Warren Alexander

Correction: NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Ladina Di Rago, Craig D Hyland, Eugenio Morelli, Jai Rautela, Nicholas D Huntington, Andreas Strasser, Warren S Alexander, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and throug..

Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome.

Keiichi Ishihara, Ryohei Shimizu, Kazuyuki Takata, Eri Kawashita, Kenji Amano, Atsushi Shimohata, Donovan Low, Takeshi Nabe, Haruhiko Sago, Warren S Alexander, Florent Ginhoux, Kazuhiro Yamakawa, Satoshi Akiba

Journal article  |  2020  |  Brain Pathology

Some mouse models of Down syndrome (DS), including Ts1Cje mice, exhibit impaired prenatal neurogenesis with yet unknown molecular ..

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6R alpha)

Jeffrey J Babon, Dina Stockwell, Ladina DiRago, Jian-Guo Zhang, Artem Laktyushin, Jose Villadangos, Alan Ching, Satoshi Ishido, Douglas J Hilton, Warren S Alexander, Nicos A Nicola

Journal article  |  2019  |  Biochemical Journal

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  Blood

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  Nucleic Acids Research

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Mathijs A Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E Miller, Adil S al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara McIennan, Remco M Hoogenboezem, Francois G Kavelaars, Stefan Froehling, Marnie E Blewitt, Eric M Bindels, Warren S Alexander, Bob Lowenberg, Andrew W Roberts, Peter JM Valk, Ian J Majewski

Journal article  |  2018  |  Blood

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2018  |  PLOS Biology

Identification of a Siglec-F plus granulocyte-macrophage progenitor

Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander, Bruce S Bochner, Matthew E Ritchie, Douglas J Hilton, Kirsten A Fairfax

Journal article  |  2018  |  Journal of Leukocyte Biology

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

Michael D Stutz, Samar Ojaimi, Cody Allison, Simon Preston, Philip Arandjelovic, Joanne M Hildebrand, Jarrod J Sandow, Andrew I Webb, John Silke, Warren S Alexander, Marc Pellegrini

Journal article  |  2018  |  Cell Death & Differentiation

Cytokine control of megakaryopoiesis

Kira Behrens, Warren S Alexander

Journal article  |  2018  |  Growth Factors

The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice

Kerstin Brinkmann, Stephanie Grabow, Craig D Hyland, Charis E Teh, Warren S Alexander, Marco J Herold, Andreas Strasser

Journal article  |  2017  |  Cell Death & Differentiation

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

Amanda E Au, Marion Lebois, Starling A Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T Kile, Kylie D Mason, Ashley P Ng, Warren S Alexander, Emma C Josefsson

Journal article  |  2017  |  Scientific Reports

The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL

Alex RD Delbridge, Brandon J Aubrey, Craig Hyland, Jonathan P Bernardini, Ladina Di Rago, Jean-Marc Garnier, Guillaume Lessene, Andreas Strasser, Warren S Alexander, Stephanie Grabow

Journal article  |  2017  |  Cell Death & Disease

A non-canonical function of Ezh2 preserves immune homeostasis

Ajithkumar Vasanthakumar, Dakang Xu, Aaron TL Lun, Andrew J Kueh, Klaas PJM van Gisbergen, Nadia Iannarella, Xiaofang Li, Liang Yu, Die Wang, Bryan RG Williams, Stanley CW Lee, Ian J Majewski, Dale I Godfrey, Gordon K Smyth, Warren S Alexander, Marco J Herold, Axel Kallies, Stephen L Nutt, Rhys S Allan

Journal article  |  2017  |  EMBO reports

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

Irina Pleines, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, Jose Ballester-Beltran, Katja Aurbach, Chiara Lincetto, Rachael M Lane, Galina Schevzov, Warren S Alexander, Douglas J Hilton, William J Astle, Kate Downes, Paquita Nurden, Sarah K Westbury, Andrew D Mumford, Samya G Obaji, Peter W Collins, Fabien Delerue, et al.

Journal article  |  2017  |  Journal of Clinical Investigation

Haematopoietic stem cells: past, present and future

Ashley P Ng, Warren S Alexander

Journal article  |  2017  |  Cell Death Discovery

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

Silvia Alvarez-Diaz, Christopher P Dillon, Najoua Lalaoui, Maria C Tanzer, Diego A Rodriguez, Ann Lin, Marion Lebois, Razq Hakem, Emma C Josefsson, Lorraine A O'Reilly, John Silke, Warren S Alexander, Douglas R Green, Andreas Strasser

Journal article  |  2016  |  Immunity

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

Carolyn A De Graaf, Jarny Choi, Tracey M Baldwin, Jessica E Bolden, Kirsten A Fairfax, Aaron J Robinson, Christine Biben, Clare Morgan, Kerry Ramsay, Ashley P Ng, Maria Kauppi, Elizabeth A Kruse, Tobias J Sargeant, Nick Seidenman, Angela D'Amico, Marthe C D'Ombrain, Erin C Lucas, Sandra Koernig, Adriana Baz Morelli, Michael J Wilson, et al.

Journal article  |  2016  |  Stem Cell Reports

Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells

Takashi Ushiki, Nicholas D Huntington, Stefan P Glaser, Hiu Kiu, Angela Georgiou, Jian-Guo Zhang, Donald Metcalf, Nicos A Nicola, Andrew W Roberts, Warren S Alexander

Journal article  |  2016  |  PLOS ONE

Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling

M Lebois, MR Dowling, P Gangatirkar, PD Hodgkin, BT Kile, WS Alexander, EC Josefsson

Journal article  |  2016  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In vivo at last: Demonstrating the biological credentials and clinical potential of GM-CSF

Warren S Alexander

Journal article  |  2016  |  Experimental Hematology

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells

Z Xu, PP Sharp, Y Yao, D Segal, CH Ang, SL Khaw, BJ Aubrey, J Gong, GL Kelly, MJ Herold, A Strasser, AW Roberts, WS Alexander, CJ Burns, DCS Huang, SP Glaser

Journal article  |  2016  |  Leukemia

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, et al.

Journal article  |  2016  |  Nature Immunology

Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

Kira Behrens, Ioanna Triviai, Maike Schwieger, Nilgun Tekin, Malik Alawi, Michael Spohn, Daniela Indenbirken, Marion Ziegler, Ursula Muller, Warren S Alexander, Carol Stocking

Journal article  |  2016  |  Blood

ROBUST HYPERPARAMETER ESTIMATION PROTECTS AGAINST HYPERVARIABLE GENES AND IMPROVES POWER TO DETECT DIFFERENTIAL EXPRESSION

Belinda Phipson, Stanley Lee, Ian J Majewski, Warren S Alexander, Gordon K Smyth

Journal article  |  2016  |  The Annals of Applied Statistics

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

Rebecca B Delconte, Wei Shi, Priyanka Sathe, Takashi Ushiki, Cyril Seillet, Martina Minnich, Tatiana B Kolesnik, Lucille C Rankin, Lisa A Mielke, Jian-Guo Zhang, Meinrad Busslinger, Mark J Smyth, Dana S Hutchinson, Stephen L Nutt, Sandra E Nicholson, Warren S Alexander, Lynn M Corcoran, Eric Vivier, Gabrielle T Belz, Sebastian Carotta, et al.

