Warren Alexander

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.

Kunlun Li, Lizeth G Meza Guzman, Lachlan Whitehead, Evelyn Leong, Andrew Kueh, Warren S Alexander, Nadia J Kershaw, Jeffrey J Babon, Karen Doggett, Sandra E Nicholson

Journal article  |  2022  |  Biosci Rep

Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice ..

Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022)

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

In this article the affiliation details for Amy Heidersbach were incorrectly given as ‘School of Dentistry and Medical Sciences, C..

Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goeknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in thi..

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

Yuqing Yang, Andrew J Kueh, Zoe L Grant, Waruni Abeysekera, Alexandra L Garnham, Stephen Wilcox, Craig D Hyland, Ladina Di Rago, Don Metcalf, Warren S Alexander, Leigh Coultas, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2022  |  BLOOD

The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylati..

Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency

Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S Alexander, Hitoshi Shimano, Hirohito Sone

Journal article  |  2021  |  ISCIENCE

The suppressors of cytokine signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive ..

Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis

Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah Coughlan, Pedro L Baldoni, Nicolas Jacquelot, Wang HJ Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P Wicks, Warren S Alexander, Leonard C Harrison, Andrew M Lew, Gordon K Smyth, Stephen L Nutt, Michael Chopin

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

Dendritic cells (DCs) and macrophages are at the forefront of immune responses, modifying their transcriptional programs in respon..

Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane-Associated Ring-CH (MARCH) proteins MARCH2, 3, 4 and 9

Jarrod J Sandow, Andrew I Webb, Dina Stockwell, Nadia J Kershaw, Cyrus Tan, Satoshi Ishido, Warren S Alexander, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola

Journal article  |  2021  |  PROTEOMICS

MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface ex..

Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice

Silvia Alvarez-Diaz, Adele Preaudet, Andre L Samson, Paul M Nguyen, Ka Yee Fung, Alexandra L Garnham, Warren S Alexander, Andreas Strasser, Matthias Ernst, Tracy L Putoczki, James M Murphy

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Chronic inflammation of the large intestine is associated with an increased risk of developing colorectal cancer (CRC), the second..

The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Diane Moujalled, Pradnya Gangatirkar, Maria Kauppi, Jason Corbin, Marion Lebois, James M Murphy, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Warren S Alexander, Emma C Josefsson

Journal article  |  2021  |  CELL DEATH & DISEASE

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). P..

T-ALL can evolve to oncogene independence

Hesham Abdulla, Anh Vo, Benjamin J Shields, Tenae J Davies, Jacob T Jackson, Raed Alserihi, Elizabeth M Viney, Tin Wong, Feng Yan, Nicholas C Wong, Lisa Demoen, David J Curtis, Warren S Alexander, Pieter Van Vlierberghe, Ross A Dickins, Matthew P McCormack

Journal article  |  2021  |  LEUKEMIA

The majority of cases of T-cell acute lymphoblastic leukemia (T-ALL) contain chromosomal abnormalities that drive overexpression o..