Stephen Fox

SP142 PD-L1 Scoring Shows High Interobserver and Intraobserver Agreement in Triple-negative Breast Carcinoma But Overall Low Percentage Agreement With Other PD-L1 Clones SP263 and 22C3

Jia-Min B Pang, Belinda Castles, David J Byrne, Peter Button, Shona Hendry, Sunil R Lakhani, Vanathi Sivasubramaniam, Wendy A Cooper, Jane Armes, Ewan KA Millar, Wendy Raymond, Samuel Roberts-Thomson, Beena Kumar, Marian Burr, Christina Selinger, Kate Harvey, Charles Chan, Jane Beith, David Clouston, Sandra A O’Toole, et al.

Journal article  |  2021  |  American Journal of Surgical Pathology

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard, Michael Lush, Jonathan Beesley, Tracy A O'Mara, Joe Dennis, Jonathan P Tyrer, Daniel R Barnes, Lesley McGuffog, Goska Leslie, Manjeet K Bolla, Muriel A Adank, Simona Agata, Thomas Ahearn, Kristiina Aittomaeki, Irene L Andrulis, Hoda Anton-Culver, Volker Arndt, Norbert Arnold, Kristan J Aronson, Banu K Arun, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants hav..

RAPID TISSUE COLLECTION INCREASES PROSTATE SPECIFIC ANTIGEN EXPRESSION IN FEMALE URETHRAL TISSUE

Britt Haller, Elena Takano, Stephen Fox, Noel Woodford, James Brock, Helen O'Connell

Conference Proceedings  |  2021  |  NEUROUROLOGY AND URODYNAMICS

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson, Sarah Maguire, Anna Morra, Pooja Middha Kapoor, Katarzyna Tomczyk, Michael E Jones, Minouk J Schoemaker, Clare Gilham, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Caroline Baynes, Laura E Beane Freeman, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cance..

Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Eun Young Kang, Dane Cheasley, Cecile LePage, Matthew J Wakefield, Michelle da Cunha Torres, Simone Rowley, Carolina Salazar, Zhongyue Xing, Prue Allan, David DL Bowtell, Anne-Marie Mes-Masson, Diane M Provencher, Kurosh Rahimi, Linda E Kelemen, Peter A Fasching, Jennifer A Doherty, Marc T Goodman, Ellen L Goode, Suha Deen, Paul DP Pharoah, et al.

Conference Proceedings  |  2021  |  MODERN PATHOLOGY

TP53 mutations are implicated in the progression of mucinous borderline tumors (MBOT) to mucinous ovarian carcinomas (MOC). Optimi..

Metaplastic carcinomas of the breast without evidence of epithelial differentiation: a diagnostic approach for management

Emad A Rakha, Cecily M Quinn, Maria Pia Foschini, Monica Munoz Martin, David J Dabbs, Sunil Lakhani, Zsuzsanna Varga, Sarah E Pinder, Fernando C Schmitt, Jorge S Reis-Filho, Stephen B Fox, Ian O Ellis, Puay-Hoon Tan, Raluca Mihai

Journal article  |  2020  |  HISTOPATHOLOGY

AIMS: Although rare, malignant sarcomatoid breast tumours without evidence of epithelial differentiation comprise a diagnostic cha..

Recurrent SPECC1L-NTRK fusions in pediatric sarcoma and brain tumors

Dong-Anh Khuong-Quang, Lauren M Brown, Marie Wong, Chelsea Mayoh, Alexandra Sexton-Oates, Amit Kumar, Mark Pinese, Sumanth Nagabushan, Loretta Lau, Louise E Ludlow, Andrew J Gifford, Michael Rodriguez, Jayesh Desai, Stephen B Fox, Michelle Haber, David S Ziegler, Jordan R Hansford, Glenn M Marshall, Mark J Cowley, Paul G Ekert

Journal article  |  2020  |  COLD SPRING HARBOR MOLECULAR CASE STUDIES

The identification of rearrangements driving expression of neurotrophic receptor tyrosine kinase (NTRK) family kinases in tumors h..

Multi-center real-world comparison of the fully automated Idylla (TM) microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer

Ana Velasco, Fatma Tokat, Jesper Bonde, Nicola Trim, Elisabeth Bauer, Adam Meeney, Wendy de Leng, George Chong, Veronique Dalstein, Lorand L Kis, Jon A Lorentzen, Snjezana Tomic, Keeley Thwaites, Martina Putzova, Astrid Birnbaum, Romena Qazi, Vanessa Primmer, Barbara Dockhorn-Dworniczak, Javier Hernandez-Losa, Fernando A Soares, et al.

Journal article  |  2020  |  VIRCHOWS ARCHIV

Microsatellite instability (MSI) is present in 15-20% of primary colorectal cancers. MSI status is assessed to detect Lynch syndro..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  AMERICAN JOURNAL OF HUMAN GENETICS

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence

Yue Zhao, Ziwei Pan, Sandeep Namburi, Andrew Pattison, Atara Posner, Shiva Balachander, Carolyn A Paisie, Honey Reddi, Jens Rueter, Anthony J Gill, Stephen Fox, Kanwal PS Raghav, William F Flynn, Richard W Tothill, Sheng Li, R Krishna Murthy Karuturi, Joshy George

Journal article  |  2020  |  EBIOMEDICINE

BACKGROUND: Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer ..