Andrew Fleetwood

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice.

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  Osteoarthritis and Cartilage

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  Journal of Clinical Investigation

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14( )CD16(-) Monocytes

Man KS Lee, Annas Al-Sharea, Waled A Shihata, Camilla Bertuzzo Veiga, Olivia D Cooney, Andrew J Fleetwood, Michelle C Flynn, Ellen Claeson, Clovis S Palmer, Graeme I Lancaster, Darren C Henstridge, John A Hamilton, Andrew J Murphy

Journal article  |  2019  |  Frontiers in Immunology

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  The Journal of Immunology

CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  The Journal of Immunology

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  Journal of Biological Chemistry

CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook

Journal article  |  2018  |  Arthritis Research & Therapy

TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17

Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Anne D Christensen, Adrian Achuthan, Andrew J Fleetwood, Derek C Lacey, Julia E Smith, Irmgard Foerster, John A Hamilton

Journal article  |  2018  |  JCI Insight

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

Adrian Achuthan, Ahmad SM Aslam, Nguyen Quyen, Pui-Yeng Lam, Andrew J Fleetwood, Ashlee T Frye, Cynthia Louis, Ming-Chin Lee, Julia E Smith, Andrew D Cook, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article  |  2018  |  Cell Death & Disease

Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

Adrian Achuthan, Ming-Chin Lee, Reem Saleh, Andrew J Fleetwood, John A Hamilton, Andrew D Cook

Book Chapter  |  2018  |  Methods in Molecular Biology

Newly identified molecular mechanism of glucocorticoid action in arthritis

Adrian Achuthan, Amy Hsu, Tanya Lupancu, Ming-Ching Lee, Reem Saleh, Andrew Fleetwood, Andrew Cook, John Hamilton

Conference Proceedings  |  2017  |  CYTOKINE

Metabolic Remodeling, Inflammasome Activation, and Pyroptosis in Macrophages Stimulated by Porphyromonas gingivalis and Its Outer Membrane Vesicles

Andrew J Fleetwood, Man KS Lee, William Singleton, Adrian Achuthan, Ming-Chin Lee, Neil M O'Brien-Simpson, Andrew D Cook, Andrew J Murphy, Stuart G Dashper, Eric C Reynolds, John A Hamilton

Journal article  |  2017  |  Frontiers in Cellular and Infection Microbiology

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook

Journal article  |  2017  |  The Journal of Immunology

Granulocyte macrophage colony-stimulating factor induces CCL17 pro uction via IRF4 to mediate inflammation

Adrian Achuthan, Andrew D Cook, Ming-Chin Lee, Reem Saleh, Hsu-Wei Khiew, Melody WN Chang, Cynthia Louis, Andrew J Fleetwood, Derek C Lacey, Anne D Christensen, Ashlee T Frye, Pui Yeng Lam, Hitoshi Kusano, Koji Nomura, Nancy Steiner, Irmgard Foerster, Stephen L Nutt, Moshe Olshansky, Stephen J Turner, John A Hamilton

Journal article  |  2016  |  Journal of Clinical Investigation

OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis

Heidi S Schultz, Li Guo, Pernille Keller, Andrew J Fleetwood, Mingyi Sun, Wei Guo, Chunyan Ma, John A Hamilton, Olle Bjorkdahl, Martin W Berchtold, Svetlana Panina

Journal article  |  2016  |  European journal of immunology

Colony Stimulating Factors

A Fleetwood, A Achuthan, JA Hamilton

Book Chapter  |  2016

As the largest integrated source of immunological knowledge currently available, Encyclopedia of Immunobiology is a go-to referenc..

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model

Roselind S Lam, Neil M O'Brien-Simpson, John A Hamilton, Jason C Lenzo, James A Holden, Gail C Brammar, Rebecca K Orth, Yan Tan, Katrina A Walsh, Andrew J Fleetwood, Eric C Reynolds

Journal article  |  2015  |  Immunology and Cell Biology

Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System

Cynthia Louis, Andrew D Cook, Derek Lacey, Andrew J Fleetwood, Ross Vlahos, Gary P Anderson, John A Hamilton

Journal article  |  2015  |  The Journal of Immunology

Porphyromonas gingivalis-derived RgpA-Kgp Complex Activates the Macrophage Urokinase Plasminogen Activator System IMPLICATIONS FOR PERIODONTITIS

Andrew J Fleetwood, Neil M O'Brien-Simpson, Paul D Veith, Roselind S Lam, Adrian Achuthan, Andrew D Cook, William Singleton, Ida K Lund, Eric C Reynolds, John A Hamilton

Journal article  |  2015  |  Journal of Biological Chemistry

Collagen Induces Maturation of Human Monocyte-Derived Dendritic Cells by Signaling through Osteoclast-Associated Receptor

Heidi S Schultz, Louise M Nitze, Louise H Zeuthen, Pernille Keller, Albrecht Gruhler, Jesper Pass, Jianhe Chen, Li Guo, Andrew J Fleetwood, John A Hamilton, Martin W Berchtold, Svetlana Panina

Journal article  |  2015  |  The Journal of Immunology

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Christine B Read, Joseph L Kuijper, Siv A Hjorth, Mark D Heipel, Xiaoting Tang, Andrew J Fleetwood, Jeffrey L Dantzler, Susanne N Grell, Jesper Kastrup, Camilla Wang, Cameron S Brandt, Anker J Hansen, Nicolai R Wagtmann, Wenfeng Xu, Vibeke W Stennicke

Journal article  |  2015  |  The Journal of Immunology

Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1

Christine B Read, Joseph L Kuijper, Siv A Hjorth, Mark D Heipel, Xiaoting Tang, Andrew J Fleetwood, Jeffrey L Dantzler, Susanne N Grell, Jesper Kastrup, Camilla Wang, undefined others

Journal article  |  2015  |  The Journal of Immunology

GM-CSF-induced CCL17 expression in monocytes/macrophages is IRF4 dependent: a pathway of potential significance in inflammation

A Achuthan, P-Y Lam, MW Chang, AJ Fleetwood, DC Lacey, AD Cook, JA Hamilton

Conference Proceedings  |  2014  |  FEBS JOURNAL

Urokinase Plasminogen Activator Is a Central Regulator of Macrophage Three-Dimensional Invasion, Matrix Degradation, and Adhesion

Andrew J Fleetwood, Adrian Achuthan, Heidi Schultz, Anneline Nansen, Kasper Almholt, Pernille Usher, John A Hamilton

Journal article  |  2014  |  Journal of Immunology

Defining GM-CSF- and Macrophage-CSF Dependent Macrophage Responses by In Vitro Models

Derek C Lacey, Adrian Achuthan, Andrew J Fleetwood, Hang Dinh, John Roiniotis, Glen M Scholz, Melody W Chang, Sandra K Beckman, Andrew D Cook, John A Hamilton

Journal article  |  2012  |  Journal of Immunology

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

Andrew J Fleetwood, Hang Dinh, Andrew D Cook, Paul J Hertzog, John A Hamilton

Journal article  |  2009  |  Journal of Leukocyte Biology

Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: Implications for CSF blockade in inflammation

Andrew J Fleetwood, Toby Lawrence, John A Hamilton, Andrew D Cook

Journal article  |  2007  |  Journal of Immunology

Macrophage lineage phenotypes and osteoclastogenesis - Complexity in the control by GM-CSF and TGF-beta

Roya Lari, Andrew J Fleetwood, Peter D Kitchener, Andrew D Cook, Durda Pavasovic, Paul J Hertzog, John A Hamilton

Journal article  |  2007  |  Bone

Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation

Andrew J Fleetwood, Toby Lawrence, John A Hamilton, Andrew D Cook

Journal article  |  2007  |  The Journal of immunology

Galectin-3 modulates T cell activity and is reduced in the inflamed intestinal epithelium in IBD.

Stefan Müller, Thomas Schaffer, Beatrice Flogerzi, Andrew Fleetwood, Rosemarie Weimann, Alain M Schoepfer, Frank Seibold

Journal article  |  2006  |  Inflammatory Bowel Diseases

BACKGROUND: Galectins are involved at different stages in inflammation. Galectin-3, although mostly described as proinflammatory, ..

Functional heterogeneity of GM-CSF- and M-CSF-derived macrophages

A Fleetwood, A Cook, E Braine, J Hamilton

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

A central role for the Hsp90(.)Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors

D De Nardo, P Masendycz, S Ho, M Cross, AJ Fleetwood, EC Reynolds, JA Hamilton, GM Scholz

Journal article  |  2005  |  Journal of Biological Chemistry

Functions of granulocyte-macrophage colony-stimulating factor

AJ Fleetwood, AD Cook, JA Hamilton

Journal article  |  2005  |  Critical Reviews in Immunology

Functions of granulocyte-macrophage colony-stimulating factor

Andrew J Fleetwood, Andrew D Cook, John A Hamilton

Journal article  |  2005  |  Critical Reviews™ in Immunology

A central role for the Hsp90· Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by Toll-like receptors

Dominic De Nardo, Paul Masendycz, Sokwei Ho, Maddalena Cross, Andrew J Fleetwood, Eric C Reynolds, John A Hamilton, Glen M Scholz

Journal article  |  2005  |  Journal of Biological Chemistry