Wendyl d'Souza

Efficacy and tolerability of adjuvant perampanel: an Australian multicenter real-world observational study in refractory focal and generalized epilepsy syndromes.

Parveen Sagar, Olivia Wawryk, Sara Vogrin, Emma Whitham, Michelle Kiley, Joseph Frasca, Ross Carne, Udaya Seneviratne, Mark J Cook, Nicholas Lawn, Armin Nikpour, Wendyl Jude D'Souza

Journal article  |  2021  |  Epilepsy & Behavior

PURPOSE: To explore the efficacy and tolerability of adjuvant perampanel (PER) and their associated risk factors in late add-on dr..

Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis.

James Broadley, Robb Wesselingh, Udaya Seneviratne, Chris Kyndt, Paul Beech, Katherine Buzzard, Cassie Nesbitt, Wendyl D'souza, Amy Brodtmann, Richard Macdonell, Tomas Kalincik, Helmut Butzkueven, Terence J O'Brien, Mastura Monif, undefined Australian Autoimmune Encephalitis Consortium

Journal article  |  2021  |  Journal of Neuroimmunology

OBJECTIVE: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). METHODS: We retrospe..

Can semiology differentiate between bilateral tonic-clonic seizures of focal-onset and generalized-onset? A systematic review

Harry Christie, Wendyl D'Souza, Mark Cook, Udaya Seneviratne

Journal article  |  2021  |  Epilepsy & Behavior

OBJECTIVE: Bilateral tonic-clonic seizures are encountered in both focal and generalized epilepsies. We reviewed the literature re..

Spatiotemporal Patterns of High-Frequency Activity (80-170 Hz) in Long-Term Intracranial EEG.

Zhuying Chen, David B Grayden, Anthony N Burkitt, Udaya Seneviratne, Wendyl J D'Souza, Chris French, Philippa J Karoly, Katrina Dell, Kent Leyde, Mark J Cook, Matias I Maturana

Journal article  |  2021  |  Neurology

OBJECTIVE: To determine the utility of high-frequency activity (HFA) and epileptiform spikes as biomarkers for epilepsy, we examin..

Multiday cycles of heart rate modulate seizure likelihood at daily, weekly and monthly timescales: An observational cohort study

Philippa Karoly, Rachel Stirling, Dean Freestone, Ewan Nurse, Brendan Doyle, Amy Halliday, Andrew Neal, Wenjuan Xiong, Tatiana Kameneva, Nicholas Gregg, Benjamin Brinkmann, Mark Richardson, Sonya Dumanis, Andre La Gerche, David Grayden, Wendyl D’Souza, Mark Cook

Journal article  |  2020

Circadian and multiday rhythms are found across many biological systems, including cardiology, endocrinology, neurology and immuno..

Enlarged hippocampal fissure in psychosis of epilepsy

James Allebone, Richard A Kanaan, Jerome J Maller, Terrence O'Brien, Saul Mullen, Mark Cook, Sophie Adams, Simon Vogrin, David Vaughan, Alan Connelly, Patrick Kwan, Samuel F Berkovic, Wendyl D'Souza, Graeme Jackson, Dennis Velakoulis, Sarah J Wilson

Journal article  |  2020  |  Epilepsy & Behavior

Psychosis of epilepsy (POE) can be a devastating condition, and its neurobiological basis remains unclear. In a previous study, we..

Domino-like transient dynamics at seizure onset in epilepsy

Jennifer Creaser, Congping Lin, Thomas Ridler, Jonathan T Brown, Wendyl D'Souza, Udaya Seneviratne, Mark Cook, John R Terry, Krasimira Tsaneva-Atanasova

Journal article  |  2020  |  PLoS Computational Biology

The International League Against Epilepsy (ILAE) groups seizures into "focal", "generalized" and "unknown" based on whether the se..

Mortality in patients with psychogenic nonepileptic seizures

Russell Nightscales, Lara McCartney, Clarissa Auvrez, Gerard Tao, Sarah Barnard, Charles B Malpas, Piero Perucca, Anne McIntosh, Zhibin Chen, Shobi Sivathamboo, Sophia Ignatiadis, Simon Jones, Sophia Adams, Mark J Cook, Patrick Kwan, Dennis Velakoulis, Wendyl D'Souza, Samuel F Berkovic, Terence J O'Brien

Journal article  |  2020  |  Neurology

OBJECTIVE: To investigate the hypothesis that patients diagnosed with psychogenic nonepileptic seizures (PNES) on video-EEG monito..

Critical slowing down as a biomarker for seizure susceptibility.

Matias I Maturana, Christian Meisel, Katrina Dell, Philippa J Karoly, Wendyl D'Souza, David B Grayden, Anthony N Burkitt, Premysl Jiruska, Jan Kudlacek, Jaroslav Hlinka, Mark J Cook, Levin Kuhlmann, Dean R Freestone

Journal article  |  2020  |  Nature Communications

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in lo..

Anti-seizure therapy with a long-term, implanted intra-cerebroventricular delivery system for drug-resistant epilepsy: A first-in-man study.

Mark Cook, Michael Murphy, Kristian Bulluss, Wendyl D'Souza, Chris Plummer, Emma Priest, Catherine Williams, Ashwini Sharan, Robert Fisher, Sharon Pincus, Eric Distad, Tom Anchordoquy, Dan Abrams

Journal article  |  2020  |  EClinicalMedicine

Background: A clinical feasibility study was undertaken at a single center of long-term intra-cerebroventricular drug delivery of ..