Helena Qin

The Novel Small-molecule Annexin-A1 Mimetic, Compound 17b, Elicits Vasoprotective Actions in Streptozotocin-induced Diabetic Mice.

Sarah A Marshall, Cheng Xue Qin, Maria Jelinic, Kelly O'Sullivan, Minh Deo, Jesse Walsh, Mandy Li, Laura J Parry, Rebecca H Ritchie, Chen Huei Leo

Journal article  |  2020  |  International Journal of Molecular Sciences

The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that play an important role in the regulation ..

Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice

Maria Jelinic, Nicola Kahlberg, Chen Huei Leo, Hooi Hooi Ng, Sarah Rosli, Minh Deo, Mandy Li, Siobhan Finlayson, Jesse Walsh, Laura J Parry, Rebecca H Ritchie, Cheng Xue Qin

Journal article  |  2020  |  British Journal of Pharmacology

BACKGROUND AND PURPOSE: Arterial stiffness, a hallmark of diabetes, increases the risk of cardiovascular complications. Potential ..

Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction

Cheng Xue Qin, Sarah Rosli, Minh Deo, Nga Cao, Jesse Walsh, Mitchel Tate, Amy E Alexander, Daniel Donner, Duncan Horlock, Renming Li, Helen Kiriazis, Man KS Lee, Jane E Bourke, Yuan Yang, Andrew J Murphy, Xiao-Jun Du, Xiao Ming Gao, Rebecca H Ritchie

Journal article  |  2019  |  Frontiers in Pharmacology

The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflamma..

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chanchal Chandramouli, Melissa E Reichelt, Claire L Curl, Upasna Varma, Laura A Bienvenu, Parisa Koutsifeli, Antonia JA Raaijmakers, Miles J De Blasio, Cheng Xue Qin, Alicia J Jenkins, Rebecca H Ritchie, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2018  |  Scientific Reports

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo.

Cheng Xue Qin, Siobhan B Finlayson, Annas Al-Sharea, Mitchel Tate, Miles J De Blasio, Minh Deo, Sarah Rosli, Darnel Prakoso, Colleen J Thomas, Helen Kiriazis, Eleanor Gould, Yuan H Yang, Eric F Morand, Mauro Perretti, Andrew J Murphy, Xiao-Jun Du, Xiao-Ming Gao, Rebecca H Ritchie

Journal article  |  2017  |  Scientific Reports

Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and functio..

Phosphoinositide 3-kinase (p110 alpha) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Darnel Prakoso, Miles J De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L Weeks, Paul Gregorevic, Julie R McMullen, Rebecca H Ritchie

Journal article  |  2017  |  Clinical Science

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Cheng Xue Qin, Lauren T May, Renming Li, Nga Cao, Sarah Rosli, Deo Minh, Amy E Alexander, Duncan Horlock, Jane E Bourke, Yuan H Yang, Alastair G Stewart, David M Kaye, Xiao-Jun Du, Patrick M Sexton, Arthur Christopoulos, Xiao-Ming Gao, Rebecca H Ritchie

Journal article  |  2017  |  Nature Communications

Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications

Cheng Xue Qin, Rochelle Sleaby, Amy J Davidoff, James R Bell, Miles J De Blasio, Leanne M Delbridge, John C Chatham, Rebecca H Ritchie

Journal article  |  2017  |  Pharmacological Research

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

Hooi Hooi Ng, Chen Huei Leo, Darnel Prakoso, Chengxue Qin, Rebecca H Ritchie, Laura J Parry

Journal article  |  2017  |  Scientific Reports

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Nicola Kahlberg, Cheng Xue Qin, Jarryd Anthonisz, Edwina Jap, Hooi Hooi Ng, Maria Jelinic, Laura J Parry, Barbara K Kemp-Harper, Rebecca H Ritchie, Chen Huei Leo

Journal article  |  2016  |  Pharmacological Research