Peter Meikle

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance.

Simon T Bond, Emily J King, Darren C Henstridge, Adrian Tran, Sarah C Moody, Christine Yang, Yingying Liu, Natalie A Mellett, Artika P Nath, Michael Inouye, Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Peter J Meikle, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  Nature Communications

The effective storage of lipids in white adipose tissue (WAT) critically impacts whole body energy homeostasis. Many genes have be..

High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort

Anne HY Chu, Mya T Tint, Hsin F Chang, Gerard Wong, Wen Lun Yuan, Dedreia Tull, Brunda Nijagal, Vinod K Narayana, Peter J Meikle, Kenneth TE Chang, Rohan M Lewis, Claudia Chi, Fabian KP Yap, Kok Hian Tan, Lynette P Shek, Yap-Seng Chong, Peter D Gluckman, Yung Seng Lee, Marielle Fortier, Keith M Godfrey, et al.

Journal article  |  2021  |  International Journal of Obesity

Background/Objectives Maternal glycaemia promotes fetal adiposity. Inositol, an insulin sensitizer, has been trialled for gestatio..

Novel Lipid Species for Detecting and Predicting Atrial Fibrillation in Patients With Type 2 Diabetes

Yow Keat Tham, Kaushala S Jayawardana, Zahir H Alshehry, Corey Giles, Kevin Huynh, Adam Alexander T Smith, Jenny YY Ooi, Sophia Zoungas, Graham S Hillis, John Chalmers, Peter J Meikle, Julie R McMullen

Journal article  |  2021  |  Diabetes

The incidence of atrial fibrillation (AF) is higher in patients with diabetes. The goal of this study was to assess if the additio..

Genome‐wide study of the human lipidome and links to Alzheimer’s disease risk

Peter J Meikle, Corey Giles, Gemma Cadby, Kevin Huynh, Natalie A Mellett, Gavriel Olshansky, Alexander Smith, Anh Nguyen, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor LL Villemagne, David Ames, Colin L Masters, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Alzheimer's & Dementia

Background Dysregulation of lipid metabolism is as an important – and modifiable – risk factor for the initiation and progression ..

Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease

Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S Jayawardana, Agus Salim, Natalie A Mellett, Adam Alexander T Smith, Gavriel Olshansky, Brian G Drew, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Matthias Arnold, Kwangsik Nho, Andrew J Saykin, et al.

Journal article  |  2020  |  Nature Communications

Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex mo..

Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein)

Hann Low, Nigora Mukhamedova, Luciano dos Santos Aggum Capettini, Yining Xia, Irena Carmichael, Stephen H Cody, Kevin Huynh, Michael Ditiatkovski, Ryunosuke Ohkawa, Michael Bukrinsky, Peter J Meikle, Soo-Ho Choi, Seth Field, Yury Miller, Dmitri Sviridov

Journal article  |  2020  |  Arteriosclerosis Thrombosis and Vascular Biology

OBJECTIVE: AIBP (apolipoprotein A-I binding protein) is an effective and selective regulator of lipid rafts modulating many metabo..

Fructose stimulated de novo lipogenesis is promoted by inflammation

Jelena Todoric, Giuseppe Di Caro, Saskia Reibe, Darren C Henstridge, Courtney R Green, Alison Vrbanac, Fatih Ceteci, Claire Conche, Reginald McNulty, Shabnam Shalapour, Koji Taniguchi, Peter J Meikle, Jeramie D Watrous, Rafael Moranchel, Mahan Najhawan, Mohit Jain, Xiao Liu, Tatiana Kisseleva, Maria T Diaz-Meco, Jorge Moscat, et al.

Journal article  |  2020  |  Nature Metabolism

Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic s..

Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans

Angie S Xiang, Corey Giles, Rebecca KC Loh, Melissa F Formosa, Nina Eikelis, Gavin W Lambert, Peter J Meikle, Bronwyn A Kingwell, Andrew L Carey

Journal article  |  2020  |  Metabolites

Brown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic home..

Short-term inhibition of autophagy benefits pancreatic beta-cells by augmenting ether lipids and peroxisomal function, and by countering depletion of n-3 polyunsaturated fatty acids after fat-feeding

Kwan Yi Chu, Natalie Mellet, Le May Thai, Peter J Meikle, Trevor J Biden

Journal article  |  2020  |  Molecular Metabolism

OBJECTIVE: Investigations of autophagy in β-cells have usually focused on its homeostatic function. More dynamic roles in inhibiti..

Insulin signaling requires glucose to promote lipid anabolism in adipocytes

James R Krycer, Lake-Ee Quek, Deanne Francis, Armella Zadoorian, Fiona C Weiss, Kristen C Cooke, Marin E Nelson, Alexis Diaz-Vegas, Sean J Humphrey, Richard Scalzo, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Kevin Huynh, Corey Giles, Bianca Varney, Shilpa R Nagarajan, Andrew J Hoy, Tomoyoshi Soga, et al.

Journal article  |  2020  |  Journal of Biological Chemistry

Adipose tissue is essential for metabolic homeostasis, balancing lipid storage and mobilization based on nutritional status. This ..