Stephen Fox

Prognostic gene expression signature for high-grade serous ovarian cancer.

J Millstein, T Budden, EL Goode, MS Anglesio, A Talhouk, MP Intermaggio, HS Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, RC Bentley, C Wang, DS Chiu, S Kommoss, SCY Leung, J Senz, A Lum, V Chow, et al.

Journal article  |  2020  |  Annals of Oncology

BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is approximately four years, yet ..

RAF1 rearrangements are common in pancreatic acinar cell carcinomas

Owen WJ Prall, Violeta Nastevski, Huiling Xu, Christopher RE McEvoy, Joep HA Vissers, David J Byrne, Elena Takano, Satwica Yerneni, Sarah Ellis, Thomas Green, Catherine A Mitchell, William K Murray, Clare L Scott, Sean M Grimmond, Oliver Hofmann, Anthony Papenfuss, Damien Kee, Andrew Fellowes, Ian S Brown, Gregory Miller, et al.

Journal article  |  2020  |  Modern Pathology

Dual targeting of CDK4/6 and BCL2 pathways augments tumor response in estrogen receptor positive breast cancer.

James R Whittle, François Vaillant, Elliot Surgenor, Antonia N Policheni, Goknur Giner, Bianca D Capaldo, Huei-Rong Chen, He K Liu, Johanna F Dekkers, Norman Sachs, Hans Clevers, Andrew Fellowes, Thomas Green, Huiling Xu, Stephen B Fox, Marco J Herold, Gordon K Smyth, Daniel HD Gray, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: Although cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors significantly extend tumor response in patients with metasta..

Preoperative beta-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial

Jonathan G Hiller, Steven W Cole, Elizabeth M Crone, David J Byrne, David M Shackleford, Jia-Min B Pang, Michael A Henderson, Sophie S Nightingale, Kwok M Ho, Paul S Myles, Stephen Fox, Bernhard Riedel, Erica K Sloan

Journal article  |  2020  |  Clinical Cancer Research

PURPOSE: The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β..

The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice

Paula Gonzalez-Ericsson, Elisabeth S Stovgaard, Luz F Sua, Emily Reisenbichler, Zuzana Kos, Jodi M Carter, Stefan Michiels, John Le Quesne, Torsten O Nielsen, Anne-Vibeke Laenkholm, Stephen B Fox, Julien Adam, John MS Bartlett, David L Rimm, Cecily Quinn, Dieter Peeters, Maria Dieci, Anne Vincent-Salomon, Ian Cree, Akira Hida, et al.

Journal article  |  2020  |  The Journal of Pathology

Immune checkpoint inhibitor therapies targeting PD-1/PD-L1 are now the standard of care in oncology across several hematologic and..

The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma

Tanjina Kader, Kenneth Elder, Magnus Zethoven, Timothy Semple, Prue Hill, David L Goode, Niko Thio, Dane Cheasley, Simone M Rowley, David J Byrne, Jia-Min Pang, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe

Journal article  |  2020  |  npj Breast Cancer

Intraductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The mole..

Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study

Helene Dano, Serdar Altinay, Laurent Arnould, Noella Bletard, Cecile Colpaert, Franceska Dedeurwaerdere, Benjamin Dessauvagie, Valerie Duwel, Giuseppe Floris, Stephen Fox, Clara Gerosa, Shabnam Jaffer, Eline Kurpershoek, Magali Lacroix-Triki, Andoni Laka, Kathleen Lambein, Gaetan Marie MacGrogan, Caterina Marchio, Dolores Martin Martinez, Sharon Nofech-Mozes, et al.

Journal article  |  2020  |  Modern Pathology

Histopathological assessment of ductal carcinoma in situ, a nonobligate precursor of invasive breast cancer, is characterized by c..

Emerging entities in NUTM1-rearranged neoplasms

Christopher R McEvoy, Stephen B Fox, Owen WJ Prall

Journal article  |  2020  |  Genes, Chromosomes and Cancer

Management of the axilla in breast cancer: outcome analysis in a series of ductal versus lobular invasive cancers

SP Corona, M Bortul, S Scomersi, C Bigal, C Bottin, F Zanconati, SB Fox, F Giudici, D Generali

Journal article  |  2020  |  Breast Cancer Research and Treatment

INTRODUCTION: Axillary lymph node dissection (ALND) has been considered essential for the staging of breast cancer (BC). As the im..

The 2019 WHO classification of tumours of the breast.

Puay Hoon Tan, Ian Ellis, Kimberly Allison, Edi Brogi, Stephen B Fox, Sunil Lakhani, Alexander J Lazar, Elizabeth A Morris, Aysegul Sahin, Roberto Salgado, Anna Sapino, Hironobu Sasano, Stuart Schnitt, Christos Sotiriou, Paul van Diest, Valerie A White, Dilani Lokuhetty, Ian A Cree, undefined WHO Classification of Tumours Editorial Board

Journal article  |  2020  |  Histopathology

The newly published World Health Organization (WHO) Classification of Tumours of the breast features significant changes compared ..

Upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast to reduce inter-observer variability: The DCISion study

Mieke Rosalie Van Bockstal, Helene Dano, Serdar Altinay, Laurent Arnould, Noella Bletard, Cecile Colpaert, Franceska Dedeurwaerdere, Benjamin Dessauvagie, Valerie Duwel, Giuseppe Floris, Stephen Fox, Clara Gerosa, Shabnam Jaffer, Eline Kurpershoek, Magali Lacroix-Triki, Andoni Laka, Kathleen Lambein, Gaetan Marie MacGrogan, Caterina Marchio, Dolores Martin Martinez, et al.

Conference Proceedings  |  2020  |  Poster Session Abstracts

Evaluation of genomic changes in ductal carcinoma in situ as potential biomarkers of recurrence risk

Dorothea Lesche, Hugo Saunders, Sakshi Mahale, Magnus Zenthoven, Siobhan Huges, Tanjina Kader, Niko Thio, Islam M Miligy, Jia-Min Pang, Andrew R Green, Emad A Rakha, Ian G Campbell, Stephen B Fox, Kylie Gorringe

Conference Proceedings  |  2020  |  Poster Session Abstracts

Matched germline and tumor profiling in male breast cancer for the discovery of molecular subtypes with clinical relevance

Veronica Zelli, Valentina Silvestri, Virginia Valentini, Agostino Bucalo, Piera Rizzolo, Ines Zanna, Laura Cortesi, Daniele Calistri, Maria Grazia Tibiletti, Giuseppe Giannini, Stephen B Fox, Domenico Palli, Laura Ottini

Conference Proceedings  |  2020  |  Poster Session Abstracts

A Malignant Neoplasm From the Jejunum With a MALAT1-GLI1 Fusion and 26-Year Survival History

Owen William John Prall, Christopher Robert Edward McEvoy, David John Byrne, Amir Iravani, Judy Browning, David Yew-Huong Choong, Bhargavi Yellapu, Sophie O'Haire, Kortnye Smith, Stephen James Luen, Paul Leslie Ross Mitchell, Jayesh Desai, Stephen Bernard Fox, Andrew Fellowes, Huiling Xu

Journal article  |  2020  |  International Journal of Surgical Pathology

The transcription factor GLI1 is a critical effector of the sonic hedgehog pathway. Gene fusions that activate GLI1 have recently ..

Adequate tumour cellularity is essential for accurate PD-L1 immunohistochemistry assessment on cytology cell-block specimens

Shona Hendry, David J Byrne, Michael Christie, Daniel P Steinfort, Louis B Irving, Carrie-Anne Wagner, Timothy Ellwood, Wendy A Cooper, Stephen B Fox

Journal article  |  2020  |  Cytopathology

OBJECTIVES: PD-L1 immunohistochemistry (IHC) is an essential predictive biomarker for patients with non-small cell lung cancer (NS..

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Laura Fachal, Hugues Aschard, Jonathan Beesley, Daniel R Barnes, Jamie Allen, Siddhartha Kar, Karen A Pooley, Joe Dennis, Kyriaki Michailidou, Constance Turman, Penny Soucy, Audrey Lemacon, Michael Lush, Jonathan P Tyrer, Maya Ghoussaini, Mahdi Moradi Marjaneh, Xia Jiang, Simona Agata, Kristiina Aittomaki, M Rosario Alonso, et al.

Journal article  |  2020  |  Nature Genetics

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underl..

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

Zuzana Kos, Elvire Roblin, Rim S Kim, Stefan Michiels, Brandon D Gallas, Weijie Chen, Koen K van de Vijver, Shom Goel, Sylvia Adams, Sandra Demaria, Giuseppe Viale, Torsten O Nielsen, Sunil S Badve, W Fraser Symmans, Christos Sotiriou, David L Rimm, Stephen Hewitt, Carsten Denkert, Sibylle Loibl, Stephen J Luen, et al.

Journal article  |  2020  |  npj Breast Cancer

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HE..

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials.

Jan Hudeček, Leonie Voorwerk, Maartje van Seijen, Iris Nederlof, Michiel de Maaker, Jose van den Berg, Koen K van de Vijver, Karolina Sikorska, Sylvia Adams, Sandra Demaria, Giuseppe Viale, Torsten O Nielsen, Sunil S Badve, Stefan Michiels, William Fraser Symmans, Christos Sotiriou, David L Rimm, Stephen M Hewitt, Carsten Denkert, Sibylle Loibl, et al.

Journal article  |  2020  |  npj Breast Cancer

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic tripl..

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.

Mohamed Amgad, Elisabeth Specht Stovgaard, Eva Balslev, Jeppe Thagaard, Weijie Chen, Sarah Dudgeon, Ashish Sharma, Jennifer K Kerner, Carsten Denkert, Yinyin Yuan, Khalid AbdulJabbar, Stephan Wienert, Peter Savas, Leonie Voorwerk, Andrew H Beck, Anant Madabhushi, Johan Hartman, Manu M Sebastian, Hugo M Horlings, Jan Hudeček, et al.

Journal article  |  2020  |  npj Breast Cancer

Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in t..

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

Cristina Gamell, Ivona Bandilovska, Twishi Gulati, Arielle Kogan, Syer Choon Lim, Zaklina Kovacevic, Elena A Takano, Clelia Timpone, Arjelle D Agupitan, Cassandra Litchfield, Giovanni Blandino, Lisa G Horvath, Stephen B Fox, Scott G Williams, Andrea Russo, Enzo Gallo, Piotr J Paul, Catherine Mitchell, Shahneen Sandhu, Simon P Keam, et al.

Journal article  |  2019  |  iScience

Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6A..

Combined Tumor Sequencing and Case-Control Analyses of RAD51C in Breast Cancer

Na Li, Simone McInerny, Magnus Zethoven, Dane Cheasley, Belle WX Lim, Simone M Rowley, Lisa Devereux, Norah Grewal, Somayeh Ahmadloo, David Byrne, Jue Er Amanda Lee, Jason Li, Stephen B Fox, Thomas John, Yoland Antill, Kylie L Gorringe, Paul A James, Ian G Campbell

Journal article  |  2019  |  JNCI: Journal of the National Cancer Institute

BACKGROUND: Loss-of-function variants in RAD51C are associated with familial ovarian cancer, but its role in hereditary breast can..

