Enzo Porrello

Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor

Choon Boon Sim, Belinda Phipson, Mark Ziemann, Haloom Rafehi, Richard J Mills, Kevin I Watt, Kwaku D Abu-Bonsrah, Ravi KR Kalathur, Holly K Voges, Doan T Dinh, Menno ter Huurne, Celine J Vivien, Antony Kaspi, Harikrishnan Kaipananickal, Alejandro Hidalgo, Leanne MD Delbridge, Rebecca L Robker, Paul Gregorevic, Cristobal G dos Remedios, Sean Lal, et al.

Journal article  |  2021  |  Circulation

Background: Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about ..

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, Mary Lor, Simon R Foster, Gregory A Quaife-Ryan, Rebecca L Johnston, Troy Dumenil, Cameron Bishop, Rajeev Rudraraju, Daniel J Rawle, Thuy Le, Wei Zhao, Leo Lee, Charley Mackenzie-Kludas, Neda R Mehdiabadi, Christopher Halliday, Dean Gilham, Li Fu, Stephen J Nicholls, et al.

Journal article  |  2021  |  Cell

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be ..

The Australia and New Zealand Cardio-Oncology Registry: evaluation of chemotherapy-related cardiotoxicity in a national cohort of paediatric cancer patients

Daniel Lapirow, Andre La Gerche, Claudia Toro, Emma Masango, Ben Costello, Enzo Porello, Louise Ludlow, Glenn Marshall, Toby Trahair, Marion Mateos, Jeremy Lewin, Jennifer Byrne, Rose Boutros, Rebecca Manudhane, John Heath, Julian Ayer, Melissa Gabriel, Thomas Walwyn, Jelena Saundankar, Jonathon Forsey, et al.

Journal article  |  2021  |  Internal Medicine Journal

Cancer therapy related cardiac dysfunction (CTRCD) is an area of increasing focus, particularly during the survivorship period, fo..

beta-Catenin drives distinct transcriptional networks in proliferative and nonproliferative cardiomyocytes

Gregory A Quaife-Ryan, Richard J Mills, George Lavers, Holly K Voges, Celine J Vivien, David A Elliott, Mirana Ramialison, James E Hudson, Enzo R Porrello

Journal article  |  2020  |  Development

The inability of the adult mammalian heart to regenerate represents a fundamental barrier in heart failure management. By contrast..

Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality

Chrishan J Nalliah, James R Bell, Antonia JA Raaijmakers, Helen M Waddell, Simon P Wells, Gabriel B Bernasochi, Magdalene K Montgomery, Simon Binny, Troy Watts, Subodh B Joshi, Elaine Lui, Choon Boon Sim, Marco Larobina, Michael O'Keefe, John Goldblatt, Alistair Royse, Geoffrey Lee, Enzo R Porrello, Matthew J Watt, Peter M Kistler, et al.

Journal article  |  2020  |  Journal of the American College of Cardiology

BACKGROUND: Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of a..

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

Zhixuan Loh, Jennifer Simpson, Ashik Ullah, Vivian Zhang, Wan J Gan, Jason P Lynch, Rhiannon B Werder, Al Amin Sikder, Katie Lane, Choon Boon Sim, Enzo Porrello, Stuart B Mazzone, Peter D Sly, Raymond J Steptoe, Kirsten M Spann, Maria B Sukkar, John W Upham, Simon Phipps

Journal article  |  2020  |  PLoS Pathogens

Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as..

Neonatal heart regeneration: Moving from phenomenology to regenerative medicine

Hesham A Sadek, Enzo R Porrello

Journal article  |  2020  |  Journal of Thoracic and Cardiovascular Surgery

Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity

Megan J Bywater, Deborah L Burkhart, Jasmin Straube, Arianna Sabo, Vera Pendino, James E Hudson, Gregory A Quaife-Ryan, Enzo R Porrello, James Rae, Robert G Parton, Theresia R Kress, Bruno Amati, Trevor D Littlewood, Gerard Evan, Catherine H Wilson

Conference Proceedings  |  2020  |  Nature Communications

REACTIVATION OF MYC TRANSCRIPTION IN THE HEART UNLOCKS ITS PROLIFERATIVE CAPACITY

MJ Bywater, DL Burkhart, A Sabo, J Straube, V Pendino, JE Hudson, GA Quaife-Ryan, ER Porrello, J Rae, RG Parton, TR Kress, B Amati, TD Littlewood, GI Evan, CH Wilson

Conference Proceedings  |  2020  |  CARDIOVASCULAR DRUGS AND THERAPY

Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction

Gopalkrishna Sreejit, Ahmed Abdel-Latif, Baskaran Athmanathan, Rahul Annabathula, Ashish Dhyani, Sunil K Noothi, Gregory A Quaife-Ryan, Annas Al-Sharea, Gerard Pernes, Dragana Dragoljevic, Hind Lal, Kate Schroder, Beatriz Y Hanaoka, Chander Raman, Maria B Grant, James E Hudson, Susan S Smyth, Enzo R Porrello, Andrew J Murphy, Prabhakara R Nagareddy

Journal article  |  2020  |  Circulation