Journal article  |  2016  |  Immunity

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

Benjamin J Shields, Jacob T Jackson, Donald Metcalf, Wei Shi, Qiutong Huang, Alexandra L Garnham, Stefan P Glaser, Dominik Beck, John E Pimanda, Clifford W Bogue, Gordon K Smyth, Warren S Alexander, Matthew P McCormack

Journal article  |  2016  |  Genes & Development

Professor Donald Metcalf, AC, BSc(Med) Sydney, MD Sydney, FRACP, HonDSc Sydney, HonMD Oslo, HonFRCPath London, FRCPA, FAA, FRS

Ashley P Ng, Warren S Alexander, Douglas J Hilton, Nicos A Nicola

Journal article  |  2015  |  STEM CELLS

Tribute to Donald Metcalf.

Ann Murphy, Martin J Murphy, C Glenn Begley, E Richard Stanley, Anna Rita Migliaccio, Kenneth Kaushansky, Ashley P Ng, Warren S Alexander, Douglas J Hilton, Nicos A Nicola

Journal article  |  2015  |  STEM CELLS

A collection of tributes and remembrances from esteemed colleagues, mentees, and friends on the life and work of "the father of he..

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

Maria C Tanzer, Anne Tripaydonis, Andrew I Webb, Samuel N Young, Leila N Varghese, Cathrine Hall, Warren S Alexander, Joanne M Hildebrand, John Silke, James M Murphy

Journal article  |  2015  |  Biochemical Journal

Out-of-Sequence Signal 3 Paralyzes Primary CD4( ) T-Cell-Dependent Immunity.

Gail D Sckisel, Myriam N Bouchlaka, Arta M Monjazeb, Marka Crittenden, Brendan D Curti, Danice EC Wilkins, Kory A Alderson, Can M Sungur, Erik Ames, Annie Mirsoian, Abhinav Reddy, Warren Alexander, Athena Soulika, Bruce R Blazar, Dan L Longo, Robert H Wiltrout, William J Murphy

Journal article  |  2015  |  Immunity

Primary T cell activation involves the integration of three distinct signals delivered in sequence: (1) antigen recognition, (2) c..

Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL

Kathryn S Potts, Tobias J Sargeant, Caleb A Dawson, Emma C Josefsson, Douglas J Hilton, Warren S Alexander, Samir Taoudi

Journal article  |  2015  |  Blood

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Stanley CW Lee, Sarah Miller, Craig Hyland, Maria Kauppi, Marion Lebois, Ladina Di Rago, Donald Metcalf, Sarah A Kinkel, Emma C Josefsson, Marnie E Blewitt, Ian J Majewski, Warren S Alexander

Journal article  |  2015  |  Blood

Brief Report: Factors Released by Megakaryocytes Thrombin Cleave Osteopontin to Negatively Regulate Hematopoietic Stem Cells

Melonie J Storan, Shen Y Heazlewood, Chad K Heazlewood, David N Haylock, Warren S Alexander, Rebecca J Neaves, Ana Oteiza, Susan K Nilsson

Journal article  |  2015  |  STEM CELLS

Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071)

JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BT Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology

NA Nicola, WS Alexander, DJ Hilton, AP Ng

Journal article  |  2015  |  Experimental hematology

In memoriam: Donald Metcalf (1929-2014) A historical perspective of his contributions to hematology

Nicos A Nicola, Warren S Alexander, Douglas J Hilton, Ashley P Ng

Journal article  |  2015  |  Experimental Hematology

In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology

NA Nicola, WS Alexander, DJ Hilton, AP Ng

Journal article  |  2015  |  Experimental hematology

Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model

Ashley P Ng, Yifang Hu, Donald Metcalf, Craig D Hyland, Helen Ierino, Belinda Phipson, Di Wu, Tracey M Baldwin, Maria Kauppi, Hiu Kiu, Ladina Di Rago, Douglas J Hilton, Gordon K Smyth, Warren S Alexander

Journal article  |  2015  |  PLoS genetics

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice

BJ Shields, R Alserihi, C Nasa, C Bogue, WS Alexander, MP McCormack

Journal article  |  2015  |  Leukemia

BCL-2 is dispensable for thrombopoiesis and platelet survival

MA Debrincat, I Pleines, M Lebois, RM Lane, ML Holmes, J Corbin, CJ Vandenberg, WS Alexander, AP Ng, A Strasser, P Bouillet, M Sola-Visner, BT Kile, EC Josefsson

Journal article  |  2015  |  Cell Death & Disease

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development

Bilal N Sheikh, Stanley CW Lee, Farrah El-Saafin, Hannah K Vanyai, Yifang Hu, Swee Heng Milon Pang, Stephanie Grabow, Andreas Strasser, Stephen L Nutt, Warren S Alexander, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2015  |  Blood

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

Sarah A Kinkel, Roman Galeev, Christoffer Flensburg, Andrew Keniry, Kelsey Breslin, Omer Gilan, Stanley Lee, Joy Liu, Kelan Chen, Linden J Gearing, Darcy L Moore, Warren S Alexander, Mark Dawson, Ian J Majewski, Alicia Oshlack, Jonas Larsson, Marnie E Blewitt

Journal article  |  2015  |  Blood

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E Lawlor, Nufail Khan, Alison Mildenhall, Motti Gerlic, Ben A Croker, Akshay A D'Cruz, Cathrine Hall, Sukhdeep Kaur Spall, Holly Anderton, Seth L Masters, Maryam Rashidi, Ian P Wicks, Warren S Alexander, Yasuhiro Mitsuuchi, Christopher A Benetatos, Stephen M Condon, W Wei-Lynn Wong, John Silke, David L Vaux, James E Vince

Journal article  |  2015  |  Nature Communications

Donald Metcalf (1929-2014) Obituary

Douglas J Hilton, Nicos A Nicola, Warren S Alexander, Andrew W Roberts, Ashley R Dunn

Journal article  |  2015  |  Cell

A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis

Jacob T Jackson, Chayanica Nasa, Wei Shi, Nicholas D Huntington, Clifford W Bogue, Warren S Alexander, Matthew P McCormack

Journal article  |  2015  |  Blood

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, et al.