Australian consensus statement for best practice ROS1 testing in advanced non-small cell lung cancer

Nick Pavlakis, Caroline Cooper, Thomas John, Steven Kao, Sonja Klebe, Chee Khoon Lee, Trishe Leong, Michael Millward, Ken O'Byrne, Prudence A Russell, Benjamin Solomon, Wendy A Cooper, Stephen Fox

Journal article  |  2019  |  Pathology

Lung cancer is the most commonly diagnosed malignancy and the leading cause of death from cancer globally. Diagnosis of advanced n..

Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J McCabe, Marie-Emilie A Gauthier, Chia-Ling Chan, Tanya J Thompson, Sunita MC De Sousa, Clare Puttick, John P Grady, Velimir Gayevskiy, Jiang Tao, Kevin Ying, Arcadi Cipponi, Niantao Deng, Alex Swarbrick, Melissa L Thomas, undefined kConFab, Reginald V Lord, Amber L Johns, Maija Kohonen-Corish, Sandra A O'Toole, Jonathan Clark, et al.

Journal article  |  2019  |  Scientific Reports

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology ..

iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric

Kortnye Smith, Sophie O'Haire, Khuong-Quang Dong-Anh, Ben Markman, Hui Gan, Paul G Ekert, Ken O'Byrne, Michael Milward, Ben Solomon, Ben Tran, Clare Scott, Grant McArthur, Damien Kee, Andrew Fellowes, Huiling Xu, Melissa Martyn, Elly Lynch, Paula Lorgelly, Clara Gaff, Stephen Fox, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca, Sandra Viz Lasheras, Roser Pujol, Johanna Kiiski, Taru A Muranen, Daniel R Barnes, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Goska Leslie, Cora M Aalfs, Muriel A Adank, Julian Adlard, Simona Agata, Karen Cadoo, Bjarni A Agnarsson, Thomas Ahearn, et al.

Journal article  |  2019  |  npj Breast Cancer

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1..

The molecular origin and taxonomy of mucinous ovarian carcinoma

Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, Michael S Anglesio, George Au-Yeung, Maret Bohm, David Dl Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

MEK Inhibitor Therapy in Carcinomas With RAF1 Fusions: Inferior Response in a Patient With Pancreatic Acinar Cell Carcinoma

Christopher R McEvoy, Damien Kee, Owen WJ Prall, Timothy D Clay, Clare Scott, Anastasia Backhouse, Stephen B Fox, Andrew P Fellowes, Huiling Xu

Journal article  |  2019  |  JCO Precision Oncology

Atypical ductal hyperplasia is a multipotent precursor of breast carcinoma

Tanjina Kader, Prue Hill, Magnus Zethoven, David L Goode, Kenneth Elder, Niko Thio, Maria Doyle, Timothy Semple, Wajiha Sufyan, David J Byrne, Jia-Min B Pang, Anand Murugasu, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe

Journal article  |  2019  |  The Journal of Pathology

ASCO/CAP 2018 breast cancer HER2 testing guidelines: summary of pertinent recommendations for practice in Australia

Gelareh Farshid, Michael Bilous, Adrienne Morey, Stephen Fox, Sunil Lakhani, Sherene Loi, Richard Bell, Andrew Spillane

Journal article  |  2019  |  Pathology

Molecular comparison of interval and screen-detected breast cancers

Dane Cheasley, Na Li, Simone M Rowley, Kenneth Elder, G Bruce Mann, Sherene Loi, Peter Savas, David L Goode, Tanjina Kader, Magnus Zethoven, Tim Semple, Stephen B Fox, Jia-Min Pang, David Byrne, Lisa Devereux, Carolyn Nickson, Pietro Procopio, Grant Lee, Siobhan Hughes, Hugo Saunders, et al.

Journal article  |  2019  |  The Journal of Pathology

Clinical impact of tissue of origin testing and mutation profiling in the Solving Unknown Primary Cancer (SUPER) national prospective study: Experience of the first two years.

Linda R Mileshkin, Tharani Sivakumaran, Dariush Etemadmoghadam, Richard Tothill, Andrew Fellowes, Stephen B Fox, Lisa Guccione, Alison E Freimund, Anna Defazio, Nicholas Wilcken, Bo Gao, Madhu Sudan Singh, Ian M Collins, Gary Edward Richardson, Christopher B Steer, Mark Andrew Warren, Christos Stelios Karapetis, Cindy Bryant, Penelope Schofield, David Bowtell

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

On-treatment changes in tumor-infiltrating lymphocytes (TIL) during neoadjuvant HER2 therapy (NAT) and clinical outcome.

Stephen James Luen, Gaia Griguolo, Paolo Nuciforo, Christine Campbell, Roberta Fasani, Javier Cortes, Michael Untch, Suling Joyce Lin, Peter Savas, Stephen B Fox, Serena Di Cosimo, Antonio Llombart Cussac, Evandro de Azambuja, Martine J Piccart-Gebhart, Lajos Pusztai, Christos Sotiriou, Roberto Salgado, Aleix Prat, Sherene Loi

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion

Christopher R McEvoy, Huiling Xu, Kortnye Smith, Dariush Etemadmoghadam, Huei San Leong, David Y Choong, David J Byrne, Amir Iravani, Sophie Beck, Linda Mileshkin, Richard W Tothill, David D Bowtell, Bindi M Bates, Violeta Nastevski, Judy Browning, Anthony H Bell, Chloe Khoo, Jayesh Desai, Andrew P Fellowes, Stephen B Fox, et al.

Journal article  |  2019  |  Journal of Clinical Investigation

CNspector: a web-based tool for visualisation and clinical diagnosis of copy number variation from next generation sequencing

John F Markham, Satwica Yerneni, Georgina L Ryland, Huei San Leong, Andrew Fellowes, Ella R Thompson, Wasanthi De Silva, Amit Kumar, Richard Lupat, Jason Li, Jason Ellul, Stephen Fox, Michael Dickinson, Anthony T Papenfuss, Piers Blombery

Journal article  |  2019  |  Scientific Reports

Next Generation Sequencing is now routinely used in the practice of diagnostic pathology to detect clinically relevant somatic and..

CCL27/CCL28-CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells

Tara Karnezis, Rae H Farnsworth, Nicole C Harris, Steven P Williams, Carol Caesar, David J Byrne, Prad Herle, Maria L Macheda, Ramin Shayan, You-Fang Zhang, Sezer Yazar, Simon J Takouridis, Craig Gerard, Stephen B Fox, Marc G Achen, Steven A Stacker

Journal article  |  2019  |  Cancer Research

Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications

Amy Ellen McCart Reed, Emarene Kalaw, Katia Nones, Mark Bettington, Malcolm Lim, James Bennett, Kate Johnstone, Jamie Rose Kutasovic, Jodi Marie Saunus, Stephen Kazakoff, Qinying Xu, Scott Wood, Oliver Holmes, Conrad Leonard, Lynne Estelle Reid, Debra Black, Colleen Niland, Kaltin Ferguson, Irma Gresshoff, Ashwini Raghavendra, et al.

Journal article  |  2019  |  The Journal of Pathology

Characterization of high TIL breast cancers reveals a prognostic and functionally distinct tissue-resident memory subpopulation

P Savas, B Virassamy, C Ye, A Salim, CP Mintoff, F Caramia, R Salgado, ZL Teo, S Dushyanthen, A Byrne, SJ Luen, SB Fox, TP Speed, LK Mackay, PJ Neeson, S Loi

Conference Proceedings  |  2019  |  Poster Discussion Abstracts

Improved next-generation sequencing pre-capture library yields and sequencing parameters using on-bead PCR

Christopher R McEvoy, Timothy Semple, Bhargavi Yellapu, David Y Choong, Huiling Xu, Gisela Mir Arnau, Andrew P Fellowes, Stephen B Fox

Journal article  |  2019  |  BioTechniques

Tumor DNA sequencing results can have important clinical implications. However, its use is often limited by low DNA input, owing t..

Current mismatch repair deficiency tumor testing practices and capabilities: A survey of Australian pathology providers

Lyon Mascarenhas, Susan Shanley, Gillian Mitchell, Amanda B Spurdle, Finlay Macrae, Nicholas Pachter, Daniel D Buchanan, Robyn L Ward, Stephen Fox, Elaine Duxbury, Rebecca Driessen, Alex Boussioutas

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma.

Piers Blombery, Ella Thompson, Georgina L Ryland, Rachel Joyce, David J Byrne, Christine Khoo, Stephen Lade, Mark Hertzberg, Greg Hapgood, Paula Marlton, Anand Deva, Geoffrey Lindeman, Stephen Fox, David Westerman, Miles Prince

Journal article  |  2018  |  Oncotarget

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma that occurs after implantati..

Mapping the EORTC-QLQ-C30 to the EQ-5D-3L: An Assessment of Existing and Newly Developed Algorithms.

Fionn Woodcock, Brett Doble, undefined CANCER 2015 Consortium

Journal article  |  2018  |  Med Decis Making

OBJECTIVES: To assess the external validity of mapping algorithms for predicting EQ-5D-3L utility values from EORTC QLQ-C30 respon..

Response to Editorial: The PD-L1 Immunohistochemistry Biomarker: Two Steps Forward, One Step Back?

Shona Hendry, Wendy A Cooper, Stephen B Fox

Journal article  |  2018  |  Journal of Thoracic Oncology

An Analysis of Multiple Biomarkers to Better Predict Prostate Cancer Metastasis after Radical Prostatectomy

A Zhang, K Chiam, Y Haupt, S Fox, S Birch, W Tilley, L Butler, K Knudsen, C Cornstock, K Rasiah, J Grogan, K Mahon, T Bianco-Miotto, M Bohm, S Henshall, W Delprado, P Stricker, L Horvath, J Kench

Conference Proceedings  |  2018  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis

Peter Savas, Balaji Virassamy, Chengzhong Ye, Agus Salim, Christopher P Mintoff, Franco Caramia, Roberto Salgado, David J Byrne, Zhi L Teo, Sathana Dushyanthen, Ann Byrne, Lironne Wein, Stephen J Luen, Catherine Poliness, Sophie S Nightingale, Anita S Skandarajah, David E Gyorki, Chantel M Thornton, Paul A Beavis, Stephen B Fox, et al.

Journal article  |  2018  |  Nature Medicine

Invasion in breast lesions: the role of the epithelial-stroma barrier

Emad A Rakha, Islam M Miligy, Kylie L Gorringe, Michael S Toss, Andrew R Green, Stephen B Fox, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Thomas Decker, Anne Vincent-Salomon, David J Dabbs, Maria P Foschini, Filipa Moreno, Wentao Yang, Felipe C Geyer, Jorge S Reis-Filho, Sarah E Pinder, Sunil R Lakhani, et al.

Journal article  |  2018  |  Histopathology

BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition

Tania Moujaber, Dariush Etemadmoghadam, Catherine J Kennedy, Yoke-Eng Chiew, Rosemary L Balleine, Catherine Saunders, Gerard Wain, Bo Gao, Russell Hogg, Sivatharsny Srirangan, Casina Kan, Sian Fereday, Nadia Traficante, Ann-Marie Patch, John Pearson, Nicola Waddell, Sean M Grimmond, Alexander Dobrovic, David DL Bowtell, Paul R Harnett, et al.

