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Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.
Analysis Of The Effect Of Ghk-Cu On Blood-Derived Lymphocytes From Copd Patients Compared ..
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilizatio..
Displaying the 4 most recent projects by Andrew Jarnicki.
Displaying the 50 most recent scholarly works by Andrew Jarnicki.
Identification and Optimization of Mechanism-Based Fluoroallylamine Inhibitors of Lysyl Oxidase-like 2/3.
Alison D Findlay, Jonathan S Foot, Alberto Buson, Mandar Deodhar, Andrew G Jarnicki, Philip M Hansbro, Gang Liu, Heidi Schilter, Craig I Turner, Wenbin Zhou, Wolfgang Jarolimek
Journal article | 2019 | Journal of Medicinal Chemistry
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-links in extracellular matrix proteins, na..
Fibulin-1c regulates transforming growth factor-β activation in pulmonary tissue fibrosis.
Gang Liu, Marion A Cooley, Andrew G Jarnicki, Theo Borghuis, Prema M Nair, Gavin Tjin, Alan C Hsu, Tatt Jhong Haw, Michael Fricker, Celeste L Harrison, Bernadette Jones, Nicole G Hansbro, Peter A Wark, Jay C Horvat, W Scott Argraves, Brian G Oliver, Darryl A Knight, Janette K Burgess, Philip M Hansbro
Journal article | 2019 | JCI Insight
Tissue remodeling/fibrosis is a major feature of all fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). It is under..
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Moritz F Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D Huntington, Margaret L Hibbs, Alex Boussioutas, Michele A Grimbaldeston, Michael Buchert, Robert JJ O'Donoghue, Frederick Masson, Matthias Ernst
Journal article | 2019 | Nature Communications
Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction.
Michael Fricker, Bridie J Goggins, Sean Mateer, Bernadette Jones, Richard Y Kim, Shaan L Gellatly, Andrew G Jarnicki, Nicholas Powell, Brian G Oliver, Graham Radford-Smith, Nicholas J Talley, Marjorie M Walker, Simon Keely, Philip M Hansbro
Journal article | 2018 | JCI Insight
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract (GIT). Cigarette smoke (CS) exposure and chro..
Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c
Gang Liu, Marion A Cooley, Prema M Nair, Chantal Donovan, Alan C Hsu, Andrew G Jarnicki, Tatt Jhong Haw, Nicole G Hansbro, Qi Ge, Alexandra C Brown, Hock Tay, Paul S Foster, Peter A Wark, Jay C Horvat, Jane E Bourke, Chris L Grainge, W Scott Argraves, Brian G Oliver, Darryl A Knight, Janette K Burgess, et al.
Journal article | 2017 | The Journal of Pathology
Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect.
NJ Camlin, AG Jarnicki, RL Vanders, KA Walters, PM Hansbro, EA McLaughlin, JE Holt
Journal article | 2017 | Human Reproduction
STUDY QUESTION: What effect does multigenerational (F2) and transgenerational (F3) cigarette smoke exposure have on female fertili..
MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.
Richard Y Kim, Jay C Horvat, James W Pinkerton, Malcolm R Starkey, Ama T Essilfie, Jemma R Mayall, Prema M Nair, Nicole G Hansbro, Bernadette Jones, Tatt Jhong Haw, Krishna P Sunkara, Thi Hiep Nguyen, Andrew G Jarnicki, Simon Keely, Joerg Mattes, Ian M Adcock, Paul S Foster, Philip M Hansbro
Journal article | 2017 | Journal of Allergy and Clinical Immunology
BACKGROUND: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, howev..
The inhibitor of semicarbazide-sensitive amine oxidase, PXS-4728A, ameliorates key features of chronic obstructive pulmonary disease in a mouse model
AG Jarnicki, H Schilter, G Liu, K Wheeldon, A-T Essilfie, JS Foot, TT Yow, W Jarolimek, PM Hansbro
Journal article | 2016 | British Journal of Pharmacology
Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model
Stefan Thiem, Moritz F Eissmann, Joachim Elzer, Anna Jonas, Tracy L Putoczki, Ashleigh Poh, Paul Nguyen, Adele Preaudet, Dustin Flanagan, Elizabeth Vincan, Paul Waring, Michael Buchert, Andrew Jarnicki, Matthias Ernst
Journal article | 2016 | Cancer Research
Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model.