Journal article  |  2014  |  eLife

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

Kathryn S Potts, Tobias J Sargeant, John F Markham, Wei Shi, Christine Biben, Emma C Josefsson, Lachlan W Whitehead, Kelly L Rogers, Anna Liakhovitskaia, Gordon K Smyth, Benjamin T Kile, Alexander Medvinsky, Warren S Alexander, Douglas J Hilton, Samir Taoudi

Journal article  |  2014  |  Blood

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick CJ Dobson, Andrew I Webb, Anne Tripaydonis, Jeffrey J Babon, Mark D Mulcair, Martin J Scanlon, Warren S Alexander, Andrew F Wilks, Peter E Czabotar, Guillaume Lessene, James M Murphy, John Silke

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

Ramanjaneyulu Allam, Kate E Lawlor, Eric Chi-Wang Yu, Alison L Mildenhall, Donia M Moujalled, Rowena S Lewis, Francine Ke, Kylie D Mason, Michael J White, Katryn J Stacey, Andreas Strasser, Lorraine A O'Reilly, Warren Alexander, Benjamin T Kile, David L Vaux, James E Vince

Journal article  |  2014  |  EMBO reports

Key Role of Suppressor of Cytokine Signaling 3 in Regulating gp130 Cytokine-Induced Signaling and Limiting Chondrocyte Responses During Murine Inflammatory Arthritis

Xiao Liu, Ben A Croker, Ian K Campbell, Stephanie J Gauci, Warren S Alexander, Brett A Tonkin, Nicole C Walsh, Edmond M Linossi, Sandra E Nicholson, Kate E Lawlor, Ian P Wicks

Journal article  |  2014  |  Arthritis & Rheumatology

Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis

Laurence C Cheung, Deborah H Strickland, Meegan Howlett, Jette Ford, Adrian K Charles, Karen M Lyons, David R Brigstock, Roel Goldschmeding, Catherine H Cole, Warren S Alexander, Ursula R Kees

Journal article  |  2014  |  Haematologica

Ablation of proximal tubular suppressor of cytokine signaling 3 enhances tubular cell cycling and modifies macrophage phenotype during acute kidney injury

Nathan Susnik, Inga Soerensen-Zender, Song Rong, Sibylle von Vietinghoff, Xia Lu, Isabelle Rubera, Michel Tauc, Christine S Falk, Warren S Alexander, Anette Melk, Herrmann Haller, Roland Schmitt

Journal article  |  2014  |  Kidney International

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.

Journal article  |  2014  |  Cell

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Diwakar R Pattabiraman, Crystal McGirr, Konstantin Shakhbazov, Valerie Barbier, Keerthana Krishnan, Pamela Mukhopadhyay, Paula Hawthorne, Ann Trezise, Jianmin Ding, Sean M Grimmond, Peter Papathanasiou, Warren S Alexander, Andrew C Perkins, Jean-Pierre Levesque, Ingrid G Winkler, Thomas J Gonda

Journal article  |  2014  |  Blood

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

Ashley P Ng, Maria Kauppi, Donald Metcalf, Craig D Hyland, Emma C Josefsson, Marion Lebois, Jian-Guo Zhang, Tracey M Baldwin, Ladina Di Rago, Douglas J Hilton, Warren S Alexander

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1-and RIPK3-dependent manner

W Wei-Lynn Wong, James E Vince, Najoua Lalaoui, Kate E Lawlor, Diep Chau, Aleksandra Bankovacki, Holly Anderton, Donald Metcalf, Lorraine O'Reilly, Philipp J Jost, James M Murphy, Warren S Alexander, Andreas Strasser, David L Vaux, John Silke

Journal article  |  2014  |  Blood

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

James M Murphy, Isabelle S Lucet, Joanne M Hildebrand, Maria C Tanzer, Samuel N Young, Pooja Sharma, Guillaume Lessene, Warren S Alexander, Jeffrey J Babon, John Silke, Peter E Czabotar

Journal article  |  2014  |  Biochemical Journal

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia

Leila N Varghese, Jian-Guo Zhang, Samuel N Young, Tracy A Willson, Warren S Alexander, Nicos A Nicola, Jeffrey J Babon, James M Murphy

Journal article  |  2014  |  Growth Factors

Transgenic Expression of GM-CSF in T Cells Causes Disseminated Histiocytosis

Annemarie E van Nieuwenhuijze, Elise Coghill, Daniel Gray, Sandro Prato, Donald Metcalf, Warren S Alexander, Ian P Wicks

Journal article  |  2014  |  American Journal of Pathology

Lymphotoxin alpha induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor

Nima Etemadi, Jessica K Holien, Diep Chau, Grant Dewson, James M Murphy, Warren S Alexander, Michael W Parker, John Silke, Ueli Nachbur

Journal article  |  2013  |  The FEBS Journal

Polycomb repressive complex 2 (PRC2) suppresses E mu-myc lymphoma

Stanley CW Lee, Belinda Phipson, Craig D Hyland, Huei San Leong, Rhys S Allan, Aaron Lun, Douglas J Hilton, Stephen L Nutt, Marnie E Blewitt, Gordon K Smyth, Warren S Alexander, Ian J Majewski

Journal article  |  2013  |  Blood

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  Immunity

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

Jian Zhong Tang, Catherine L Carmichael, Wei Shi, Donald Metcalf, Ashley P Ng, Craig D Hyland, Nancy A Jenkins, Neal G Copeland, Viive M Howell, Zhizhuang Joe Zhao, Gordon K Smyth, Benjamin T Kile, Warren S Alexander

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals

Paul Koenen, Susanne Heinzel, Emma M Carrington, Lina Happo, Warren S Alexander, Jian-Guo Zhang, Marco J Herold, Clare L Scott, Andrew M Lew, Andreas Strasser, Philip D Hodgkin

Journal article  |  2013  |  Nature Communications

The Myb-p300-CREB axis modulates intestine homeostasis, radiosensitivity and tumorigenesis

S Sampurno, A Bijenhof, D Cheasley, H Xu, S Robine, D Hilton, WS Alexander, L Pereira, T Mantamadiotis, J Malaterre, RG Ramsay

Journal article  |  2013  |  Cell Death & Disease

Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Lee, Jason Corbin, Miha Pakusch, James M Murphy, Ian J Majewski, Gordon K Smyth, Warren S Alexander, Douglas J Hilton, Marnie E Blewitt

Journal article  |  2013  |  Cancer Research

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function

N Hansen, H Ågerstam, M Wahlestedt, N Landberg, M Askmyr, M Ehinger, M Rissler, H Lilljebjörn, P Johnels, J Ishiko, JV Melo, WS Alexander, D Bryder, M Järås, T Fioretos

Journal article  |  2013  |  Leukemia

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function

N Hansen, H Agerstam, M Wahlestedt, N Landberg, M Askmyr, M Ehinger, M Rissler, H Lilljebjorn, P Johnels, J Ishiko, JV Melo, WS Alexander, D Bryder, M Jaras, T Fioretos

Journal article  |  2013  |  Leukemia

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

Seth L Masters, Motti Gerlic, Donald Metcalf, Simon Preston, Marc Pellegrini, Joanne A O'Donnell, Kate McArthur, Tracey M Baldwin, Stephane Chevrier, Cameron J Nowell, Louise H Cengia, Katya J Henley, Janelle E Collinge, Daniel L Kastner, Lionel Feigenbaum, Douglas J Hilton, Warren S Alexander, Benjamin T Kile, Ben A Croker

Journal article  |  2012  |  Immunity

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia

Catherine L Carmichael, Donald Metcalf, Katya J Henley, Elizabeth A Kruse, Ladina Di Rago, Sandra Mifsud, Warren S Alexander, Benjamin T Kile

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential

Ashley P Ng, Maria Kauppi, Donald Metcalf, Ladina Di Rago, Craig D Hyland, Warren S Alexander

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

Stefan P Glaser, Erinna F Lee, Evelyn Trounson, Philippe Bouillet, Andrew Wei, W Douglas Fairlie, David J Izon, Johannes Zuber, Amy R Rappaport, Marco J Herold, Warren S Alexander, Scott W Lowe, Lorraine Robb, Andreas Strasser

Journal article  |  2012  |  Genes & Development

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin beta minor chain

Maria Kauppi, Adrienne A Hilton, Donald Metcalf, Ashley P Ng, Craig D Hyland, Janelle E Collinge, Benjamin T Kile, Douglas J Hilton, Warren S Alexander

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3

Ben A Croker, Hiu Kiu, Marc Pellegrini, Jesse Toe, Simon Preston, Donald Metcalf, Joanne A O'Donnell, Louise H Cengia, Kate McArthur, Nicos A Nicola, Warren S Alexander, Andrew W Roberts

Journal article  |  2012  |  Immunology and Cell Biology

SOCS3 Deletion in B Cells Alters Cytokine Responses and Germinal Center Output

Sarah A Jones, Christine A White, Lorraine Robb, Warren S Alexander, David M Tarlinton

Journal article  |  2011  |  Journal of Immunology

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

Ashley P Ng, Stephen J Loughran, Donald Metcalf, Craig D Hyland, Carolyn A de Graaf, Yifang Hu, Gordon K Smyth, Douglas J Hilton, Benjamin T Kile, Warren S Alexander

Journal article  |  2011  |  Blood

Mouse models of diseases of megakaryocyte and platelet homeostasis

Catherine L Carmichael, Warren S Alexander

Journal article  |  2011  |  Mammalian Genome

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

Samir Taoudi, Thomas Bee, Adrienne Hilton, Kathy Knezevic, Julie Scott, Tracy A Willson, Caitlin Collin, Tim Thomas, Anne K Voss, Benjamin T Kile, Warren S Alexander, John E Pimanda, Douglas J Hilton

Journal article  |  2011  |  Genes & Development

Regulation of hematopoietic stem cells by their mature progeny

Carolyn A de Graaf, Maria Kauppi, Tracey Baldwin, Craig D Hyland, Donald Metcalf, Tracy A Willson, Marina R Carpinelli, Gordon K Smyth, Warren S Alexander, Douglas J Hilton

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

William S Stevenson, Craig D Hyland, Jian-Guo Zhang, Phillip O Morgan, Tracy A Willson, Anthony Gill, Adrienne A Hilton, Elizabeth M Viney, Melanie Bahlo, Seth L Masters, Sarah Hennebry, Samantha J Richardson, Nicos A Nicola, Donald Metcalf, Douglas J Hilton, Andrew W Roberts, Warren S Alexander

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

Ian J Majewski, Matthew E Ritchie, Belinda Phipson, Jason Corbin, Miha Pakusch, Anja Ebert, Meinrad Busslinger, Haruhiko Koseki, Yifang Hu, Gordon K Smyth, Warren S Alexander, Douglas J Hilton, Marnie E Blewitt

Journal article  |  2010  |  Blood

SOCS3 regulates graft-versus-host disease

Geoffrey R Hill, Rachel D Kuns, Neil C Raffelt, Alistair LJ Don, Stuart D Olver, Kate A Markey, Yana A Wilson, Joel Tocker, Warren S Alexander, Andrew D Clouston, Andrew W Roberts, Kelli PA MacDonald

Journal article  |  2010  |  BLOOD

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2

Hiu Kiu, Christopher J Greenhalgh, Anne Thaus, Douglas J Hilton, Nicos A Nicola, Warren S Alexander, Andrew W Roberts

Journal article  |  2009  |  GROWTH FACTORS

SOCS-1 Binding to Tyrosine 441 of IFN-gamma Receptor Subunit 1 Contributes to the Attenuation of IFN-gamma Signaling In Vivo

Robyn Starr, Martina Fuchsberger, Lei Shong Lau, Adam P Uldrich, Ankita Goradia, Tracy A Willson, Anne M Verhagen, Warren S Alexander, Mark J Smyth

Journal article  |  2009  |  The Journal of Immunology

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia

Douglas J Hilton, Benjamin T Kile, Warren S Alexander

Journal article  |  2009  |  Blood

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

Catherine L Carmichael, Ian J Majewski, Warren S Alexander, Donald Metcalf, Douglas J Hilton, Chelsee A Hewitt, Hamish S Scott

Journal article  |  2009  |  Blood

Two distinct types of murine blast colony-forming cells are multipotential hematopoietic precursors

D Metcalf, KT Greig, CA de Graaf, SJ Loughran, WS Alexander, M Kauppi, CD Hyland, L Di Rago, S Mifsud

Journal article  |  2008  |  Proceedings of the National Academy of Sciences

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

Stephen J Loughran, Elizabeth A Kruse, Douglas F Hacking, Carolyn A de Graaf, Craig D Hyland, Tracy A Willson, Katya J Henley, Sarah Ellis, Anne K Voss, Donald Metcalf, Douglas J Hilton, Warren S Alexander, Benjamin T Kile

Journal article  |  2008  |  Nature Immunology

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

Ben A Croker, Lisa A Mielke, Sam Wormald, Donald Metcalf, Hiu Kiu, Warren S Alexander, Douglas J Hilton, Andrew W Roberts

Journal article  |  2008  |  Exp. Hematol.

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3

Hayley A Croom, David J Izon, Mark M Chong, David J Curtis, Andrew W Roberts, Thomas WH Kay, Douglas J Hilton, Warren S Alexander, Robyn Starr

Journal article  |  2008  |  Molecular Immunology

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity

Ian J Majewski, Marnie E Blewitt, Carolyn A de Graaf, Edward J McManus, Melanie Bahlo, Adrienne A Hilton, Craig D Hyland, Gordon K Smyth, Jason E Corbin, Donald Metcalf, Warren S Alexander, Douglas J Hilton

Journal article  |  2008  |  PLoS Biology

Discussion

WS Alexander, P Gros, D Hume, C Schönbach, C Vinuesa

Conference Proceedings  |  2007  |  Novartis Foundation Symposium

Discussion

WS Alexander, G Belz, WJ Britton, M Cook, J Cyster, CC Goodnow, D Hume, J Kaufman, C Mackay, S Stacker, S Turner

Conference Proceedings  |  2007  |  Novartis Foundation Symposium

Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells

Hong Qian, Natalija Buza-Vidas, Craig D Hyland, Christina T Jensen, Jennifer Antonchuk, Robert Mansson, Lina A Thoren, Marja Ekblorn, Warren S Alexander, Sten Eirik W Jacobsen

Journal article  |  2007  |  Cell Stem Cell

A novel mutation in the Nfkb2 gene generates-an NF-kappa B2 "Super repressor"

Elena Tucker, Kristy O'Donnel, Martina Fuchsberger, Adrienne A Hilton, Donald Metcalft, Kylie Greig, Natalie A Sims, Julian M Quinn, Warren S Alexander, Douglas J Hilton, Benjamin T Kile, David M Tarlinton, Robyn Starr

Journal article  |  2007  |  Journal of Immunology

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1

Donald Metcalf, Ian Majewski, Sandra Mifsud, Ladina Di Rago, Warren S Alexander

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

Mice rendered severely deficient in megakaryocytes through targeted gene deletion of the thrombopoietin receptor c-Mpl have a normal skeletal phenotype

Mark J Perry, Katrina A Redding, Warren S Alexander, Jonathan H Tobias

Journal article  |  2007  |  Calcified Tissue International

Agm1/Pgm-3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

Kylle T Greig, Jennifer Antonchuk, Donald Metcalf, Phillip O Morgan, Danielle L Krebs, Jian-Guo Zhang, Douglas F Hacking, Lars Bode, Lorraine Robb, Christian Kranz, Carolyn de Graaf, Melanie Bahlo, Nicos A Nicola, Stephen L Nutt, Hudson H Freeze, Warren S Alexander, Douglas J Hilton, Benjamin T Kile

Journal article  |  2007  |  Molecular and Cellular Biology

Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.