Journal article  |  2018  |  JCO Precision Oncology

SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response

Christopher R McEvoy, Lisa Koe, David Y Choong, Huei San Leong, Huiling Xu, Deme Karikios, Jeffrey D Plew, Owen W Prall, Andrew P Fellowes, Stephen B Fox

Journal article  |  2018  |  npj Precision Oncology

Comparison of Four PD-L1 Immunohistochemical Assays in Lung Cancer

Shona Hendry, David J Byrne, Gavin M Wright, Richard J Young, Sue Sturrock, Wendy A Cooper, Stephen B Fox

Journal article  |  2018  |  Journal of Thoracic Oncology

Prognostic Significance of PD-L1( ) and CD8( ) Immune Cells in HPV Oropharyngeal Squamous Cell Carcinoma

Benjamin Solomon, Richard J Young, Mathias Bressel, Damien Urban, Shona Hendry, Alesha Thai, Christopher Angel, Afaf Haddad, Marcin Kowanetz, Tsien Fua, June Corry, Stephen Fox, Danny Rischin

Journal article  |  2018  |  Cancer Immunology Research

An analysis of multiple biomarkers to better predict prostate cancer metastasis and death after radical prostatectomy.

Alison Yan Zhang, Karen Chiam, Ygal Haupt, Stephen B Fox, Simone Birch, Wayne Tilley, Lisa Butler, Karen E Knudsen, Christopher Cornstock, Krishan Rasiah, Judith Grogan, Kate Lynette Mahon, Tina Bianco-Miotto, Maret Bohm, Susan M Henshall, Warick Delprado, Phillip Stricker, Lisa Horvath, James Kench

Conference Proceedings  |  2018  |  Journal of Clinical Oncology

Genomic analysis of cancers arising in breasts with different mammographic density

Kylie L Gorringe, Siobhan Hughes, Carolyn Nickson, Lisa Devereux, Vicki Pridmore, Simone M Rowley, David J Byrne, Dane Cheasley, Anne M Kavanagh, G Bruce Mann, Stephen B Fox, Ian G Campbell

Conference Proceedings  |  2018  |  CANCER RESEARCH

Precision oncology using a clinician-directed, tailored approach to molecular profiling

Michael Lam, Ben Tran, Sophie Beck, Jeanne Tie, Dishan Herath, James Whittle, Edmond M Kwan, Stephen B Fox, Andrew Fellowes, Sumitra Ananda, Lara Lipton, Peter Gibbs, Mark A Rosenthal, Jayesh Desai

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

Determinants of variability of five programmed death ligand-1 immunohistochemistry assays in non-small cell lung cancer samples

RA Soo, JSY Lim, BR Asuncion, Z Fazreen, MC Herrera, MFM Omar, NHD Phuong, JE Seet, B Amanuel, B Iacopetta, D Byrne, S Hendry, S Fox, R Soong

Journal article  |  2018  |  Oncotarget

Survival difference according to mutation status in a prospective cohort study of Australian patients with metastatic non-small-cell lung carcinoma

Lavinia Tan, Marliese Alexander, Ann Officer, Michael MacManus, Linda Mileshkin, Ross Jennens, Dishan Herath, Richard de Boer, Stephen B Fox, David Ball, Benjamin Solomon

Journal article  |  2018  |  Internal Medicine Journal

Canary: an atomic pipeline for clinical amplicon assays

Kenneth D Doig, Jason Ellul, Andrew Fellowes, Ella R Thompson, Georgina Ryland, Piers Blombery, Anthony T Papenfuss, Stephen B Fox

Journal article  |  2017  |  BMC Bioinformatics

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen van de Vijver, MV Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin Solomon, Cinzia Solinas, Gert GGM Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, et al.

Journal article  |  2017  |  Advances In Anatomic Pathology

Ductal Carcinoma In Situ Biology, Biomarkers, and Diagnosis

Kylie L Gorringe, Stephen B Fox

Journal article  |  2017  |  Frontiers in Oncology

LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness

Jia-Min B Pang, Ramyar Molania, Ashwini Chand, Kevin Knower, Elena A Takano, David J Byrne, Thomas Mikeska, Ewan KA Millar, Cheok Soon Lee, Sandra A O'Toole, Colin Clyne, Kylie L Gorringe, Alexander Dobrovic, Stephen B Fox

Journal article  |  2017  |  Oncotarget

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.

Journal article  |  2017  |  Science Signaling

Hypoxia-related biological markers as predictors of epirubicin-based treatment responsiveness and resistance in locally advanced breast cancer

Manuela Milani, Sergio Venturini, Simone Bonardi, Giovanni Allevi, Carla Strina, Maria Rosa Cappelletti, Silvia Paola Corona, Sergio Aguggini, Alberto Bottini, Alfredo Berruti, Adrian Jubb, Leticia Campo, Adrian L Harris, Kevin Gatter, Stephen B Fox, Daniele Generali, Giandomenico Roviello

Journal article  |  2017  |  Oncotarget

HER2 testing in advanced gastric and gastro-oesophageal cancer: analysis of an Australia-wide testing program

M Priyanthi Kumarasinghe, Adrienne Morey, Michael Bilous, Gelareh Farshid, Glenn Francis, Guy Lampe, Glenda McCue, Vita Von Neumann-Cosel, Stephen B Fox

Journal article  |  2017  |  Pathology

BRCA2 carriers with male breast cancer show elevated tumour methylation

Siddhartha Deb, Kylie L Gorringe, Jia-Min B Pang, David J Byrne, Elena A Takano, Alexander Dobrovic, Stephen B Fox

Journal article  |  2017  |  BMC Cancer

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

Shona Hendry, Roberto Salgado, Thomas Gevaert, Prudence A Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen van de Vijver, MV Estrada, Paula I Gonzalez-Ericsson, Melinda Sanders, Benjamin sss Solomon, Cinzia Solinas, Gert GGM Van den Eynden, Yves Allory, Matthias Preusser, Johannes Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, et al.

Journal article  |  2017  |  Advances In Anatomic Pathology

Relationship of the Breast Ductal Carcinoma In Situ Immune Microenvironment with Clinicopathological and Genetic Features

Shona Hendry, Jia-Min B Pang, David J Byrne, Sunil R Lakhani, Margaret C Cummings, Ian G Campbell, G Bruce Mann, Kylie L Gorringe, Stephen B Fox

Journal article  |  2017  |  Clinical Cancer Research

Intra- and Interobserver Reproducibility Assessment of PD-L1 Biomarker in Non-Small Cell Lung Cancer

Wendy A Cooper, Prudence A Russell, Maya Cherian, Edwina E Duhig, David Godbolt, Peter J Jessup, Christine Khoo, Connull Leslie, Annabelle Mahar, David F Moffat, Vanathi Sivasubramaniam, Celine Faure, Alena Reznichenko, Amanda Grattan, Stephen B Fox

Journal article  |  2017  |  Clinical Cancer Research

Lessons learnt from implementation of a Lynch syndrome screening program for patients with gynaecological malignancy

Fedaa Najdawi, Ashley Crook, Jayne Maidens, Christopher McEvoy, Andrew Fellowes, Justine Pickett, Musei Ho, David Nevell, Kirsten McIlroy, Amy Sheen, Loretta Sioson, Mahsa Ahadi, John Turchini, Adele Clarkson, Russell Hogg, Sue Valmadre, Greg Gard, Susan J Dooley, Rodney J Scott, Stephen B Fox, et al.

Journal article  |  2017  |  Pathology

Australian recommendations for EGFR T790M testing in advanced non-small cell lung cancer

Thomas John, Jeffrey J Bowden, Stephen Clarke, Stephen B Fox, Kerryn Garrett, Keith Horwood, Christos S Karapetis

Journal article  |  2017  |  Asia-Pacific Journal of Clinical Oncology

Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma

Clare E Weeden, Aliaksei Z Holik, Richard J Young, Stephen B Ma, Jean-Marc Garnier, Stephen B Fox, Phillip Antippa, Louis B Irving, Daniel P Steinfort, Gavin M Wright, Prudence A Russell, Matthew E Ritchie, Christopher J Burns, Benjamin Solomon, Marie-Liesse Asselin-Labat

Journal article  |  2017  |  Molecular Cancer Therapeutics

Cousins not twins: intratumoural and intertumoural heterogeneity in syndromic neuroendocrine tumours

Aidan Flynn, Trisha Dwight, Diana Benn, Siddhartha Deb, Andrew J Colebatch, Stephen Fox, Jessica Harris, Emma L Duncan, Bruce Robinson, Annette Hogg, Jason Ellul, Henry To, Duong Cuong, Julie A Miller, Christopher Yates, Paul James, Alison Trainer, Anthony J Gill, Roderick Clifton-Bligh, Rodney J Hicks, et al.

Journal article  |  2017  |  The Journal of Pathology

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

Jia-Min B Pang, Peter Savas, Andrew P Fellowes, Gisela Mir Arnau, Tanjina Kader, Ravikiran Vedururu, Chelsee Hewitt, Elena A Takano, David J Byrne, David YH hoong, Ewan KA Millar, C Soon Lee, Sandra A O'Toole, Sunil R Lakhani, Margaret C Cummings, G Bruce Mann, Ian G Campbell, Alexander Dobrovic, Sherene Loi, Kylie L Gorringe, et al.

Journal article  |  2017  |  Modern Pathology

GATA3 expression in triple-negative breast cancers

David J Byrne, Siddhartha Deb, Elena A Takano, Stephen B Fox

Journal article  |  2017  |  Histopathology

E6AP promotes prostate cancer by reducing p27 expression

Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt

Journal article  |  2017  |  Oncotarget

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

Journal article  |  2017  |  Science translational medicine

Cost-effectiveness of precision medicine in the fourth-line treatment of metastatic lung adenocarcinoma: An early decision analytic model of multiplex targeted sequencing

Brett Doble, Thomas John, David Thomas, Andrew Fellowes, Stephen Fox, Paula Lorgelly

Journal article  |  2017  |  Lung Cancer

PathOS: a decision support system for reporting high throughput sequencing of cancers in clinical diagnostic laboratories

Kenneth D Doig, Andrew Fellowes, Anthony H Bell, Andrei Seleznev, David Ma, Jason Ellul, Jason Li, Maria A Doyle, Ella R Thompson, Amit Kumar, Luis Lara, Ravikiran Vedururu, Gareth Reid, Thomas Conway, Anthony T Papenfuss, Stephen B Fox

Journal article  |  2017  |  Genome Medicine

MDM4 is a rational target for treating breast cancers with mutant p53

Panimaya Jeffreena Miranda, Daniel Buckley, Dinesh Raghu, Jia-Min B Pang, Elena A Takano, Reshma Vijayakumaran, Amina FAS Teunisse, Atara Posner, Tahlia Procter, Marco J Herold, Cristina Gamell, Jean-Christophe Marine, Stephen B Fox, Aart Jochemsen, Sue Haupt, Ygal Haupt

Journal article  |  2017  |  The Journal of Pathology

Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer

Toni-Maree Rogers, Gisela Mir Arnau, Georgina L Ryland, Stephen Huang, Maruja E Lira, Yvette Emmanuel, Omar D Perez, Darryl Irwin, Andrew P Fellowes, Stephen Q Wong, Stephen B Fox

Journal article  |  2017  |  Scientific Reports

Tumour-infiltrating lymphocytes and the emerging role of immunotherapy in breast cancer

Stephen J Luen, Peter Savas, Stephen B Fox, Roberto Salgado, Sherene Loi

Journal article  |  2017  |  Pathology

Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing

Wolff Schmiegel, Rodney J Scott, Susan Dooley, Wendy Lewis, Cliff J Meldrum, Peter Pockney, Brian Draganic, Steve Smith, Chelsee Hewitt, Hazel Philimore, Amanda Lucas, Elva Shi, Kateh Namdarian, Timmy Chan, Danilo Acosta, Su Ping-Chang, Andrea Tannapfel, Anke Reinacher-Schick, Waldemar Uhl, Christian Teschendorf, et al.

