David Gonsalvez

Partial deletion of p75(NTR)in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neuronsin vivo

Zuoheng Qin, David G Gonsalvez, Rhiannon J Wood, Fatemeh Daemi, Sangwon Yoo, Jason J Ivanusic, Elizabeth J Coulson, Simon S Murray, Junhua Xiao

Journal article  |  2020  |  JOURNAL OF NEUROSCIENCE RESEARCH

The p75 neurotrophin receptor (p75NTR ) is required for maintaining peripheral sensory neuron survival and function; however, the ..

Spectral Confocal Reflectance Microscopy can Quantify Myelin and Myelin Debris in a Murine Model of Demyelination and is Compatible for use on Post-Mortem Human Tissue

David Gonsalvez, Sangwon Yoo, Georgina Craig, Rhiannon Wood, Ryan O'Rafferty, Jessica Fletcher, Junhua Xiao, Simon Murray

Conference Proceedings  |  2020  |  JOURNAL OF ANATOMY

An axonal calibre-independent program that promotes central myelination and repair

F Daemi, T Aumann, M Biemond, RJ Wood, JL Fletcher, E Hoffmann, J Pasquet, S Yoo, KA Vessey, M Nicholson, DG Gonsalvez, JM Gunnersen, EL Fletcher, SS Murray, J Xiao

Conference Proceedings  |  2020  |  MULTIPLE SCLEROSIS JOURNAL

Imaging and Quantification of Myelin Integrity After Injury With Spectral Confocal Reflectance Microscopy

David G Gonsalvez, SangWon Yoo, Jessica L Fletcher, Rhiannon J Wood, Georgina A Craig, Simon S Murray, Junhua Xiao

Journal article  |  2019  |  FRONTIERS IN MOLECULAR NEUROSCIENCE

Developing a high-throughput approach to quantify the extent of myelin integrity in preclinical models of demyelinating diseases w..

Environmental enrichment promotes oligodendrocyte production and adaptive myelination in the young adult brain

M Nicholson, R Wood, A Hannan, D Gonsalvez, S Murray, J Xiao

Conference Proceedings  |  2019  |  GLIA

Activity-dependent central nervous system myelination throughout life

Omar de Faria, David G Gonsalvez, Madeline Nicholson, Junhua Xiao

Journal article  |  2019  |  JOURNAL OF NEUROCHEMISTRY

Myelin, the multilayered membrane surrounding many axons in the nervous system, increases the speed by which electrical signals tr..

Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain

Jessica L Fletcher, Rhiannon J Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa R Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan E Northfield, Richard A Hughes, David G Gonsalvez, Junhua Xiao, Simon S Murray

Journal article  |  2018  |  JOURNAL OF NEUROSCIENCE

Methods to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of clinical dis..

From proliferation to target innervation: signaling molecules that direct sympathetic nervous system development

WH Chan, CR Anderson, David G Gonsalvez

Journal article  |  2018  |  CELL AND TISSUE RESEARCH

The sympathetic division of the autonomic nervous system includes a variety of cells including neurons, endocrine cells and glial ..

Myelin Protein Zero(180-199) Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice

David G Gonsalvez, SangWon Yoo, Georgina A Craig, Rhiannon J Wood, Jessica L Fletcher, Simon S Murray, Junhua Xiao

Book Chapter  |  2018  |  Methods in Molecular Biology

Mouse models of peripheral demyelinating neuropathy play an important role in enabling the study of disease pathogenesis. Further,..

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

David G Gonsalvez, Jessica L Fletcher, Sang Won Yoo, Rhiannon J Wood, Simon S Murray, Junhua Xiao

Journal article  |  2017  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Experimental autoimmune neuritis (EAN) is a well-appreciated experimental model of autoimmune peripheral demyelinating diseases. E..