RJ Rigby, JG Simmons, CJ Greenhalgh, WS Alexander, PK Lund

Journal article  |  2007  |  Oncogene

Intestinal injury or chronic inflammation induce cytokines that promote crypt regeneration and mucosal repair. If excessive or pro..

c-Myb is required for progenitor cell homeostasis in colonic crypts

Jordane Malaterre, Marina Carpinelli, Matthias Ernst, Warren Alexander, Michael Cooke, Susan Sutton, Sebastian Dworkin, Joan K Heath, Jon Frampton, Grant McArthur, Hans Clevers, Douglas Hilton, Theo Mantamadiotis, Robert G Ramsay

Journal article  |  2007  |  Proceedings of the National Academy of Sciences of the United States of America

Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation

Marlyse A Debrincat, Jian-Guo Zhang, Tracy A Willson, John Silke, Lisa M Connolly, Richard J Simpson, Warren S Alexander, Nicos A Nicola, Benjamin T Kile, Douglas J Hilton

Journal article  |  2007  |  Journal of Biological Chemistry

Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation

George CT Yeoh, Matthias Ernst, Stefan Rose-John, Barbara Akhurst, Christine Payne, Sarah Long, Warren Alexander, Ben Croker, Dianne Grail, Vance B Matthews

Journal article  |  2007  |  Hepatology

c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3

Kate D Sutherland, Francois Vaillant, Warren S Alexander, Tim M Wintermantel, Natasha C Forrest, Sheridan L Holroyd, Edward J McManus, Gunther Schutz, Christine J Watson, Lewis A Chodosh, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2006  |  The EMBO Journal

General nature of the STAT3-activated anti-inflammatory response

Karim C El Kasmi, Jeff Holst, Maryaline Coffre, Lisa Mielke, Antoine de Pauw, Nouara Lhocine, Amber M Smith, Robert Rutschman, Deepak Kaushal, Yuhong Shen, Takashi Suda, Raymond P Donnelly, Martin G Myers, Warren Alexander, Dario AA Vignali, Stephanie S Watowich, Matthias Ernst, Douglas J Hilton, Peter J Murray

Journal article  |  2006  |  Journal of Immunology

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

Warren S Alexander, Elizabeth M Viney, Jian-Guo Zhang, Donald Metcalf, Maria Kauppi, Craig D Hyland, Marina R Carpinelli, William Stevenson, Ben A Croker, Adrienne A Hilton, Sarah Ellis, Carly Selan, Harshal H Nandurkar, Christopher C Goodnow, Benjamin T Kile, Nicos A Nicola, Andrew W Roberts, Douglas J Hilton

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

Ian J Majewski, Donald Metcalf, Lisa A Mielke, Danielle L Krebs, Sarah Ellis, Marina R Carpinelli, Sandra Mifsud, Ladina Di Rago, Jason Corbin, Nicos A Nicola, Douglas J Hilton, Warren S Alexander

Journal article  |  2006  |  Proceedings of the National Academy of Sciences of the United States of America

Socs2 and Elf5 mediate prolactin-induced mammary gland development

J Harris, PM Stanford, K Sutherland, SR Oakes, MJ Naylor, FG Robertson, KD Blazek, M Kazlauskas, HN Hilton, S Wittlin, WS Alexander, GJ Lindeman, JE Visvader, CJ Ormandy

Journal article  |  2006  |  Molecular Endocrinology

The comparative roles of suppressor of cytokine signaling-1 and-3 in the inhibition and desensitization of cytokine signaling

S Wormald, JG Zhang, DL Krebes, LA Mielke, J Silver, WS Alexander, TP Speed, NA Nicola, DJ Hilton

Journal article  |  2006  |  Journal of Biological Chemistry

Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells

Ariel Forrai, Kristy Boyle, Adam H Hart, Lynne Hartley, Steven Rakar, Tracy A Willson, Ken M Simpson, Andrew W Roberts, Warren S Alexander, Anne K Voss, Lorraine Robb

Journal article  |  2006  |  Stem Cells

Screening and counseling for thalassemia.

David HK Chui, Melody J Cunningham, Hong-Yuan Luo, Lawrence C Wolfe, Ellis J Neufeld, Martin H Steinberg

Journal article  |  2006  |  Blood

Phase I and pharmacokinetic study of once-daily dosing of intravenously administered busulfan in the setting of a reduced-intensity preparative regimen and allogeneic hematopoietic stem cell transplantation as immunotherapy for renal cell carcinoma.

Paul Shaughnessy, Warren Alexander, Hai Tran, David Ririe, James Splichal, Marilyn Pollack, Carlos Bachier, Charles LeMaistre

Journal article  |  2006  |  Military Medicine

We performed a Phase I and pharmacokinetic study of once-daily, intravenously administered busulfan in the setting of a reduced-in..

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

JE Fenner, R Starr, AL Cornish, JG Zhang, D Metcalf, RD Schreiber, K Sheehan, DJ Hilton, WS Alexander, PJ Hertzog

Journal article  |  2006  |  Nature Immunology

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

L Robb, K Boyle, S Rakar, L Hartley, J Lochland, AW Roberts, WS Alexander, D Metcalf

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia

SL Masters, KR Palmer, WS Stevenson, D Metcalf, EM Viney, NS Sprigg, WS Alexander, NA Nicola, SE Nicholson

Journal article  |  2005  |  Molecular and Cellular Biology

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene

D Metcalf, MR Carpinelli, C Hyland, S Mifsud, L DiRago, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2005  |  Blood

Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects

E Rico-Bautista, CJ Greenhalgh, P Tollet-Egnell, DJ Hilton, WS Alexander, G Norstedt, A Flores-Morales

Journal article  |  2005  |  Molecular Endocrinology

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

SE Nicholson, D Metcalf, NS Sprigg, R Columbus, F Walker, A Silva, D Cary, TA Willson, JG Zhang, DJ Hilton, WS Alexander, NA Nicola

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

SOCS2 negatively regulates growth hormone action in vitro and in vivo

CJ Greenhalgh, E Rico-Bautista, M Lorentzon, AL Thaus, PO Morgan, TA Willson, P Zervoudakis, D Metcalf, I Street, NA Nicola, AD Nash, LJ Fabri, G Norstedt, C Ohlsson, A Flores-Morales, WS Alexander, DJ Hilton

Journal article  |  2005  |  Journal of Clinical Investigation

Reduced bone mineral density in SOCS-2-deficient mice

M Lorentzon, CJ Greenhalgh, S Mohan, WS Alexander, C Ohlsson

Journal article  |  2005  |  Pediatric Research

The developmental potential of hematopoietic stem cells

WS Alexander

Conference Proceedings  |  2004  |  Transactions - 7th World Biomaterials Congress

