Peter Meikle

Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial.

Himawan Fernando, Thy Duong, Kevin Huynh, Jonathan Noonan, James Shaw, Stephen J Duffy, Ziad Nehme, Karen Smith, Paul S Myles, Peter J Meikle, Karlheinz Peter, Dion Stub

Journal article  |  2021  |  Eur Heart J

AIMS: We assessed the impact of intravenous fentanyl and lignocaine on the pharmacokinetics and pharmacodynamics of ticagrelor in ..

Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.

Hui-Ming Lin, Nicole Yeung, Jordan F Hastings, David R Croucher, Kevin Huynh, Thomas G Meikle, Natalie A Mellett, Edmond M Kwan, Ian D Davis, Ben Tran, Kate L Mahon, Alison Zhang, Martin R Stockler, Karen Briscoe, Gavin Marx, Patricia Bastick, Megan L Crumbaker, Anthony M Joshua, Arun A Azad, Peter J Meikle, et al.

Journal article  |  2021  |  Cancers (Basel)

Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This stu..

Clinical Lipidomics: Realizing the potential of lipid profiling.

Thomas G Meikle, Kevin Huynh, Corey Giles, Peter J Meikle

Journal article  |  2021  |  J Lipid Res

Dysregulation of lipid metabolism plays a major role in the aetiology and sequelae of inflammatory disorders, cardiometabolic and ..

SOD2 in skeletal muscle: New insights from an inducible deletion model.

Aowen Zhuang, Christine Yang, Yingying Liu, Yanie Tan, Simon T Bond, Shannen Walker, Tim Sikora, Adrienne Laskowski, Arpeeta Sharma, Judy B de Haan, Peter J Meikle, Takahiko Shimizu, Melinda T Coughlan, Anna C Calkin, Brian G Drew

Journal article  |  2021  |  Redox Biol

Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in ske..

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

Geraldine J Ooi, Peter J Meikle, Kevin Huynh, Wendy Brown, Paul Burton, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF HEPATOLOGY

BACKGROUNDS & AIMS: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..

Lipidomic Signatures of Changes in Adiposity: A Large Prospective Study of 5849 Adults from the Australian Diabetes, Obesity and Lifestyle Study

Habtamu B Beyene, Gavriel Olshansky, Corey Giles, Kevin Huynh, Michelle Cinel, Natalie A Mellett, Adam Alexander T Smith, Jonathan E Shaw, Dianna J Magliano, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Lipid metabolism is tightly linked to adiposity. Comprehensive lipidomic profiling offers new insights into the dysregulation of l..

Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in ANGPTL3

Nicholas B Blackburn, Peter J Meikle, Juan M Peralta, Satish Kumar, Ana C Leandro, Melissa A Bellinger, Corey Giles, Kevin Huynh, Michael C Mahaney, Harald HH Goring, John L VandeBerg, Sarah Williams-Blangero, David C Glahn, Ravindranath Duggirala, John Blangero, Laura F Michael, Joanne E Curran

Journal article  |  2021  |  CIRCULATION-GENOMIC AND PRECISION MEDICINE

BACKGROUND: The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundament..

The Impact of Simvastatin on Lipidomic Markers of Cardiovascular Risk in Human Liver Cells Is Secondary to the Modulation of Intracellular Cholesterol

Yvette L Schooneveldt, Corey Giles, Michael F Keating, Natalie A Mellett, Aaron W Jurrjens, Sudip Paul, Anna C Calkin, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Statins are the first-line lipid-lowering therapy for reducing cardiovascular disease (CVD) risk. A plasma lipid ratio of two phos..

Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice

Sudip Paul, Aliki A Rasmiena, Kevin Huynh, Adam Alexander T Smith, Natalie A Mellett, Karin Jandeleit-Dahm, Graeme I Lancaster, Peter J Meikle

Journal article  |  2021  |  METABOLITES

Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to..

Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer

Hui-Ming Lin, Kevin Huynh, Manish Kohli, Winston Tan, Arun A Azad, Nicole Yeung, Kate L Mahon, Blossom Mak, Peter D Sutherland, Andrew Shepherd, Natalie Mellett, Maria Docanto, Corey Giles, Margaret M Centenera, Lisa M Butler, Peter J Meikle, Lisa G Horvath

Journal article  |  2021  |  PROSTATE CANCER AND PROSTATIC DISEASES

BACKGROUND: Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC..