Doug started his career as a basic scientist, working on genes involved in establishing the nervous system of the fruit fly. After completing his undergraduate degree (University of Cambridge, UK) and his PhD (University of Glasgow) he moved to the Newcastle upon Tyne to study medicine.
He completed general medical training in hospitals in and around Newcastle, then embarked on Specialty training in Neurology. This began in Neuroscience centres in North-East England (2002-2006) followed by a Clinical Fellowship in Epilepsy at the University of Melbourne, Austin Health, with Professors Sam Berkovic and Ingrid Scheffer (2006-2009). Doug then returned to the UK as Senior Clinical Lecturer in Neurogenetics at Newcastle University and Honorary Consultant Neurologist at James Cook University Hospital, Middlesbrough (2009-2012) before coming back to Melbourne as full time Neurologist at Northern Health in March 2012. Doug~s clinical practice is in all areas of Neurology, but his research focus is in the genetics of epilepsies, and he continues to work closely with Professors Berkovic and Scheffer at the University of Melbourne, Austin Health, who are world leaders in this field.
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Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to ..
Displaying the most recent project by Douglas Crompton.
Displaying the 38 most recent scholarly works by Douglas Crompton.
Quantitative analysis of phenotypic elements augments traditional electroclinical classification of common familial epilepsies
Bassel Abou-Khalil, Zaid Afawi, Andrew S Allen, Jocelyn F Bautista, Susannah T Bellows, Samuel F Berkovic, Judith Bluvstein, Rosemary Burgess, Gregory Cascino, Patrick Cossette, Sabrina Cristofaro, Douglas E Crompton, Norman Delanty, Orrin Devinsky, Dennis Dlugos, Colin A Ellis, Michael P Epstein, Nathan B Fountain, Catharine Freyer, Eric B Geller, et al.
Journal article | 2019 | Epilepsia
Intronic ATTTC repeat expansions in STARD7 in familial adult myoclonic epilepsy linked to chromosome 2
Mark A Corbett, Thessa Kroes, Liana Veneziano, Mark F Bennett, Rahel Florian, Amy L Schneider, Antonietta Coppola, Laura Licchetta, Silvana Franceschetti, Antonio Suppa, Aaron Wenger, Davide Mei, Manuela Pendziwiat, Sabine Kaya, Massimo Delledonne, Rachel Straussberg, Luciano Xumerle, Brigid Regan, Douglas Crompton, Anne-Fleur van Rootselaar, et al.
Journal article | 2019 | Nature Communications
Familial Adult Myoclonic Epilepsy (FAME) is characterised by cortical myoclonic tremor usually from the second decade of life and ..
Phenotypic analysis of 303 multiplex families with common epilepsies
Bassel Abou-Khalil, Zaid Afawi, Andrew S Allen, Jocelyn F Bautista, Susannah T Bellows, Samuel F Berkovic, Judith Bluvstein, Rosemary Burgess, Gregory Cascino, Elisa J Cops, Patrick Cossette, Sabrina Cristofaro, Douglas E Crompton, Norman Delanty, Orrin Devinsky, Dennis Dlugos, Michael P Epstein, Nathan B Fountain, Catharine Freyer, Sarah I Garry, et al.
Journal article | 2017 | Brain
Familial Mesial Temporal Lobe Epilepsy and the Borderland of Deja Vu
Piero Perucca, Douglas E Crompton, Susannah T Bellows, Anne M McIntosh, Tomas Kalincik, Mark R Newton, Frank JE Vajda, Ingrid E Scheffer, Patrick Kwan, Terence J O'Brien, K Meng Tan, Samuel F Berkovic
Journal article | 2017 | Annals of Neurology
Risk-adjusted hospital mortality rates for stroke: evidence from the Australian Stroke Clinical Registry (AuSCR)
Dominique A Cadilhac, Monique F Kilkenny, Christopher R Levi, Natasha A Lannin, Amanda G Thrift, Joosup Kim, Brenda Grabsch, Leonid Churilov, Helen M Dewey, Kelvin Hill, Steven G Faux, Rohan Grimley, Helen Castley, Peter J Hand, Andrew Wong, Geoffrey K Herkes, Melissa Gill, Douglas Crompton, Sandy Middleton, Geoffrey A Donnan, et al.