Journal article  |  2017  |  Molecular Oncology

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

Cristina Gamell, Twishi Gulati, Yaara Levav-Cohen, Richard J Young, Hongdo Do, Pat Pilling, Elena Takano, Neil Watkins, Stephen B Fox, Prudence Russell, Doron Ginsberg, Brendon J Monahan, Gavin Wright, Alex Dobrovic, Sue Haupt, Ben Solomon, Ygal Haupt

Journal article  |  2017  |  Science Signaling

The fibrinolysis inhibitor alpha(2)-antiplasmin restricts lymphatic remodelling and metastasis in a mouse model of cancer

Sophie Paquet-Fifield, Sally Roufail, You-Fang Zhang, Trifina Sofian, David J Byrne, Paul B Coughlin, Stephen B Fox, Steven A Stacker, Marc G Achen

Journal article  |  2017  |  Growth Factors

Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study

Stephen J Luen, Roberto Salgado, Stephen Fox, Peter Savas, Jennifer Eng-Wong, Emma Clark, Astrid Kiermaier, Sandra M Swain, Jose Baselga, Stefan Michiels, Sherene Loi

Journal article  |  2017  |  The Lancet Oncology

Biobanking in cancer research

L Devereux, H Thorne, SB Fox

Book Chapter  |  2017

Introduction: Setting the scene, morphology to molecular

SB Fox, SR Lakhani

Book Chapter  |  2017

The Role of the Tumor vasculature in the Host immune Response: implications for Therapeutic Strategies Targeting the Tumor Microenvironment

Shona A Hendry, Rae H Farnsworth, Benjamin Solomon, Marc G Achen, Steven A Stacker, Stephen B Fox

Journal article  |  2016  |  Frontiers in Immunology

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

Journal article  |  2016  |  ONCOGENE

The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE"

Peter Savas, Zhi Ling Teo, Christophe Lefevre, Christoffer Flensburg, Franco Caramia, Kathryn Alsop, Mariam Mansour, Prudence A Francis, Heather A Thorne, Maria Joao Silva, Nnennaya Kanu, Michelle Dietzen, Andrew Rowan, Maik Kschischo, Stephen Fox, David D Bowtell, Sarah-Jane Dawson, Terence P Speed, Charles Swanton, Sherene Loi

Journal article  |  2016  |  PLOS Medicine

Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue

Tanjina Kader, David L Goode, Stephen Q Wong, Jacquie Connaughton, Simone M Rowley, Lisa Devereux, David Byrne, Stephen B Fox, Gisela Mir Arnau, Richard W Tothill, Ian G Campbell, Kylie L Gorringe

Journal article  |  2016  |  GENOME MEDICINE

Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis

Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt

Journal article  |  2016  |  BREAST CANCER RESEARCH

Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group

Carsten Denkert, Stephan Wienert, Audrey Poterie, Sibylle Loibl, Jan Budczies, Sunil Badve, Zsuzsanna Bago-Horvath, Anita Bane, Shahinaz Bedri, Jane Brock, Ewa Chmielik, Matthias Christgen, Cecile Colpaert, Sandra Demaria, Gert Van den Eynden, Giuseppe Floris, Stephen B Fox, Dongxia Gao, Barbara Ingold Heppner, S Rim Kim, et al.

Journal article  |  2016  |  Modern Pathology

Determining HER2 (ERBB2) amplification status in women with breast cancer: final results from the Australian in situ hybridisation program

Adrienne L Morey, Belinda Brown, Gelareh Farshid, Stephen B Fox, Glenn D Francis, Glenda McCue, Vita von Neumann-Cosel, Michael Bilous

Journal article  |  2016  |  Pathology

Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with T2 to T4, N0 and N1 breast cancer

D Andreis, S Bonardi, G Allevi, S Aguggini, F Gussago, M Milani, C Strina, D Spada, G Ferrero, M Ungari, A Rocca, O Nanni, G Roviello, A Berruti, AL Harris, SB Fox, F Roviello, K Polom, A Bottini, D Generali

Journal article  |  2016  |  The Breast

Reply to the Baader-Meinhof phenomenon in ductal carcinoma in situ of the breast

Jia-Min B Pang, Kylie L Gorringe, Stephen B Fox

Journal article  |  2016  |  Histopathology

Is it time for everolimus-based combination in castration-resistant prostate cancer?

Giandomenico Roviello, Andrea Ravelli, Sandro Barni, Fausto Petrelli, Alberto Bottini, Stephen B Fox, Daniele Generali

Journal article  |  2016  |  Future Oncology

Apatinib for the treatment of gastric cancer

Giandomenico Roviello, Andrea Ravelli, Anna Ida Fiaschi, Maria Rosa Cappelletti, Angela Gobbi, Chiara Senti, Laura Zanotti, Karol Polom, Andrew R Reynolds, Stephen B Fox, Daniele Generali

Journal article  |  2016  |  Expert Review of Gastroenterology & Hepatology

The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling (Retracted article. See vol. 79, pg. 3008, 2019)

Mariam Mansour, Sue Haupt, Ai-Leen Chan, Nathan Godde, Alexandra Rizzitelli, Sherene Loi, Franco Caramia, Siddhartha Deb, Elena A Takano, Mark Bishton, Cameron Johnstone, Brendon Monahan, Yarra Levav-Cohen, Yong-Hui Jiang, Alpha S Yap, Stephen Fox, Ora Bernard, Robin Anderson, Ygal Haupt

Journal article  |  2016  |  Cancer Research

Role of the novel generation of androgen receptor pathway targeted agents in the management of castration-resistant prostate cancer: A literature based meta-analysis of randomized trials

Giandomenico Roviello, Sandra Sigala, Shahneen Sandhu, Alberto Bonetta, Maria Rosa Cappelletti, Laura Zanotti, Alberto Bottini, Cora N Sternberg, Stephen B Fox, Daniele Generali

Journal article  |  2016  |  European Journal of Cancer

VEGF-D promotes pulmonary oedema in hyperoxic acute lung injury

Teruhiko Sato, Sophie Paquet-Fifield, Nicole C Harris, Sally Roufail, Debra J Turner, Yinan Yuan, You-Fang Zhang, Stephen B Fox, Margaret L Hibbs, Jennifer L Wilkinson-Berka, Richard A Williams, Steven A Stacker, Peter D Sly, Marc G Achen

Journal article  |  2016  |  The Journal of Pathology

KRAS mutation testing in colorectal cancer: the model for molecular pathology testing in the future

Stephen Q Wong, Rodney Scott, Stephen B Fox

Journal article  |  2016  |  Colorectal Cancer

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Valentina Silvestri, Daniel Barrowdale, Anna Marie Mulligan, Susan L Neuhausen, Stephen Fox, Beth Y Karlan, Gillian Mitchell, Paul James, Darcy L Thull, Kristin K Zorn, Natalie J Carter, Katherine L Nathanson, Susan M Dornchek, Timothy R Rebbeck, Susan J Ramus, Robert L Nussbaum, Olufunrnilayo I Olopade, Johanna Rantala, Sook-Yee Yoon, Maria A Caligo, et al.

Journal article  |  2016  |  BREAST CANCER RESEARCH

Realising the Value of Linked Data to Health Economic Analyses of Cancer Care: A Case Study of Cancer 2015

Paula K Lorgelly, Brett Doble, Rachel J Knott

Journal article  |  2016  |  PharmacoEconomics

Differential expression of immunohistochemical markers in primary lung and breast cancers enriched for triple-negative tumours

Elena Provenzano, David J Byrne, Prudence A Russell, Gavin M Wright, Daniele Generali, Stephen B Fox

Journal article  |  2016  |  Histopathology

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer

Rosemary Millen, Jordane Malaterre, Ryan S Cross, Sandra Carpinteri, Jayesh Desai, Ben Tran, Phillip Darcy, Peter Gibbs, Oliver Sieber, Nikolajs Zeps, Paul Waring, Stephen Fox, Lloyd Pereira, Robert G Ramsay

Journal article  |  2016  |  OncoImmunology

Ductal carcinoma in situ - update on risk assessment and management

Jia-Min B Pang, Kylie L Gorringe, Stephen B Fox

Journal article  |  2016  |  Histopathology

Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management

Emad A Rakha, Sunil Badve, Vincenzo Eusebi, Jorge S Reis-Filho, Stephen B Fox, David J Dabbs, Thomas Decker, Zsolt Hodi, Shu Ichihara, Andrew HS Lee, Jose Palacios, Andrea L Richardson, Anne Vincent-Salomon, Fernando C Schmitt, Tan Puay-Hoon, Gary M Tse, Ian O Ellis

Journal article  |  2016  |  Histopathology

Colorectal cancer

Alex Boussioutas, Stephen Fox, Iris Nagtegaal, Alexander Heriot, Jonathan Knowles, Michael Michael, Sam Ngan, Kathryn Field, John Zalcberg

Book Chapter  |  2016

This chapter covers colorectal cancer, and includes information on epidemiology, risk factors (chronic inflammation/inflammatory b..

Phyllodes tumours of the breast: a consensus review

Benjamin Y Tan, Geza Acs, Sophia K Apple, Sunil Badve, Ira J Bleiweiss, Edi Brogi, Jose P Calvo, David J Dabbs, Ian O Ellis, Vincenzo Eusebi, Gelareh Farshid, Stephen B Fox, Shu Ichihara, Sunil R Lakhani, Emad A Rakha, Jorge S Reis-Filho, Andrea L Richardson, Aysegul Sahin, Fernando C Schmitt, Stuart J Schnitt, et al.

Journal article  |  2016  |  Histopathology

Assessing Tumor Angiogenesis in Histological Samples

Jia-Min Pang, Nicholas Jene, Stephen B Fox

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

The cancer genetics and pathology of male breast cancer

Siddhartha Deb, Sunil R Lakhani, Laura Ottini, Stephen B Fox

Journal article  |  2016  |  Histopathology

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

Stephen Q Wong, Kelly Waldeck, Ismael A Vergara, Jan Schroeder, Jason Madore, James S Wilmott, Andrew J Colebatch, Ricardo De Paoli-Iseppi, Jason Li, Richard Lupat, Timothy Semple, Gisela Mir Arnau, Andrew Fellowes, J Helen Leonard, George Hruby, Graham J Mann, John F Thompson, Carleen Cullinane, Meredith Johnston, Mark Shackleton, et al.