Synergistic effects on erythropoiesis, thrombopoiesis, and stem cell competitiveness in mice deficient in thrombopoietin and steel factor receptors

J Antonchuk, CD Hyland, DJ Hilton, WS Alexander

Journal article  |  2004  |  Blood

Thrombopoietin signalling in physiology and disease

B Fishley, WS Alexander

Journal article  |  2004  |  Growth Factors

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

C Brender, R Columbus, D Metcalf, E Handman, R Starr, N Huntington, D Tarlinton, N Odum, SE Nicholson, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2004  |  Molecular and Cellular Biology

Suppressors of cytokine signalling and regulation of growth hormone action

CJ Greenhalgh, WS Alexander

Journal article  |  2004  |  Growth Hormone & IGF Research

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

BA Croker, D Metcalf, L Robb, W Wei, S Mifsud, L DiRago, LA Cluse, KD Sutherland, L Hartley, E Williams, JG Zhang, DJ Hilton, NA Nicola, WS Alexander, AW Roberts

Journal article  |  2004  |  Immunity

The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immuneresponse

WS Alexander, DJ Hilton

Journal article  |  2004  |  Annual Review of Immunology

Thrombopoietin bioassay.

Warren S Alexander, Craig Hyland

Journal article  |  2004  |  Methods in molecular biology (Clifton, N.J.)

The lethal effects of transplantation of Socs1(-/-) bone marrow cells into irradiated adult syngeneic recipients

D Metcalf, S Mifsud, L Di Rago, WS Alexander

Journal article  |  2003  |  Proceedings of the National Academy of Sciences

SOCS3 negatively regulates IL-6 signaling in vivo

BA Croker, DL Krebs, JG Zhang, S Wormald, TA Willson, EG Stanley, L Robb, CJ Greenhalgh, I Forster, BE Clausen, NA Nicola, D Metcalf, DJ Hilton, AW Roberts, WS Alexander

Journal article  |  2003  |  Nat. Immunol.

Differential regulation of SOCS genes in normal and transformed erythroid cells

MK Sarna, E Ingley, SJ Busfield, VS Cull, W Lepere, DJ McCarthy, MJ Wright, GA Palmer, D Chappell, MS Sayer, WS Alexander, DJ Hilton, R Starr, SS Watowich, T Bittorf, SP Klinken, PA Tilbrook

Journal article  |  2003  |  Oncogene

Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major

DVR Bullen, TM Baldwin, JM Curtis, WS Alexander, E Handman

Journal article  |  2003  |  The Journal of Immunology

The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA

DVR Bullen, DS Hansen, MAV Siomos, L Schofield, WS Alexander, E Handman

Journal article  |  2003  |  Parasite Immunology

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

CJ Greenhalgh, D Metcalf, AL Thaus, JE Corbin, R Uren, PO Morgan, LJ Fabri, JG Zhang, HM Martin, TA Willson, N Billestrup, NA Nicola, M Baca, WS Alexander, DJ Hilton

Journal article  |  2002  |  Journal of Biological Chemistry

Suppressors of cytokine signalling (SOCS) in the immune system

WS Alexander

Journal article  |  2002  |  Nature Reviews Immunology

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

CJ Greenhalgh, P Bertolino, SL Asa, D Metcalf, JE Corbin, TE Adams, HW Davey, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2002  |  Molecular Endocrinology

The SOCS box: a tale of destruction and degradation

BT Kile, BA Schulman, WS Alexander, NA Nicola, HME Martin, DJ Hilton

Journal article  |  2002  |  Trends Biochem. Sci.

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

D Metcalf, S Mifsud, L Di Rago, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2002  |  Proceedings of the National Academy of Sciences

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

JG Zhang, D Metcalf, S Rakar, M Asimakis, CJ Greenhalgh, TA Willson, R Starr, SE Nicholson, W Carter, WS Alexander, DJ Hilton, NA Nicola

Journal article  |  2001  |  Proceedings of the National Academy of Sciences

Production of colony-stimulating factors and IL-5 by organs from three types of mice with inflammatory disease due to loss of the suppressor of cytokine signaling-1

D Metcalf, WS Alexander, PJ Ryan, S Mifsud, L Di Rago

Journal article  |  2001  |  The Journal of Immunology

The multi-organ origin of interleukin-5 in the mouse

PJ Ryan, T Willson, WS Alexander, L Di Rago, S Mifsud, D Metcalf

Journal article  |  2001  |  Leukemia

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

AW Roberts, L Robb, S Rakar, L Hartley, L Cluse, NA Nicola, D Metcalf, DJ Hilton, WS Alexander

Journal article  |  2001  |  Proceedings of the National Academy of Sciences

Suppressor of cytokine signaling-1 attenuates the duration of interferon gamma signal transduction in vitro and in vivo

M Brysha, JG Zhang, P Bertolino, JE Corbin, WS Alexander, NA Nicola, DJ Hilton, R Starr

Journal article  |  2001  |  Journal of Biological Chemistry

Thrombopoietin signaling is required for in vivo expansion of IL-11-responsive hematopoietic progenitor cells in the steady state

CL Scott, L Robb, HH Nandurkar, R Mansfield, WS Alexander, CG Begley

Journal article  |  2001  |  Experimental Hematology

Quantum chemical study on the mechanism of enantioselective reduction of prochiral ketones catalyzed by oxazaborolidines

PJ Ryan, T Willson, WS Alexander, L Di Rago, S Mifsud, D Metcalf

Journal article  |  2001  |  Science in China Series B: Chemistry

SOCS proteins - Negative regulators of cytokine signal transduction

R Starr, T Willson, E Viney, R Richardson, W Alexander, D Metcalf, N Nicola, D Hilton

Journal article  |  2000  |  Australian Journal of Medical Science

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4

BT Kile, EM Viney, TA Willson, TC Brodnicki, MR Cancilla, AS Herlihy, BA Croker, M Baca, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2000  |  Gene

Granulocyte-macrophage colony-stimulating factor is not responsible for residual thrombopoiesis in mpl null mice

CL Scott, L Robb, R Mansfield, WS Alexander, CG Begley

Journal article  |  2000  |  Experimental Hematology

The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene.

D Metcalf, L Di Rago, S Mifsud, L Hartley, WS Alexander

Journal article  |  2000  |  Proceedings of the National Academy of Sciences

Mice lacking the gene encoding the suppressor of cytokine signaling-1 (SOCS-1 -/-) and heterozygous for the IFN-gamma gene (IFN-ga..

Gigantism in mice lacking suppressor of cytokine signalling-2

D Metcalf, CJ Greenhalgh, E Viney, TA Willson, R Starr, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2000  |  Nature

The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.

T Gainsford, H Nandurkar, D Metcalf, L Robb, CG Begley, WS Alexander

Journal article  |  2000  |  Blood

Mice lacking thrombopoietin (TPO) or its receptor c-Mpl are severely thrombocytopenic, consistent with a dominant physiological ro..

