Peter Meikle

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

Sih Min Tan, Mark Ziemann, Vicki Thallas-Bonke, Matthew Snelson, Vinod Kumar, Adrienne Laskowski, Tuong-Vi Nguyen, Kevin Huynh, Michele V Clarke, Renata Libianto, Scott T Baker, Alison Skene, David A Power, Richard J MacIsaac, Darren C Henstridge, Rick A Wetsel, Assam El-Osta, Peter J Meikle, Scott G Wilson, Josephine M Forbes, et al.

Journal article  |  2020  |  Diabetes

The sequelae of diabetes mellitus include microvascular complications such as diabetic kidney disease (DKD), which involves glucos..

Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease

Wei Ling Florence Lim, Kevin Huynh, Pratishtha Chatterjee, Ian Martins, Kaushala S Jayawardana, Corey Giles, Natalie A Mellett, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Brian G Drew, Colin L Masters, Peter J Meikle, Ralph N Martins

Journal article  |  2020  |  Journal of Alzheimer's Disease

BACKGROUND: Lipid metabolism is altered in Alzheimer's disease (AD); however, the relationship between AD risk factors (age, APOEɛ..

Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming

MT Coughlan, S Tan, M Ziemann, M Snelson, A El-Osta, RJ MacIsaac, PJ Meikle, JM Forbes, ME Cooper, EI Ekinci, TM Woodruff

Conference Proceedings  |  2019  |  DIABETOLOGIA

Changes in plasma lipids predict pravastatin efficacy in secondary prevention

Kaushala S Jayawardana, Piyushkumar A Mundra, Corey Giles, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Ian C Marschner, Gerard Wong, Bronwyn A Kingwell, et al.

Journal article  |  2019  |  JCI Insight

HDL Phospholipids, but Not Cholesterol Distinguish Acute Coronary Syndrome From Stable Coronary Artery Disease

Peter J Meikle, Melissa F Formosa, Natalie A Mellett, Kaushala S Jayawardana, Corey Giles, David A Bertovic, Garry L Jennings, Wayne Childs, Medini Reddy, Andrew L Carey, Arul Baradi, Shane Nanayakkara, Andrew M Wilson, Stephen J Duffy, Bronwyn A Kingwell

Journal article  |  2019  |  Journal of the American Heart Association

Background Although acute coronary syndromes (ACS) are a major cause of morbidity and mortality, relationships with biologically a..

An integrative systems genetic analysis of mammalian lipid metabolism

Benjamin L Parker, Anna C Calkin, Marcus M Seldin, Michael F Keating, Elizabeth J Tarling, Pengyi Yang, Sarah C Moody, Yingying Liu, Eser J Zerenturk, Elise J Needham, Matthew L Miller, Bethan L Clifford, Pauline Morand, Matthew J Watt, Ruth CR Meex, Kang-Yu Peng, Richard Lee, Kaushala Jayawardana, Calvin Pan, Natalie A Mellett, et al.

Journal article  |  2019  |  Nature

A blood-based signature of cerebrospinal fluid A beta(1-42) status

Benjamin Goudey, Bowen J Fung, Christine Schieber, Noel G Faux, Michael W Weiner, Paul Aisen, Ronald Petersen, Clifford R Jack, William Jagust, John Q Trojanowki, Arthur W Toga, Laurel Beckett, Robert C Green, Andrew J Saykin, John Morris, Leslie M Shaw, Jeffrey Kaye, Joseph Quinn, Lisa Silbert, Betty Lind, et al.

