Nancy Wang is a Postdoctoral Research Fellow at the University of Melbourne. Her main research interest is to understand the mechanism of cellular immunity that confers protection against bacterial infections, including those caused by pathogenic serovars of Salmonella enterica (e.g.
Typhi and Typhimurium), Klebsiella pneumoniae and Listeria monocytogenes. She has recently received a Discovery Project grant from the Australian Research Council (ARC) for defining antigen selection mechanisms that control T cell immunity against bacteria.
Nancy completed her PhD training in Dr Tom Brodnicki’s laboratory at St Vincent’s Institute of Medical Research in Melbourne (2013). The PhD project bridged genetics and immunology and led to the discovery of a novel genetic switch point with dual roles in bacterial infection and autoimmune diabetes. Since then, she has been a postdoctoral researcher in Prof Dick Strugnell’s laboratory at the Department of Microbiology and Immunology, one of the partners at the Peter Doherty Institute for Infection and Immunity. Nancy's work has been presented at national and international conferences, and as invited seminars at several research institutes. She has also supervised a number of under- and post-graduate students, including three RHD students to completion to date.
Nancy's recent research highlights include the identification of a novel collection of Salmonella proteins that are targeted by CD4+ T cells, an essential subset of the adaptive immune response that confers vaccine-induced protection against many bacterial infections. Ongoing work aims to define the 'selection criteria' for immunodominant T cell antigens that may, for example, act as candidates for future vaccine design, while the formation of antigen-specific T cell memory may provide a useful biomarker for predicting protection efficacy in vaccinated individuals.
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CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance..
Staphylococcus aureus small colony variants impair host immunity by activating host cell g..
Influence Of Intestinal Ccl17-Producing Migratory Dendritic Cells On Immune Defense Agains..
Internal Research Grant
Displaying the 4 most recent projects by Nancy Wang.
Internal Research Grant
Displaying the 25 most recent scholarly works by Nancy Wang.
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.
Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.
Journal article | 2020 | Immunity
Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..
CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells
Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew
Journal article | 2020 | Cellular & Molecular Immunology
A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..
Staphylococcus aureus small colony variants impair host immunity by activating host cell glycolysis and inducing necroptosis
Tania Wong Fok Lung, Ian R Monk, Karen P Acker, Andre Mu, Nancy Wang, Sebastian A Riquelme, Silvia Pires, Loreani P Noguera, Felix Dach, Stanislaw J Gabryszewski, Benjamin P Howden, Alice Prince
Journal article | 2020 | Nature Microbiology
Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic infection, yet they lack expression of m..
Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment
Chenghao Ge, Ian R Monk, Angela Pizzolla, Nancy Wang, James G Bedford, Timothy P Stinear, Glen P Westall, Linda M Wakim
Journal article | 2019 | Cell Reports
Tissue-resident memory T (Trm) cells are described as having a "sensing and alarming" function, meaning they can rapidly release c..
The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium
Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell
Journal article | 2019 | Biochemical Journal
Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..
Effect of a pneumococcal whole cell vaccine on influenza A-induced pneumococcal otitis media in infant mice
Jayne Manning, Eileen M Dunne, Nancy Wang, John S Pedersen, Jacqueline M Ogier, Rachel A Burt, E Kim Mulholland, Roy M Robins-Browne, Richard Malley, Odilia L Wijburg, Catherine Satzke
Journal article | 2019 | Vaccine
Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways
Joshua PM Newson, Nichollas E Scott, Ivy Yeuk Wah Chung, Tania Wong Fok Lung, Cristina Giogha, Jiyao Gan, Nancy Wang, Richard A Strugnell, Nathaniel F Brown, Miroslaw Cygler, Jaclyn S Pearson, Elizabeth L Hartland
Journal article | 2019 | Molecular & Cellular Proteomics
Mus musculus deficient for secretory antibodies show delayed growth with an altered urinary metabolome
Kim R Simpfendorfer, Nancy Wang, Dedreia L Tull, David P De Souza, Amsha Nahid, Andre Mu, Dianna M Hocking, John S Pedersen, Odilia LC Wijburg, Malcolm J McConville, Richard A Strugnell
Journal article | 2019 | Molecular Medicine
Resistance mechanisms and population structure of highly drug resistant Klebsiella in Pakistan during the introduction of the carbapenemase NDM-1
Eva Heinz, Hasan Ejaz, Josefin Bartholdson Scott, Nancy Wang, Shruti Gujaran, Derek Pickard, Jonathan Wilksch, Hanwei Cao, Ikram-ul Haq, Gordon Dougan, Richard A Strugnell
Journal article | 2019 | Scientific Reports
Optimal protection against Salmonella infection requires noncirculating memory
Joseph M Benoun, Newton G Peres, Nancy Wang, Oanh H Pham, Victoria L Rudisill, Zachary N Fogassy, Paul G Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Pham Quynh-Mai, Lynn Puddington, Sammy Bedoui, Richard A Strugnell, Stephen J McSorley
Journal article | 2018 | Proceedings of the National Academy of Sciences
MAIT cells protect against pulmonary Legionella longbeachae infection
Huimeng Wang, Criselle D'Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J Pediongco, Sidonia BG Eckle, Bronwyn S Meehan, Mai Shi, Nancy Wang, Shihan Li, Ligong Liu, Jeffrey YW Mak, David P Fairlie, Yoichiro Iwakura, Jennifer M Gunnersen, Andrew W Stent, Dale I Godfrey, Jamie Rossjohn, Glen P Westall, Lars Kjer-Nielsen, et al.
