Helena Qin

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

Cheng Peng, Alastair G Stewart, Owen L Woodman, Rebecca H Ritchie, Cheng Xue Qin

Journal article  |  2020  |  FRONTIERS IN PHARMACOLOGY

Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the populat..

Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice

Maria Jelinic, Nicola Kahlberg, Chen Huei Leo, Hooi Hooi Ng, Sarah Rosli, Minh Deo, Mandy Li, Siobhan Finlayson, Jesse Walsh, Laura J Parry, Rebecca H Ritchie, Cheng Xue Qin

Journal article  |  2020  |  British Journal of Pharmacology

Background and purpose Arterial stiffness, a characteristic feature of diabetes, increases the risk of cardiovascular complication..

The Novel Small-molecule Annexin-A1 Mimetic, Compound 17b, Elicits Vasoprotective Actions in Streptozotocin-induced Diabetic Mice.

Sarah A Marshall, Cheng Xue Qin, Maria Jelinic, Kelly O'Sullivan, Minh Deo, Jesse Walsh, Mandy Li, Laura J Parry, Rebecca H Ritchie, Chen Huei Leo

Journal article  |  2020  |  International Journal of Molecular Sciences

The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that play an important role in the regulation ..

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl.

Cheng Xue Qin, Jarryd Anthonisz, Chen Huei Leo, Nicola Kahlberg, Anida Velagic, Mandy Li, Edwina Jap, Owen L Woodman, Laura J Parry, John D Horowitz, Barbara K Kemp-Harper, Rebecca H Ritchie

Journal article  |  2020  |  Antioxidants and Redox Signaling

Aim: Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO•), known as NO• resistance, occurs in many c..

Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights

Chen Huei Leo, Hooi Hooi Ng, Sarah A Marshall, Maria Jelinic, Thusitha Rupasinghe, Chengxue Qin, Ute Roessner, Rebecca H Ritchie, Marianne Tare, Laura J Parry

Journal article  |  2019  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Endothelium-derived vasoconstriction is a hallmark of vascular dysfunction in hypertension. In some cases,..

Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Girdhar Singh Deora, Cheng Xue Qin, Elizabeth A Vecchio, Aaron J Debono, Daniel L Priebbenow, Ryan M Brady, Julia Beveridge, Silvia C Teguh, Deo Minh, Lauren T May, Guy Krippner, Rebecca H Ritchie, Jonathan B Baell

Journal article  |  2019  |  JOURNAL OF MEDICINAL CHEMISTRY

Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) ..

Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction

Cheng Xue Qin, Sarah Rosli, Minh Deo, Nga Cao, Jesse Walsh, Mitchel Tate, Amy E Alexander, Daniel Donner, Duncan Horlock, Renming Li, Helen Kiriazis, Man KS Lee, Jane E Bourke, Yuan Yang, Andrew J Murphy, Xiao-Jun Du, Xiao Ming Gao, Rebecca H Ritchie

Journal article  |  2019  |  FRONTIERS IN PHARMACOLOGY

The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflamma..

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chanchal Chandramouli, Melissa E Reichelt, Claire L Curl, Upasna Varma, Laura A Bienvenu, Parisa Koutsifeli, Antonia JA Raaijmakers, Miles J De Blasio, Cheng Xue Qin, Alicia J Jenkins, Rebecca H Ritchie, Kimberley M Mellor, Lea MD Delbridge

Journal article  |  2018  |  SCIENTIFIC REPORTS

Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascula..

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice In Vivo.

Cheng Xue Qin, Siobhan B Finlayson, Annas Al-Sharea, Mitchel Tate, Miles J De Blasio, Minh Deo, Sarah Rosli, Darnel Prakoso, Colleen J Thomas, Helen Kiriazis, Eleanor Gould, Yuan H Yang, Eric F Morand, Mauro Perretti, Andrew J Murphy, Xiao-Jun Du, Xiao-Ming Gao, Rebecca H Ritchie

Journal article  |  2017  |  Sci Rep

Endogenous anti-inflammatory annexin-A1 (ANX-A1) plays an important role in preserving left ventricular (LV) viability and functio..

Phosphoinositide 3-kinase (p110 alpha) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Darnel Prakoso, Miles J De Blasio, Chengxue Qin, Sarah Rosli, Helen Kiriazis, Hongwei Qian, Xiao-Jun Du, Kate L Weeks, Paul Gregorevic, Julie R McMullen, Rebecca H Ritchie

Journal article  |  2017  |  CLINICAL SCIENCE

Phosphoinositide 3-kinase [PI3K (p110α)] is able to negatively regulate the diabetes-induced increase in NADPH oxidase in the hear..