Journal article  |  2019  |  SCIENTIFIC REPORTS

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

Amanda E Brandon, Bing M Liao, Barbara Diakanastasis, Benjamin L Parker, Katy Raddatz, Sophie A McManus, Liam O'Reilly, Erica Kimber, A Gabrielle van der Kraan, Dale Hancock, Darren C Henstridge, Peter J Meikle, Gregory J Cooney, David E James, Saskia Reibe, Mark A Febbraio, Trevor J Biden, Carsten Schmitz-Peiffer

Journal article  |  2019  |  Cell Metabolism

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance

Kim Loh, Shanna Tam, Lisa Murray-Segal, Kevin Huynh, Peter J Meikle, John W Scott, Bryce van Denderen, Zhiping Chen, Rohan Steel, Nicholas D LeBlond, Leah A Burkovsky, Conor O'Dwyer, Julia RC Nunes, Gregory R Steinberg, Morgan D Fullerton, Sandra Galic, Bruce E Kemp

Journal article  |  2019  |  Hepatology Communications

The PI 3-kinase PI3KC2 alpha regulates mouse platelet membrane structure and function independently of membrane lipid composition

Maria V Selvadurai, Rose J Brazilek, Mitchell J Moon, Jean-Yves Rinckel, Anita Eckly, Christian Gachet, Peter J Meikle, Harshal H Nandurkar, Warwick S Nesbitt, Justin R Hamilton

Journal article  |  2019  |  FEBS Letters

Brown adipose tissue and lipid metabolism: New strategies for identification of activators and biomarkers with clinical potential

Angie S Xiang, Peter J Meikle, Andrew L Carey, Bronwyn A Kingwell

Journal article  |  2018  |  Pharmacology & Therapeutics

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

Kang-Yu Peng, Matthew J Watt, Sander Rensen, Jan Willem Greve, Kevin Huynh, Kaushala S Jayawardana, Peter J Meikle, Ruth CR Meex

Journal article  |  2018  |  Journal of Lipid Research

Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention

Piyushkumar A Mundra, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Kaushala S Jayawardana, Corey Giles, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Gerard Wong, Bronwyn A Kingwell, John Simes, et al.

Journal article  |  2018  |  JCI Insight

Lipidomic Profiles of the Heart and Circulation in Response to Exercise versus Cardiac Pathology: A Resource of Potential Biomarkers and Drug Targets

Yow Keat Tham, Bianca C Bernardo, Kevin Huynh, Jenny YY Ooi, Xiao Ming Gao, Helen Kiriazis, Corey Giles, Peter J Meikle, Julie R McMullen

Journal article  |  2018  |  Cell Reports

Acute coronary syndromes: mechanistic insights and risk prediction through lipoprotein lipidomics

BA Kingwell, MF Formosa, NA Mellett, KA Jayawardana, C Giles, DA Bertovic, GL Jennings, W Childs, M Reddy, A Baradi, S Nanayakkara, AM Wilson, SJ Duffy, PJ Meikle

Conference Proceedings  |  2018  |  EUROPEAN HEART JOURNAL

Changes in plasma lipid species following pravastatin treatment predict cardiovascular outcomes and represent a measure of the relative risk reduction in secondary prevention

P Meikle, KS Jayawardana, PA Mundra, PJ Nestel, EH Barnes, A Kirby, P Thompson, DR Sullivan, ZH Alshehry, K Huynh, C Giles, IC Marschner, BA Kingwell, J Simes, AM Tonkin

Conference Proceedings  |  2018  |  EUROPEAN HEART JOURNAL

Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality in Metabolic Syndrome

Anmar A Khan, Piyushkumar A Mundra, Nora E Straznicky, Paul J Nestel, Gerard Wong, Ricardo Tan, Kevin Huynh, Theodore W Ng, Natalie A Mellett, Jacquelyn M Weir, Christopher K Barlow, Zahir H Alshehry, Gavin W Lambert, Bronwyn A Kingwell, Peter J Meikle

Journal article  |  2018  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Gestational Age and the Cord Blood Lipidomic Profile in Late Preterm and Term Infants

Kate McCloskey, Alysha M De Livera, Fiona Collier, Anne-Louise Ponsonby, John B Carlin, Peter Vuillermin, Natalie A Mellett, Kaushala Jayawardana, Jacqueline M Weir, John Blangero, Joanne E Curran, David Burgner, Peter J Meikle

