Josef Wagner

Exclusive enteral nutrition mediates gut microbial and metabolic changes that are associated with remission in children with Crohn's disease.

Kay Diederen, Jia V Li, Gillian E Donachie, Tim G de Meij, Dirk R de Waart, Theodorus BM Hakvoort, Angelika Kindermann, Josef Wagner, Victoria Auyeung, Anje A Te Velde, Sigrid EM Heinsbroek, Marc A Benninga, James Kinross, Alan W Walker, Wouter J de Jonge, Jurgen Seppen

Journal article  |  2020  |  Scientific Reports

A nutritional intervention, exclusive enteral nutrition (EEN) can induce remission in patients with pediatric Crohn's disease (CD)..

Relative abundance of the Prevotella genus within the human gut microbiota of elderly volunteers determines the inter-individual responses to dietary supplementation with wheat bran arabinoxylan-oligosaccharides.

Wing Sun Faith Chung, Alan W Walker, Douwina Bosscher, Vicenta Garcia-Campayo, Josef Wagner, Julian Parkhill, Sylvia H Duncan, Harry J Flint

Journal article  |  2020  |  BMC Microbiology

BACKGROUND: The human colon is colonised by a dense microbial community whose species composition and metabolism are linked to hea..

Pivotal Roles for pH, Lactate, and Lactate-Utilizing Bacteria in the Stability of a Human Colonic Microbial Ecosystem.

Shui Ping Wang, Luis A Rubio, Sylvia H Duncan, Gillian E Donachie, Grietje Holtrop, Galiana Lo, Freda M Farquharson, Josef Wagner, Julian Parkhill, Petra Louis, Alan W Walker, Harry J Flint

Journal article  |  2020  |  mSystems

Lactate can be produced by many gut bacteria, but in adults its accumulation in the colon is often an indicator of microbiota pert..

Analysis of Hepatitis B virus haplotype diversity detects striking sequence conservation across genotypes and chronic disease phase.

Josef Wagner, Lilly Yuen, Margaret Littlejohn, Vitina Sozzi, Kathy Jackson, Vithika Suri, Susanna Tan, Becket Feierbach, Anuj Gaggar, Patrick Marcellin, Maria Buti Ferret, Harry LA Janssen, Ed Gane, Henry LY Chan, Danni Colledge, Gillian Rosenberg, Julianne Bayliss, Benjamin P Howden, Stephen A Locarnini, Darren Wong, et al.

Journal article  |  2020  |  Hepatology

BACKGROUND: We conducted haplotype analysis of complete hepatitis B virus (HBV) genomes following deep sequencing from 368 patient..

HBV variants are common in the 'immune-tolerant' phase of chronic hepatitis B

Lilly Yuen, Peter A Revill, Gillian Rosenberg, Josef Wagner, Margaret Littlejohn, Julianne Bayliss, Kathy Jackson, Susanna K Tan, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Ed Gane, Henry LY Chan, Xin Li, Scott Bowden, Stephen Locarnini, Alexander Thompson

Journal article  |  2020  |  Journal of Viral Hepatitis

Nucleos(t)ide analouges (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However..

Variation of Gut Mucosal Microbiome With Anti-Saccharomyces cerevisiae Antibody Status in Pediatric Crohn Disease.

Shivani Kansal, Anthony G Catto-Smith, Karen Boniface, Sarah Thomas, Donald J Cameron, Mark Oliver, George Alex, Carl D Kirkwood, Josef Wagner

Journal article  |  2019  |  Journal of pediatric gastroenterology and nutrition

OBJECTIVES: Crohn disease (CD) is a chronic relapsing condition possibly caused by a dysbiotic microbiome. Approximately 30% to 60..

Variation of Gut Mucosal Microbiome With Anti-Saccharomyces cerevisiae Antibody Status in Pediatric Crohn Disease

Shivani Kansal, Anthony G Catto-Smith, Karen Boniface, Sarah Thomas, Donald J Cameron, Mark Oliver, George Alex, Carl D Kirkwood, Josef Wagner

Journal article  |  2019  |  Journal of Pediatric Gastroenterology and Nutrition

OBJECTIVES: Crohn's Disease (CD) is a chronic relapsing condition possibly caused by a dysbiotic microbiome. About 30-60% of CD pa..

The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.

Josef Wagner, Ewan M Harrison, Marcos Martinez Del Pero, Beth Blane, Gert Mayer, Johannes Leierer, Seerapani Gopaluni, Mark A Holmes, Julian Parkhill, Sharon J Peacock, David RW Jayne, Andreas Kronbichler

Journal article  |  2019  |  Microbiome

BACKGROUND: Ear, nose and throat involvement in granulomatosis with polyangiitis (GPA) is frequently the initial disease manifesta..

Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child.

Anisha Wijeyesekera, Josef Wagner, Marcus De Goffau, Sarah Thurston, Adilson Rodrigues Sabino, Sara Zaher, Deborah White, Jenna Ridout, Mark J Peters, Padmanabhan Ramnarayan, Ricardo G Branco, M Estee Torok, Frederic Valla, Rosan Meyer, Nigel Klein, Gary Frost, Julian Parkhill, Elaine Holmes, Nazima Pathan

Journal article  |  2019  |  Critical Care Medicine

OBJECTIVES: Adverse physiology and antibiotic exposure devastate the intestinal microbiome in critical illness. Time and cost impl..

The Microbiome in Paediatric Crohn's Disease-A Longitudinal, Prospective, Single-Centre Study

Shivani Kansal, Anthony G Catto-Smith, Karen Boniface, Sarah Thomas, Donald J Cameron, Mark Oliver, George Alex, Carl D Kirkwood, Josef Wagner

Journal article  |  2019  |  Journal of Crohn's and Colitis

BACKGROUND AND AIMS: The gut mucosa is the principal site where Crohn's disease [CD] inflammation occurs. Limited information is a..