Kim Mellor

Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice

CP Hedges, B Shetty, SC Broome, C MacRae, P Koutsifeli, EJ Buckels, C MacIndoe, J Boix, T Tsiloulis, BG Matthews, S Sinha, M Arendse, JK Jaiswal, KM Mellor, AJR Hickey, PR Shepherd, TL Merry

Journal article  |  2023  |  Nature Aging

Diminished insulin and insulin-like growth factor-1 signaling extends the lifespan of invertebrates1–4; however, whether it is a f..

Metformin improves diastolic function and cardiac lipid accumulation in type 1 diabetes

Claire Curl, Upasna Varma, Antonia Raaijmakers, Kurt Hemphill, Johannes Janssens, Alicia Jenkins, Kimberley Mellor, Lea Delbridge

Journal article  |  2022  |  Journal of Molecular and Cellular Cardiology

HFpEF etiology - Can focus on sex-specific mechanisms deliver insights for all?

LMD Delbridge, JR Bell, KL Weeks, AJA Raaijmakers, KM Mellor

Journal article  |  2022  |  J Mol Cell Cardiol

Glycophagy — the physiological perspective on a newly characterized glycogen-selective autophagy

LM Delbridge, P Koutsifeli, SP Fong, M Annandale, KL Weeks, JR Bell, KM Mellor

Journal article  |  2022  |  Current Opinion in Physiology

Degradation of intracellular components through autophagy is a fundamental process to maintain cellular integrity and homeostasis...

Utilising field stimulation frequency to identify potential cross-bridge contribution to cardiomyocyte stiffness in cardiometabolic disease

Johannes Janssens, Antonia Raaijmakers, Parisa Koutsifeli, Kimberley Mellor, Claire Curl, James Bell, Lea Delbridge

Journal article  |  2022  |  Journal of Molecular and Cellular Cardiology

HFpEF with diabetic comorbidity is linked to cardiac lipid accumulation with severe diastolic dysfunction in female but not male hearts

Antonia Raaijmakers, Claire Curl, Johannes Janssens, Upasna Varma, Stephen Harrap, Kate Weeks, Kimberley Mellor, James Bell, Lea Delbridge

Journal article  |  2022  |  Journal of Molecular and Cellular Cardiology

The big picture: cardiac sex-age interactions and proteogenomic insights.

Johannes V Janssens, James R Bell, Kate L Weeks, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2022  |  Am J Physiol Heart Circ Physiol

Guidelines on models of diabetic heart disease.

Lisa C Heather, Anne D Hafstad, Ganesh V Halade, Romain Harmancey, Kimberley M Mellor, Paras K Mishra, Erin E Mulvihill, Miranda Nabben, Michinari Nakamura, Oliver J Rider, Matthieu Ruiz, Adam R Wende, John R Ussher

Journal article  |  2022  |  Am J Physiol Heart Circ Physiol

Diabetes is a major risk factor for cardiovascular diseases, including diabetic cardiomyopathy, atherosclerosis, myocardial infarc..

Glycogen-autophagy: Molecular machinery and cellular mechanisms of glycophagy.

Parisa Koutsifeli, Upasna Varma, Lorna J Daniels, Marco Annandale, Xun Li, Joshua PH Neale, Sarah Hayes, Kate L Weeks, Samuel James, Lea MD Delbridge, Kimberley M Mellor

Journal article  |  2022  |  J Biol Chem

Autophagy is an essential cellular process involving degradation of superfluous or defective macromolecules and organelles as a fo..

Treatment of Type 1 Diabetes With Metformin Reduces Diastolic Dysfunction and Cardiac Lipid Accumulation

C Curl, U Varma, A Raaijmakers, K Hemphill, J Janssens, A Jenkins, K Mellor, L Delbridge

Journal article  |  2022  |  Heart, Lung and Circulation