Journal article  |  2018  |  Neonatology

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study

Woei-Yuh Saw, Erwin Tantoso, Husna Begum, Lihan Zhou, Ruiyang Zou, Cheng He, Sze Ling Chan, Linda Wei-Lin Tan, Lai-Ping Wong, Wenting Xu, Don Kyin, Nwe Moong, Yenly Lim, Bowen Li, Nisha Esakimuthu Pillai, Trevor A Peterson, Tomasz Bielawny, Peter J Meikle, Piyushkumar A Mundra, Wei-Yen Lim, et al.

Journal article  |  2017  |  Nature Communications

Immunometabolic and Lipidomic Markers Associated With the Frailty Index and Quality of Life in Aging HIV Men on Antiretroviral Therapy

Hui-Ling Yeoh, Allen C Cheng, Catherine L Cherry, Jacquelyn M Weir, Peter J Meikle, Jennifer F Hoy, Suzanne M Crowe, Clovis S Palmer

Journal article  |  2017  |  EBioMedicine

Baseline serum phosphatidylcholine plasmalogen concentrations are inversely associated with incident myocardial infarction in patients with mixed peripheral artery disease presentations

Joseph V Moxon, Rhondda E Jones, Gerard Wong, Jacquelyn M Weir, Natalie A Mellett, Bronwyn A Kingwell, Peter J Meikle, Jonathan Golledge

Journal article  |  2017  |  Atherosclerosis

The association of the lipidomic profile with features of polycystic ovary syndrome

LJ Moran, PA Mundra, HJ Teede, PJ Meikle

Journal article  |  2017  |  Journal of Molecular Endocrinology

Breaking Up Prolonged Sitting Alters the Postprandial Plasma Lipidomic Profile of Adults With Type 2 Diabetes

Megan S Grace, Paddy C Dempsey, Parneet Sethi, Piyushkumar A Mundra, Natalie A Mellett, Jacquelyn M Weir, Neville Owen, David W Dunstan, Peter J Meikle, Bronwyn A Kingwell

Journal article  |  2017  |  The Journal of Clinical Endocrinology & Metabolism

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

Peter J Meikle, Scott A Summers

Journal article  |  2017  |  Nature Reviews Endocrinology

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

David Braig, Tracy L Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R Thiele, Craig J Morton, Johannes Zeller, Jurij Kiefer, Lawrence A Potempa, Natalie A Mellett, Luke A Miles, Xiao-Jun Du, Peter J Meikle, Markus Huber-Lang, G Bjoern Stark, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt

Journal article  |  2017  |  NATURE COMMUNICATIONS

Markers of sympathetic nervous system activity associate with complex plasma lipids in metabolic syndrome subjects

Paul J Nestel, Anmar A Khan, Nora E Straznicky, Natalie A Mellett, Kaushala Jayawardana, Piyushkumar A Mundra, Gavin W Lambert, Peter J Meikle

Journal article  |  2017  |  Atherosclerosis

Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism

Bhagirath Chaurasia, Vincent Andre Kaddai, Graeme Iain Lancaster, Darren C Henstridge, Sandhya Sriram, Dwight Lark Anolin Galam, Venkatesh Gopalan, KN Bhanu Prakash, S Sendhil Velan, Sarada Bulchand, Teh Jing Tsong, Mei Wang, Monowarul Mobin Siddique, Yuguang Guan, Kristmundur Sigmundsson, Natalie A Mellet, Jacquelyn M Weir, Peter J Meikle, M Shabeer Bin M Yassin, Asim Shabbir, et al.

