Chris French

Effects of antipsychotic drugs and potassium channel modulators on spectral properties of local field potentials in mouse hippocampus and pre-frontal cortex

Dechuan Sun, Mojtaba Kermani, Matthew Hudson, Xin He, Ranjith Rajasekharan Unnithan, Chris French

Journal article  |  2021  |  NEUROPHARMACOLOGY

Local field potentials (LFPs) recorded intracranially display a range of location-specific oscillatory spectra which have been rel..

Effects of Several Classes of Voltage-Gated Ion Channel Conductances on Gamma and Theta Oscillations in a Hippocampal Microcircuit Model

Chris Olteanu, Forough Habibollahi, Chris French

Journal article  |  2021  |  FRONTIERS IN COMPUTATIONAL NEUROSCIENCE

Gamma and theta oscillations have been functionally associated with cognitive processes, such as learning and memory. Synaptic con..

Scopolamine Impairs Spatial Information Recorded With "Miniscope" Calcium Imaging in Hippocampal Place Cells

Dechuan Sun, Ranjith Rajasekharan Unnithan, Chris French

Journal article  |  2021  |  FRONTIERS IN NEUROSCIENCE

The hippocampus and associated cholinergic inputs have important roles in spatial memory in rodents. Muscarinic acetylcholine rece..

Spatiotemporal Patterns of High-Frequency Activity (80-170 Hz) in Long-Term Intracranial EEG

Zhuying Chen, David B Grayden, Anthony N Burkitt, Udaya Seneviratne, Wendyl J D'Souza, Chris French, Philippa J Karoly, Katrina Dell, Kent Leyde, Mark J Cook, Matias I Maturana

Journal article  |  2021  |  NEUROLOGY

OBJECTIVE: To determine the utility of high-frequency activity (HFA) and epileptiform spikes as biomarkers for epilepsy, we examin..

Spatiotemporal patterns of high-frequency activity (80-170 Hz) in long-term intracranial EEG

Zhuying Chen, David Grayden, Anthony Burkitt, Udaya Seneviratne, Wendyl D’Souza, Chris French, Philippa Karoly, Katrina Dell, Mark Cook, Matias Maturana

Journal article  |  2020

Objective To assess the variability in the rates and locations of high-frequency activity (HFA) and epileptiform spikes after elec..

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring

Shobi Sivathamboo, Sarah Farrand, Zhibin Chen, Elise J White, Andrew Andreas Pattichis, Callum Hollis, John Carino, Caitlin J Roberts, Thomas Minogue, Nigel C Jones, Raju Yerra, Christopher French, Piero Perucca, Patrick Kwan, Dennis Velakoulis, Terence J O'Brien, Jeremy Goldin

Journal article  |  2019  |  NEUROLOGY

OBJECTIVE: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychog..

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Mojtaba Kermani, Zahra Fatahi, Dechuan Sun, Abbas Haghparast, Chris French

Journal article  |  2018  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Reinforcement-guided decision making is the ability to choose between competing courses of action based on the relative value of t..

Neuropeptide Y affects thalamic reticular nucleus neuronal firing and network synchronization associated with suppression of spike-wave discharges

Idrish Ali, Arun Gandrathi, Thomas Zheng, Margaret J Morris, Terence J O'Brien, Chris French

Journal article  |  2018  |  EPILEPSIA

OBJECTIVES: Neuropeptide Y (NPY) potently suppresses spike-wave discharges (SWDs) in a genetic rat model of absence epilepsy (GAER..

Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate

Det Taing Kim, Terence J O'Brien, David A Williams, Chris R French

Journal article  |  2017  |  PLOS ONE

In this study, we investigated the relative efficacy of different classes of commonly used anti-epileptic drugs (AEDs) with differ..

Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons

Zhen Zeng, Elisa L Hill-Yardin, David Williams, Terence O'Brien, Andris Serelis, Christopher R French

Journal article  |  2016  |  JOURNAL OF NEUROPHYSIOLOGY

The antiepileptic drug phenytoin (PHT) is thought to reduce the excitability of neural tissue by stabilizing sodium channels (NaV)..