Chris French

High synaptic threshold for dendritic NMDA spike generation in human layer 2/3 pyramidal neurons

Guilherme Testa-Silva, Marius Rosier, Suraj Honnuraiah, Robertas Guzulaitis, Ana Morello Megias, Chris French, James King, Katharine Drummond, Lucy M Palmer, Greg J Stuart

Journal article  |  2022  |  CELL REPORTS

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in ..

Exciting insights into tumour-associated epilepsy with electrophysiological and optical recording

Chris R French

Journal article  |  2022  |  BRAIN

This scientific commentary refers to ‘Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory ..

Serious Cardiac Arrhythmias Detected by Subcutaneous Long-term Cardiac Monitors in Patients With Drug-Resistant Epilepsy

Shobi Sivathamboo, Zining Liu, Fiona Sutherland, Erica Minato, Pablo Casillas-Espinosa, Nigel C Jones, Marian Todaro, Udaya Seneviratne, Varduhi Cahill, Raju Yerra, Christopher French, John-Paul Nicolo, Piero Perucca, Patrick Kwan, Paul Sparks, Terence J O'Brien

Journal article  |  2022  |  NEUROLOGY

BACKGROUND AND OBJECTIVES: Epilepsy is associated with an increased risk of cardiovascular disease and premature mortality, includ..

Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study

Muhammad Shahid Javaid, Ana Antonic-Baker, Eleni Pitsillou, Julia Liang, Chris French, Andrew Hung, Terence J O'Brien, Patrick Kwan, Tom C Karagiannis, Alison Anderson

Journal article  |  2022  |  JOURNAL OF MOLECULAR GRAPHICS & MODELLING

OBJECTIVE: Oxidative stress is one of the pathophysiological mechanisms implicated in drug-resistant epilepsy. Recurrent seizures ..

Effects of antipsychotic drugs and potassium channel modulators on spectral properties of local field potentials in mouse hippocampus and pre-frontal cortex

Dechuan Sun, Mojtaba Kermani, Matthew Hudson, Xin He, Ranjith Rajasekharan Unnithan, Chris French

Journal article  |  2021  |  NEUROPHARMACOLOGY

Local field potentials (LFPs) recorded intracranially display a range of location-specific oscillatory spectra which have been rel..

Effects of Several Classes of Voltage-Gated Ion Channel Conductances on Gamma and Theta Oscillations in a Hippocampal Microcircuit Model

Chris Olteanu, Forough Habibollahi, Chris French

Journal article  |  2021  |  FRONTIERS IN COMPUTATIONAL NEUROSCIENCE

Gamma and theta oscillations have been functionally associated with cognitive processes, such as learning and memory. Synaptic con..

Scopolamine Impairs Spatial Information Recorded With "Miniscope" Calcium Imaging in Hippocampal Place Cells

Dechuan Sun, Ranjith Rajasekharan Unnithan, Chris French

Journal article  |  2021  |  FRONTIERS IN NEUROSCIENCE

The hippocampus and associated cholinergic inputs have important roles in spatial memory in rodents. Muscarinic acetylcholine rece..

Spatiotemporal Patterns of High-Frequency Activity (80-170 Hz) in Long-Term Intracranial EEG

Zhuying Chen, David B Grayden, Anthony N Burkitt, Udaya Seneviratne, Wendyl J D'Souza, Chris French, Philippa J Karoly, Katrina Dell, Kent Leyde, Mark J Cook, Matias I Maturana

Journal article  |  2021  |  NEUROLOGY

OBJECTIVE: To determine the utility of high-frequency activity (HFA) and epileptiform spikes as biomarkers for epilepsy, we examin..

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring

Shobi Sivathamboo, Sarah Farrand, Zhibin Chen, Elise J White, Andrew Andreas Pattichis, Callum Hollis, John Carino, Caitlin J Roberts, Thomas Minogue, Nigel C Jones, Raju Yerra, Christopher French, Piero Perucca, Patrick Kwan, Dennis Velakoulis, Terence J O'Brien, Jeremy Goldin

Journal article  |  2019  |  NEUROLOGY

OBJECTIVE: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychog..

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Mojtaba Kermani, Zahra Fatahi, Dechuan Sun, Abbas Haghparast, Chris French

Journal article  |  2018  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Reinforcement-guided decision making is the ability to choose between competing courses of action based on the relative value of t..