Tom Brodnicki

T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities

Florian Wiede, Thomas C Brodnicki, Pei Kee Goh, Yew A Leong, Gareth W Jones, Di Yu, Alan G Baxter, Simon A Jones, Thomas WH Kay, Tony Tiganis

Journal article  |  2019  |  Diabetes

Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjogren Syndrome

Yury Chaly, Jennifer Y Barr, David A Sullivan, Helen E Thomas, Thomas C Brodnicki, Scott M Lieberman

Journal article  |  2018  |  International Journal of Molecular Sciences

GSK3 inhibition, but not epigenetic remodeling, mediates efficient derivation of germline embryonic stem cells from nonobese diabetic mice

Jun Liu, Michelle P Ashton, Moira K O'Bryan, Thomas C Brodnicki, Paul J Verma

Journal article  |  2018  |  Stem Cell Research

Autoimmune-diseaseprone NOD mice help to reveal a new genetic locus for reducing pulmonary disease caused by Mycoplasma pulmonis

NK Wawegama, PF Markham, CM Elso, A Kanci, MS Marenda, GF Browning, TC Brodnicki

Journal article  |  2018  |  Infection and Immunity

© 2018 American Society for Microbiology. Mycoplasmas are bacterial pathogens of a range of animals, including humans, and are a c..

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M Trivedi, Kate L Graham, Nicholas A Scott, Misty R Jenkins, Suktilang Majaw, Robyn M Sutherland, Stacey Fynch, Andrew M Lew, Christopher J Burns, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering, Thomas W Kay, Helen E Thomas

Journal article  |  2017  |  Diabetes

Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility

Edward PF Chu, Colleen M Elso, Abigail H Pollock, May A Alsayb, Leanne Mackin, Helen E Thomas, Thomas WH Kay, Pablo A Silveira, Ashley S Mansell, Katharina Gaus, Thomas C Brodnicki

Journal article  |  2017  |  Molecular Immunology

How to Make Mice Tell the Truth

Helen E Thomas, Thomas C Brodnicki, Thomas WH Kay

Journal article  |  2016  |  Diabetes

Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes

Colleen M Elso, Edward PF Chu, May A Alsayb, Leanne Mackin, Sean T Ivory, Michelle P Ashton, Stefan Broeer, Pablo A Silveira, Thomas C Brodnicki

Journal article  |  2015  |  G3: Genes|Genomes|Genetics

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N Gurzov, Thomas C Brodnicki, Kate L Graham, Jibran A Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E Thomas, Thomas WH Kay

Journal article  |  2015  |  Diabetes

Increased Autoimmune Diabetes in pIgR-Deficient NOD Mice Is Due to a "Hitchhiking" Interval that Refines the Genetic Effect of Idd5.4

Kim R Simpfendorfer, Richard A Strugnell, Thomas C Brodnicki, Odilia LC Wijburg

Journal article  |  2015  |  PLOS ONE

Protein tyrosine phosphatases: molecular switches in metabolism and diabetes

Esteban N Gurzov, William J Stanley, Thomas C Brodnicki, Helen E Thomas

Journal article  |  2015  |  Trends in Endocrinology & Metabolism

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4( ) T Cells Infiltrate Islets in Type 1 Diabetes

Vimukthi Pathiraja, Janine P Kuehlich, Peter D Campbell, Balasubramanian Krishnamurthy, Thomas Loudovaris, P Toby H Coates, Thomas C Brodnicki, Philip J O'Connell, Katherine Kedzierska, Christine Rodda, Philip Bergman, Erin Hill, Anthony W Purcell, Nadine L Dudek, Helen E Thomas, Thomas WH Kay, Stuart I Mannering

Journal article  |  2015  |  Diabetes

Deficiency in Type I Interferon Signaling Prevents the Early Interferon-Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Hong Sheng Quah, Socorro Miranda-Hernandez, Aimee Khoo, Ashley Harding, Stacey Fynch, Lorraine Elkerbout, Thomas C Brodnicki, Alan G Baxter, Thomas WH Kay, Helen E Thomas, Kate L Graham

Journal article  |  2014  |  Diabetes

Systemic infection of Mice with Listeria monocytogenes to characterize host immune responses.

Nancy Wang, Richard A Strugnell, Odilia L Wijburg, Thomas C Brodnicki

Book Chapter  |  2013  |  Methods in Molecular Biology

Listeria monocytogenes is a Gram-positive facultative intracellular bacterium that is widely used to characterize bacterial pathog..

Granzyme B Is Dispensable in the Development of Diabetes in Non-Obese Diabetic Mice

Zia U Mollah, Kate L Graham, Balasubramanian Krishnamurthy, Prerak Trivedi, Thomas C Brodnicki, Joseph A Trapani, Thomas W Kay, Helen E Thomas

Journal article  |  2012  |  PLoS One

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes

Nancy Wang, Richard Strugnell, Odilia Wijburg, Thomas Brodnicki

Journal article  |  2011  |  Journal of Visualized Experiments

The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse

Zia UA Mollah, Jibran Wali, Mark D McKenzie, Balasubramanian Krishnamurthy, Kate L Graham, Stacey Fynch, Joshua Szanyi, Pere Santamaria, Thomas Brodnicki, Janette Allison, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2011  |  Apoptosis

Generation of Stable Pluripotent Stem Cells From NOD Mouse Tail-Tip Fibroblasts

Jun Liu, Michelle P Ashton, Huseyin Sumer, Moira K O'Bryan, Thomas C Brodnicki, Paul J Verma

Journal article  |  2011  |  Diabetes

Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).