Journal article | 2018 | NATURE COMMUNICATIONS
Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium
Asma Ul Husna, Nancy Wang, Simon A Cobbold, Hayley J Newton, Dianna M Hocking, Jonathan J Wilksch, Timothy A Scott, Mark R Davies, Jay C Hinton, Jai J Tree, Trevor Lithgow, Malcolm J McConville, Richard A Strugnell
Journal article | 2018 | JOURNAL OF BIOLOGICAL CHEMISTRY
Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan
Hasan Ejaz, Nancy Wang, Jonathan J Wilksch, Andrew J Page, Hanwei Cao, Shruti Gujaran, Jacqueline A Keane, Trevor Lithgow, Ikram ul-Haq, Gordon Dougan, Richard A Strugnell, Eva Heinz
Journal article | 2017 | Emerging Infectious Diseases
MAIT cells protect against fatal intracellular pulmonary legionella infection via IFN-gamma
Timothy Hinks, Huimeng Wang, Criselle D'Souza, Lyudmila Kostenko, Xin Yi Lim, Troi Pediongco, Shihan Li, Sidonia Eckle, Bronwyn Meehan, Nancy Wang, Alexandra Corbett, Lars Kjer-Nielsen, Richard Strugnell, James McCluskey, Zhenjun Chen
Conference Proceedings | 2017 | Respiratory Infections
Reduced PU.1 expression underlies aberrant neutrophil maturation and function in beta-thalassemia mice and patients
Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Garrett Zhen-Wei Ng, Philip Sutton, Nancy Wang, Isabelle Ooi, Chayada Thiengtavor, Suthat Fucharoen, Pornthip Chaichompoo, Saovaros Svasti, Odilia Wijburg, Jim Vadolas
Journal article | 2017 | Blood
Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals
Z Chen, H Wang, C D'Souza, S Sun, L Kostenko, SBG Eckle, BS Meehan, DC Jackson, RA Strugnell, H Cao, N Wang, DP Fairlie, L Liu, DI Godfrey, J Rossjohn, J McCluskey, AJ Corbett
Journal article | 2017 | Mucosal Immunology
Positive Autoregulation of mrkHI by the Cyclic Di-GMP-Dependent MrkH Protein in the Biofilm Regulatory Circuit of Klebsiella pneumoniae
Jason WH Tan, Jonathan J Wilksch, Dianna M Hocking, Nancy Wang, Yogitha N Srikhanta, Marija Tauschek, Trevor Lithgow, Roy M Robins-Browne, Ji Yang, Richard A Strugnell
Journal article | 2015 | JOURNAL OF BACTERIOLOGY
Systemic infection of Mice with Listeria monocytogenes to characterize host immune responses.
Nancy Wang, Richard A Strugnell, Odilia L Wijburg, Thomas C Brodnicki
Book Chapter | 2013 | Methods in Molecular Biology
Listeria monocytogenes is a Gram-positive facultative intracellular bacterium that is widely used to characterize bacterial pathog..
GM-CSF increases cross-presentation and CD103 expression by mouse CD8( ) spleen dendritic cells
Yifan Zhan, Emma M Carrington, Annemarie van Nieuwenhuijze, Sammy Bedoui, Shirley Seah, Yuekang Xu, Nancy Wang, Justine D Mintern, Jose A Villadangos, Ian P Wicks, Andrew M Lew
Journal article | 2011 | European Journal of Immunology
Microbiology And Immunology
Doctor of Philosophy
University of Melbourne
Bachelor of Science (Hons)
University of Melbourne
Bachelor of Biomedical Science
University of Melbourne