Sheila Patel

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Plasma ACE2 Activity Predicts Mortality in Aortic Stenosis and Is Associated With Severe Myocardial Fibrosis

Jay Ramchand, Sheila K Patel, Leighton G Kearney, George Matalanis, Omar Farouque, Piyush M Srivastava, Louise M Burrell

Journal article  |  2020  |  JACC: Cardiovascular Imaging

OBJECTIVES: This study investigated the relationship between plasma angiotensin-converting enzyme 2 (ACE2) activity levels and the..

Gamma-glutamyltransferase, arterial remodeling and prehypertension in a healthy population at low cardiometabolic risk

M Kozakova, A Gastaldelli, C Morizzo, K Højlund, PM Nilssson, E Ferrannini, RJ Heine, J Dekker, S de Rooij, G Nijpels, W Boorsma, A Kok, A Mitrakou, S Tournis, K Kyriakopoulou, P Thomakos, N Lalic, K Lalic, A Jotic, L Lukic, et al.

Journal article  |  2020  |  Journal of Human Hypertension

Plasma endothelin-1 and adrenomedullin are associated with coronary artery function and cardiovascular outcomes in humans

James Theuerle, Omar Farouque, Sheran Vasanthakumar, Sheila K Patel, Louise M Burrell, David J Clark, Ali H Al-Fiadh

Journal article  |  2019  |  International Journal of Cardiology

Development of Acute Decompensated Heart Failure Among Hospital Inpatients: Incidence, Causes and Outcomes

Luke D Plant, David McDonald Taylor, Thomas Worland, Arvind Puri, Antony Ugoni, Sheila K Patel, Douglas F Johnson, Louise M Burrell

Journal article  |  2019  |  Heart, Lung and Circulation

APOE epsilon 4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke

Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Toby Cumming, Jennifer Bradshaw, Wasim Khan, Matthew Pase, Carolina Restrepo, Michele Veldsman, Natalia Egorova, Sheila K Patel, Elie Gottlieb, Amy Brodtmann

Journal article  |  2019  |  Journal of Alzheimer's Disease

INVESTIGATION OF THE PEGUERO-LO PRESTI CRITERIA TO IMPROVE THE SENSITIVITY OF THE ELECTROCARDIOGRAM TO DIAGNOSE LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH TYPE 2 DIABETES

Thalys Sampaio Rodrigues, Jay Ramchand, Bryan Wai, Piyush M Srivastava, Ronan O'Donnabhain, Sheila K Patel, Louise M Burrell

Conference Proceedings  |  2018  |  Journal of Hypertension

CEREBRAL ATROPHY IN PATIENTS WITH TYPE 2 DIABETES AND LEFT VENTRICULAR HYPERTROPHY: PRELIMINARY DATA FROM THE DIABETES AND DEMENTIA (D2) STUDY

Sheila Patel, Sheila K Patel, Mohamed S Khlif, Jay Ramchand, Carolina Restrepo, Elise Harrison, Amanda Shanks, Emilio Werden, Piyush M Srivastava, Elif I Ekinci, Louise M Burrell, Amy Brodtmann

Conference Proceedings  |  2018  |  Journal of Hypertension

REDUCED EXPRESSION OF CARDIAC KRUPPEL LIKE FACTOR 15 IS ASSOCIATED WITH CARDIAC HYPERTROPHY IN PATIENTS WITH AORTIC STENOSIS

Sheila Patel, Sheila K Patel, Jay Ramchand, Vincenzo Crocitti, Leighton G Kearney, Piyush M Srivastava, Louise M Burrell

Conference Proceedings  |  2018  |  Journal of Hypertension

Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease

J Ramchand, SK Patel, PM Srivastava, O Farouque, LM Burrell

Conference Proceedings  |  2018  |  EUROPEAN HEART JOURNAL

Role of novel biomarkers to improve risk stratification in aortic stenosis: focus on plasma ACE2 activity

J Ramchand, SK Patel, LG Kearney, G Matalanis, O Farouque, PM Srivastava, LM Burrell

Conference Proceedings  |  2018  |  EUROPEAN HEART JOURNAL

Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15

Sheila K Patel, Elena Velkoska, Daniel Gayed, Jay Ramchand, Jessica Lesmana, Louise M Burrell

Journal article  |  2018  |  BMC Nephrology

Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD

Eveline Bruinstroop, Rinkoo Dalan, Yang Cao, Yong Mong Bee, Kurumbian Chandran, Li Wei Cho, Shui Boon Soh, Eng Kiong Teo, Sue-Anne Toh, Melvin Khee Shing Leow, Rohit A Sinha, Suresh Anand Sadananthan, Navin Michael, Heather M Stapleton, Christopher Leung, Peter W Angus, Sheila K Patel, Louise M Burrell, Su Chi Lim, Chee Fang Sum, et al.