Journal article  |  2016  |  Cell Metabolism

Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics

Anubhav Srivastava, Greg M Kowalski, Damien L Callahan, Peter J Meikle, Darren J Creek

Journal article  |  2016  |  Metabolites

The Effects of Long-Term Saturated Fat Enriched Diets on the Brain Lipidome

Corey Giles, Ryusuke Takechi, Natalie A Mellett, Peter J Meikle, Satvinder Dhaliwal, John C Mamo

Journal article  |  2016  |  PLOS ONE

Plasma Lipidomic Profiles Improve on Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes Mellitus

Zahir H Alshehry, Piyushkumar A Mundra, Christopher K Barlow, Natalie A Mellett, Gerard Wong, Malcolm J McConville, John Simes, Andrew M Tonkin, David R Sullivan, Elizabeth H Barnes, Paul J Nestel, Bronwyn A Kingwell, Michel Marre, Bruce Neal, Neil R Poulter, Anthony Rodgers, Bryan Williams, Sophia Zoungas, Graham S Hillis, John Chalmers, et al.

Journal article  |  2016  |  Circulation

Pathways of Acetyl-CoA Metabolism Involved in the Reversal of Palmitate-Induced Glucose Production by Metformin and Salicylate

B Hayward, JC Molero, K Windmill, A Sanigorski, J Weir, NL McRae, K Aston-Mourney, B Osborne, B Liao, KR Walder, PJ Meikle, N Konstantopoulos, C Schmitz-Peiffer

Journal article  |  2016  |  Experimental and Clinical Endocrinology & Diabetes

Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia

Alexina Orsoni, Patrice Therond, Ricardo Tan, Philippe Giral, Paul Robillard, Anatol Kontush, Peter J Meikle, M John Chapman

Journal article  |  2016  |  Journal of Lipid Research

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice (vol 243, pg 598, 2015)

Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle

Journal article  |  2016  |  Atherosclerosis

Drug induced exocytosis of glycogen in Pompe disease

Christopher T Turner, Maria Fuller, John J Hopwood, Peter J Meikle, Doug A Brooks

Journal article  |  2016  |  Biochemical and Biophysical Research Communications

Lipidomic analyses in epidemiology

Piyushkumar A Mundra, Jonathan E Shaw, Peter J Meikle

Journal article  |  2016  |  International Journal of Epidemiology

Plasma lipidomic profiling in patients with rheumatoid arthritis

Lu Fang, Piyushkumar A Mundra, Fenling Fan, Abby Galvin, Jacquelyn M Weir, Gerard Wong, Jaye Chin-Dusting, Flavia Cicuttini, Peter Meikle, Anthony Michael Dart

Journal article  |  2016  |  Metabolomics

Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells

Hann Low, Nigora Mukhamedova, Huanhuan L Cui, Brian P McSharry, Selmir Avdic, Anh Hoang, Michael Ditiatkovski, Yingying Liu, Ying Fu, Peter J Meikle, Martin Blomberg, Konstantinos A Polyzos, William E Miller, Piotr Religa, Michael Bukrinsky, Cecilia Soderberg-Naucler, Barry Slobedman, Dmitri Sviridov

Journal article  |  2016  |  Cell Reports

Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia

Maaike Kockx, Elias Glaros, Betty Leung, Theodore W Ng, Jimmy FP Berbee, Virginie Deswaerte, Diana Nawara, Carmel Quinn, Kerry-Anne Rye, Wendy Jessup, Patrick CN Rensen, Peter J Meikle, Leonard Kritharides

Journal article  |  2016  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Effects of the BET-inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial

Andrew L Siebel, Khiang Trinh Si, Melissa F Formosa, Piyushkumar A Mundra, Alaina K Natoli, Medini Reddy-Luthmoodo, Kevin Huynh, Anmar A Khan, Andrew L Carey, Gerrit van Hall, Claudio Cobelli, Chiara Dalla-Man, Jim D Otvos, Kerry-Anne Rye, Jan Johansson, Allan Gordon, Norman CW Wong, Dmitri Sviridov, Philip Barter, Stephen J Duffy, et al.