Journal article  |  2015  |  Cancer Res

Cancer 2015: a longitudinal whole-of-system study of genomic cancer medicine

David M Thomas, Stephen Fox, Paula K Lorgelly, David Ashley, Gary Richardson, Lara Lipton, John P Parisot, Mark Lucas, John McNeil, Michael Wright

Journal article  |  2015  |  Drug Discovery Today

"Cancer 2015": A Prospective, Population-Based Cancer Cohort-Phase 1: Feasibility of Genomics-Guided Precision Medicine in the Clinic

John P Parisot, Heather Thorne, Andrew Fellowes, Ken Doig, Mark Lucas, John J McNeil, Brett Doble, Alexander Dobrovic, Thomas John, Paul A James, Lara Lipton, David Ashley, Theresa Hayes, Paul McMurrick, Gary Richardson, Paula Lorgelly, Stephen B Fox, David M Thomas

Journal article  |  2015  |  Journal of Personalized Medicine

Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context

Ella R Thompson, Kylie L Gorringe, Simone M Rowley, Na Li, Simone McInerny, Michelle W Wong-Brown, Lisa Devereux, Jason Li, Alison H Trainer, Gillian Mitchell, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2015  |  Sci Rep

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

Katie T Huang, Thomas Mikeska, Jason Li, Elena A Takano, Ewan KA Millar, Peter H Graham, Samantha E Boyle, Ian G Campbell, Terence P Speed, Alexander Dobrovic, Stephen B Fox

Journal article  |  2015  |  BMC Cancer

Clinical cancer genomic analysis: data engineering required

Kenneth Doig, Anthony T Papenfuss, Stephen Fox

Journal article  |  2015  |  The Lancet Oncology

Copy number analysis of ductal carcinoma in situ with and without recurrence

Kylie L Gorringe, Sally M Hunter, Jia-Min Pang, Ken Opeskin, Prue Hill, Simone M Rowley, David YH Choong, Ella R Thompson, Alexander Dobrovic, Stephen B Fox, G Bruce Mann, Ian G Campbell

Journal article  |  2015  |  Modern Pathology

Searching for ROS1 Rearrangements in Lung Cancer by Fluorescent In Situ Hybridization The Importance of Probe Design Response

Toni-Maree Rogers, Stephen B Fox

Journal article  |  2015  |  Journal of Thoracic Oncology

Altered significance of D'Amico risk classification in patients with prostate cancer linked to a familial breast cancer (kConFab) cohort

Damien Bolton, Yuan Cheng, Amber J Willems-Jones, Jason Li, Eveline Niedermeyr, Gillian Mitchell, David Clouston, Nathan Lawrentschuk, Ania Sliwinski, Stephen Fox, Heather Thorne

Journal article  |  2015  |  BJU INTERNATIONAL

Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

Max Yan, Kristy Shield-Artin, David Byrne, Siddhartha Deb, Nic Waddell, Izhak Haviv, Stephen B Fox

Journal article  |  2015  |  BMC Cancer

Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt, D Buckley, J-MB Pang, J Panimaya, PJ Paul, C Gamell, EA Takano, Y Ying Lee, S Hiddingh, T-M Rogers, AFAS Teunisse, MJ Herold, J-C Marine, SB Fox, A Jochemsen, Y Haupt

Journal article  |  2015  |  Cell Death & Disease

Breast Tissue Composition and Immunophenotype and Its Relationship with Mammographic Density in Women at High Risk of Breast Cancer

Jia-Min B Pang, David J Byrne, Elena A Takano, Nicholas Jene, Lara Petelin, Joanne McKinley, Catherine Poliness, Christobel Saunders, Donna Taylor, Gillian Mitchell, Stephen B Fox

Journal article  |  2015  |  PLOS ONE

Appraisal of the technologies and review of the genomic landscape of ductal carcinoma in situ of the breast

Jia-Min B Pang, Kylie L Gorringe, Stephen Q Wong, Alexander Dobrovic, Ian G Campbell, Stephen B Fox

Journal article  |  2015  |  Breast Cancer Research

Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features

Paul A James, Sarah Sawyer, Samantha Boyle, Mary-Anne Young, Serguei Kovalenko, Rebecca Doherty, Joanne McKinley, Kathryn Alsop, Victoria Beshay, Marion Harris, Stephen Fox, Geoffrey J Lindeman, Gillian Mitchell

Journal article  |  2015  |  Familial Cancer

Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous

Elena A Takano, Sally M Hunter, Ian G Campbell, Stephen B Fox

Journal article  |  2015  |  Journal of Clinical Pathology

The genomic landscape of phaeochromocytoma

Aidan Flynn, Diana Benn, Roderick Clifton-Bligh, Bruce Robinson, Alison H Trainer, Paul James, Annette Hogg, Kelly Waldeck, Joshy George, Jason Li, Stephen B Fox, Anthony J Gill, Grant McArthur, Rodney J Hicks, Richard W Tothill

Journal article  |  2015  |  J Pathol

International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fifth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2013).

Vito Amoroso, Daniele Generali, Thomas Buchholz, Massimo Cristofanilli, Rebecca Pedersini, Giuseppe Curigliano, Maria Grazia Daidone, Serena Di Cosimo, Mitchell Dowsett, Stephen Fox, Adrian L Harris, Andreas Makris, Lucia Vassalli, Andrea Ravelli, Maria Rosa Cappelletti, Christos Hatzis, Clifford A Hudis, Paolo Pedrazzoli, Anna Sapino, Vladimir Semiglazov, et al.

Journal article  |  2015  |  JNCI Monographs

Expert consensus-based recommendations regarding key issues in the use of primary (or neoadjuvant) systemic treatment (PST) in pat..

Effect of Primary Letrozole Treatment on Tumor Expression of mTOR and HIF-1α and Relation to Clinical Response.

Daniele Generali, Alfredo Berruti, Maria Rosa Cappelletti, Laura Zanotti, Giulia Brugnoli, Michela Forti, Francesca Bedussi, Maria Elena Vailati, Manuela Milani, Carla Strina, Mara Ardine, Sergio Aguggini, Giovanni Allevi, Giuseppina Ferrero, Ramona Bertoni, Alberto Bottini, Adrian L Harris, Stephen B Fox

Journal article  |  2015  |  JNCI Monographs

INTRODUCTION: Recently the combination of the mammalian target of rapamycin (mTOR) inhibitor everolimus and the aromatase inhibito..

Neoadjuvant Model in Cancer Treatment: From Clinical Opportunity to Health-Care Utility.

Daniele Generali, Stephen B Fox, Massimo Cristofanilli, Giampaolo Bianchini, Alberto Zambelli, Christos Hatzis, Massimo Barberis, Rosanna Tarricone, Alberto Bottini, Camillo Rossi, Michele Tringali

Journal article  |  2015  |  JNCI Monographs

In the last few decades, research has demonstrated that cancer can be treated and cured if diagnosed at very early stage and a pro..

Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients

SQ Wong, A Fellowes, K Doig, J Ellul, TJ Bosma, D Irwin, R Vedururu, AY-C Tan, J Weiss, KS Chan, M Lucas, DM Thomas, A Dobrovic, JP Parisot, SB Fox

Journal article  |  2015  |  British Journal of Cancer

Molecular methods for somatic mutation testing in lung adenocarcinoma: EGFR and beyond

Christine Khoo, Toni-Maree Rogers, Andrew Fellowes, Anthony Bell, Stephen Fox

Journal article  |  2015  |  Translational Lung Cancer Research

Comparison of Methods in the Detection of ALK and ROS1 Rearrangements in Lung Cancer

Toni-Maree Rogers, Prudence A Russell, Gavin Wright, Zoe Wainer, Jia-Min Pang, Leigh A Henricksen, Shalini Singh, Stacey Stanislaw, James Grille, Esteban Roberts, Benjamin Solomon, Stephen B Fox

Journal article  |  2015  |  Journal of Thoracic Oncology

Applicability of Next Generation Sequencing Technology in Microsatellite Instability Testing

Chun Gan, Clare Love, Victoria Beshay, Finlay Macrae, Stephen Fox, Paul Waring, Graham Taylor

Journal article  |  2015  |  Genes

Combination of letrozole, metronomic cyclophosphamide and sorafenib is well-tolerated and shows activity in patients with primary breast cancer

L Bazzola, C Foroni, D Andreis, V Zanoni, MR Cappelletti, G Allevi, S Aguggini, C Strina, M Milani, S Venturini, F Ferrozzi, R Giardini, R Bertoni, H Turley, K Gatter, PG Petronini, SB Fox, AL Harris, M Martinotti, A Berruti, et al.

Journal article  |  2015  |  British Journal of Cancer

Would the combination of everolimus with endocrine-therapy help in FGFR2 positive serous endometrial cancer?

Maria Rosa Cappelletti, Letizia Gnetti, Daniele Santini, Daniele Spada, Stephen B Fox, Daniele Generali

Journal article  |  2015  |  Oncoscience

Role of p53 in the progression of gastric cancer

Rita A Busuttil, Giada V Zapparoli, Sue Haupt, Christina Fennell, Stephen Q Wong, Jia-Min B Pang, Elena A Takeno, Catherine Mitchell, Natasha Di Costanzo, Stephen Fox, Ygal Haupt, Alexander Dobrovic, Alex Boussioutas

Journal article  |  2014  |  ONCOTARGET

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Huiling Xu, Yuqian Yan, Siddhartha Deb, Danny Rangasamy, Markus Germann, Jordane Malaterre, Noreen C Eder, Robyn L Ward, Nicholas J Hawkins, Richard W Tothill, Long Chen, Neil J Mortensen, Stephen B Fox, Michael J McKay, Robert G Ramsay

Journal article  |  2014  |  Cell Reports

A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma

J Lewin, KK Khamly, RJ Young, C Mitchell, RJ Hicks, GC Toner, SYK Ngan, S Chander, GJ Powell, A Herschtal, L Te Marvelde, J Desai, PFM Choong, SA Stacker, MG Achen, N Ferris, S Fox, J Slavin, DM Thomas

Journal article  |  2014  |  British Journal of Cancer

Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations

S Deb, SQ Wong, J Li, H Do, J Weiss, D Byrne, A Chakrabarti, T Bosma, A Fellowes, A Dobrovic, SB Fox

Journal article  |  2014  |  Br J Cancer

Expression of E6AP and PML predicts for prostate cancer progression and cancer-specific death

SE Birch, JG Kench, E Takano, P Chan, A-L Chan, K Chiam, A-S Veillard, P Stricker, S Haupt, Y Haupt, L Horvath, SB Fox

Journal article  |  2014  |  Annals of Oncology

Diagnostic issues with significant tumour displacement in breast biopsies

Nicole Lightfoot, Bassam Tawfik, Stephen B Fox

Journal article  |  2014  |  Journal of Clinical Pathology

Nuclear HIF1A expression is strongly prognostic in sporadic but not familial male breast cancer

Siddhartha Deb, Ida Johansson, David Byrne, Cecilia Nilsson, Leonie Constable, Marie-Louise Fjallskog, Alexander Dobrovic, Ingrid Hedenfalk, Stephen B Fox

Journal article  |  2014  |  Modern Pathology

KRAS mutation testing of metastatic colorectal cancer in Australia: Where are we at?

Rodney J Scott, Stephen B Fox, Jayesh Desai, Fabienne Grieu, Benhur Amanuel, Kerryn Garrett, James Harraway, Glenice Cheetham, Neville Pattle, Afaf Haddad, Keith Byron, Barney Rudzki, Paul Waring, Barry Iacopetta

Journal article  |  2014  |  Asia Pacific Journal of Clinical Oncology

Controversies in the management of gastrointestinal stromal tumors

Desmond Yip, John Zalcberg, Stephen Ackland, Andrew P Barbour, Jayesh Desai, Stephen Fox, Dusan Kotasek, Grant McArthur, B Mark Smithers

Journal article  |  2014  |  Asia-Pacific Journal of Clinical Oncology

Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome

Annette M Lim, Hongdo Do, Richard J Young, Stephen Q Wong, Christopher Angel, Marnie Collins, Elena A Takano, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Stephen B Fox, Danny Rischin, Alexander Dobrovic, Benjamin Solomon

Journal article  |  2014  |  International Journal of Cancer

COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast, and is a target for treatment

D Generali, FM Buffa, S Deb, M Cummings, LE Reid, M Taylor, D Andreis, G Allevi, G Ferrero, D Byrne, M Martinotti, A Bottini, AL Harris, SR Lakhani, SB Fox

Journal article  |  2014  |  British Journal of Cancer

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

Richard J Young, Kelly Waldeck, Claire Martin, Jung H Foo, Donald P Cameron, Laura Kirby, Hongdo Do, Catherine Mitchell, Carleen Cullinane, Wendy Liu, Stephen B Fox, Ken Dutton-Regester, Nicholas K Hayward, Nicholas Jene, Alexander Dobrovic, Richard B Pearson, James G Christensen, Sophia Randolph, Grant A McArthur, Karen E Sheppard

Journal article  |  2014  |  PIGMENT CELL & MELANOMA RESEARCH

Targeting fibroblast growth factor receptor in breast cancer: a promise or a pitfall?

