Christopher Reid

Carbogen-Induced Respiratory Acidosis Blocks Experimental Seizures by a Direct and Specific Inhibition of NaV1.2 Channels in the Axon Initial Segment of Pyramidal Neurons.

Robert J Hatch, Géza Berecki, Nikola Jancovski, Melody Li, Ben Rollo, Paymaan Jafar-Nejad, Frank Rigo, Kai Kaila, Christopher A Reid, Steven Petrou

Journal article  |  2023  |  J Neurosci

Brain pH is a critical factor for determining neuronal activity, with alkalosis increasing and acidosis reducing excitability. Aci..

Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy.

Da Zhao, Paulo Pinares-Garcia, Chaseley E McKenzie, Lauren E Bleakley, Ian C Forster, Vickie HY Wong, Christine TO Nguyen, Ingrid E Scheffer, Christopher A Reid, Bang V Bui

Journal article  |  2023  |  J Neurosci

Pathogenic variants in HCN1 are associated with a range of epilepsy syndromes including a developmental and epileptic encephalopat..

Fundamental Neurochemistry Review: GABA(A) receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy

Alexander Bryson, Christopher Reid, Steven Petrou

Journal article  |  2023  |  JOURNAL OF NEUROCHEMISTRY

Epilepsy is a common neurological disorder associated with alterations of excitation-inhibition balance within brain neuronal netw..

Altered EEG power spectrum, but not sleep-wake architecture, in HCN1 knockout mice

Lauren E Bleakley, Ryan J Keenan, Rachel D Graven, Jeremy A Metha, Sherie Ma, Heather Daykin, Linda Cornthwaite-Duncan, Daniel Hoyer, Christopher A Reid, Laura H Jacobson

Journal article  |  2023  |  BEHAVIOURAL BRAIN RESEARCH

Sleep is a complex biological state characterized by large populations of neurons firing in a rhythmic or synchronized manner. HCN..

Chapter 4 Ion channels and febrile seizures: It’s not just SCN1A

Kay Richards, Katherine Howell, Snezana Maljevic, Christopher A Reid, Steven Petrou

Book Chapter  |  2023

Antisense oligonucleotide therapy for KCNT1 encephalopathy

Lisseth Estefania Burbano, Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Kay Richards, Alicia Sedo, Armand Soriano, Ben Rollo, Linghan Jia, Elena V. Gazina, Sandra Piltz, Fatwa Adikusuma, Paul Q Thomas, Helen Kopsidas, Frank Rigo, Christopher A Reid, Snezana Maljevic, Steven Petrou

Journal article  |  2022  |  JCI INSIGHT

Developmental and epileptic encephalopathies (DEEs) are characterized by pharmaco-resistant seizures with concomitant intellectual..

A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3-WG4 omics working group of the ILAE/AES joint translational TASK force

Laura Bindila, Tore Eid, James D Mills, Michael S Hildebrand, Gary P Brennan, Susan A Masino, Vicky Whittemore, Piero Perucca, Christopher A Reid, Manisha Patel, Kevin K Wang, Erwin A van Vliet

Journal article  |  2022  |  EPILEPSIA OPEN

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK..

Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Lauren E Bleakley, Chaseley E McKenzie, Christopher A Reid

Journal article  |  2022  |  EPILEPSIA

Acquisition of drug-sensitivity profiles is challenging in rare epilepsies. Anecdotal evidence suggests that antiseizure medicatio..

A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3-WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force

Anna-Maria Katsarou, Hana Kubova, Stephane Auvin, Massimo Mantegazza, Melissa Barker-Haliski, Aristea S Galanopoulou, Christopher A Reid, Bridgette D Semple

Journal article  |  2022  |  EPILEPSIA OPEN

Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic-ischemic injury, infect..

A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3-WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force

Massimo Mantegazza, Stephane Auvin, Melissa Barker-Haliski, Anna-Maria Katsarou, Hana Kubova, Aristea S Galanopoulou, Bridgette Semple, Christopher A Reid

Journal article  |  2022  |  EPILEPSIA OPEN

Rodent models of epilepsy remain the cornerstone of research into the mechanisms underlying genetic epilepsy. Reproducibility of e..