Andrew Fleetwood

CCL17 in Inflammation and Pain

Kevin M-C Lee, Andrew Jarnicki, Adrian Achuthan, Andrew J Fleetwood, Gary P Anderson, Christian Ellson, Maria Feeney, Louise K Modis, Julia E Smith, John A Hamilton, Andrew Cook

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

It has been reported that a GM-CSF→CCL17 pathway, originally identified in vitro in macrophage lineage populations, is implicated ..

IL-23 in arthritic and inflammatory pain development in mice

Kevin M-C Lee, Zihao Zhang, Adrian Achuthan, Andrew J Fleetwood, Julia E Smith, John A Hamilton, Andrew D Cook

Journal article  |  2020  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthriti..

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Journal article  |  2020  |  OSTEOARTHRITIS AND CARTILAGE

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given th..

Origins and diversity of macrophages in health and disease.

Gopalkrishna Sreejit, Andrew J Fleetwood, Andrew J Murphy, Prabhakara R Nagareddy

Journal article  |  2020  |  Clin Transl Immunology

Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunit..

Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages

David P De Souza, Adrian Achuthan, Man KS Lee, Katrina J Binger, Ming-Chin Lee, Sophia Davidson, Dedreia L Tull, Malcolm J McConville, Andrew D Cook, Andrew J Murphy, John A Hamilton, Andrew J Fleetwood

Journal article  |  2019  |  JOURNAL OF CLINICAL INVESTIGATION

Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle inter..

Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14( )CD16(-) Monocytes

Man KS Lee, Annas Al-Sharea, Waled A Shihata, Camilla Bertuzzo Veiga, Olivia D Cooney, Andrew J Fleetwood, Michelle C Flynn, Ellen Claeson, Clovis S Palmer, Graeme I Lancaster, Darren C Henstridge, John A Hamilton, Andrew J Murphy

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Monocytes in humans consist of 3 subsets; CD14+CD16- (classical), CD14+CD16+ (intermediate) and CD14dimCD16+ (non-classical), whic..

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

Ming-Chin Lee, Derek C Lacey, Andrew J Fleetwood, Adrian Achuthan, John A Hamilton, Andrew D Cook

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

Studies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/m..

CSF-1 in Inflammatory and Arthritic Pain Development

Reem Saleh, Ming-Chin Lee, Stella H Khiew, Cynthia Louis, Andrew J Fleetwood, Adrian Achuthan, Irmgard Foerster, Andrew D Cook, John A Hamilton

Journal article  |  2018  |  JOURNAL OF IMMUNOLOGY

Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, ..

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

Amy T Hsu, Tanya J Lupancu, Ming-Chin Lee, Andrew J Fleetwood, Andrew D Cook, John A Hamilton, Adrian Achuthan

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, w..

CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Irmgard Foerster, John A Hamilton, Andrew D Cook

Journal article  |  2018  |  ARTHRITIS RESEARCH & THERAPY

BACKGROUND: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of infla..