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Dr

Daniel Bird

Anatomy And Neuroscience
Glucocorticoid Receptor and CREB signalling
ProRenin Receptor
FGF and WNT signalling
DSDs.
science & technology
life sciences & biomedicine
animals
mice
lung
Daniel Bird's Profile Picture
Dr

Daniel Bird

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Mammalian gonadal development and sex determination
Daniel Bird's Profile Picture
Dr

Daniel Bird

 

Dr Bird is an expert developmental biologist and endocrinologist with >15 years’ experience in the generation and phenotypic analysis of transgenic and knockout mouse models for elucidating complex developmental and endocrine mechanisms. His initial PhD and postdoctoral studies at Monash University, Melbourne, led to seminal work demonstrating how glucocorticoid steroid hormone signalling via the mesenchymal Glucocorticoid Receptor is required for lung maturation and survival at birth in mammals.

For this publication, he received the Endocrine Society of Australia (ESA) Servier Young Investigator Award. Similar work by Dr Bird was the first to reveal that molecular signalling via CREB in non-respiratory tissues is also required for lung maturation . Dr Bird was also the first to characterise a novel 11-beta hydroxysteroid dehydrogenase enzyme (11 b HSD1-like) to demonstrate its involvement as a reproductive hormone modulator.

In later studies with Prof Vincent Harley at the Hudson Institute of Medical Research, involving testicular development and DSD mechanisms (2016-ongoing), he has focused on investigating the function of FGF9, FGFR2, ATRX and the ProRenin Receptor in gonadal development and how gene mutations in these factors lead to DSD and/or infertility in humans. Of note, Dr Bird recently showed that the FGF9 signalling required for testicular development acts via FGFR2c and represses the ovarian FOXL2 pathway. This publication was selected as the feature article for Endocrinology in 2017, and its is summarised in a Youtube video (https://www.youtube.com/watch?v=OQNteR-LNxE). Dr Bird is now working with Dr Dagmar Wilhelm, to understand the function of ProRenin Receptor signalling in gonadal development.

Scholarly Works

Displaying the 15 most recent scholarly works by Daniel Bird.

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Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes

Anthony D Bird, Brittany M Croft, Masayo Harada, Lingyun Tang, Liang Zhao, Zhenhua Ming, Stefan Bagheri-Fam, Peter Koopman, Zhugang Wang, Keiichi Akita, Vincent R Harley

Journal article  |  2020  |  Human Molecular Genetics

Abstract In mice, male sex determination depends on FGF9 signalling via FGFR2c in the bipotential gonads to maintai..

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Mutant NR5A1/SF-1 in patients with disorders of sex development shows defective activation of the SOX9 TESCO enhancer

Rajini Sreenivasan, Louisa Ludbrook, Brett Fisher, Faustine Declosmenil, Kevin C Knower, Brittany Croft, Anthony D Bird, Janelle Ryan, Anu Bashamboo, Andrew H Sinclair, Peter Koopman, Ken McElreavey, Francis Poulat, Vincent R Harley

Journal article  |  2018  |  Human Mutation

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Fresh Noncultured Endothelial Progenitor Cells Improve Neonatal Lung Hyperoxia-Induced Alveolar Injury

Alexandra B Firsova, Daniel Bird, Degu Abebe, Judy Ng, Richard Mollard, Timothy J Cole

Journal article  |  2017  |  STEM CELLS Translational Medicine

Treatment of preterm human infants with high oxygen can result in disrupted lung alveolar and vascular development. Local or syste..

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In vivo evidence that RBM5 is a tumour suppressor in the lung

Duangporn Jamsai, D Neil Watkins, Anne E O'Connor, D Jo Merriner, Selen Gursoy, Anthony D Bird, Beena Kumar, Alistair Miller, Timothy J Cole, Brendan J Jenkins, Moira K O'Bryan

Journal article  |  2017  |  Scientific Reports

Cigarette smoking is undoubtedly a risk factor for lung cancer. Moreover, smokers with genetic mutations on chromosome 3p21.3, a r..