Journal article  |  2018  |  The Journal of Clinical Endocrinology & Metabolism

Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease

Jay Ramchand, Sheila K Patel, Piyush M Srivastava, Omar Farouque, Louise M Burrell

Journal article  |  2018  |  PLoS ONE

Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophygj

Sheila K Patel, Jay Ramchand, Vincenzo Crocitti, Louise M Burrell

Journal article  |  2018  |  International Journal of Molecular Sciences

Left ventricular hypertrophy and cognitive function: a systematic review

C Restrepo, SK Patel, V Rethnam, E Werden, J Ramchand, L Churilov, LM Burrell, A Brodtmann

Journal article  |  2018  |  Journal of Human Hypertension

The Peguero-Lo Presti Electrocardiographic Criteria Predict All-Cause Mortality in Patients With Aortic Stenosis

Jay Ramchand, Thalys Sampaio Rodrigues, Leighton G Kearney, Sheila K Patel, Piyush M Srivastava, Louise M Burrell

Journal article  |  2017  |  Journal of the American College of Cardiology

Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling

Tomos E Walters, Jonathan M Kalman, Sheila K Patel, Megan Mearns, Elena Velkoska, Louise M Burrell

Journal article  |  2017  |  Europace

Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure

Francine Z Marques, Priscilla R Prestes, Sean G Byars, Scott C Ritchie, Peter Wurtz, Sheila K Patel, Scott A Booth, Indrajeetsinh Rana, Yosuke Minoda, Stuart P Berzins, Claire L Curl, James R Bell, Bryan Wai, Piyush M Srivastava, Antti J Kangas, Pasi Soininen, Saku Ruohonen, Mika Kahonen, Terho Lehtimaki, Emma Raitoharju, et al.

Journal article  |  2017  |  Journal of the American Heart Association

Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

Sheila K Patel, Carolina Restrepo, Emilio Werden, Leonid Churilov, Elif I Ekinci, Piyush M Srivastava, Jay Ramchand, Bryan Wai, Brian Chambers, Christopher J O'Callaghan, David Darby, Vladimir Hachinski, Toby Cumming, Geoff Donnan, Louise M Burrell, Amy Brodtmann

Journal article  |  2017  |  BMC Endocrine Disorders

Genetic Variation in Kruppel like Factor 15 Is Associated with Left Ventricular Hypertrophy in Patients with Type 2 Diabetes: Discovery and Replication Cohorts

Sheila K Patel, Bryan Wai, Chim C Lang, Daniel Levin, Colin NA Palmer, Helen M Parry, Elena Velkoska, Stephen B Harrap, Piyush M Srivastava, Louise M Burrell

Journal article  |  2017  |  EBioMedicine

Adverse cardiac effects of exogenous angiotensin 1-7 in rats with subtotal nephrectomy are prevented by ACE inhibition

Louise M Burrell, Daniel Gayed, Karen Griggs, Sheila K Patel, Elena Velkoska

Journal article  |  2017  |  PLOS ONE

The Receptor for Advanced Glycation End Products (RAGE) Is Associated with Persistent Atrial Fibrillation

Terase F Lancefield, Sheila K Patel, Melanie Freeman, Elena Velkoska, Bryan Wai, Piyush M Srivastava, Mark Horrigan, Omar Farouque, Louise M Burrell

Journal article  |  2016  |  PLOS ONE

Angiotensin converting enzyme 2 and diminazene: role in cardiovascular and blood pressure regulation

Elena Velkoska, Sheila K Patel, Louise M Burrell

Journal article  |  2016  |  Current Opinion in Nephrology and Hypertension

Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease

Elena Velkoska, Sheila K Patel, Karen Griggs, Louise M Burrell

Journal article  |  2016  |  PLoS One

MicroRNAs mediate the cardioprotective effect of angiotensin-converting enzyme inhibition in acute kidney injury

Indrajeetsinh Rana, Elena Velkoska, Sheila K Patel, Louise M Burrell, Fadi J Charchar

Journal article  |  2015  |  American Journal of Physiology-Renal Physiology

Obesity and carotid artery remodeling

M Kozakova, C Palombo, C Morizzo, K Højlund, M Hatunic, B Balkau, PM Nilsson, E Ferrannini, RJ Heine, J Dekker, S De Rooij, G Nijpels, W Boorsma, A Mitrakou, S Tournis, K Kyriakopoulou, P Thomakos, N Lalic, K Lalic, A Jotic, et al.

