Tom Brodnicki

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice

Satoru Akazawa, Leanne Mackin, Gaurang Jhala, Stacey Fynch, Tara Catterall, Claudia Selck, Kate L Graham, Balasubramanian Krishnamurthy, Evan G Pappas, Chun-Ting J Kwong, Andrew PR Sutherland, Thomas WH Kay, Thomas C Brodnicki, Helen E Thomas

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in..

T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities

Florian Wiede, Thomas C Brodnicki, Pei Kee Goh, Yew A Leong, Gareth W Jones, Di Yu, Alan G Baxter, Simon A Jones, Thomas WH Kay, Tony Tiganis

Journal article  |  2019  |  DIABETES

Genome-wide association studies have identified PTPN2 as an important non-MHC gene for autoimmunity. Single nucleotide polymorphis..

Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome

Yury Chaly, Jennifer Y Barr, David A Sullivan, Helen E Thomas, Thomas C Brodnicki, Scott M Lieberman

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonobese diabetic (NOD) mice spontaneously develop lacrimal and salivary gland autoimmunity similar to human Sjögren syndrome. In ..

GSK3 inhibition, but not epigenetic remodeling, mediates efficient derivation of germline embryonic stem cells from nonobese diabetic mice

Jun Liu, Michelle P Ashton, Moira K O'Bryan, Thomas C Brodnicki, Paul J Verma

Journal article  |  2018  |  STEM CELL RESEARCH

The nonobese diabetic (NOD) mouse strain is a predominant animal model of type 1 diabetes. However, this mouse strain is considere..

Autoimmune-diseaseprone NOD mice help to reveal a new genetic locus for reducing pulmonary disease caused by Mycoplasma pulmonis

NK Wawegama, PF Markham, CM Elso, A Kanci, MS Marenda, GF Browning, TC Brodnicki

Journal article  |  2018  |  Infection and Immunity (Online)

© 2018 American Society for Microbiology. Mycoplasmas are bacterial pathogens of a range of animals, including humans, and are a c..

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  DIABETES

Recent advances in immunotherapeutics have not yet changed the routine management of autoimmune type 1 diabetes. There is an oppor..

Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility

Edward PF Chu, Colleen M Elso, Abigail H Pollock, May A Alsayb, Leanne Mackin, Helen E Thomas, Thomas WH Kay, Pablo A Silveira, Ashley S Mansell, Katharina Gaus, Thomas C Brodnicki

Journal article  |  2017  |  MOLECULAR IMMUNOLOGY

During immune cell activation, serine-derived lipids such as phosphatidylserine and sphingolipids contribute to the formation of p..

How to Make Mice Tell the Truth

Helen E Thomas, Thomas C Brodnicki, Thomas WH Kay

Journal article  |  2016  |  DIABETES

Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes

Colleen M Elso, Edward PF Chu, May A Alsayb, Leanne Mackin, Sean T Ivory, Michelle P Ashton, Stefan Broeer, Pablo A Silveira, Thomas C Brodnicki

Journal article  |  2015  |  G3-GENES GENOMES GENETICS

A number of different strategies have been used to identify genes for which genetic variation contributes to type 1 diabetes (T1D)..

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N Gurzov, Thomas C Brodnicki, Kate L Graham, Jibran A Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E Thomas, Thomas WH Kay

Journal article  |  2015  |  DIABETES

Because regulatory T-cell (Treg) development can be induced by the same agonist self-antigens that induce negative selection, pert..