Joan E Hilner, Letitia H Perdue, Elizabeth G Sides, June J Pierce, Ana M Wägner, Alan Aldrich, Amanda Loth, Lotte Albret, Lynne E Wagenknecht, Concepcion Nierras, Beena Akolkar, undefined T1DGC

Journal article  |  2010  |  Clinical Trials: Journal of the Society for Clinical Trials

BACKGROUND AND PURPOSE: The Type 1 Diabetes Genetics Consortium (T1DGC) is an international project whose primary aims are to: (a)..

Insulin teaches a new lesson in tolerance

Thomas WH Kay, Bala Krishnamurthy, Thomas C Brodnicki, Stuart I Mannering

Journal article  |  2009  |  The EMBO Journal

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Jeffrey C Barrett, David G Clayton, Patrick Concannon, Beena Akolkar, Jason D Cooper, Henry A Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Vincent Plagnol, Flemming Pociot, Helen Schuilenburg, Deborah J Smyth, Helen Stevens, John A Todd, Neil M Walker, Stephen S Rich, undefined Type 1 Diabetes Genetics Consortium

Journal article  |  2009  |  Nature Genetics

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk facto..

APPROACHES TO THE STUDY OF THE GENETICS OF BEHAVIOURAL VARIATION USING MICE AND RATS

MC Jawahar, YM Wilson, AJ Lawrence, TC Brodnicki, M Murphy

Book Chapter  |  2009

Somatic mutation and autoimmunity.

Thomas C Brodnicki

Journal article  |  2007  |  Cell

Recent insights into CD4 T-cell specificity and function in type 1 diabetes

SI Mannering, TC Brodnicki

Journal article  |  2007  |  Expert Review of Clinical Immunology

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

T Thomas, LM Corcoran, R Gugasyan, MP Dixon, T Brodnicki, SL Nutt, D Metcalf, AK Voss

Journal article  |  2006  |  Genes Dev.

Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains

NJ Armstrong, TC Brodnicki, TP Speed

Journal article  |  2006  |  Mammalian Genome

Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE

Irina Caminschi, Stephane Vandenabeele, Mariam Sofi, Andrew J McKnight, Neil Ward, Thomas C Brodnicki, Tracey Toy, Mireille Lahoud, Eugene Maraskovsky, Ken Shortman, Mark D Wright

Journal article  |  2006  |  DNA Sequence

Congenic nonobese diabetic mouse strains fail to confirm linkage of a marginal zone B lymphocyte phenotype to the Idd11 locus on chromosome 4

TC Brodnicki, K O'Donnell, F Quirk, DM Tarlinton

Journal article  |  2006  |  The Journal of Immunology

Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development

M O'Keeffe, TC Brodnicki, B Fancke, D Vremec, G Morahan, E Maraskovsky, R Steptoe, LC Harrison, K Shortman

Journal article  |  2005  |  International Immunology

Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues.

Anne M Johnston, Gaetano Naselli, Hideo Niwa, Thomas Brodnicki, Leonard C Harrison, L Jorge Góñez

Journal article  |  2004  |  Genes to Cells

Mutations in the triple PDZ domain-containing protein harmonin have been identified as the cause of Usher deafness syndrome type 1..

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

L Coultas, P Bouillet, EG Stanley, TC Brodnicki, JM Adams, A Strasser

Journal article  |  2004  |  Mol. Cell. Biol.

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.

Thomas C Brodnicki, Fiona Quirk, Grant Morahan

Journal article  |  2003  |  Diabetes

The nonobese diabetic (NOD) mouse is genetically predisposed for the spontaneous development of type 1 diabetes. Linkage analyses ..

Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8 alpha(-) splenic dendritic cells

I Caminschi, KM Lucas, MA O'Keeffe, H Hochrein, Y Laabi, TC Brodnicki, AM Lew, K Shortman, MD Wright

Conference Proceedings  |  2001  |  Molecular Immunology

Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus Mix gene

L Robb, L Hartley, CG Begley, TC Brodnicki, NG Copeland, DJ Gilbert, NA Jenkins, AG Elefanty

Journal article  |  2000  |  Developmental Dynamics

Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4

BT Kile, EM Viney, TA Willson, TC Brodnicki, MR Cancilla, AS Herlihy, BA Croker, M Baca, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2000  |  Gene

Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.

CC Wang, T Brodnicki, NG Copeland, NA Jenkins, RP Harvey

Journal article  |  2000  |  Mammalian Genome

Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene.

TC Brodnicki, P McClive, S Couper, G Morahan

Journal article  |  2000  |  Immunogenetics

Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps best characterized in the nonobese diab..

Assignment of the human helix-loop-helix transcription factor gene musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its mouse homologue (Msc) to the proximal region of chromosome 1.

L Robb, T Brodnicki, NG Copeland, DJ Gilbert, NA Jenkins, RP Harvey

Journal article  |  1999  |  Genomics

Human cerberus related gene CER1 maps to chromosome 9

M Lah, T Brodnicki, P Maccarone, A Nash, E Stanley, RP Harvey

Journal article  |  1999  |  Genomics