Journal article  |  2015  |  Nutrition & Diabetes

Longitudinal Development of Left Ventricular Diastolic Dysfunction in Patients With Type 2 Diabetes. Diabetes Care 2014;37:3092-3097

Louise M Burrell, Bryan Wai, Piyush M Srivastava, Sheila K Patel

Journal article  |  2015  |  Diabetes Care

Short-Term Treatment with Diminazene Aceturate Ameliorates the Reduction in Kidney ACE2 Activity in Rats with Subtotal Nephrectomy

Elena Velkoska, Sheila K Patel, Karen Griggs, Raelene J Pickering, Chris Tikellis, Louise M Burrell

Journal article  |  2015  |  PLOS ONE

Usefulness of Retinal Microvascular Endothelial Dysfunction as a Predictor of Coronary Artery Disease

Ali H Al-Fiadh, Tien Y Wong, Ryo Kawasaki, David J Clark, Sheila K Patel, Melanie Freeman, Andrew Wilson, Louise M Burrell, Omar Farouque

Journal article  |  2015  |  The American Journal of Cardiology

From gene to protein-experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

Sheila K Patel, Elena Velkoska, Melanie Freeman, Bryan Wai, Terase F Lancefield, Louise M Burrell

Journal article  |  2014  |  Frontiers in Physiology

Retinal microvascular structure and function in patients with risk factors of atherosclerosis and coronary artery disease

Ali H Al-Fiadh, Omar Farouque, Ryo Kawasaki, TT Nguyen, Nazim Uddin, Melanie Freeman, Sheila K Patel, Louise M Burrell, Tien Y Wong

Journal article  |  2014  |  Atherosclerosis

Prevalence, predictors and evolution of echocardiographically defined cardiac abnormalities in adults with type 1 diabetes: an observational cohort study

Bryan Wai, Sheila K Patel, Michelle Ord, Richard J MacIsaac, George Jerums, Piyush M Srivastava, Louise M Burrell

Journal article  |  2014  |  Journal of Diabetes and its Complications

Angiotensin-(1-7) and Kidney Disease: Friend or Foe

Elena Velkoska, Sheila K Patel, Louise M Burrell

Journal article  |  2013  |  Hypertension

Progression of aortic stenosis in elderly patients over long-term follow up

LG Kearney, M Ord, BF Buxton, G Matalanis, SK Patel, LM Burrell, PM Srivastava

Journal article  |  2013  |  International Journal of Cardiology

Progression of aortic stenosis in elderly patients over long-term follow up

LG Kearney, M Ord, BF Buxton, G Matalanis, SK Patel, LM Burrell, PM Srivastava

Journal article  |  2013  |  International Journal of Cardiology

Multiple vascular reactivity measures improves our ability to predict underlying coronary artery disease

A Alfiadh, N Uddin, S Patel, A Wilson, D Clark, R Kawasaki, L Burrell, T Wong, O Farouque

Conference Proceedings  |  2013  |  European Heart Journal

Emerging markers in cardiovascular disease: Where does angiotensin-converting enzyme 2 fit in?

Sheila K Patel, Elena Velkoska, Louise M Burrell

Journal article  |  2013  |  Clinical and Experimental Pharmacology and Physiology

The ACE2 gene: its potential as a functional candidate for cardiovascular disease

Louise M Burrell, Stephen B Harrap, Elena Velkoska, Sheila K Patel

Journal article  |  2013  |  Clinical Science

Age-dependent regulation of renal vasopressin V-1A and V-2 receptors in rats with genetic hypertension: implications for the treatment of hypertension

Louise M Burrell, John Risvanis, Rachael G Dean, Sheila K Patel, Elena Velkoska, Colin I Johnston

Journal article  |  2013  |  Journal of the American Society of Hypertension

Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions

Luke J Burchill, Elena Velkoska, Rachael G Dean, Karen Griggs, Sheila K Patel, Louise M Burrell

Journal article  |  2012  |  Clinical Science

Angiotensin-converting enzyme 2 polymorphisms and cardiovascular risk

JA Grace, LM Burrell, SK Patel

Journal article  |  2012  |  Internal Medicine Journal

Global longitudinal strain is a strong independent predictor of all-cause mortality in patients with aortic stenosis

LG Kearney, K Lu, M Ord, SK Patel, K Profitis, G Matalanis, LM Burrell, PM Srivastava

Journal article  |  2012  |  European Heart Journal

Usefulness of the Charlson Co-Morbidity Index to Predict Outcomes in Patients > 60 Years Old With Aortic Stenosis During 18 Years of Follow-Up

Leighton Kearney, Michelle Ord, Brian Buxton, George Matalanis, Sheila Patel, Louise Burrell, Piyush Srivastava

Journal article  |  2012  |  American Journal of Cardiology

The CTGF gene-945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes

Sheila K Patel, Bryan Wai, Richard J MacIsaac, Sharon Grant, Elena Velkoska, Michelle Ord, Sianna Panagiotopoulos, George Jerums, Piyush M Srivastava, Louise M Burrell

Journal article  |  2012  |  Cardiovascular Diabetology

Chronic kidney disease: cardiac and renal angiotensin-converting enzyme (ACE) 2 expression in rats after subtotal nephrectomy and the effect of ACE inhibition

LM Burrell, L Burchill, RG Dean, K Griggs, SK Patel, E Velkoska

Journal article  |  2012  |  Experimental Physiology

Association of ACE2 Genetic Variants With Blood Pressure, Left Ventricular Mass, and Cardiac Function in Caucasians With Type 2 Diabetes

Sheila K Patel, Bryan Wai, Michelle Ord, Richard J MacIsaac, Sharon Grant, Elena Velkoska, Sianna Panagiotopoulos, George Jerums, Piyush M Srivastava, Louise M Burrell

Journal article  |  2012  |  American Journal of Hypertension

Common variation in the adiponectin gene has an effect on systolic blood pressure

PJ Avery, SK Patel, IM Ibrahim, M Walker, BD Keavney

Journal article  |  2011  |  Journal of Human Hypertension

Advanced Glycation Urinary Protein-Bound Biomarkers and Severity of Diabetic Nephropathy in Man

Melinda T Coughlan, Sheila K Patel, George Jerums, Sally A Penfold, Nguyen Tuong-Vi, Karly C Sourris, Sianna Panagiotopoulos, Piyush M Srivastava, Mark E Cooper, Louise M Burrell, Richard J MacIsaac, Josephine M Forbes

Journal article  |  2011  |  American Journal of Nephrology

Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy

Sally A Penfold, Melinda T Coughlan, Sheila K Patel, Piyush M Srivastava, Karly C Sourris, David Steer, Diane E Webster, Merlin C Thomas, Richard J MacIsaac, George Jerums, Louise M Burrell, Mark E Cooper, Josephine M Forbes

Journal article  |  2010  |  Kidney International

Fasting insulin has a stronger association with an adverse cardiometabolic risk profile than insulin resistance: the RISC study

Susanne R de Rooij, Jacqueline M Dekker, Nlichaela Kozakova, Asimina Mitrakou, Olle Melander, Rafael Gabriel, Caterina Guidone, Kurt Hojlund, Matthew S Murphy, Giel Nijpels

Journal article  |  2009  |  European Journal of Endocrinology

Fatty Liver Is Associated with Insulin Resistance, Risk of Coronary Heart Disease, and Early Atherosclerosis in a Large European Population

Amalia Gastaldelli, Michaela Kozakova, Kurt Hojlund, Allan Flyvbjerg, Angela Favuzzi, Asimina Mitrakou, Beverley Balkau

Journal article  |  2009  |  Hepatology

The Effect of Menopause on Carotid Artery Remodeling, Insulin Sensitivity, and Plasma Adiponectin in Healthy Women

Elza Muscelli, Michaela Kozakova, Allan Flyvbjerg, Konstantina Kyriakopoulou, Brenno D Astiarraga, Dorte Glintborg, Thomas Konrad, Angela Favuzzi, Jhon Petrie

Journal article  |  2009  |  American Journal of Hypertension

Age-related decline in mitochondrial DNA copy number in isolated human pancreatic islets

LM Cree, SK Patel, A Pyle, S Lynn, DM Turnbull, PF Chinnery, M Walker

Journal article  |  2008  |  Diabetologia

Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects

Fabrice Bonnet, Sheila Patel, Martine Laville, Beverley Balkau, Angela Favuzzi, Lucilla D Monti, Nebojsa Lalic, Mark Walker