Francesca Bedussi, Alberto Bottini, Maurizio Memo, Stephen B Fox, Sandra Sigala, Daniele Generali

Journal article  |  2014  |  Expert Opinion On Therapeutic Targets

Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

Stephen Q Wong, Jason Li, Angela Y-C Tan, Ravikiran Vedururu, Jia-Min B Pang, Hongdo Do, Jason Ellul, Ken Doig, Anthony Bell, Grant A McArthur, Stephen B Fox, David M Thomas, Andrew Fellowes, John P Parisot, Alexander Dobrovic

Journal article  |  2014  |  BMC Medical Genomics

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao, Amanda Russell, Jonathan Beesley, Xiao Qing Chen, Sue Healey, Michelle Henderson, Mark Wong, Catherine Emmanuel, Laura Galletta, Sharon E Johnatty, David Bowtell, Michelle Haber, Murray Norris, Paul Harnett, Georgia Chenevix-Trench, Rosemary L Balleine, Anna deFazio

Journal article  |  2014  |  SCIENTIFIC REPORTS

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

Monique D Topp, Lynne Hartley, Michele Cook, Valerie Heong, Emma Boehm, Lauren McShane, Jan Pyman, Orla McNally, Sumitra Ananda, Marisol Harrell, Dariush Etemadmoghadam, Laura Galletta, Kathryn Alsop, Gillian Mitchell, Stephen B Fox, Jeffrey B Kerr, Karla J Hutt, Scott H Kaufmann, Elizabeth M Swisher, David D Bowtell, et al.

Journal article  |  2014  |  Molecular Oncology

HER2 status in gastric/gastro-oesophageal junctional cancers: should determination of gene amplification by SISH use HER2 copy number or HER2: CEP17 ratio?

Marian Priyanthi Kumarasinghe, Willem Bastiaan de Boer, Tze Sheng Khor, Esther M Ooi, Nic Jene, Sureshini Jayasinghe, Stephen B Fox

Journal article  |  2014  |  Pathology

National Working Group Meeting on ALK diagnostics in lung cancer

Wendy Cooper, Stephen Fox, Sandra O'Toole, Adrienne Morey, Glenn Frances, Nick Pavlakis, Kenneth O'Byrne, Andrew Dettrick, Trishe Leong, Vivek Rathi, Dominic Spagnolo, Chris Hemmings, Mahendra Singh, David Moffat, Ming-Sound Tsao, Keith Wilner, Richard Buller, Susan Pitman Lowenthal, Shams Arifeen, Justin Binko, et al.

Journal article  |  2014  |  Asia-Pacific Journal of Clinical Oncology

RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas

S Deb, H Xu, J Tuynman, J George, Y Yan, J Li, RL Ward, N Mortensen, NJ Hawkins, MJ McKay, RG Ramsay, SB Fox

Journal article  |  2014  |  BRITISH JOURNAL OF CANCER

Lymphangiogenesis and lymphatic vessel remodelling in cancer

Steven A Stacker, Steven P Williams, Tara Karnezis, Ramin Shayan, Stephen B Fox, Marc G Achen

Journal article  |  2014  |  Nature Reviews Cancer

Pure anti-tumor effect of zoledronic acid in na < ve bone-only metastatic and locally advanced breast cancer: proof from the "biological window therapy"

Chiara Foroni, Manuela Milan, Carla Strina, Mariarosa Cappelletti, Claudia Fumarola, Mara Bonelli, Ramona Bertoni, Giuseppina Ferrero, Mara Maldotti, Elena Takano, Daniele Andreis, Sergio Venturini, Giulia Brugnoli, Pier Giorgio Petronini, Vanessa Zanoni, Laura Pritzker, Kenneth Pritzker, Amadeo Parissenti, Daniele Santini, Stephen B Fox, et al.

Journal article  |  2014  |  Breast Cancer Research and Treatment

Molecular profiling in colorectal cancer: current state of play and future directions

Siddhartha Deb, Stephen B Fox

Journal article  |  2014  |  Colorectal Cancer

Mutations in EGFR, BRAF and RAS are rare in triple-negative and basal-like breast cancers from Caucasian women

E Tilch, T Seidens, S Cocciardi, LE Reid, D Byrne, PT Simpson, AC Vargas, MC Cummings, SB Fox, SR Lakhani, G Chenevix Trench

Journal article  |  2014  |  Breast Cancer Research and Treatment

Methylation profiling of ductal carcinoma in situ and its relationship to histopathological features

Jia-Min B Pang, Siddhartha Deb, Elena A Takano, David J Byrne, Nicholas Jene, Alice Boulghourjian, Anne Holliday, Ewan Millar, C Soon Lee, Sandra A O'Toole, Alexander Dobrovic, Stephen B Fox

Journal article  |  2014  |  Breast Cancer Research

Blood vessel invasion and other variables as predictors of long-term survival in Japanese and British patients with primary invasive breast cancer

Takao Kato, Francesco Pezzella, Graham Steers, Leticia Campo, Russell D Leek, Helen Turley, Shingo Kameoka, Toshio Nishikawa, Adrian L Harris, Kevin C Gatter, Stephen Fox

Journal article  |  2014  |  International Journal of Clinical and Experimental Pathology

Testing for ALK rearrangement in lung adenocarcinoma: a multicenter comparison of immunohistochemistry and fluorescent in situ hybridization

Christina I Selinger, Toni-Maree Rogers, Prudence A Russell, Sandra O'Toole, PoYee Yip, Gavin M Wright, Zoe Wainer, Lisa G Horvath, Michael Boyer, Brian McCaughan, Maija RJ Kohonen-Corish, Stephen Fox, Wendy A Cooper, Benjamin Solomon

Journal article  |  2013  |  Modern Pathology

Massively-parallel sequencing assists the diagnosis and guided treatment of cancers of unknown primary

Richard W Tothill, Jason Li, Linda Mileshkin, Ken Doig, Terence Siganakis, Prue Cowin, Andrew Fellowes, Timothy Semple, Stephen Fox, Keith Byron, Adam Kowalczyk, David Thomas, Penelope Schofield, David D Bowtell

Journal article  |  2013  |  JOURNAL OF PATHOLOGY

The G-Protein-Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis

Leonid L Nikitenko, Russell Leek, Stephen Henderson, Nischalan Pillay, Helen Turley, Daniele Generali, Sarah Gunningham, Helen R Morrin, Andrea Pellagatti, Margaret CP Rees, Adrian L Harris, Stephen B Fox

Journal article  |  2013  |  Clinical Cancer Research

Metastatic gastrointestinal stromal tumour of the ileum with dual primary c-KIT missence mutations

Laeeq Malik, Christine Hemmings, Victoria Beshay, Stephen Fox, Desmond Yip

Journal article  |  2013  |  Pathology

A Fully Human Inhibitory Monoclonal Antibody to the Wnt Receptor RYK

Michael M Halford, Maria L Macheda, Clare L Parish, Elena A Takano, Stephen Fox, Daniel Layton, Edouard Nice, Steven A Stacker

Journal article  |  2013  |  PLOS ONE

Multiomics medicine in oncology: assessing effectiveness, cost-effectiveness and future research priorities for the molecularly unique individual

Brett Doble, Anthony Harris, David M Thomas, Stephen Fox, Paula Lorgelly

Journal article  |  2013  |  Pharmacogenomics

Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-Cadherin Immunohistochemistry

David J Dabbs, Stuart J Schnitt, Felipe C Geyer, Britta Weigelt, Frederick L Baehner, Thomas Decker, Vincenzo Eusebi, Stephen B Fox, Shu Ichihara, Sunil R Lakhani, Jose Palacios, Emad Rakha, Andrea L Richardson, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Anne Vincent-Salomon, Ian O Ellis, Sunil Badve, Jorge S Reis-Filho

Journal article  |  2013  |  American Journal of Surgical Pathology

HER2-positive breast cancer metastatic to intracranial meningioma: a case report

Mikkaela McCormack, Cesar Salinas-La Rosa, Michael Murphy, Stephen B Fox

Journal article  |  2013  |  Journal of Clinical Pathology

Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes

Enilze Ribeiro, Monica Ganzinelli, Daniele Andreis, Ramona Bertoni, Roberto Giardini, Stephen B Fox, Massimo Broggini, Alberto Bottini, Vanessa Zanoni, Letizia Bazzola, Chiara Foroni, Daniele Generali, Giovanna Damia

Journal article  |  2013  |  PLoS One

Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome

Richard J Young, Annette M Lim, Christopher Angel, Marnie Collins, Siddhartha Deb, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Prudence A Russell, Gavin Wright, Grant A McArthur, Stephen B Fox, Danny Rischin, Benjamin Solomon

Journal article  |  2013  |  Oral Oncology

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

Sue Haupt, Catherine Mitchell, Vincent Corneille, Jake Shortt, Stephen Fox, Pier Paolo Pandolfi, Mireia Castillo-Martin, Dennis M Bonal, Carlos Cordon-Cardo, Guillermina Lozano, Ygal Haupt

Journal article  |  2013  |  CELL CYCLE

Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer

G Allevi, C Strina, D Andreis, V Zanoni, L Bazzola, S Bonardi, C Foroni, M Milani, MR Cappelletti, F Gussago, S Aguggini, R Giardini, M Martinotti, SB Fox, AL Harris, A Bottini, A Berruti, D Generali

Journal article  |  2013  |  British Journal of Cancer

A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma

Anna Richter, Fabienne Grieu, Amerigo Carrello, Benhur Amanuel, Kateh Namdarian, Aleksandra Rynska, Amanda Lucas, Victoria Michael, Anthony Bell, Stephen B Fox, Chelsee A Hewitt, Hongdo Do, Grant A McArthur, Stephen Q Wong, Alexander Dobrovic, Barry Iacopetta

Journal article  |  2013  |  Scientific Reports

PIK3CA mutations are frequently observed in BRCAX but not BRCA2-associated male breast cancer

Siddhartha Deb, Hongdo Do, David Byrne, Nicholas Jene, Alexander Dobrovic, Stephen B Fox

Journal article  |  2013  |  Breast Cancer Research

HIF-1 alpha stimulates aromatase expression driven by prostaglandin E-2 in breast adipose stroma

Nirukshi U Samarajeewa, Fangyuan Yang, Maria M Docanto, Minako Sakurai, Keely M McNamara, Hironobu Sasano, Stephen B Fox, Evan R Simpson, Kristy A Brown

Journal article  |  2013  |  Breast Cancer Research

DNA methylation in ductal carcinoma in situ of the breast

Jia-Min B Pang, Alexander Dobrovic, Stephen B Fox

Journal article  |  2013  |  Breast Cancer Research

High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer

Amber Willems-Jones, Liam Kavanagh, David Clouston, Damien Bolton, Stephen Fox, Heather Thorne

Journal article  |  2012  |  BJU International

A Prospective Pathologic Study to Define the Clinical Target Volume for Partial Breast Radiation Therapy in Women With Early Breast Cancer

Brandon T Nguyen, Siddhartha Deb, Stephen Fox, Prudence Hill, Marnie Collins, Boon H Chua

Journal article  |  2012  |  International Journal of Radiation: Oncology - Biology - Physics

Genotypic and phenotypic analysis of familial male breast cancer shows under representation of the HER2 and basal subtypes in BRCA-associated carcinomas

Siddhartha Deb, Nicholas Jene, Stephen B Fox

Journal article  |  2012  |  BMC CANCER

Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study

D Ross Camidge, Yung-Jue Bang, Eunice L Kwak, A John Iafrate, Marileila Varella-Garcia, Stephen B Fox, Gregory J Riely, Benjamin Solomon, Sai-Hong I Ou, Dong-Wan Kim, Ravi Salgia, Panagiotis Fidias, Jeffrey A Engelman, Leena Gandhi, Pasi A Jaenne, Daniel B Costa, Geoffrey I Shapiro, Patricia LoRusso, Katherine Ruffner, Patricia Stephenson, et al.

