Renwick Dobson

Molecular basis of a redox switch: molecular dynamics simulations and surface plasmon resonance provide insight into reduced and oxidised angiotensinogen.

Jennifer M Crowther, Letitia H Gilmour, Benjamin T Porebski, Sarah G Heath, Neil R Pattinson, Maurice C Owen, Rayleen Fredericks, Ashley M Buckle, Conan J Fee, Christoph Göbl, Renwick CJ Dobson

Journal article  |  2021  |  Biochem J

Angiotensinogen fine-tunes the tightly controlled activity of the renin-angiotensin system by modulating the release of angiotensi..

N-Acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization.

Michael J Currie, Lavanyaa Manjunath, Christopher R Horne, Phillip M Rendle, Ramaswamy Subramanian, Rosmarie Friemann, Antony J Fairbanks, Andrew C Muscroft-Taylor, Rachel A North, Renwick CJ Dobson

Journal article  |  2021  |  J Biol Chem

There are five known general catalytic mechanisms used by enzymes to catalyze carbohydrate epimerization. The amino sugar epimeras..

Antibody responses to collagen peptides and streptococcal collagen-like 1 proteins in acute rheumatic fever patients.

Devaki H Pilapitiya, Paul WR Harris, Paulina Hanson-Manful, Reuben McGregor, Renata Kowalczyk, Jeremy M Raynes, Lauren H Carlton, Renwick CJ Dobson, Michael G Baker, Margaret Brimble, Slawomir Lukomski, Nicole J Moreland

Journal article  |  2021  |  Pathog Dis

Acute rheumatic fever (ARF) is a serious post-infectious immune sequelae of Group A streptococcus (GAS). Pathogenesis remains poor..

Selective Nutrient Transport in Bacteria: Multicomponent Transporter Systems Reign Supreme

James S Davies, Michael J Currie, Joshua D Wright, Michael C Newton-Vesty, Rachel A North, Peter D Mace, Jane R Allison, Renwick CJ Dobson

Journal article  |  2021  |  FRONTIERS IN MOLECULAR BIOSCIENCES

Multicomponent transporters are used by bacteria to transport a wide range of nutrients. These systems use a substrate-binding pro..

The Molecular Basis for Escherichia coli O157:H7 Phage FAHEc1 Endolysin Function and Protein Engineering to Increase Thermal Stability

Michael J Love, David Coombes, Sarah H Manners, Gayan S Abeysekera, Craig Billington, Renwick CJ Dobson

Journal article  |  2021  |  VIRUSES-BASEL

Bacteriophage-encoded endolysins have been identified as antibacterial candidates. However, the development of endolysins as mains..

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

Christopher R Horne, Hariprasad Venugopal, Santosh Panjikar, David M Wood, Amy Henrickson, Emre Brookes, Rachel A North, James M Murphy, Rosmarie Friemann, Michael DW Griffin, Georg Ramm, Borries Demeler, Renwick CJ Dobson

Journal article  |  2021  |  NATURE COMMUNICATIONS

Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat ..

New flow control systems in capillarics: off valves

Julian Menges, Claude Meffan, Fabian Dolamore, Conan Fee, Renwick Dobson, Volker Nock

Journal article  |  2021  |  LAB ON A CHIP

Capillary systems are a promising technology for point-of-care microfluidics, since they are pre-programmable and self-powered. Th..

Amino acid-derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development

Anutthaman Parthasarathy, Eli J Borrego, Michael A Savka, Renwick CJ Dobson, Andre O Hudson

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

For millennia, humanity has relied on plants for its medicines, and modern pharmacology continues to reexamine and mine plant meta..

Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2

Alexander Peskin, Flavia C Meotti, Kelsey M Kean, Christoph Gobl, Albert Souza Peixoto, Paul E Pace, Christopher R Horne, Sarah G Heath, Jennifer M Crowther, Renwick CJ Dobson, P Andrew Karplus, Christine C Winterbourn

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxiredoxin 2 (Prdx2) is a thiol peroxidase with an active site Cys (C52) that reacts rapidly with H2O2 and other peroxides. The..

TRANSISTOR OFF-VALVE BASED FEEDBACK, METERING AND LOGIC OPERATIONS IN CAPILLARY MICROFLUIDICS

Claude Meffan, Julian Menges, Fabian Dolamore, Conan Fee, Renwick Dobson, Volker Nock

Conference Proceedings  |  2021  |  2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021)

Capillary microfluidic devices enable portable, pre-programmed assays without the need for external equipment. Automation of liqui..