Shane Liddelow

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes.

Lilianne Barbar, Tanya Jain, Matthew Zimmer, Ilya Kruglikov, Jessica S Sadick, Minghui Wang, Kriti Kalpana, Indigo VL Rose, Suzanne R Burstein, Tomasz Rusielewicz, Madhura Nijsure, Kevin A Guttenplan, Angelique di Domenico, Gist Croft, Bin Zhang, Hiroko Nobuta, Jean M Hébert, Shane A Liddelow, Valentina Fossati

Journal article  |  2020  |  Neuron

New methods for investigating human astrocytes are urgently needed, given their critical role in the central nervous system. Here ..

Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues

Jessica S Sadick, Lorin A Crawford, Harry C Cramer, Christian Franck, Shane A Liddelow, Eric M Darling

Journal article  |  2020  |  Annals of Biomedical Engineering

Here we demonstrate a technique to generate proteomic signatures of specific cell types within heterogeneous populations. While ou..

Don't you know that you're ToxSeq?

Shane A Liddelow

Journal article  |  2020  |  Nature Immunology

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

Brian Lananna, Collin J Nadarajah, Mariko Izumo, Michelle R Cedeno, David D Xiong, Julie Dimitry, Chak Foon Tso, Celia A McKee, Percy Griffin, Patrick W Sheehan, Jeffery A Haspel, Ben A Barres, Shane A Liddelow, Joseph S Takahashi, Ilia N Karatsoreos, Erik S Musiek

Journal article  |  2018  |  Cell Reports

Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poor..

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.

Seung Pil Yun, Tae-In Kam, Nikhil Panicker, SangMin Kim, Yumin Oh, Jong-Sung Park, Seung-Hwan Kwon, Yong Joo Park, Senthilkumar S Karuppagounder, Hyejin Park, Sangjune Kim, Nayeon Oh, Nayoung Alice Kim, Saebom Lee, Saurav Brahmachari, Xiaobo Mao, Jun Hee Lee, Manoj Kumar, Daniel An, Sung-Ung Kang, et al.

Journal article  |  2018  |  Nature Medicine

Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of ..

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg, Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roth, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, et al.

Journal article  |  2017  |  Nature

APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-β pathology relative to..

Neurobiology: Diversity reaches the stars.

Laura E Clarke, Shane A Liddelow

Journal article  |  2017  |  Nature

The Neuroscientist Comments: Astrocytes: heroes or hooligans?

SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer

Journal article  |  2017  |  The Neuroscientist

Reactive Astrocytes: Production, Function, and Therapeutic Potential.

Shane A Liddelow, Ben A Barres

Journal article  |  2017  |  Immunity

Astrocytes constitute approximately 30% of the cells in the mammalian central nervous system (CNS). They are integral to brain and..

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A Liddelow, Kevin A Guttenplan, Laura EC Larke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Munch, Won-Suk Chung, Todd C Peterson, Daniel K Wilton, Arnaud Frouin, Brooke A Napier, Nikhil Panicker, Manoj Kumar, Marion S Buckwalter, David H Rowitch, Valina L Dawson, Ted M Dawson, Beth Stevens, et al.

Journal article  |  2017  |  Nature

Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but their role is poorly understood. ..