Sternocleidomastoid pseudotumour and congenital muscular torticollis

PJ Ryan, T Willson, WS Alexander, L Di Rago, S Mifsud, D Metcalf

Journal article  |  2000  |  European Journal of Pediatrics

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

WS Alexander, R Starr, D Metcalf, SE Nicholson, A Farley, AG Elefanty, M Brysha, BT Kile, R Richardson, M Baca, JG Zhang, TA Willson, EM Viney, NS Sprigg, S Rakar, J Corbin, S Mifsud, L DiRago, D Cary, NA Nicola, et al.

Journal article  |  1999  |  Journal of Leukocyte Biology

Thrombopoietin and the c-Mpl receptor: insights from gene targeting.

WS Alexander

Journal article  |  1999  |  The International Journal of Biochemistry & Cell Biology

The availability of thrombopoietin (TPO) in recombinant form has revolutionized the study of megakaryocytopoiesis and provided an ..

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine

WS Alexander, R Starr, JE Fenner, GL Scott, E Handman, NS Sprigg, JE Corbin, AL Cornish, R Darwiche, CM Owczarek, TWH Kay, NA Nicola, PJ Hertzog, D Metcalf, DJ Hilton

Journal article  |  1999  |  Cell

Suckling defect in mice lacking the soluble haemopoietin receptor NR6

WS Alexander, S Rakar, L Robb, A Farley, TA Willson, JG Zhang, L Hartley, Y Kikuchi, T Kojima, H Nomura, M Hasegawa, M Maeda, L Fabri, K Jachno, A Nash, D Metcalf, NA Nicola, DJ Hilton

Journal article  |  1999  |  Current Biology

Aberrant hematopoiesis in mice with inactivation of the gene encoding SOCS-1

D Metcalf, WS Alexander, AG Elefanty, NA Nicola, DJ Hilton, R Starr, S Mifsud, L Di Rago

Journal article  |  1999  |  Leukemia

A role for leptin in hemopoieses?

T Gainsford, WS Alexander

Journal article  |  1999  |  Molecular Biotechnology

The recent discovery of leptin as a major controller of appetite has led to a detailed analysis of its specific actions in this pr..

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BJ Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function.

BA Henry, JW Goding, WS Alexander, AJ Tilbrook, BJ Canny, F Dunshea, A Rao, A Mansell, IJ Clarke

Journal article  |  1999  |  Endocrinology

We have studied the effect of leptin on food intake and neuroendocrine function in ovariectomized ewes. Groups (n = 5) received in..

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

SE Nicholson, TA Willson, A Farley, R Starr, JG Zhang, M Baca, WS Alexander, D Metcalf, DJ Hilton, NA Nicola

Journal article  |  1999  |  The EMBO Journal

Negative regulation of cytokine signaling by the SOCS proteins

NA Nicola, SE Nicholson, D Metcalf, JG Zhang, M Baca, A Farley, TA Willson, R Starr, W Alexander, DJ Hilton

Conference Proceedings  |  1999  |  Cold Spring Harbor Symposia on Quantitative Biology

Thrombopoietin.

WS Alexander

Journal article  |  1999  |  Growth Factors

Thrombopoietin (TPO) was first described as an activity in thrombocytopenic serum that could stimulate platelet production upon tr..

Hemopoietic growth factor receptor abnormalities in leukemia

WS Alexander, NA Nicola

Journal article  |  1998  |  Leukemia Research

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

R Starr, D Metcalf, AG Elefanty, M Brysha, TA Willson, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  1998  |  Proceedings of the National Academy of Sciences

Cytokine production and function in c-mpl-deficient mice: No physiologic role for interleukin-3 in residual megakaryocyte and platelet production

T Gainsford, AW Roberts, S Kimura, D Metcalf, G Dranoff, RC Mulligan, CG Begley, L Robb, WS Alexander

Journal article  |  1998  |  Blood

recessive spotting: a linked locus that interacts with W/Kit but is not allelic.

DC Bennett, ID Trayner, X Piao, DJ Easty, M Klüppel, WS Alexander, EF Wagner, A Bernstein

Journal article  |  1998  |  Genes to Cells

BACKGROUND: The murine coat-colour mutation recessive spotting (rs) maps very closely to the W/Kit locus, encoding the proto-oncop..

Thrombopoietin in vitro and in vivo.

WS Alexander, CG Begley

Journal article  |  1998  |  Cytokines, Cellular and Molecular Therapy

The characterization of the c-Mpl receptor resulted from studies on a murine retrovirus, and proved an important step in the ident..

The biological consequences of excess GM-CSF levels in transgenic mice also lacking high-affinity receptors for GM-CSF

D Metcalf, S Mifsud, L Di Rago, L Robb, NA Nicola, W Alexander

Journal article  |  1998  |  Leukemia

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin

S Kimura, AW Roberts, D Metcalf, WS Alexander

Conference Proceedings  |  1998  |  Proceedings of the National Academy of Sciences

Twenty proteins containing a C-terminal SOCS box form five structural classes

DJ Hilton, RT Richardson, WS Alexander, EM Viney, TA Willson, NS Sprigg, R Starr, SE Nicholson, D Metcalf, NA Nicola

Journal article  |  1998  |  Proceedings of the National Academy of Sciences

Cytokines in hematopoiesis.

WS Alexander

Journal article  |  1998  |  International Reviews of Immunology

Hematopoiesis is the process by which mature, functional progeny of the eight major lineages of blood cells are produced from a hi..

CSF-1 and interferon-gamma act synergistically to promote differentiation of FDC-P1 cells into macrophages.

U Novak, S Nicholson, RP Bourette, LR Rohrschneider, W Alexander, L Paradiso

Journal article  |  1998  |  Growth Factors

FDC-P1 cells expressing the wildtype CSF-1 receptor, FDwtfms, differentiate into macrophages during incubation with CSF-1. This re..

Cellular and viral mutants of the MPL rezeptor transform primary hemopoietic cells and lead to constitutive activation of SHC and stats

AB Maurer, D Metcalf, M Grez, WS Alexander

Journal article  |  1997  |  Experimental Hematology

Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction

R Starr, U Novak, TA Willson, M Inglese, V Murphy, WS Alexander, D Metcalf, NA Nicola, DJ Hilton, M Ernst

Journal article  |  1997  |  Journal of Biological Chemistry

A family of cytokine-inducible inhibitors of signalling

R Starr, TA Willson, EM Viney, LJL Murray, JR Rayner, BJ Jenkins, TJ Gonda, WS Alexander, D Metcalf, NA Nicola, DJ Hilton

Journal article  |  1997  |  Nature

Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor

AW Roberts, S Foote, WS Alexander, C Scott, L Robb, D Metcalf

Journal article  |  1997  |  Blood

Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein - Evidence that it is distinct from the cloned IL-13 receptor and IL-4 receptor alpha-chains

JG Zhang, DJ Hilton, TA Willson, C McFarlane, BA Roberts, RL Moritz, RJ Simpson, WS Alexander, D Metcalf, NA Nicola

Journal article  |  1997  |  Journal of Biological Chemistry

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

T Gainsford, TA Willson, D Metcalf, E Handman, C McFarlane, A Ng, NA Nicola, WS Alexander, DJ Hilton

Conference Proceedings  |  1996  |  Proceedings of the National Academy of Sciences

Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation.

WS Alexander, AB Maurer, U Novak, M Harrison-Smith

Journal article  |  1996  |  The EMBO Journal

Interaction of thrombopoietin (TPO) with its receptor, c-Mpl, triggers cell growth and differentiation responses controlling primi..

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl

WS Alexander, AW Roberts, NA Nicola, RL Li, D Metcalf

Journal article  |  1996  |  Blood

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

DJ Hilton, JG Zhang, D Metcalf, WS Alexander, NA Nicola, TA Willson

Journal article  |  1996  |  Proceedings of the National Academy of Sciences

Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.

WS Alexander, AW Roberts, AB Maurer, NA Nicola, AR Dunn, D Metcalf

Journal article  |  1996  |  Stem Cells

The c-mpl gene encodes a receptor for thrombopoietin (TPO), a cytokine that potently stimulates megakaryocytopoiesis. To study the..

Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity.

WS Alexander, D Metcalf, AR Dunn

Journal article  |  1995  |  The EMBO Journal

c-Mpl, a receptor for thrombopoietin (TPO), belongs to the haemopoietin/cytokine receptor superfamily, a group of cell surface mol..

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

KJ Fowler, F Walker, W Alexander, ML Hibbs, EC Nice, RM Bohmer, GB Mann, C Thumwood, R Maglitto, JA Danks

Journal article  |  1995  |  Proceedings of the National Academy of Sciences

The mutant mouse waved-2 (wa-2) is strikingly similar to transforming growth factor alpha-deficient mice generated by gene targeti..

Structure and transcription of the genomic locus encoding murine c-Mpl, a receptor for thrombopoietin.

WS Alexander, AR Dunn

Journal article  |  1995  |  Oncogene

We have cloned and characterised the murine gene encoding c-Mpl, a receptor for thrombopoietin and member of the hematopoietin rec..

Insights into the physiology of TGF alpha and signaling through the EGF receptor revealed by gene targeting and acts of nature.

AR Dunn, GB Mann, KJ Fowler, D Grail, ML Hibbs, WS Alexander, F Walker, AW Burgess

Journal article  |  1994  |  Princess Takamatsu symposia

Transforming growth factor alpha (TGF alpha) is one of a group of structurally-related growth factors (the epidermal growth factor..

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

WS Alexander, SD Lyman, EF Wagner

Journal article  |  1991  |  The EMBO Journal

Loss-of-function mutations in the gene for the c-kit tyrosine kinase receptor are strongly implicated in the developmental abnorma..

NOVEL ZINC FINGER GENE IMPLICATED AS MYC COLLABORATOR BY RETROVIRALLY ACCELERATED LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE

Y HAUPT, WS ALEXANDER, G BARRI, SP KLINKEN, JM ADAMS

Journal article  |  1991  |  Cell

Of kit and mouse and man

EF Wagner, WS Alexander

Journal article  |  1991  |  Current Biology

THE TRANSGENIC WINDOW ON LYMPHOID MALIGNANCY

JM ADAMS, AW HARRIS, DL VAUX, WS ALEXANDER, H ROSENBAUM, SP KLINKEN, A STRASSER, ML BATH, J MCNEALL, S CORY

Journal article  |  1990  |  Princess Takamatsu symposia

LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE CAN INVOLVE RAS MUTATIONS

WS ALEXANDER, O BERNARD, S CORY, JM ADAMS

Journal article  |  1989  |  Oncogene

ONCOGENE COOPERATION IN LYMPHOCYTE-TRANSFORMATION - MALIGNANT CONVERSION OF E-MU-MYC TRANSGENIC PRE-B CELLS-INVITRO IS ENHANCED BY V-H-RAS OR V-RAF BUT NOT V-ABL

WS ALEXANDER, JM ADAMS, S CORY

Journal article  |  1989  |  Molecular and Cellular Biology

LYMPHOID NEOPLASIA AND THE CONTROL OF HEMATOPOIETIC DIFFERENTIATION

JM ADAMS, AW HARRIS, WY LANGDON, SP KLINKEN, K KONGSUWAN, WS ALEXANDER, I HARIHARAN, D VAUX, H ROSENBAUM, M CRAWFORD, E WEBB, H ABUD, S CORY

Journal article  |  1989  |  Ciba Foundation symposium

Oncogene cooperation and B-lymphoid tumorigenesis in Emu-myc transgenic mice.

WS Alexander, O Bernard, WY Langdon, AW Harris, JM Adams, S Cory

Journal article  |  1989  |  Haematology and blood transfusion

HEMATOPOIETIC LINEAGE SWITCH - V-RAF ONCOGENE CONVERTS E-MU-MYC TRANSGENIC B-CELLS INTO MACROPHAGES

SP KLINKEN, WS ALEXANDER, JM ADAMS

Journal article  |  1988  |  Cell

Hemopoietic lineage commitment can be breached by concomitant expression of the c-myc and v-raf oncogenes. Switching to the myeloi..

TRANSGENIC MOUSE MODELS FOR HEMATOPOIETIC TUMORIGENESIS

AW HARRIS, WY LANGDON, WS ALEXANDER, IK HARIHARAN, H ROSENBAUM, D VAUX, E WEBB, O BERNARD, M CRAWFORD, H ABUD, JM ADAMS, S CORY

Journal article  |  1988  |  Current topics in microbiology and immunology

IMMUNOLOGICAL COMPETENCE OF B-CELLS SUBJECTED TO CONSTITUTIVE C-MYC ONCOGENE EXPRESSION IN IMMUNOGLOBULIN HEAVY-CHAIN ENHANCER MYC TRANSGENIC MICE

DL VAUX, JM ADAMS, WS ALEXANDER, BL PIKE

Journal article  |  1987  |  Journal of Immunology

EXPRESSION OF THE C-MYC ONCOGENE UNDER CONTROL OF AN IMMUNOGLOBULIN ENHANCER IN E-MU-MYC TRANSGENIC MICE

WS ALEXANDER, JW SCHRADER, JM ADAMS

Journal article  |  1987  |  Molecular and Cellular Biology

Transgenic mice bearing a cellular myc oncogene coupled to the immunoglobulin heavy-chain enhancer (E mu) exhibit perturbed B-lymp..

The myc oncogene and lymphoid neoplasia: from translocations to transgenic mice.

S Cory, AW Harris, WY Langdon, WS Alexander, LM Corcoran, RD Palmiter, CA Pinkert, RL Brinster, JM Adams

Journal article  |  1987  |  Haematology and blood transfusion

C-MYC-INDUCED LYMPHOMAGENESIS IN TRANSGENIC MICE AND THE ROLE OF THE THE PVT-1 LOCUS IN LYMPHOID NEOPLASIA

JM ADAMS, AW HARRIS, WY LANGDON, CA PINKERT, RL BRINSTER, RD PALMITER, L CORCORAN, WS ALEXANDER, MW GRAHAM, S CORY

Journal article  |  1986  |  Current Topics in Microbiology and Immunology

THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE

JM ADAMS, AW HARRIS, CA PINKERT, LM CORCORAN, WS ALEXANDER, S CORY, RD PALMITER, RL BRINSTER

Journal article  |  1985  |  Nature