Journal article  |  2008  |  Diabetes Care

Variation in the ADIPOQ gene promoter is associated with carotid intima media thickness independent of plasma adiponectin levels in healthy subjects

Sheila Patel, Allan Flyvbjerg, Michaela Kozakova, Jan Frystyk, Ibrahim M Ibrahim, John R Petrie, Peter J Avery, Ele Ferrannini, Mark Walker

Journal article  |  2008  |  European Heart Journal

Prevalence and predictors of cardiac hypertrophy and dysfunction in patients with Type 2 diabetes

Piyush M Srivastava, Paul Calafiore, Richard J Macisaac, Sheila K Patel, Merlin C Thomas, George Jerums, Louise M Burrell

Journal article  |  2008  |  Clinical Science

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

Laura Pascoe, Andrea Tura, Sheila K Patel, M Ibrahim Ibrahim, Ele Ferrannini, Eleftheria Zeggini, Michael N Weedon, Andrea Mari, Andrew T Hattersley, Mark I McCarthy, Timothy M Frayling, Mark Walker

Journal article  |  2007  |  Diabetes

Insulin resistance, insulin response, and obesity as indicators of metabolic risk

Ele Ferrannini, Beverley Balkau, Simon W Coppack, Jacqueline M Dekker, Andrea Mari, John Nolan, Mark Walker, Andrea Natali, Henning Beck-Nielsen

Journal article  |  2007  |  The Journal of Clinical Endocrinology & Metabolism

A comparison of the new international diabetes federation definition of metabolic syndrome to WHO and NCEP definitions in Chinese, European and South Asian origin adults

Nigel Unwin, Raj Bhopal, Louise Hayes, Martin White, Sheila Patel, Dalip Ragoobirsingh, George Alberti

Journal article  |  2007  |  Ethnicity & Disease

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls

PF Chinnery, C Mowbray, SK Patel, JL Elson, M Sampson, GA Hitman, MI McCarthy, AT Hattersley, M Walker

Journal article  |  2007  |  Journal of Medical Genetics

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

LP PASCOE, AT TURA, S PATEL, IMI IBRAHIM, EF FERRANNINI, EZ ZEGGINI, MNW WEEDON, AM MARI, ATH HATTERSLEY, MIM MCCARTHY, TMF FRAYLING, MW WALKER

Journal article  |  2007  |  Diabetes

Changes in blood pressure and lipids associated with rural to urban migration in Tanzania

N Unwin, D McLarty, H Machibya, T Aspray, B Tamin, L Carlin, S Patel, M Walker, KGMM Alberti

Journal article  |  2006  |  Journal of Human Hypertension

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population

S Patel, JAL Minton, MN Weedon, TM Frayling, C Ricketts, GA Hitman, MI McCarthy, AT Hattersley, M Walker, TG Barrett

Journal article  |  2006  |  Diabetologia

Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes

PF Chinnery, HR Elliott, S Patel, C Lambert, SM Keers, SE Durham, MI McCarthy, GA Hitman, AT Hattersley, M Walker

Journal article  |  2005  |  The Lancet

Mismatch between perceived and actual overweight in diabetic and non-diabetic populations: a comparative study of South Asian and European women

S Patel, R Bhopal, N Unwin, M White, KGMM Alberti, J Yallop

Journal article  |  2001  |  Journal of Epidemiology & Community Health

Anaemia in Chinese, South Asian, and European populations in Newcastle upon Tyne: cross sectional study

C Fischbacher, R Bhopal, S Patel, M White, N Unwin, KGMM Alberti

Journal article  |  2001  |  British Medical Journal

A comparison of proxy measures of abdominal obesity in Chinese, European and South Asian adults

S Patel, N Unwin, R Bhopal, M White, J Harland, SAM Ayis, W Watson, KGMM Alberti

Journal article  |  1999  |  Diabetic Medicine

Heterogeneity of coronary heart disease risk factors in Indian, Pakistani, Bangladeshi, and European origin populations: cross sectional study

R Bhopal, N Unwin, M White, J Yallop, L Walker, KGMM Alberti, J Harland, S Patel, N Ahmad, C Turner, B Watson, D Kaur, A Kulkarni, M Laker, A Tavridou

Journal article  |  1999  |  BMJ