Anthony Hannan

Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington?s disease transgenic mice

Farheen Farzana, Malcolm J McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J Hannan, Danny M Hatters, Berin A Boughton

Journal article  |  2023  |  NEUROBIOLOGY OF DISEASE

In Huntington's disease (HD), a key pathological feature includes the development of inclusion-bodies of fragments of the mutant h..

Group I Metabotropic Glutamate Receptors Modulate Motility and Enteric Neural Activity in the Mouse Colon

Anita JL Leembruggen, Yuqing Lu, Haozhe Wang, Volkan Uzungil, Thibault Renoir, Anthony JJ Hannan, Lincon AA Stamp, Marlene MM Hao, Joel CC Bornstein

Journal article  |  2023  |  BIOMOLECULES

Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is evidence that Group-I metabotropic ..

Environmental enrichment and exercise housing protocols for mice.

Chloe J Love, Carolina Gubert, Thibault Renoir, Anthony J Hannan

Journal article  |  2022  |  STAR Protoc

Here, we present a protocol that allows comparison of the effects of the standard home cage, environmentally enriched home cage wi..

Microbiota DNA isolation, 16S rRNA amplicon sequencing, and bioinformatic analysis for bacterial microbiome profiling of rodent fecal samples.

Chloe J Love, Carolina Gubert, Saritha Kodikara, Geraldine Kong, Kim-Anh Lê Cao, Anthony J Hannan

Journal article  |  2022  |  STAR Protoc

Fecal samples are frequently used to characterize bacterial populations of the gastrointestinal tract. A protocol is provided to p..

Chorea me a river: depression in Huntington's disease as an exemplar of precision medicine

Anthony J Hannan

Journal article  |  2022  |  BRAIN COMMUNICATIONS

This scientific commentary refers to 'Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's..

Phosphoproteomic dysregulation in Huntington's disease mice is rescued by environmental enrichment

Isaline Mees, Shanshan Li, Harvey Tran, Ching-Seng Ang, Nicholas A Williamson, Anthony J Hannan, Thibault Renoir

Journal article  |  2022  |  BRAIN COMMUNICATIONS

Huntington's disease is a fatal autosomal-dominant neurodegenerative disorder, characterized by neuronal cell dysfunction and loss..

Use it or lose it: gene-environment interactions at the nexus of expanding genes and shrinking brains in Huntington's disease and other experience-dependent disorders of ageing

Anthony J Hannan

Journal article  |  2022  |  BRAIN COMMUNICATIONS

This scientific commentary refers to 'Intellectual enrichment and genetic modifiers of cognition and brain volume in Huntington's ..

Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain

Madeline Nicholson, Rhiannon J Wood, David G Gonsalvez, Anthony J Hannan, Jessica L Fletcher, Junhua Xiao, Simon S Murray

Journal article  |  2022  |  EUROPEAN JOURNAL OF NEUROSCIENCE

Oligodendrocyte production and myelination continues lifelong in the central nervous system (CNS), and all stages of this process ..

Professor Sir Colin Blakemore FRS, a brilliant force for good within neuroscience and beyond (1944-2022) obituary

Zoltan Molnar, Anthony J Hannan

Journal article  |  2022  |  NATURE NEUROSCIENCE

Activity-dependent remodeling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment

Junhua Xiao, Madeline Nicholson, Rhiannon Wood, Jessica Fletcher, David Gonsalvez, Anthony Hannan, Simon Murray

Conference Proceedings  |  2022  |  JOURNAL OF NEUROCHEMISTRY