David Izon

Asymmetric cell division during T cell development controls downstream fate

Pham Kim, Raz Shimoni, Mirren Charnley, Mandy J Ludford-Menting, Edwin D Hawkins, Kelly Ramsbottom, Jane Oliaro, David Izon, Stephen B Ting, Joseph Reynolds, Grant Lythe, Carmen Molina-Paris, Heather Melichar, Ellen Robey, Patrick O Humbert, Min Gu, Sarah M Russell

Journal article  |  2015  |  JOURNAL OF CELL BIOLOGY

During mammalian T cell development, the requirement for expansion of many individual T cell clones, rather than merely expansion ..

Src family kinases and their role in hematological malignancies

Matthew Ku, Meaghan Wall, Ruth N MacKinnon, Carl R Walkley, Louise E Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng, Harshal Nandurkar

Journal article  |  2015  |  LEUKEMIA & LYMPHOMA

The Src family protein tyrosine kinases (SFKs) are non-receptor intracellular kinases that have important roles in both hematopoie..

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

Monique F Smeets, Elisabetta DeLuca, Meaghan Wall, Julie M Quach, Alistair M Chalk, Andrew J Deans, Joerg Heierhorst, Louise E Purton, David J Izon, Carl R Walkley

Journal article  |  2014  |  JOURNAL OF CLINICAL INVESTIGATION

Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmun..

Fli-1 Overexpression in Hematopoietic Progenitors Deregulates T Cell Development and Induces Pre-T Cell Lymphoblastic Leukaemia/Lymphoma

Monique FMA Smeets, Angela C Chan, Samantha Dagger, Cara K Bradley, Andrew Wei, David J Izon

Journal article  |  2013  |  PLOS ONE

The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but..

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim

Sabine Jurado, Kimberly Gleeson, Kristy O'Donnell, David J Izon, Carl R Walkley, Andreas Strasser, David M Tarlinton, Joerg Heierhorst

Journal article  |  2012  |  JOURNAL OF EXPERIMENTAL MEDICINE

Developing B lymphocytes expressing defective or autoreactive pre-B or B cell receptors (BCRs) are eliminated by programmed cell d..

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Stacey Fynch, Kate L Graham, Pere Santamaria, Grant Morahan, Janette Allison, David Izon, Helen E Thomas, Thomas WH Kay

Journal article  |  2012  |  DIABETES

Prevention of autoimmunity requires the elimination of self-reactive T cells during their development in the thymus and maturation..

ATM Substrate Chk2-interacting Zn2 Finger (ASCIZ) Is a Bi-functional Transcriptional Activator and Feedback Sensor in the Regulation of Dynein Light Chain (DYNLL1) Expression

Sabine Jurado, Lindus A Conlan, Emma K Baker, Jane-Lee Ng, Nora Tenis, Nicolas C Hoch, Kimberly Gleeson, Monique Smeets, David Izon, Joerg Heierhorst

Journal article  |  2012  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The highly conserved DYNLL1 (LC8) protein was originally discovered as a light chain of the dynein motor complex, but is increasin..

Hematopoietic AMPK beta 1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

Sandra Galic, Morgan D Fullerton, Jonathan D Schertzer, Sarah Sikkema, Katarina Marcinko, Carl R Walkley, David Izon, Jane Honeyman, Zhi-Ping Chen, Bryce J van Denderen, Bruce E Kemp, Gregory R Steinberg

Journal article  |  2011  |  JOURNAL OF CLINICAL INVESTIGATION

Individuals who are obese are frequently insulin resistant, putting them at increased risk of developing type 2 diabetes and its a..

Identification of Flt3( )CD150(-) myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential

Anthony WS Chi, Alejandro Chavez, Lanwei Xu, Brittany N Weber, Olga Shestova, Andras Schaffer, Gerald Wertheim, Warren S Pear, David Izon, Avinash Bhandoola

Journal article  |  2011  |  BLOOD

Common myeloid progenitors (CMPs) were first identified as progenitors that were restricted to myeloid and erythroid lineages. How..

Taking HSCs Down a Notch in Leukemia

Carl R Walkley, David J Izon, Louise E Purton

Journal article  |  2011  |  CELL STEM CELL

The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity..