strategies for new treatments.

Lauren K Wareham, Shane A Liddelow, Sally Temple, Larry I Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A Davis, Karthik Shekhar, Anna La Torre, David C Chan, M Valeria Canto-Soler, John G Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E Bovenkamp, et al.

Journal article  |  2022  |  Mol Neurodegener

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or..

Single-cell delineation of lineage and genetic identity in the mouse brain.

Rachel C Bandler, Ilaria Vitali, Ryan N Delgado, May C Ho, Elena Dvoretskova, Josue S Ibarra Molinas, Paul W Frazel, Maesoumeh Mohammadkhani, Robert Machold, Sophia Maedler, Shane A Liddelow, Tomasz J Nowakowski, Gord Fishell, Christian Mayer

Journal article  |  2022  |  Nature

During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cel..