David Izon

Asymmetric cell division during T cell development controls downstream fate

Pham Kim, Raz Shimoni, Mirren Charnley, Mandy J Ludford-Menting, Edwin D Hawkins, Kelly Ramsbottom, Jane Oliaro, David Izon, Stephen B Ting, Joseph Reynolds, Grant Lythe, Carmen Molina-Paris, Heather Melichar, Ellen Robey, Patrick O Humbert, Min Gu, Sarah M Russell

Journal article  |  2015  |  JOURNAL OF CELL BIOLOGY

During mammalian T cell development, the requirement for expansion of many individual T cell clones, rather than merely expansion ..

Src family kinases and their role in hematological malignancies

Matthew Ku, Meaghan Wall, Ruth N MacKinnon, Carl R Walkley, Louise E Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng, Harshal Nandurkar

Journal article  |  2015  |  LEUKEMIA & LYMPHOMA

The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoie..

Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes gamma delta T-cell commitment by enhancing TCR signal strength

Monique FMA Smeets, David L Wiest, David J Izon

Journal article  |  2014  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Friend leukemia integration 1 (Fli-1) is a member of the Ets transcription factor family and is expressed during T-cell developmen..

RETINOIC ACID RECEPTOR gamma REGULATES LYMPHOPOIESIS VIA NESTIN plus BONE MARROW AND THYMIC MICROENVIRONMENT CELLS

Chacko Joseph, Celeste Nota, Racheal Costanzo, Alanna Green, Tanja Jovic, Julie Quach, David Izon, Louise Purton

Conference Proceedings  |  2014  |  EXPERIMENTAL HEMATOLOGY

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

Monique F Smeets, Elisabetta DeLuca, Meaghan Wall, Julie M Quach, Alistair M Chalk, Andrew J Deans, Joerg Heierhorst, Louise E Purton, David J Izon, Carl R Walkley

Journal article  |  2014  |  JOURNAL OF CLINICAL INVESTIGATION

Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmun..

A Mouse Model Of Rothmund-Thomson Syndrome Reveals A Essential Role For Recql4 In Maintenance Of Hematopoiesis

Elisabetta DeLuca, Monique Smeets, Meaghan Wall, Julie Quach, Andrew Deans, Jorg Heierhorst, Louise E Purton, David Izon, Carl R Walkley

Conference Proceedings  |  2013  |  BLOOD

Abstract Rothmund-Thomson Syndrome (RTS) is a rare autosomal recessive disorder that presents with congenital skele..

Removal of myeloid cytokines from the cellular environment enhances T-cell development in vitro

Monique FMA Smeets, Charley Mackenzie-Kludas, Mahmood Mohtashami, Hui-Hua Zhang, Juan Carlos Zuniga-Pfluecker, David J Izon

Journal article  |  2013  |  INTERNATIONAL IMMUNOLOGY

The majority of T-cell development occurs in the thymus. Thymic epithelial cells are specialized cells that express NOTCH ligands ..

Fli-1 Overexpression in Hematopoietic Progenitors Deregulates T Cell Development and Induces Pre-T Cell Lymphoblastic Leukaemia/Lymphoma

Monique FMA Smeets, Angela C Chan, Samantha Dagger, Cara K Bradley, Andrew Wei, David J Izon

Journal article  |  2013  |  PLOS ONE

The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but..

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim

Sabine Jurado, Kimberly Gleeson, Kristy O'Donnell, David J Izon, Carl R Walkley, Andreas Strasser, David M Tarlinton, Joerg Heierhorst

Journal article  |  2012  |  JOURNAL OF EXPERIMENTAL MEDICINE

Developing B lymphocytes expressing defective or autoreactive pre-B or B cell receptors (BCRs) are eliminated by programmed cell d..

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Stacey Fynch, Kate L Graham, Pere Santamaria, Grant Morahan, Janette Allison, David Izon, Helen E Thomas, Thomas WH Kay

Journal article  |  2012  |  DIABETES

Prevention of autoimmunity requires the elimination of self-reactive T cells during their development in the thymus and maturation..