Journal article  |  2012  |  Lancet Oncology

The connection between lymphangiogenic signalling and prostglandin biology: A missing link in the metastatsic pathway

Tara Karnezis, Ramin Shayan, Stephen Fox, Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Oncotarget

Correlation of Ataxia-Telangiectasia-Mutated (ATM) gene loss with outcome in head and neck squamous cell carcinoma

Annette M Lim, Richard J Young, Marnie Collins, Stephen B Fox, Grant A McArthur, June Corry, Lester Peters, Danny Rischin, Benjamin Solomon

Journal article  |  2012  |  Oral Oncology

The molecular characterisation of unusual subcutaneous spindle cell lesion of breast

Elena A Takano, Toni-Maree Rogers, Richard J Young, Mukta Rayoo, Phillip Kostos, Ross Ferguson, Ian G Campbell, Maria Debiec-Rychter, Stephen B Fox

Journal article  |  2012  |  Journal of Clinical Pathology

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Kamil Wolyniec, Jake Shortt, Elisa de Stanchina, Yaara Levav-Cohen, Osnat Alsheich-Bartok, Igal Louria-Hayon, Vincent Corneille, Beena Kumar, Simone J Woods, Stephen Opat, Ricky W Johnstone, Clare L Scott, David Segal, Pier Paolo Pandolfi, Stephen Fox, Andreas Strasser, Yong-Hui Jiang, Scott W Lowe, Sue Haupt, Ygal Haupt

Journal article  |  2012  |  BLOOD

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

Kathryn Alsop, Sian Fereday, Cliff Meldrum, Anna deFazio, Catherine Emmanuel, Joshy George, Alexander Dobrovic, Michael J Birrer, Penelope M Webb, Colin Stewart, Michael Friedlander, Stephen Fox, David Bowtell, Gillian Mitchell

Journal article  |  2012  |  JOURNAL OF CLINICAL ONCOLOGY

Assessing HER2 amplification in breast cancer: findings from the Australian In Situ Hybridization Program

Michael Bilous, Adrienne L Morey, Jane E Armes, Richard Bell, Peter H Button, Margaret C Cummings, Stephen B Fox, Glenn D Francis, Brigid Waite, Glenda McCue, Wendy A Raymond, Peter D Robbins, Gelareh Farshid

Journal article  |  2012  |  Breast Cancer Research and Treatment

Gastric HER2 Testing Study (GaTHER): An Evaluation of Gastric/Gastroesophageal Junction Cancer Testing Accuracy in Australia

Stephen B Fox, Marian Priyanthi Kumarasinghe, Jane E Armes, Michael Bilous, Margaret C Cummings, Gelareh Farshid, Nicole Fitzpatrick, Glenn D Francis, Philip I McCloud, Wendy Raymond, Adrienne Morey

Journal article  |  2012  |  American Journal of Surgical Pathology

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

Samantha R Oakes, Francois Vaillant, Elgene Lim, Lily Lee, Kelsey Breslin, Frank Feleppa, Siddhartha Deb, Matthew E Ritchie, Elena Takano, Teresa Ward, Stephen B Fox, Daniele Generali, Gordon K Smyth, Andreas Strasser, David CS Huang, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

Tara Karnezis, Ramin Shayan, Carol Caesar, Sally Roufail, Nicole C Harris, Kathryn Ardipradja, You Fang Zhang, Steven P Williams, Rae H Farnsworth, Ming G Chai, Thusitha WT Rupasinghe, Dedreia L Tull, Megan E Baldwin, Erica K Sloan, Stephen B Fox, Marc G Achen, Steven A Stacker

Journal article  |  2012  |  Cancer Cell

Enhanced RAD21 cohesin expression confers poor prognosis in BRCA2 and BRCAX, but not BRCA1 familial breast cancers

Max Yan, Huiling Xu, Nic Waddell, Kristy Shield-Artin, Izhak Haviv, Michael J McKay, Stephen B Fox

Journal article  |  2012  |  Breast Cancer Research

Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

Nasim Mavaddat, Daniel Barrowdale, Irene L Andrulis, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Amanda Spurdle, Mark Robson, Mark Sherman, Anna Marie Mulligan, Fergus J Couch, Christoph Engel, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Melissa C Southey, Mary Beth Terry, David Goldgar, Frances O'Malley, et al.

Journal article  |  2012  |  Cancer Epidemiology, Biomarkers & Prevention

MET Amplification Identifies a Small and Aggressive Subgroup of Esophagogastric Adenocarcinoma With Evidence of Responsiveness to Crizotinib

Jochen K Lennerz, Eunice L Kwak, Allison Ackerman, Michael Michael, Stephen B Fox, Kristin Bergethon, Gregory Y Lauwers, James G Christensen, Keith D Wilner, Daniel A Haber, Ravi Salgia, Yung-Jue Bang, Jeffrey W Clark, Benjamin J Solomon, A John Iafrate

Journal article  |  2011  |  Journal of Clinical Oncology

Gata-3 Negatively Regulates the Tumor-Initiating Capacity of Mammary Luminal Progenitor Cells and Targets the Putative Tumor Suppressor Caspase-14

Marie-Liesse Asselin-Labat, Kate D Sutherland, Francois Vaillant, David E Gyorki, Di Wu, Sheridan Holroyd, Kelsey Breslin, Teresa Ward, Wei Shi, Mary L Bath, Siddhartha Deb, Stephen B Fox, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Journal article  |  2011  |  Molecular and Cellular Biology

Australian perspective on the role of targeted therapies in gastroesophageal cancer

Sid Deb, Danielle Ferraro, Niall C Tebbutt, Stephen B Fox

Journal article  |  2011  |  Cancer Forum

Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer

Katie T Huang, Elena A Takano, Thomas Mikeska, David J Byrne, Alexander Dobrovic, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research and Treatment

"Overcoming breast cancer drug resistance with mTOR inhibitors". Could it be a myth or a real possibility in the short-term future?

Nadia Margariti, Stephen B Fox, Alberto Bottini, Daniele Generali

Journal article  |  2011  |  Breast Cancer Research and Treatment

Decreased Prostate Cancer-Specific Survival of Men with BRCA2 Mutations from Multiple Breast Cancer Families

Heather Thorne, Amber J Willems, Eveline Niedermayr, Ivan MY Hoh, Jason Li, David Clouston, Gillian Mitchell, Stephen Fox, John L Hopper, Damien Bolton

Journal article  |  2011  |  Cancer prevention research

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes

Heather L Hondow, Stephen B Fox, Gillian Mitchell, Rodney J Scott, Victoria Beshay, Stephen Q Wong, Alexander Dobrovic

Journal article  |  2011  |  BMC Cancer

Antitumor activities and on-target toxicities mediated by a TRAIL receptor agonist following cotreatment with panobinostat

Ben P Martin, Ailsa J Frew, Michael Bots, Stephen Fox, Fenella Long, Kazuyoshi Takeda, Hideo Yagita, Peter Atadja, Mark J Smyth, Ricky W Johnstone

Journal article  |  2011  |  International Journal of Cancer

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

X Zhang, J George, S Deb, JL Degoutin, EA Takano, SB Fox, DDL Bowtell, KF Harvey

Journal article  |  2011  |  Oncogene

Relationship between Epidermal Growth Factor Receptor Status, p16(INK4A), and Outcome in Head and Neck Squamous Cell Carcinoma

Richard J Young, Danny Rischin, Richard Fisher, Grant A McArthur, Stephen B Fox, Lester J Peters, June Corry, Annette Lim, Kelly Waldeck, Benjamin Solomon

Journal article  |  2011  |  Cancer Epidemiology, Biomarkers & Prevention

Where and by Whom Should Gastric Cancer HER2/neu Status Be Assessed? Lessons From Breast Cancer

Manuel Salto-Tellez, Ee Xuan Yau, Benedict Yan, Stephen B Fox

Journal article  |  2011  |  Archives of Pathology & Laboratory Medicine

Nuclear and cytoplasmic expressions of ER beta 1 and ER beta 2 are predictive of response to therapy and alters prognosis in familial breast cancers

Max Yan, Mukta Rayoo, Elena A Takano, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research and Treatment

Nuclear Localization of Factor Inhibitor Hypoxia-Inducible Factor in Prostate Cancer Is Associated With Poor Prognosis

Nadeem Shaida, Peter Chan, Helen Turley, Catherine M Jones, Suresh Kanga, Robert W Ritchie, Peter R Malone, Adrian L Harris, Stephen B Fox

Journal article  |  2011  |  Journal of Urology

Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival

John Q Davies, Hsi-Hsien Lin, Martin Stacey, Simon Yona, Gin-Wen Chang, Siamon Gordon, Jorg Hamann, Leticia Campo, Cheng Han, Peter Chan, Stephen B Fox

Journal article  |  2011  |  Oncology Reports

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

Sunil Badve, David J Dabbs, Stuart J Schnitt, Frederick L Baehner, Thomas Decker, Vincenzo Eusebi, Stephen B Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R Lakhani, Jose Palacios, Emad A Rakha, Andrea L Richardson, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Britta Weigelt, Ian O Ellis, Jorge S Reis-Filho

Journal article  |  2011  |  Modern Pathology

kConFab: a familial breast cancer consortium facilitating research and translational oncology.

Heather Thorne, Gillian Mitchell, Stephen Fox, undefined kConFab consortium

Journal article  |  2011  |  JNCI Monographs

In 2005, 100,514 Australians were diagnosed with cancer, and over 10,000 of these cancers will be due to heritable causes. The imp..

Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer

Ee Ming Wong, Melissa C Southey, Stephen B Fox, Melissa A Brown, James G Dowty, Mark A Jenkins, Graham G Giles, John L Hopper, Alexander Dobrovic

Journal article  |  2011  |  Cancer prevention research

The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1 alpha and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen

Stephen B Fox, Daniele Generali, Alfredo Berruti, Maria P Brizzi, Leticia Campo, Simone Bonardi, Alessandra Bersiga, Giovanni Allevi, Manuela Milani, Sergio Aguggini, Teresa Mele, Luigi Dogliotti, Alberto Bottini, Adrian L Harris

Journal article  |  2011  |  Breast Cancer Research

Contribution of large genomic BRCA1 alterations to early-onset breast cancer selected for family history and tumour morphology: a report from The Breast Cancer Family Registry

Letitia D Smith, Andrea A Tesoriero, Ee M Wong, Susan J Ramus, Frances P O'Malley, Anna Marie Mulligan, Mary Beth Terry, Ruby T Senie, Regina M Santella, Esther M John, Irene L Andrulis, Hilmi Ozcelik, Mary B Daly, Andrew K Godwin, Saundra S Buys, Stephen Fox, David E Goldgar, Graham G Giles, John L Hopper, Melissa C Southey

Journal article  |  2011  |  Breast Cancer Research

The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression

Peter Chan, Andreas Moeller, Mira CP Liu, Jaclyn E Sceneay, Christina SF Wong, Nic Waddell, Katie T Huang, Alexander Dobrovic, Ewan KA Millar, Sandra A O'Toole, Catriona M McNeil, Robert L Sutherland, David D Bowtell, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research

Predictive immunohistochemical biomarkers in the context of neoadjuvant therapy for breast cancer.

Daniele Generali, William F Symmans, Alfredo Berruti, Stephen B Fox

Journal article  |  2011  |  Journal of the National Cancer Institute

The adoption of personalized medicine has led to the search for prognostic and predictive markers that can be applied to individua..

Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers

Max Yan, Nicholas Jene, David Byrne, Ewan KA Millar, Sandra A O'Toole, Catriona M McNeil, Gaynor J Bates, Adrian L Harris, Alison H Banham, Robert L Sutherland, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research

International expert consensus on primary systemic therapy in the management of early breast cancer: highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010).

Alfredo Berruti, Daniele Generali, Manfred Kaufmann, Lajos Puztai, Giuseppe Curigliano, Massimo Aglietta, Luca Gianni, William R Miller, Michael Untch, Christos Sotiriou, Mariagrazia Daidone, Pierfranco Conte, Derek Kennedy, Giovanna Damia, Piergiorgio Petronini, Serena Di Cosimo, Paolo Bruzzi, Mitch Dowsett, Christine Desmedt, Robert E Mansel, et al.

Journal article  |  2011  |  Journal of the National Cancer Institute

A panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of prima..

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Anna Marie Mulligan, Fergus J Couch, Daniel Barrowdale, Susan M Domchek, Diana Eccles, Heli Nevanlinna, Susan J Ramus, Mark Robson, Mark Sherman, Amanda B Spurdle, Barbara Wappenschmidt, Andrew Lee, Lesley McGuffog, Sue Healey, Olga M Sinilnikova, Ramunas Janavicius, Thomas VO Hansen, Finn C Nielsen, Bent Ejlertsen, Ana Osorio, et al.

Journal article  |  2011  |  BREAST CANCER RESEARCH

Positron emission tomography and neoadjuvant therapy of breast cancer.

Alexandre Cochet, Daniele Generali, Stephen B Fox, Francesco Ferrozzi, Rodney J Hicks

Journal article  |  2011  |  JNCI Monographs

The increasing use of neoadjuvant therapy for breast cancer has led to the development of early surrogate markers of response. Pos..

Molecular oncology and the neoadjuvant setting: the perfect blend for treatment personalization and clinical trial design.

Daniele Generali, Alfredo Berruti, Chiara Foroni, Letizia Bazzola, Daniele Andreis, Giovanni Allevi, Alessandra Bersiga, Luigi Dogliotti, Stephen B Fox, Adrian L Harris, Alberto Bottini

Journal article  |  2011  |  JNCI Monographs

Breast cancer is a heterogeneous disease. Predictive molecular markers are crucial in patient management, but the only recommended..

Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers

Huiling Xu, Max Yan, Jennifer Patra, Rachael Natrajan, Yuqian Yan, Sigrid Swagemakers, Jonathan M Tomaszewski, Sandra Verschoor, Ewan KA Millar, Peter van der Spek, Jorge S Reis-Filho, Robert G Ramsay, Sandra A O'Toole, Catriona M McNeil, Robert L Sutherland, Michael J Mckay, Stephen B Fox

Journal article  |  2011  |  Breast Cancer Research

A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues

Elena A Takano, Thomas Mikeska, Alexander Dobrovic, David J Byrne, Stephen B Fox

Journal article  |  2010  |  BMC Biotechnology

No evidence for DNA methylation of von Hippel-Lindau ubiquitin ligase complex genes in breast cancer

Katie T Huang, Alexander Dobrovic, Stephen B Fox

Journal article  |  2010  |  Breast Cancer Research and Treatment

Establishment of the Australian In Situ Hybridization Program for the Assessment of HER2 Amplification in Breast Cancer: A Model for the Introduction of New Biomarkers Into Clinical Practice

Gelareh Farshid, Jane E Armes, Richard Bell, Margaret Cummings, Stephen Fox, Glenn Francis, Martin Haswell, Adrienne Morey, Glenda McCue, Wendy Raymond, Peter Robbins, Michael Bilous

Journal article  |  2010  |  Diagnostic Molecular Pathology

Synergistic activity of letrozole and sorafenib on breast cancer cells

Mara A Bonelli, Claudia Fumarola, Roberta R Alfieri, Silvia La Monica, Andrea Cavazzoni, Maricla Galetti, Rita Gatti, Silvana Belletti, Adrian L Harris, Stephen B Fox, Dean B Evans, Mitch Dowsett, Lesley-Ann Martin, Alberto Bottini, Daniele Generali, Pier Giorgio Petronini

Journal article  |  2010  |  Breast Cancer Research and Treatment

DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast

Katie T Huang, Alexander Dobrovic, Max Yan, Rooshdiya Z Karim, C Soon Lee, Sunil R Lakhani, Stephen B Fox

Journal article  |  2010  |  Breast Cancer Research and Treatment

Anti-angiogenic effect of tamoxifen combined with epirubicin in breast cancer patients

Teresa Mele, Daniele Generali, Stephen Fox, Maria Pia Brizzi, Alessandra Bersiga, Manuela Milani, Giovanni Allevi, Simone Bonardi, Sergio Aguggini, Marco Volante, Luigi Dogliotti, Alberto Bottini, Adrian Harris, Alfredo Berruti

Journal article  |  2010  |  Breast Cancer Research and Treatment

Subtypes of familial breast tumours revealed by expression and copy number profiling

Nic Waddell, Jeremy Arnold, Sibylle Cocciardi, Leonard da Silva, Anna Marsh, Joan Riley, Cameron N Johnstone, Mohammed Orloff, Guillaume Assie, Charis Eng, Lynne Reid, Patricia Keith, Max Yan, Stephen Fox, Peter Devilee, Andrew K Godwin, Frans BL Hogervorst, Fergus Couch, Sean Grimmond, James M Flanagan, et al.

Journal article  |  2010  |  Breast Cancer Research and Treatment

DNA methylation analysis of the HIF-1 alpha prolyl hydroxylase domain genes PHD1, PHD2, PHD3 and the factor inhibiting HIF gene FIH in invasive breast carcinomas

Katie T Huang, Thomas Mikeska, Alexander Dobrovic, Stephen B Fox

Journal article  |  2010  |  Histopathology

Loss of STARD 10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status

Niamh C Murphy, Andrew V Biankin, Ewan KA Millar, Catriona M McNeil, Sandra A O'Toole, Davendra Segara, Paul Crea, Monilola A Olayioye, C Soon Lee, Stephen B Fox, Adrienne L Morey, Michael Christie, Elizabeth A Musgrove, Roger J Daly, Geoffrey J Lindeman, Susan M Henshall, Jane E Visvader, Robert L Sutherland

Journal article  |  2010  |  International Journal of Cancer

The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3

Christopher P Guise, Maria R Abbattista, Rachelle S Singleton, Samuel D Holford, Joanna Connolly, Gabi U Dachs, Stephen B Fox, Robert Pollock, Justin Harvey, Parry Guilford, Fernando Donate, William R Wilson, Adam V Patterson

Journal article  |  2010  |  Cancer Research

Breast cancer prognostic classification in the molecular era: the role of histological grade

Emad A Rakha, Jorge S Reis-Filho, Frederick Baehner, David J Dabbs, Thomas Decker, Vincenzo Eusebi, Stephen B Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R Lakhani, Jose Palacios, Andrea L Richardson, Stuart J Schnitt, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Ian O Ellis

Journal article  |  2010  |  Breast Cancer Research

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

Leonard Da Silva, Peter T Simpson, Chanel E Smart, Sibylle Cocciardi, Nic Waddell, Annette Lane, Brian J Morrison, Ana Cristina Vargas, Sue Healey, Jonathan Beesley, Pria Pakkiri, Suzanne Parry, Nyoman Kurniawan, Lynne Reid, Patricia Keith, Paulo Faria, Emilio Pereira, Alena Skalova, Michael Bilous, Rosemary L Balleine, et al.

Journal article  |  2010  |  Breast Cancer Research

BRCA1 tumours correlate with a HIF-1 alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression (vol 101, pg 1168, 2009)

M Yan, M Rayoo, EA Takano, SB Fox

Journal article  |  2009  |  British Journal of Cancer

Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

AM Jubb, H Turley, HC Moeller, G Steers, C Han, J-L Li, R Leek, EY Tan, B Singh, NJ Mortensen, I Noguera-Troise, F Pezzella, KC Gatter, G Thurston, SB Fox, AL Harris

Journal article  |  2009  |  British Journal of Cancer

Does cyclin D1 discriminate between BRCA2 and BRCAX breast cancers?

Max Yan, Stephen B Fox

Journal article  |  2009  |  Histopathology

A Multicenter Blinded Study to Evaluate KRAS Mutation Testing Methodologies in the Clinical Setting

Vicki Whitehall, Kayla Tran, Aarti Umapathy, Fabienne Grieu, Chelsee Hewitt, Tiffany-Jane Evans, Tuty Ismail, Wei Qi Li, Peter Collins, Paul Ravetto, Barbara Leggett, Manuel Salto-Tellez, Richie Soong, Stephen Fox, Rodney J Scott, Alexander Dobrovic, Barry Iacopetta

Journal article  |  2009  |  Journal of Molecular Diagnostics

Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers

M Rayoo, M Yan, EA Takano, GJ Bates, PJ Brown, AH Banham, SB Fox

Journal article  |  2009  |  Journal of Clinical Pathology

BRCA1 tumours correlate with a HIF-1 alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression

M Yan, M Rayoo, EA Takano, H Thorne, SB Fox

Journal article  |  2009  |  British Journal of Cancer

No evidence for promoter region methylation of the succinate dehydrogenase and fumarate hydratase tumour suppressor genes in breast cancer.

Katie T Huang, Alexander Dobrovic, Stephen B Fox

Journal article  |  2009  |  BMC Research Notes

BACKGROUND: Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes that are also kno..

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, Francois Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen, Frank Feleppa, Lily I Huschtscha, Heather J Thorne, Stephen B Fox, Max Yan, Juliet D French, Melissa A Brown, Gordon K Smyth, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2009  |  Nature Medicine

A Randomized Controlled Trial Investigating the Effects of Celecoxib in Patients with Localized Prostate Cancer

Prasanna Sooriakumaran, Helen M Coley, Stephen B Fox, Patricia Macanas-Pirard, David P Lovell, Alastair Henderson, Chris G Eden, Paul D Miller, Stephen EM Langley, Robert W Laing

Journal article  |  2009  |  Anticancer Research