Enzo Porrello

Alpha-protein kinase 3 (ALPK3) truncating variants are a cause of autosomal dominant hypertrophic cardiomyopathy.

Luis R Lopes, Soledad Garcia-Hernández, Massimiliano Lorenzini, Marta Futema, Olga Chumakova, Dmitry Zateyshchikov, Maria Isidoro-Garcia, Eduardo Villacorta, Luis Escobar-Lopez, Pablo Garcia-Pavia, Raquel Bilbao, David Dobarro, Maria Sandin-Fuentes, Claudio Catalli, Blanca Gener Querol, Ainhoa Mezcua, Jose Garcia Pinilla, Torsten Bloch Rasmussen, Ana Ferreira-Aguar, Pablo Revilla-Martí, et al.

Journal article  |  2021  |  Eur Heart J

AIMS: The aim of this study was to determine the frequency of heterozygous truncating ALPK3 variants (ALPK3tv) in patients with hy..

Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.

Meredith A Redd, Sarah E Scheuer, Natalie J Saez, Yusuke Yoshikawa, Han Sheng Chiu, Ling Gao, Mark Hicks, Jeanette E Villanueva, Yashutosh Joshi, Chun Yuen Chow, Gabriel Cuellar-Partida, Jason N Peart, Louise E See Hoe, Xiaoli Chen, Yuliangzi Sun, Jacky Y Suen, Robert J Hatch, Ben Rollo, Mubarak AH Alzubaidi, Snezana Maljevic, et al.

Journal article  |  2021  |  Circulation

Background: Ischemia-reperfusion injury (IRI) is one of the major risk factors implicated in morbidity and mortality associated wi..

Towards spatio-temporally resolved developmental cardiac gene regulatory networks in zebrafish.

Jeannette C Hallab, Hieu T Nim, Julian Stolper, Gulrez Chahal, Lisa Waylen, Francesca Bolk, David A Elliott, Enzo Porrello, Mirana Ramialison

Journal article  |  2021  |  Brief Funct Genomics

Heart formation in the zebrafish involves a rapid, complex series of morphogenetic events in three-dimensional space that spans ca..

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

Aowen Zhuang, Anna C Calkin, Shannen Lau, Helen Kiriazis, Daniel G Donner, Yingying Liu, Simon T Bond, Sarah C Moody, Eleanor AM Gould, Timothy D Colgan, Sergio Ruiz Carmona, Michael Inouye, Thomas Q de Aguiar Vallim, Elizabeth J Tarling, Gregory A Quaife-Ryan, James E Hudson, Enzo R Porrello, Paul Gregorevic, Xiao-Ming Gao, Xiao-Jun Du, et al.

Journal article  |  2021  |  ISCIENCE

Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the..

Stimulation of the four isoforms of receptor tyrosine kinase ErbB4, but not ErbB1, confers cardiomyocyte hypertrophy

Zhen Wang, Hsiu-Wen Chan, Giovanna Gambarotta, Nicola J Smith, Brooke W Purdue, David J Pennisi, Enzo R Porrello, Shannon L O'Brien, Melissa E Reichelt, Walter G Thomas, Tamara M Paravicini

Journal article  |  2021  |  JOURNAL OF CELLULAR PHYSIOLOGY

Epidermal growth factor (EGF) receptors (ErbB1-ErbB4) promote cardiac development and growth, although the specific EGF ligands an..

From Fragrances to Heart Regeneration Malonate Repairs Broken Hearts

James W McNamara, Enzo R Porrello

Journal article  |  2021  |  CIRCULATION

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J Mills, Kevin I Watt, Kwaku D Abu-Bonsrah, Ravi KR Kalathur, Holly K Voges, Doan T Dinh, Menno ter Huurne, Celine J Vivien, Antony Kaspi, Harikrishnan Kaipananickal, Alejandro Hidalgo, Leanne MD Delbridge, Rebecca L Robker, Paul Gregorevic, Cristobal G dos Remedios, Sean Lal, et al.

Journal article  |  2021  |  CIRCULATION

BACKGROUND: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about ..

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, Mary Lor, Simon R Foster, Gregory A Quaife-Ryan, Rebecca L Johnston, Troy Dumenil, Cameron Bishop, Rajeev Rudraraju, Daniel J Rawle, Thuy Le, Wei Zhao, Leo Lee, Charley Mackenzie-Kludas, Neda R Mehdiabadi, Christopher Halliday, Dean Gilham, Li Fu, Stephen J Nicholls, et al.

Journal article  |  2021  |  CELL

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be ..

The Australia and New Zealand Cardio-Oncology Registry: evaluation of chemotherapy-related cardiotoxicity in a national cohort of paediatric cancer patients

Daniel Lapirow, Andre La Gerche, Claudia Toro, Emma Masango, Ben Costello, Enzo Porello, Louise Ludlow, Glenn Marshall, Toby Trahair, Marion Mateos, Jeremy Lewin, Jennifer Byrne, Rose Boutros, Rebecca Manudhane, John Heath, Julian Ayer, Melissa Gabriel, Thomas Walwyn, Jelena Saundankar, Jonathon Forsey, et al.

Journal article  |  2021  |  INTERNAL MEDICINE JOURNAL

Cancer therapy related cardiac dysfunction (CTRCD) is an area of increasing focus, particularly during the survivorship period, fo..