Renwick Dobson

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism.

Christopher R Horne, Hariprasad Venugopal, Santosh Panjikar, David M Wood, Amy Henrickson, Emre Brookes, Rachel A North, James M Murphy, Rosmarie Friemann, Michael DW Griffin, Georg Ramm, Borries Demeler, Renwick CJ Dobson

Journal article  |  2021  |  Nature Communications

Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat ..

New flow control systems in capillarics: off valves

Julian Menges, Claude Meffan, Fabian Dolamore, Conan Fee, Renwick Dobson, Volker Nock

Journal article  |  2021  |  Lab on a Chip

Capillary systems are a promising technology for point-of-care microfluidics, since they are pre-programmable and self-powered. Th..

Structure and Function of N-Acetylmannosamine Kinases from Pathogenic Bacteria

Thanuja Gangi Setty, Arunabha Sarkar, David Coombes, Renwick CJ Dobson, Ramaswamy Subramanian

Journal article  |  2020  |  ACS Omega

Several pathogenic bacteria import and catabolize sialic acids as a source of carbon and nitrogen. Within the sialic acid cataboli..

Multi-wavelength analytical ultracentrifugation as a tool to characterise protein-DNA interactions in solution

Christopher R Horne, Amy Henrickson, Borries Demeler, Renwick CJ Dobson

Journal article  |  2020  |  European Biophysics Journal

Understanding how proteins interact with DNA, and particularly the stoichiometry of a protein-DNA complex, is key information need..

Analytical ultracentrifugation: still the gold standard that offers multiple solutions

Renwick CJ Dobson, Trushar R Patel

Journal article  |  2020  |  European Biophysics Journal

Understanding the nature of macromolecules and their interactions in solution underpins many fields, including biology, chemistry ..

On the utility of fluorescence-detection analytical ultracentrifugation in probing biomolecular interactions in complex solutions: a case study in milk

Jennifer M Crowther, Marita Broadhurst, Thomas M Laue, Geoffrey B Jameson, Alison J Hodgkinson, Renwick CJ Dobson

Journal article  |  2020  |  European Biophysics Journal

β-Lactoglobulin is the most abundant protein in the whey fraction of ruminant milks, yet is absent in human milk. It has been stud..

G-quadruplex structures bind to EZ-Tn5 transposase

Simone L Cree, Eng Wee Chua, Jennifer Crowther, Renwick CJ Dobson, Martin A Kennedy

Journal article  |  2020  |  Biochimie

Next generation DNA sequencing and analysis of amplicons spanning the pharmacogene CYP2D6 suggested that the Nextera transposase u..

The lid domain is important, but not essential, for catalysis ofEscherichia colipyruvate kinase

Elena Sugrue, David Coombes, David Wood, Tong Zhu, Katherine A Donovan, Renwick CJ Dobson

Journal article  |  2020  |  European Biophysics Journal

Pyruvate kinase catalyses the final step of the glycolytic pathway in central energy metabolism. The monomeric structure comprises..

Quaternary variations in the structural assembly of N-acetylglucosamine-6-phosphate deacetylase from Pasteurella multocida

Lavanyaa Manjunath, David Coombes, James Davies, Mugdha Dhurandhar, Vikas R Tiwari, Renwick CJ Dobson, R Sowdhamini, S Ramaswamy, Sucharita Bose

Journal article  |  2020  |  Proteins Structure Function and Bioinformatics

N-acetylglucosamine 6-phosphate deacetylase (NagA) catalyzes the conversion of N-acetylglucosamine-6-phosphate to glucosamine-6-ph..

Sub-Angstrom structure of collagen model peptide (GPO)(10) shows a hydrated triple helix with pitch variation and two proline ring conformations

Hironori Suzuki, Deepti Mahapatra, Amanda J Board, Peter J Steel, Jolon M Dyer, Juliet A Gerrard, Renwick CJ Dobson, Celine Valery

Journal article  |  2020  |  Food Chemistry

Collagens are large structural proteins that are prevalent in mammalian connective tissue. Peptides designed to include a glycine-..