Journal article | 2017 | Medical Journal of Australia
Mortality in Dravet syndrome
Monica S Cooper, Anne Mcintosh, Douglas E Crompton, Jacinta M McMahon, Amy Schneider, Kevin Farrell, Vijeya Ganesan, Deepak Gill, Sara Kivity, Tally Lerman-Sagie, Ailsa McLellan, James Pelekanos, Venkateswaran Ramesh, Lynette Sadleir, Elaine Wirrell, Ingrid E Scheffer
Journal article | 2016 | Epilepsy Research
Identity by descent fine mapping of familial adult myoclonus epilepsy (FAME) to 2p11.2-2q11.2
Lyndal Henden, Saskia Freytag, Zaid Afawi, Sara Baldassari, Samuel F Berkovic, Francesca Bisulli, Laura Canafoglia, Giorgio Casari, Douglas Ewan Crompton, Christel Depienne, Jozef Gecz, Renzo Guerrini, Ingo Helbig, Edouard Hirsch, Boris Keren, Karl Martin Klein, Pierre Labauge, Eric LeGuern, Laura Licchetta, Davide Mei, et al.
Journal article | 2016 | Human Genetics
Exome-based analysis of cardiac arrhythmia, respiratory control, and epilepsy genes in sudden unexpected death in epilepsy
Richard D Bagnall, Douglas E Crompton, Slave Petrovski, Lien Lam, Carina Cutmore, Sarah I Garry, Lynette G Sadleir, Leanne M Dibbens, Anita Cairns, Sara Kivity, Zaid Afawi, Brigid M Regan, Johan Duflou, Samuel F Berkovic, Ingrid E Scheffer, Christopher Semsarian
Journal article | 2016 | Annals of Neurology
Epileptic spasms are a feature of DEPDC5 mTORopathy
Gemma L Carvill, Douglas E Crompton, Brigid M Regan, Jacinta M McMahon, Julia Saykally, Matthew Zemel, Amy L Schneider, Leanne Dibbens, Katherine B Howell, Simone Mandelstam, Richard J Leventer, A Simon Harvey, Saul A Mullen, Samuel F Berkovic, Joseph Sullivan, Ingrid E Scheffer, Heather C Mefford
Journal article | 2015 | Neurology Genetics
MUTATIONS IN DEPDC5 ARE A MAJOR CAUSE OF LESIONAL AND NON-LESIONAL FOCAL EPILEPSY
LM Dibbens, IE Scheffer, BM Regan, S Mandelstam, DE Crompton, BL Hodgson, L Licchetta, F Provini, F Bisulli, L Vadlamudi, J Gecz, A Connelly, P Tinuper, MG Ricos, SF Berkovic, SE Heron
Conference Proceedings | 2014 | EPILEPSIA
Mutations in Mammalian Target of Rapamycin Regulator DEPDC5 Cause Focal Epilepsy with Brain Malformations
Ingrid E Scheffer, Sarah E Heron, Brigid M Regan, Simone Mandelstam, Douglas E Crompton, Bree L Hodgson, Laura Licchetta, Federica Provini, Francesca Bisulli, Lata Vadlamudi, Jozef Gecz, Alan Connelly, Paolo Tinuper, Michael G Ricos, Samuel F Berkovic, Leanne M Dibbens
Journal article | 2014 | Annals of Neurology
EXTENDING THE SPECTRUM OF KCNQ2 ENCEPHALOPATHY: DESCRIPTION OF 11 ADDITIONAL PATIENTS
S Weckhuysen, V Ivanovic, R Hendrickx, R Van Coster, H Hjalgrim, RS Moller, S Gronborg, A-S Schoonjans, B Ceulemans, S Heavin, C Eltze, R Horvath, T Pisano, G Casara, DE Crompton, L Giordano, R Guerrini, M Angriman, I Scheffer, P Striano, et al.
Conference Proceedings | 2013 | EPILEPSIA
MUTATIONS IN DEPDC5: A MAJOR CAUSE OF FAMILIAL FOCAL EPILEPSY
LM Dibbens, B de Vries, S Donatello, SE Heron, BL Hodgson, S Chintawar, DE Crompton, JN Hughes, ST Bellows, KM Klein, PM Callenbach, MA Corbett, AE Gardner, S Kivity, X Iona, BM Regan, CM Weller, D Crimmins, T O'Brien, R Guerrero-Lopez, et al.
