Linda Wakim

Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response

EA Monson, KM Crosse, M Duan, W Chen, RD O'Shea, LM Wakim, JM Carr, DR Whelan, KJ Helbig

Journal article  |  2021  |  NATURE COMMUNICATIONS

Lipid droplets (LDs) are increasingly recognized as critical organelles in signalling events, transient protein sequestration and ..

CD8( ) T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph

Luca Hensen, Patricia T Illing, E Bridie Clemens, Thi HO Nguyen, Marios Koutsakos, Carolien E van de Sandt, Nicole A Mifsud, Andrea T Nguyen, Christopher Szeto, Brendon Y Chua, Hanim Halim, Simone Rizzetto, Fabio Luciani, Liyen Loh, Emma J Grant, Phillipa M Saunders, Andrew G Brooks, Steve Rockman, Tom C Kotsimbos, Allen C Cheng, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indig..

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud, et al.

Journal article  |  2021  |  IMMUNITY

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

High Precursor Frequency and Promiscuity in Αβ T Cell Receptor Pairing Underpin CD8 T-Cell Responses to an Immunodominant SARS-CoV-2 Nucleocapsid Epitope

Thi Nguyen, Louise Rowntree, Jan Petersen, B Chua, Luca Hensen, Lukasz Kedzierski, van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer Habel, Wuji Zhang, Lily Allen, Linda Earnest, Kai Yan Mak, Jennifer Juno, Kathleen Wragg, Francesca Mordant, Fatima Amanat, Florian Krammer, Denise Doolan, et al.

Journal article  |  2020

T-cell responses to SARS-CoV-2-derived peptide pools have been documented, however it remains largely unclear whether prominent SA..

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  ELIFE

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

Intranasal Delivery of a Chitosan-Hydrogel Vaccine Generates Nasal Tissue Resident Memory CD8( ) T Cells That Are Protective against Influenza Virus Infection

James G Bedford, Irina Caminschi, Linda M Wakim

Journal article  |  2020  |  VACCINES

Rapid antigen clearance from the nasal mucosa is one of the major challenges in the development of intranasal vaccines. Here, we t..

Unresponsiveness to inhaled antigen is governed by conventional dendritic cells and overridden during infection by monocytes

James G Bedford, Melanie Heinlein, Alexandra L Garnham, Thi HO Nguyen, Tom Loudovaris, Chenghao Ge, Stuart Mannering, Michael Elliott, Stuart G Tangye, Katherine Kedzierska, Daniel HD Gray, William R Heath, Linda M Wakim

Journal article  |  2020  |  SCIENCE IMMUNOLOGY

The nasal-associated lymphoid tissues (NALTs) are mucosal-associated lymphoid organs embedded in the submucosa of the nasal passag..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Neutrophils play an ongoing role in preventing bacterial pneumonia by blocking the dissemination of Staphylococcus aureus from the upper to the lower airways

Chenghao Ge, Ian R Monk, Sarah C Monard, James G Bedford, Jessica Braverman, Timothy P Stinear, Linda M Wakim

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

Staphylococcus aureus is found in the nasal cavity of up to 30% of the human population. Persistent nasal carriage of S. aureus is..