Vickie Wong

Progressive impairments in executive function in the APP/PS1 model of Alzheimer's disease as measured by translatable touchscreen testing.

Amy Shepherd, Jeremiah KH Lim, Vicky HY Wong, Ariel M Zeleznikow-Johnston, Leonid Churilov, Christine TO Nguyen, Bang V Bui, Anthony J Hannan, Emma L Burrows

Journal article  |  2021  |  Neurobiol Aging

Executive function deficits in Alzheimer's disease (AD) occur early in disease progression and may be predictive of cognitive decl..

Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model

Yue Ding, Seong H Chow, Jinying Chen, Anton P Le Brun, Chun-Ming Wu, Anthony P Duff, Yajun Wang, Jiangning Song, Jiang-Hui Wang, Vickie HY Wong, Da Zhao, Tomoharu Nishimura, Tzong-Hsien Lee, Charlotte E Conn, Hsien-Yi Hsu, Bang Bui, Guei-Sheung Liu, Hsin-Hui Shen

Journal article  |  2021  |  ACTA BIOMATERIALIA

Glaucoma, a major cause of irreversible blindness worldwide, is associated with elevated intraocular pressure (IOP) and progressiv..

Retinal ganglion cell dysfunction in mice following acute intraocular pressure is exacerbated by P2X7 receptor knockout

Anna YM Wang, Vickie HY Wong, Pei Ying Lee, Bang V Bui, Stefanie Dudczig, Kirstan A Vessey, Erica L Fletcher

Journal article  |  2021  |  SCIENTIFIC REPORTS

There is increasing evidence for the vulnerability of specific retinal ganglion cell (RGC) types in those with glaucoma and in ani..

Increased episcleral venous pressure in a mouse model of circumlimbal suture induced ocular hypertension

Vickie HY Wong, Da Zhao, Bang Bui, Cameron J Millar, Christine TO Nguyen

Journal article  |  2021  |  EXPERIMENTAL EYE RESEARCH

PURPOSE: To investigate changes in aqueous humor dynamics during intraocular pressure (IOP) elevation induced by circumlimbal sutu..

Gene Therapy Intervention in Neovascular Eye Disease: A Recent Update

Fan-Li Lin, Peng-Yuan Wang, Yu-Fan Chuang, Jiang-Hui Wang, Vickie HY Wong, Bang Bui, Guei-Sheung Liu

Journal article  |  2020  |  MOLECULAR THERAPY

Aberrant growth of blood vessels (neovascularization) is a key feature of severe eye diseases that can cause legal blindness, incl..

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization

Jinying Chen, Fan-Li Lin, Jacqueline YK Leung, Leilei Tu, Jiang-Hui Wang, Yu-Fan Chuang, Fan Li, Hsin-Hui Shen, Gregory J Dusting, Vickie HY Wong, Leszek Lisowski, Alex W Hewitt, Bang V Bui, Jingxiang Zhong, Guei-Sheung Liu

Journal article  |  2020  |  ANGIOGENESIS

Gene therapies that chronically suppress vascular endothelial growth factor (VEGF) represent a new approach for managing retinal v..

Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina

Farrah Blades, Vickie HY Wong, Christine TO Nguyen, Bang V Bui, Trevor J Kilpatrick, Michele D Binder

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons..

Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

Zoe L Grant, Lachlan Whitehead, Vickie HY Wong, Zheng He, Richard Y Yan, Abigail R Miles, Andrew Benest, David O Bates, Claudia Prahst, Katie Bentley, Bang Bui, Robert CA Symons, Leigh Coultas

Journal article  |  2020  |  JOURNAL OF CLINICAL INVESTIGATION

Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven ..

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy

Samuel Mills, Andrew Jobling, Michael Dixon, Bang Bui, Kirstan Vessey, Joanna Phipps, Ursula Greferath, Gene Venables, Vickie HY Wong, Connie HY Wong, Zheng He, Flora Hui, James Young, Josh Tonc, Elena Ivanova, Botir Sagdullaev, Erica Fletcher

Journal article  |  2020

Local blood flow control within the CNS is critical to proper function and is dependent on coordination between neurons, glia and ..

Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes

Da Zhao, Zheng He, Lin Wang, Brad Fortune, Jeremiah KH Lim, Vickie HY Wong, Christine TO Nguyen, Bang Bui

Journal article  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Purpose: The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus..