Wendyl d'Souza

Spatiotemporal Patterns of High-Frequency Activity (80-170 Hz) in Long-Term Intracranial EEG.

Zhuying Chen, David B Grayden, Anthony N Burkitt, Udaya Seneviratne, Wendyl J D'Souza, Chris French, Philippa J Karoly, Katrina Dell, Kent Leyde, Mark J Cook, Matias I Maturana

Journal article  |  2021  |  Neurology

OBJECTIVE: To determine the utility of high-frequency activity (HFA) and epileptiform spikes as biomarkers for epilepsy, we examin..

Can semiology differentiate between bilateral tonic-clonic seizures of focal-onset and generalized-onset? A systematic review.

Harry Christie, Wendyl D'Souza, Mark Cook, Udaya Seneviratne

Journal article  |  2021  |  Epilepsy & Behavior

OBJECTIVE: Bilateral tonic-clonic seizures are encountered in both focal and generalized epilepsies. We reviewed the literature re..

Multiday cycles of heart rate modulate seizure likelihood at daily, weekly and monthly timescales: An observational cohort study

Philippa Karoly, Rachel Stirling, Dean Freestone, Ewan Nurse, Brendan Doyle, Amy Halliday, Andrew Neal, Wenjuan Xiong, Tatiana Kameneva, Nicholas Gregg, Benjamin Brinkmann, Mark Richardson, Sonya Dumanis, Andre La Gerche, David Grayden, Wendyl D’Souza, Mark Cook

Journal article  |  2020

Circadian and multiday rhythms are found across many biological systems, including cardiology, endocrinology, neurology and immuno..

Enlarged hippocampal fissure in psychosis of epilepsy

James Allebone, Richard A Kanaan, Jerome J Maller, Terrence O'Brien, Saul Mullen, Mark Cook, Sophie Adams, Simon Vogrin, David Vaughan, Alan Connelly, Patrick Kwan, Samuel F Berkovic, Wendyl D'Souza, Graeme Jackson, Dennis Velakoulis, Sarah J Wilson

Journal article  |  2020  |  Epilepsy & Behavior

Psychosis of epilepsy (POE) can be a devastating condition, and its neurobiological basis remains unclear. In a previous study, we..

Domino-like transient dynamics at seizure onset in epilepsy

Jennifer Creaser, Congping Lin, Thomas Ridler, Jonathan T Brown, Wendyl D'Souza, Udaya Seneviratne, Mark Cook, John R Terry, Krasimira Tsaneva-Atanasova

Journal article  |  2020  |  PLoS Computational Biology

The International League Against Epilepsy (ILAE) groups seizures into "focal", "generalized" and "unknown" based on whether the se..

Mortality in patients with psychogenic nonepileptic seizures

Russell Nightscales, Lara McCartney, Clarissa Auvrez, Gerard Tao, Sarah Barnard, Charles B Malpas, Piero Perucca, Anne McIntosh, Zhibin Chen, Shobi Sivathamboo, Sophia Ignatiadis, Simon Jones, Sophia Adams, Mark J Cook, Patrick Kwan, Dennis Velakoulis, Wendyl D'Souza, Samuel F Berkovic, Terence J O'Brien

Journal article  |  2020  |  Neurology

OBJECTIVE: To investigate the hypothesis that patients diagnosed with psychogenic nonepileptic seizures (PNES) on video-EEG monito..

Critical slowing down as a biomarker for seizure susceptibility.

Matias I Maturana, Christian Meisel, Katrina Dell, Philippa J Karoly, Wendyl D'Souza, David B Grayden, Anthony N Burkitt, Premysl Jiruska, Jan Kudlacek, Jaroslav Hlinka, Mark J Cook, Levin Kuhlmann, Dean R Freestone

Journal article  |  2020  |  Nature Communications

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in lo..

Anti-seizure therapy with a long-term, implanted intra-cerebroventricular delivery system for drug-resistant epilepsy: A first-in-man study.

Mark Cook, Michael Murphy, Kristian Bulluss, Wendyl D'Souza, Chris Plummer, Emma Priest, Catherine Williams, Ashwini Sharan, Robert Fisher, Sharon Pincus, Eric Distad, Tom Anchordoquy, Dan Abrams

Journal article  |  2020  |  EClinicalMedicine

Background: A clinical feasibility study was undertaken at a single center of long-term intra-cerebroventricular drug delivery of ..

"Sleep Surge": The impact of sleep onset and offset on epileptiform discharges in idiopathic generalized epilepsies

Udaya Seneviratne, Alan Lai, Mark Cook, Wendyl D'Souza, Ray C Boston

Journal article  |  2020  |  Clinical Neurophysiology

Objective To investigate the impact of sleep onset and offset on the rate of epileptiform discharges (ED) in idiopathic generalize..

Computer-assisted estimation of interictal discharge burden in idiopathic generalized epilepsy.

Dominique Eden, Ewan S Nurse, Shannon Clarke, Philippa J Karoly, Udaya Seneviratne, Mark Cook, Dean R Freestone, Wendyl D'Souza

Journal article  |  2020  |  Epilepsy & Behavior