Robin McAllen

Sympathetic nerves control bacterial clearance

Yugeesh R Lankadeva, Clive N May, Michael J McKinley, Melanie R Neeland, Shuai Ma, Dianna M Hocking, Roy Robins-Browne, Sammy Bedoui, David GS Farmer, Simon R Bailey, Davide Martelli, Robin M McAllen

Journal article  |  2020  |  SCIENTIFIC REPORTS

A neural reflex mediated by the splanchnic sympathetic nerves regulates systemic inflammation in negative feedback fashion, but it..

A new algorithm for drift compensation in multi-unit recordings of action potentials in peripheral autonomic nerves over time.

Catherine E Davey, Artemio Soto-Breceda, Anthony Shafton, Robin M McAllen, John B Furness, David B Grayden, Martin J Stebbing

Journal article  |  2020  |  Journal of Neuroscience Methods

BACKGROUND: Peripheral autonomic nerves control visceral organs and convey information regarding their functional states and are, ..

Prior Ablation of the Splanchnic Sympathetic Nerves Increases Plasma Inflammatory Cytokine Levels and Suppresses Bacteremia in Response to Systemically Administered E. coli in Sheep

Michael McKinley, Kaylani Almeida, Sammy Bedoui, David Farmer, Dianna Hocking, Yugeesh Lankadeva, Davide Martelli, Clive May, Roy Robins-Browne, Robin McAllen

Conference Proceedings  |  2020  |  FASEB JOURNAL

The splanchnic anti-inflammatory pathway requires the brain stem but not the hypothalamus

A Occhinegro, DGS Farmer, MJ McKinley, RM McAllen, D Martellia

Conference Proceedings  |  2019  |  ACTA PHYSIOLOGICA

The splanchnic anti-inflammatory pathway can be exogenously activated to inhibit inflammation

D Martelli, MJ McKinley, RM McAllen

Conference Proceedings  |  2019  |  ACTA PHYSIOLOGICA

On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat

David GS Farmer, Natasha Pracejus, Bowen Dempsey, Anita Turner, Phillip Bokiniec, Julian FR Paton, Anthony E Pickering, Jasmine Burguet, Philippe Andrey, Ann K Goodchild, Robin M McAllen, Simon McMullan

Journal article  |  2019  |  JOURNAL OF PHYSIOLOGY-LONDON

KEY POINTS: Spinally-projecting neurons of the rostral ventrolateral medulla (RVLM) determine sympathetic outflow to different ter..

An arterially perfused brainstem preparation of guinea pig to study central mechanisms of airway defense

Mathias Dutschmann, Rishi Dhingra, Robin McAllen, Stuart B Mazzone, David GS Farmer

Journal article  |  2019  |  JOURNAL OF NEUROSCIENCE METHODS

The perfused working heart brainstem preparation of rodents has become a widely used tool to study brainstem function. Here, we ad..

Anti-inflammatory reflex action of splanchnic sympathetic nerves is distributed across abdominal organs

Davide Martelli, David GS Farmer, Michael J McKinley, Song T Yao, Robin M McAllen

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The splanchnic anti-inflammatory pathway has been proposed as the efferent arm of the inflammatory reflex. Although much evidence ..

Circulating epinephrine is not required for chronic stress to enhance metastasis

Adam K Walker, Davide Martelli, Alexandra I Ziegler, Gavin W Lambert, Sarah E Phillips, Stephen J Hill, Robin M McAllen, Erica K Sloan

Journal article  |  2019  |  PSYCHONEUROENDOCRINOLOGY

Signaling through β-adrenergic receptors drives cancer progression and β-blockers are being evaluated as a novel therapeutic strat..

Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway

Evilin Naname Komegae, David George Stephen Farmer, Virginia Leah Brooks, Michael Joseph McKinley, Robin Michael McAllen, Davide Martelli

Journal article  |  2018  |  BRAIN BEHAVIOR AND IMMUNITY

Electrical stimulation of the vagus nerve (VNS) is a novel strategy used to treat inflammatory conditions. Therapeutic VNS activat..