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Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2

Stefan Bagheri-Fam, Anthony D Bird, Liang Zhao, Janelle M Ryan, Meiyun Yong, Dagmar Wilhelm, Peter Koopman, Veraragavan P Eswarakumar, Vincent R Harley

Journal article  |  2017  |  Endocrinology

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Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary-gonadal axis of primates

A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, Timothy J Cole

Journal article  |  2017  |  Endocrine Connections

Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and ..

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Adrenal steroids regulate specific cellular and genetic programs during lung and kidney organogenesis in the developing mouse embryo

Timothy James Cole, Bennet Seow, Kelly Short, Anthony Daniel Bird, Judy Ng

Conference Proceedings  |  2017  |  Mechanisms of Development

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Glucocorticoid mediated regulation of versican cell signalling during mouse lung development

Kelly Short, Anthony Bird, Judy Ng, Timothy Cole

Conference Proceedings  |  2017  |  Mechanisms of Development

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Creb1 regulates late stage mammalian lung development via respiratory epithelial and mesenchymal-independent mechanisms

N Antony, AR McDougall, T Mantamadiotis, TJ Cole, AD Bird

Journal article  |  2016  |  SCIENTIFIC REPORTS

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Minireview: Glucocorticoid Regulation of Lung Development: Lessons Learned From Conditional GR Knockout Mice

A Daniel Bird, Annie RA McDougall, Bennet Seow, Stuart B Hooper, Timothy J Cole

Journal article  |  2015  |  Molecular Endocrinology

Glucocorticoid (GC) steroid hormones have well-characterized roles in the regulation of systemic homeostasis, yet less understood ..

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Mesenchymal Glucocorticoid Receptor Regulates the Development of Multiple Cell Layers of the Mouse Lung

A Daniel Bird, Yuen L Choo, Stuart B Hooper, Annie RA McDougall, Timothy J Cole

Journal article  |  2014  |  American Journal of Respiratory Cell and Molecular Biology

Endogenous glucocorticoid (GC) hormones, signaling via the GC receptor (GR), are essential for normal lung development, and synthe..

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cAMP Response Element Binding Protein1 Is Essential for Activation of Steroyl Co-Enzyme A Desaturase 1 (Scd1) in Mouse Lung Type II Epithelial Cells

Nisha Antony, Jacqui R Weir, Annie RA McDougall, Theo Mantamadiotis, Peter J Meikle, Timothy J Cole, Anthony D Bird

Journal article  |  2013  |  PLoS One

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cAMP Response Element Binding Protein Is Required for Differentiation of Respiratory Epithelium during Murine Development

A Daniel Bird, Sharon J Flecknoe, Kheng H Tan, P Fredrik Olsson, Nisha Antony, Theo Mantamadiotis, Stuart B Hooper, Timothy J Cole

Journal article  |  2011  |  PLOS ONE

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Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development

Anthony D Bird, Kheng H Tan, P Fredrik Olsson, Malgorzata Zieba, Sharon J Flecknoe, Douglas R Liddicoat, Richard Mollard, Stuart B Hooper, Timothy J Cole

Journal article  |  2007  |  Journal of Physiology

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Altered epithelial cell proportions in the fetal lung of glucocorticoid receptor null mice

TJ Cole, NM Solomon, R Van Driel, JA Monk, D Bird, SJ Richardson, RJ Dilley, SB Hooper

Journal article  |  2004  |  American Journal of Respiratory Cell and Molecular Biology

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Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Clinical Health (organs, Diseases and Abnormal Conditions)
Genetics
Other Health
Cardiovascular Medicine and Haematology
Clinical (organs, Diseases and Abnormal Conditions)
Immunology
Medical Physiology
Non-Oriented Research
Other Biological Sciences

Honours, Awards and Fellowships

2014

Servier Young Investigator Award

Endocrine Society of Australia

1

Award

Credentials

Positions

Academic Research

Anatomy And Neuroscience

Education

Doctor of Philosophy

Monash University

Bachelor of Science (honours)

University of Melbourne

Links