Christopher Reid

Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling.

Andrew Hung, Ian C Forster, Chaseley E Mckenzie, Géza Berecki, Steven Petrou, Anirudh Kathirvel, Ming S Soh, Christopher A Reid

Journal article  |  2021  |  Prog Biophys Mol Biol

Hyperpolarization-gated, cyclic nucleotide-activated (HCN1-4) channels are inwardly rectifying cation channels that display voltag..

Loss-of-function variants in K(v)11.1 cardiac channels as a biomarker for SUDEP

Ming S Soh, Richard D Bagnall, Mark F Bennett, Lauren E Bleakley, Erlina S Mohamed Syazwan, A Marie Phillips, Mathew DF Chiam, Chaseley E McKenzie, Michael Hildebrand, Douglas Crompton, Melanie Bahlo, Christopher Semsarian, Ingrid E Scheffer, Samuel F Berkovic, Christopher A Reid

Journal article  |  2021  |  ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

OBJECTIVE: To compare the frequency and impact on the channel function of KCNH2 variants in SUDEP patients with epilepsy controls ..

Role of beta blockers following percutaneous coronary intervention for acute coronary syndrome

Kah Yong Peck, Nick Andrianopoulos, Diem Dinh, Louise Roberts, Stephen J Duffy, Martin Sebastian, David Clark, Angela Brennan, Ernesto Oqueli, Andrew E Ajani, Christopher M Reid, Melanie Freeman, Andrew W Teh

Journal article  |  2021  |  HEART

AIMS: There is a paucity of evidence supporting routine beta blocker (BB) use in patients undergoing percutaneous coronary interve..

Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy.

Lauren E Bleakley, Chaseley E McKenzie, Ming S Soh, Ian C Forster, Paulo Pinares-Garcia, Alicia Sedo, Anirudh Kathirvel, Leonid Churilov, Nikola Jancovski, Snezana Maljevic, Samuel F Berkovic, Ingrid E Scheffer, Steven Petrou, Bina Santoro, Christopher A Reid

Journal article  |  2021  |  Brain

Pathogenic variants in HCN1 are associated with developmental and epileptic encephalopathies. The recurrent de novo HCN1 M305L pat..

Predicting Acute Kidney Injury After Cardiac Surgery Using a Simpler Model

Tim Coulson, Michael Bailey, Dave Pilcher, Christopher M Reid, Siven Seevanayagam, Jenni Williams-Spence, Rinaldo Bellomo

Journal article  |  2021  |  JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

OBJECTIVE: To develop a simple model for the prediction of acute kidney injury (AKI) and renal replacement therapy (RRT) that coul..

Effect of Aspirin on Cancer Incidence and Mortality in Older Adults

John J McNeil, Peter Gibbs, Suzanne G Orchard, Jessica E Lockery, Wendy B Bernstein, Yin Cao, Leslie Ford, Andrew Haydon, Brenda Kirpach, Finlay Macrae, Catriona McLean, Jeremy Millar, Anne M Murray, Mark R Nelson, Galina Polekhina, Christopher M Reid, Ellen Richmond, Luz Maria Rodriguez, Raj C Shah, Jeanne Tie, et al.

Journal article  |  2021  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: ASPirin in Reducing Events in the Elderly, a randomized, double-blind, placebo-controlled trial of daily low-dose aspi..

Outcomes of Percutaneous Coronary Intervention in Patients With Rheumatoid Arthritis

Luke P Dawson, Diem Dinh, Jessica O'Brien, Stephen J Duffy, Emma Guymer, Angela Brennan, David Clark, Ernesto Oqueli, Chin Hiew, Melanie Freeman, Christopher M Reid, Andrew E Ajani

Journal article  |  2021  |  AMERICAN JOURNAL OF CARDIOLOGY

Rheumatoid arthritis (RA) is the most common inflammatory arthritis and is associated with increased risk of cardiovascular events..

Testing broad-spectrum and isoform-preferring HCN channel blockers for anticonvulsant properties in mice

Qays Kharouf, Paulo Pinares-Garcia, M Novella Romanelli, Christopher A Reid

Journal article  |  2020  |  EPILEPSY RESEARCH

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and conseq..

National cardiac registries: a systematic review

L Dawson, S Biswas, D Stub, J Lefkovits, L Burchill, C Reid, D Eccleston

Journal article  |  2020  |  European Heart Journal

Abstract Background Over the last thirty years, there has been exponential gro..

Are Variants Causing Cardiac Arrhythmia Risk Factors in Sudden Unexpected Death in Epilepsy?

Lauren E Bleakley, Ming S Soh, Richard D Bagnall, Lynette G Sadleir, Samuel Gooley, Christopher Semsarian, Ingrid E Scheffer, Samuel F Berkovic, Christopher A Reid

Journal article  |  2020  |  FRONTIERS IN NEUROLOGY

Sudden unexpected death in epilepsy (SUDEP) is the most common cause of premature mortality in individuals with epilepsy. Acute an..