Conference Proceedings | 2013 | EPILEPSIA
Mutations in DEPDC5 cause familial focal epilepsy with variable foci
Leanne M Dibbens, Boukje de Vries, Simona Donatello, Sarah E Heron, Bree L Hodgson, Satyan Chintawar, Douglas E Crompton, James N Hughes, Susannah T Bellows, Karl Martin Klein, Petra MC Callenbach, Mark A Corbett, Alison E Gardner, Sara Kivity, Xenia Iona, Brigid M Regan, Claudia M Weller, Denis Crimmins, Terence J O'Brien, Rosa Guerrero-Lopez, et al.
Journal article | 2013 | Nature Genetics
Early onset absence epilepsy: 1 in 10 cases is caused by GLUT1 deficiency
Todor Arsov, Saul A Mullen, John A Damiano, Kate M Lawrence, Linda L Huh, Melinda Nolan, Helen Young, Anais Thouin, Hans-Henrik M Dahl, Samuel F Berkovic, Douglas E Crompton, Lynette G Sadleir, Ingrid E Scheffer
Journal article | 2012 | Epilepsia
Familial Adult Myoclonic Epilepsy Recognition of Mild Phenotypes and Refinement of the 2q Locus
Douglas E Crompton, Lynette G Sadleir, Catherine J Bromhead, Melanie Bahlo, Susannah T Bellows, Todor Arsov, Rosemary Harty, Kate M Lawrence, John W Dunne, Samuel F Berkovic, Ingrid E Scheffer
Journal article | 2012 | Archives of Neurology
Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance
Douglas E Crompton, Ingrid E Scheffer, Isabella Taylor, Mark J Cook, Penelope A McKelvie, Danya F Vears, Kate M Lawrence, Jacinta M McMahon, Bronwyn E Grinton, Anne M McIntosh, Samuel F Berkovic
Journal article | 2010 | Brain
Optic perineuritis as a rare initial presentation of sarcoidosis
Patrick Yu-Wai-Man, Douglas E Crompton, James Y Graham, Fiona M Black, Margaret R Dayan
Journal article | 2007 | Clinical & Experimental Ophthalmology
Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology and establishing the correct diagnosis can be challenging..
Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation
Patrick F Chinnery, Douglas E Crompton, Daniel Birchall, Margaret J Jackson, Alan Coulthard, Anne Lombes, Niall Quinn, Adrian Wills, Nicholas Fletcher, John P Mottershead, Paul Cooper, Mark Kellett, David Bates, John Burn
Journal article | 2007 | Brain
Neuroferritinopathy is a progressive potentially treatable adult-onset movement disorder caused by mutations in the ferritin light..
Spectrum of movement disorders in neuroferritinopathy
DE Crompton, PF Chinnery, D Bates, TJ Walls, MJ Jackson, AJ Curtis, J Burn
Journal article | 2005 | Movement Disorders
Neuroferritinopathy is a recently recognized, dominantly inherited movement disorder caused by a mutation of the ferritin light ch..
ANALYSIS OF A CDNA FROM THE NEUROLOGICALLY ACTIVE LOCUS SHAKING-B (PASSOVER) OF DROSOPHILA-MELANOGASTER
DE CROMPTON, A GRIFFIN, JA DAVIES, GLG MIKLOS
Journal article | 1992 | Gene
We have isolated and sequenced a cDNA from the shaking-B locus of Drosophila melanogaster. The cDNA contains an open reading frame..
Honours, Awards and Fellowships
Membership of the Academy of Clinical Teachers
FRACP - Fellow of the Royal Australasian College of Physicians
MRCP - Member of the Royal College of Physicians of London
Member Of The Australia And New Zealand Association Of Neurologists
Australia and New Zealand Association of Neurologists
Member Of The Epilepsy Society Of Australia
Epilepsy Society of Australia
Member Of The Association Of British Neurologists
Association of British Neurologists
University of Newcastle Upon Tyne
The University of Glasgow
Master of Arts (Natural Sciences)
University of Cambridge