Nicole J Camlin, Alexander P Sobinoff, Jessie M Sutherland, Emma L Beckett, Andrew G Jarnicki, Rebecca L Vanders, Philip M Hansbro, Eileen A McLaughlin, Janet E Holt
Journal article | 2016 | Biology of Reproduction
The theory of fetal origins of adult disease was first proposed in 1989, and in the decades since, a wide range of other diseases ..
TLR2, TLR4 AND MyD88 Mediate Allergic Airway Disease (AAD) and Streptococcus pneumoniae-Induced Suppression of AAD.
Alison N Thorburn, Hsin-Yi Tseng, Chantal Donovan, Nicole G Hansbro, Andrew G Jarnicki, Paul S Foster, Peter G Gibson, Philip M Hansbro
Journal article | 2016 | PLOS ONE
BACKGROUND: Exposure to non-pathogenic Streptococcus pneumoniae and vaccination are inversely associated with asthma. Studies in a..
Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.
Hock L Tay, Gerard E Kaiko, Maximilian Plank, JingJing Li, Steven Maltby, Ama-Tawiah Essilfie, Andrew Jarnicki, Ming Yang, Joerg Mattes, Philip M Hansbro, Paul S Foster
Journal article | 2015 | PLOS Pathogens
Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ..
Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity.
Ihssane Zouikr, Abdulrzag F Ahmed, Jay C Horvat, Kenneth W Beagley, Vicki L Clifton, Allyson Ray, Rick F Thorne, Andrew G Jarnicki, Philip M Hansbro, Deborah M Hodgson
Journal article | 2015 | Brain, Behavior, and Immunity
The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful ex..
Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.
AP Sobinoff, JM Sutherland, EL Beckett, SJ Stanger, R Johnson, AG Jarnicki, A McCluskey, JC St John, PM Hansbro, EA McLaughlin
Journal article | 2014 | Human Reproduction
STUDY QUESTION: What are the effects on fertility of cigarette smoke-induced toxicity on male offspring exposed during the gestati..
Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery.
Daniel J McIlroy, Andrew G Jarnicki, Gough G Au, Natalie Lott, Doug W Smith, Philip M Hansbro, Zsolt J Balogh
Journal article | 2014 | Journal of Critical Care
INTRODUCTION: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil ext..
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
Bernardo S Franklin, Lukas Bossaller, Dominic De Nardo, Jacqueline M Ratter, Andrea Stutz, Gudrun Engels, Christoph Brenker, Mark Nordhoff, Sandra R Mirandola, Ashraf Al-Amoudi, Matthew S Mangan, Sebastian Zimmer, Brian G Monks, Martin Fricke, Reinhold E Schmidt, Terje Espevik, Bernadette Jones, Andrew G Jarnicki, Philip M Hansbro, Patricia Busto, et al.
Journal article | 2014 | Nature Immunology
Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis.
Philip M Hansbro, Matthew J Hamilton, Michael Fricker, Shaan L Gellatly, Andrew G Jarnicki, Dominick Zheng, Sandra M Frei, G William Wong, Sahar Hamadi, Saijun Zhou, Paul S Foster, Steven A Krilis, Richard L Stevens
Journal article | 2014 | Journal of Biological Chemistry
Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-γ is a mast cell (MC)-restricted protease of unknown function ..
Scrambled and fried: cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress.
AP Sobinoff, EL Beckett, AG Jarnicki, JM Sutherland, A McCluskey, PM Hansbro, EA McLaughlin
Journal article | 2013 | Toxicology and Applied Pharmacology
Cigarette smoke is a reproductive hazard associated with pre-mature reproductive senescence and reduced clinical pregnancy rates i..
Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically
Tracy L Putoczki, Stefan Thiem, Andrea Loving, Rita A Busutti, Nicholas J Wilson, Paul K Ziegler, Paul M Nguyen, Adele Preaudet, Ryan Farid, Kirsten M Edwards, Yeliz Boglev, Rodney B Luwor, Andrew Jarnicki, David Horst, Alex Boussioutas, Joan K Heath, Oliver M Sieber, Irina Pleines, Benjamin T Kile, Andrew Nash, et al.
Journal article | 2013 | Cancer Cell
Murine models of infectious exacerbations of airway inflammation.
Malcolm Ronald Starkey, Andrew Gregory Jarnicki, Ama-Tawiah Essilfie, Shaan Lae Gellatly, Richard Yong Kim, Alexandra Cerelina Brown, Paul Stephen Foster, Jay Christopher Horvat, Philip Michael Hansbro
Journal article | 2013 | Current Opinion in Pharmacology
Airway inflammation underpins the pathogenesis of the major human chronic respiratory diseases. It is now well recognized that res..
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.
