Hayley McQuilten

In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance

Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Divya Narayanan, Nagaraj Moily, Hayley A McQuilten, Sandra E Nicholson, John K Fazakerley

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

Central nervous system virus infections are a major cause of morbidity and mortality worldwide and a significant global public hea..

Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C Rowntree, Thi HO Nguyen, Hayley A McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R Habel, Kevin J Selva, Adam K Wheatley, Bruce D Wines, P Mark Hogarth, Stephen J Kent, Amy W Chung, David C Jackson, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their effi..

SARS-CoV-2-specific T cell memory with common TCR alpha beta motifs is established in unvaccinated children who seroconvert after infection

Louise C Rowntree, Thi HO Nguyen, Lukasz Kedzierski, Melanie R Neeland, Jan Petersen, Jeremy Chase Crawford, Lilith F Allen, E Bridie Clemens, Brendon Chua, Hayley A McQuilten, Anastasia A Minervina, Mikhail Pogorelyy, Priyanka Chaurasia, Hyon-Xhi Tan, Adam K Wheatley, Xiaoxiao Jia, Fatima Amanat, Florian Krammer, E Kaitlynn Allen, Sabrina Sonda, et al.

Journal article  |  2022  |  IMMUNITY

As the establishment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell memory in children remains la..

Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections

Divya Narayanan, Nagaraj Moily, Hayley A McQuilten, Katherine Kedzierska, Jason M Mackenzie, Lukasz Kedzierski, John K Fazakerley

Journal article  |  2022  |  JOURNAL OF INNATE IMMUNITY

Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, innate a..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response

Acep R Wijayadikusumah, Weiguang Zeng, Hayley A McQuilten, Chinn Yi Wong, David C Jackson, Brendon Y Chua

Journal article  |  2019  |  MOLECULAR PHARMACEUTICS

Targeted delivery of otherwise nonimmunogenic antigens to Toll-like receptors (TLRs) expressed on dendritic cells (DCs) has proven..

CD4( ) T help promotes influenza virus-specific CD8( ) T cell memory by limiting metabolic dysfunction

Jolie G Cullen, Hayley A McQuilten, Kylie M Quinn, Moshe Olshansky, Brendan E Russ, Alison Morey, Sanna Wei, Julia E Prier, Nicole L La Gruta, Peter C Doherty, Stephen J Turner

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

There is continued interest in developing novel vaccine strategies that induce establish optimal CD8+ cytotoxic T lymphocyte (CTL)..

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8( ) T Cell-Lineage-Specific Function

Brendan E Russ, Moshe Olshansky, Jasmine Li, Michelle LT Nguyen, Linden J Gearing, Thi HO Nguyen, Matthew R Olson, Hayley A McQuilton, Simone Nussing, Georges Khoury, Damian FJ Purcell, Paul J Hertzog, Sudha Rao, Stephen J Turner

Journal article  |  2017  |  CELL REPORTS

Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the ge..

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8 T cell response magnitude

Kylie M Quinn, Wan-Ting Kan, Katherine A Watson, Brian J Liddicoat, Natasha G Swan, Hayley McQuilten, Alice E Denton, Jasmine Li, Weisan Chen, Lorena E Brown, David C Jackson, Patrick C Reading, Peter C Doherty, Katherine Kedzierska, Lukasz Kedzierski, Stephen J Turner, Nicole L La Gruta

Journal article  |  2017  |  PLOS ONE

TNF is a pro-inflammatory cytokine produced by both lymphoid and non-lymphoid cells. As a consequence of the widespread expression..

A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8( ) T Cell Responses

Sergio M Quinones-Parra, E Bridie Clemens, Zhongfang Wang, Hayley A Croom, Lukasz Kedzierski, Jodie McVernon, Dhanasekaran Vijaykrishna, Katherine Kedzierska

Journal article  |  2016  |  JOURNAL OF VIROLOGY

UNLABELLED: Novel influenza viruses often cause differential infection patterns across different age groups, an effect that is def..