Damien Hudson

Loss of TOP3B leads to increased R-loop formation and genome instability

Tao Zhang, Mathew Wallis, Vida Petrovic, Jackie Challis, Paul Kalitsis, Damien F Hudson

Journal article  |  2019  |  Open Biology

Topoisomerase III beta (TOP3B) is one of the least understood members of the topoisomerase family of proteins and remains enigmati..

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

Henrike Johanna Gothe, Britta Annika Maria Bouwman, Eduardo Gade Gusmao, Rossana Piccinno, Giuseppe Petrosino, Sergi Sayols, Oliver Drechsel, Vera Minneker, Natasa Josipovic, Athanasia Mizi, Christian Friberg Nielsen, Eva-Maria Wagner, Shunichi Takeda, Hiroyuki Sasanuma, Damien Francis Hudson, Thomas Kindler, Laura Baranello, Argyris Papantonis, Nicola Crosetto, Vassilis Roukos

Journal article  |  2019  |  Molecular Cell

Knocking in Multifunctional Gene Tags into SMC Complex Subunits Using Gene Editing

Paul Kalitsis, Tao Zhang, Ji Hun Kim, Christian F Nielsen, Kathryn M Marshall, Damien F Hudson

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Condensin, a highly conserved pentameric chromosome complex, is required for the correct organization and folding of the genome. H..

Polymyxin B causes DNA damage in HK-2 cells and mice

B Yun, T Zhang, MAK Azad, J Wang, CJ Nowell, P Kalitsis, T Velkov, DF Hudson, J Li

Journal article  |  2018  |  Archives of Toxicology

Condensins under the microscope

Kazuhiro Maeshima, Kayo Hibino, Damien F Hudson

Journal article  |  2018  |  Journal of Cell Biology

Condensin, master organizer of the genome

Paul Kalitsis, Tao Zhang, Kathryn M Marshall, Christian F Nielsen, Damien F Hudson

Journal article  |  2017  |  Chromosome Research

Loss of RMI2 Increases Genome Instability and Causes a Bloom-Like Syndrome

Damien F Hudson, David J Amor, Amber Boys, Kathy Butler, Lorna Williams, Tao Zhang, Paul Kalitsis

Journal article  |  2016  |  PLOS Genetics

Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes

Shinya Ohta, Luis F Montano-Gutierrez, Flavia de Lima Alves, Hiromi Ogawa, Iyo Toramoto, Nobuko Sato, Ciaran G Morrison, Shunichi Takeda, Damien F Hudson, Juri Rappsilber, William C Earnshaw

Journal article  |  2016  |  Molecular & Cellular Proteomics

Condensin I and II behaviour in interphase nuclei and cells undergoing premature chromosome condensation

Tao Zhang, James R Paulson, Muhammed Bakhrebah, Ji Hun Kim, Cameron Nowell, Paul Kalitsis, Damien F Hudson

Journal article  |  2016  |  Chromosome Research

Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

Candice L Wike, Hillary K Graves, Reva Hawkins, Matthew D Gibson, Michelle B Ferdinand, Tao Zhang, Zhihong Chen, Damien F Hudson, Jennifer J Ottesen, Michael G Pokier, Jill Schumacher, Jessica K Tyler

Journal article  |  2016  |  eLife

Condensin recruitment to chromatin is inhibited by Chk2 kinase in response to DNA damage

Tao Zhang, San Ling Si-Hoe, Damien F Hudson, Uttam Surana

Journal article  |  2016  |  Cell Cycle

Disruption of a Conserved CAP-D3 Threonine Alters Condensin Loading on Mitotic Chromosomes Leading to Chromosome Hypercondensation

Muhammed Bakhrebah, Tao Zhang, Jeff R Mann, Paul Kalitsis, Damien F Hudson

Journal article  |  2015  |  Journal of Biological Chemistry

Contribution of the Two Genes Encoding Histone Variant H3.3 to Viability and Fertility in Mice

Michelle CW Tang, Shelley A Jacobs, Deidre M Mattiske, Yu May Soh, Alison N Graham, Tran An, Shu Ly Lim, Damien F Hudson, Paul Kalitsis, Moira K O'Bryan, Lee H Wong, Jeffrey R Mann

Journal article  |  2015  |  PLOS Genetics

Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling

Helena Barysz, Ji Hun Kim, Zhuo Angel Chen, Damien F Hudson, Juri Rappsilber, Dietlind L Gerloff, William C Earnshaw

Journal article  |  2015  |  Open Biology

Activation by zinc of the human gastrin gene promoter in colon cancer cells in vitro and in vivo

Kathryn M Marshall, Marie Laval, Ortis Estacio, Damien F Hudson, Paul Kalitsis, Arthur Shulkes, Graham S Baldwina, Oneel Patel

Journal article  |  2015  |  Metallomics

Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes

Ji Hun Kim, Tao Zhang, Nicholas C Wong, Nadia Davidson, Jovana Maksimovic, Alicia Oshlack, William C Earnshaw, Paul Kalitsis, Damien F Hudson

Journal article  |  2013  |  Nature Communications

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase II alpha

Kumiko Samejima, Itaru Samejima, Paola Vagnarelli, Hiromi Ogawa, Giulia Vargiu, David A Kelly, Flavia de Lima Alves, Alastair Kerr, Lydia C Green, Damien F Hudson, Shinya Ohta, Carol A Cooke, Christine J Farr, Juri Rappsilber, William C Earnshaw

Journal article  |  2012  |  Journal of Cell Biology

Contrasting roles of condensin I and condensin II in mitotic chromosome formation

Lydia C Green, Paul Kalitsis, Tsz M Chang, Miri Cipetic, Ji Hun Kim, Owen Marshall, Lynne Turnbull, Cynthia B Whitchurch, Paola Vagnarelli, Kumiko Samejima, William C Earnshaw, KH Andy Choo, Damien F Hudson

Journal article  |  2012  |  Journal of Cell Science

Molecular and genetic analysis of condensin function in vertebrate cells

Damien F Hudson, Shinya Ohta, Tina Freisinger, Fiona MacIsaac, Lau Sennels, Flavia Alves, Fan Lai, Alastair Kerr, Juri Rappsilber, William C Earnshaw

Journal article  |  2008  |  Molecular Biology of the Cell

Nucleic Acids: Hybridisation

Ji Hun Kim, Paul Kalitsis, Mark D Pertile, Dianna Magliano, Lee Wong, Andy Choo, Damien F Hudson

Book Chapter