Emma L Beckett, Richard L Stevens, Andrew G Jarnicki, Richard Y Kim, Irwan Hanish, Nicole G Hansbro, Andrew Deane, Simon Keely, Jay C Horvat, Ming Yang, Brian G Oliver, Nico van Rooijen, Mark D Inman, Roberto Adachi, Roy J Soberman, Sahar Hamadi, Peter A Wark, Paul S Foster, Philip M Hansbro
Journal article | 2013 | Journal of Allergy and Clinical Immunology
BACKGROUND: Cigarette smoke-induced chronic obstructive pulmonary disease (COPD) is a life-threatening inflammatory disorder of th..
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice
Stefan Thiem, Thomas P Pierce, Michelle Palmieri, Tracy L Putoczki, Michael Buchert, Adele Preaudet, Ryan O Farid, Chris Love, Bruno Catimel, Zhengdeng Lei, Steve Rozen, Veena Gopalakrishnan, Fred Schaper, Michael Hallek, Alex Boussioutas, Patrick Tan, Andrew Jarnicki, Matthias Ernst
Journal article | 2013 | Journal of Clinical Investigation
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis
Robert JJ O'Donoghue, Darryl A Knight, Carl D Richards, Cecilia M Prele, Hui Ling Lau, Andrew G Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S McKenzie, Bo Wang, Philip Stumbles, Geoffrey J Laurent, Robin J McAnulty, Stefan Rose-John, Hong Jian Zhu, Gary P Anderson, Matthias R Ernst, Steven E Mutsaers
Journal article | 2012 | EMBO Molecular Medicine
Polymyxin B inadequately quenches the effects of contaminating lipopolysaccharide on murine dendritic cells.
Graham A Tynan, Anne McNaughton, Andrew Jarnicki, Takao Tsuji, Ed C Lavelle
Journal article | 2012 | PLoS ONE
Dendritic cell (DC) activation is commonly used as a measure of the immunomodulatory potential of candidate exogenous and endogeno..
Sensitizing and Th2 Adjuvant Activity of Cysteine Protease Allergens
Paula T Cunningham, Claire E Elliot, Jason C Lenzo, Andrew G Jarnicki, Alexander N Larcombe, Graeme R Zosky, Patrick G Holt, Wayne R Thomas
Journal article | 2012 | International Archives of Allergy and Immunology
BACKGROUND: Innate properties that enhance immune responses might increase the propensity of certain allergens to induce allergic ..
Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/beta-Catenin Pathway In Vivo
Michael Buchert, Dimitris Athineos, Helen E Abud, Zoe D Burke, Maree C Faux, Michael S Samuel, Andrew G Jarnicki, Catherine E Winbanks, Ian P Newton, Valerie S Meniel, Hiromu Suzuki, Steven A Stacker, Inke S Nathke, David Tosh, Joerg Huelsken, Alan R Clarke, Joan K Heath, Owen J Sansom, Matthias Ernst
Journal article | 2010 | PLoS Genetics
Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma.
Deirdre Toomey, Helen Conroy, Andrew G Jarnicki, Sarah C Higgins, Caroline Sutton, Kingston HG Mills
Journal article | 2008 | Vaccine
Prophylactic immunization of mice with autologous tumor-derived heat shock proteins (Hsp) generates effective anti-tumor immunity...
Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics.
Andrew G Jarnicki, Helen Conroy, Corinna Brereton, Graham Donnelly, Deirdre Toomey, Kevin Walsh, Cheryl Sweeney, Olive Leavy, Jean Fletcher, Ed C Lavelle, Padraic Dunne, Kingston HG Mills
Journal article | 2008 | The Journal of Immunology
TLR ligands are potent adjuvants and promote Th1 responses to coadministered Ags by inducing innate IL-12 production. We found tha..
Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumor immunity.
Joanne Lysaght, Andrew G Jarnicki, Kingston HG Mills
Journal article | 2007 | Cancer Immunology, Immunotherapy
We have addressed the hypothesis that pathogen-associated immunomodulatory molecules may influence anti-tumor immunity through the..
TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.
Sarah C Higgins, Andrew G Jarnicki, Ed C Lavelle, Kingston HG Mills
Journal article | 2006 | The Journal of Immunology
Whole cell pertussis vaccines (Pw) induce Th1 responses and protect against Bordetella pertussis infection, whereas pertussis acel..
Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4 and CD8 regulatory T cells.
Andrew G Jarnicki, Joanne Lysaght, Stephen Todryk, Kingston HG Mills
Journal article | 2006 | The Journal of Immunology
We examined the hypothesis that a failure of the immune system to eradicate tumors is due to the immunosuppressive environment cre..
Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent.
Ed C Lavelle, Andrew Jarnicki, Edel McNeela, Michelle E Armstrong, Sarah C Higgins, Olive Leavy, Kingston HG Mills
Conference Proceedings | 2004 | Journal of Leukocyte Biology
Cholera toxin (CT) is a potent vaccine adjuvant when administered via parenteral, mucosal, or transcutaneous routes. It also inhib..
Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology.
Sarah C Higgins, Ed C Lavelle, Chantelle McCann, Brian Keogh, Edel McNeela, Patricia Byrne, Brian O'Gorman, Andrew Jarnicki, Peter McGuirk, Kingston HG Mills
Journal article | 2003 | The Journal of Immunology
Signaling through Toll-like receptors (TLR) activates dendritic cell (DC) maturation and IL-12 production, which directs the induc..
Hypersensitivity reactions after respiratory sensitization: effect of intranasal peptides containing T-cell epitopes.
Andrew G Jarnicki, Takao Tsuji, Wayne R Thomas
Journal article | 2002 | Journal of Allergy and Clinical Immunology
BACKGROUND: The intranasal administration of peptides containing T-cell epitopes has been shown to inhibit T-cell and antibody res..
Stimulatory and inhibitory epitopes in the T cell responses of mice to Der p 1.
AG Jarnicki, WR Thomas
Journal article | 2002 | Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy
BACKGROUND: The responses of mice to the mite allergen Der p 1 have been used to study the mechanisms of allergic sensitization an..
Inhibition of mucosal and systemic T(h)2-type immune responses by intranasal peptides containing a dominant T cell epitope of the allergen Der p 1.
AG Jarnicki, T Tsuji, WR Thomas
Journal article | 2001 | International Immunology
Although the intranasal administration of peptides containing T cell epitopes has been shown to be a potent method of inhibiting r..
Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression.
GF Hoyne, AG Jarnicki, WR Thomas, JR Lamb
Journal article | 1997 | International Immunology
Mucosal administration of antigens in experimental animals leads to the induction of peripheral T cell tolerance. We have previous..
Altered CD3 chain and cytokine gene expression in tumor infiltrating T lymphocytes during the development of mesothelioma.
AG Jarnicki, DR Fitzpatrick, BW Robinson, H Bielefeldt-Ohmann
Journal article | 1996 | Cancer Letters
The mechanisms whereby tumors escape immunosurveillance remain poorly understood. De-activation or deviation of T lymphocyte respo..
Interleukin-6 involvement in mesothelioma pathobiology: inhibition by interferon alpha immunotherapy.
H Bielefeldt-Ohmann, AL Marzo, RP Himbeck, AG Jarnicki, BW Robinson, DR Fitzpatrick
Journal article | 1995 | Cancer Immunology Immunotherapy
A role for interleukin-6 (IL-6) in malignant mesothelioma has been suggested by the clinically presenting symptoms of mesothelioma..
Potential for interferon-alpha-based therapy in mesothelioma: assessment in a murine model.
H Bielefeldt-Ohmann, DR Fitzpatrick, AL Marzo, AG Jarnicki, AW Musk, BW Robinson
Journal article | 1995 | Journal of Interferon & Cytokine Research
Malignant mesothelioma is an aggressive tumor, usually induced by asbestos exposure, that has a poor prognosis and is unresponsive..
Patho- and immunobiology of malignant mesothelioma: characterisation of tumour infiltrating leucocytes and cytokine production in a murine model.
H Bielefeldt-Ohmann, DR Fitzpatrick, AL Marzo, AG Jarnicki, RP Himbeck, MR Davis, LS Manning, BW Robinson
Journal article | 1994 | Cancer Immunology Immunotherapy
Malignant mesothelioma (MM) is an aggressive, uniformly fatal serosal tumour, usually associated with asbestos exposure, for which..
Transforming growth factor-beta: antisense RNA-mediated inhibition affects anchorage-independent growth, tumorigenicity and tumor-infiltrating T-cells in malignant mesothelioma.
DR Fitzpatrick, H Bielefeldt-Ohmann, RP Himbeck, AG Jarnicki, AL Marzo, BW Robinson
Journal article | 1994 | Growth Factors
Transforming growth factor-beta (TGF-beta) is produced by a number of tumor cell types including human malignant mesothelioma (MM)..
Pharmacology And Therapeutics
The University of Western Australia
Bachelor of Science (honours)