Journal article  |  2016  |  Metabolism

A comprehensive lipidomic screen of pancreatic beta-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

Gemma L Pearson, Natalie Mellett, Kwan Yi Chu, Ebru Boslem, Peter J Meikle, Trevor J Biden

Journal article  |  2016  |  Molecular Metabolism

Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: results from diverse cohorts

Manju Mamtani, Hemant Kulkarni, Gerard Wong, Jacquelyn M Weir, Christopher K Barlow, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, David C Glahn, Dianna J Magliano, Paul Zimmet, Jonathan Shaw, Sarah Williams-Blangero, Ravindranath Duggirala, John Blangero, Peter J Meikle, Joanne E Curran

Journal article  |  2016  |  Lipids in Health and Disease

G(M3) ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

JM Wentworth, G Naselli, K Ngui, GK Smyth, R Liu, PE O'Brien, C Bruce, J Weir, M Cinel, PJ Meikle, LC Harrison

Journal article  |  2016  |  International Journal of Obesity

Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans

Katherine T Tonks, Adelle CF Coster, Michael J Christopher, Rima Chaudhuri, Aimin Xu, Johann Gagnon-Bartsch, Donald J Chisholm, David E James, Peter J Meikle, Jerry R Greenfield, Dorit Samocha-Bonet

Journal article  |  2016  |  Obesity

Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain

Peter Meikle, Hann Low, Melissa J Churchill, Michael Bukrinsky, Dmitri Sviridov

Journal article  |  2016  |  Data in Brief

Zebrafish Embryonic Lipidomic Analysis Reveals that the Yolk Cell Is Metabolically Active in Processing Lipid

Daniel Fraher, Andrew Sanigorski, Natalie A Mellett, Peter J Meikle, Andrew J Sinclair, Yann Gibert

Journal article  |  2016  |  Cell Reports

High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein

Aliki A Rasmiena, Christopher K Barlow, Theodore W Ng, Dedreia Tull, Peter J Meikle

Journal article  |  2016  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis

Anne Julie Overgaard, Jacquelyn M Weir, David Peter De Souza, Dedreia Tull, Claus Haase, Peter J Meikle, Flemming Pociot

Journal article  |  2016  |  Metabolomics

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain

Hann Low, Lesley Cheng, Maria-Silvana Di Yacovo, Melissa J Churchill, Peter Meikle, Michael Bukrinsky, Andrew F Hill, Dmitri Sviridov

Journal article  |  2016  |  Atherosclerosis

Statin action favors normalization of the plasma lipidome in the atherogenic mixed dyslipidemia of MetS: potential relevance to statin-associated dysglycemia

Peter J Meikle, Gerard Wong, Ricardo Tan, Philippe Giral, Paul Robillard, Alexina Orsoni, Neil Hounslow, Dianna J Magliano, Jonathan E Shaw, Joanne E Curran, John Blangero, Bronwyn A Kingwell, M John Chapman

Journal article  |  2015  |  Journal of Lipid Research

Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice

Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle

Journal article  |  2015  |  Atherosclerosis

Postprandial Plasma Phospholipids in Men Are Influenced by the Source of Dietary Fat

Peter J Meikle, Christopher K Barlow, Natalie A Mellett, Piyushkumar A Mundra, Maxine P Bonham, Amy Larsen, David Cameron-Smith, Andrew Sinclair, Paul J Nestel, Gerard Wong

Journal article  |  2015  |  The Journal of Nutrition

Lipidomic Profiling in Inflammatory Bowel Disease: Comparison Between Ulcerative Colitis and Crohn's Disease

Fenling Fan, Piyushkumar A Mundra, Lu Fang, Abby Galvin, Xiao Lei Moore, Jacquelyn M Weir, Gerard Wong, David A White, Jaye Chin-Dusting, Miles P Sparrow, Peter J Meikle, Anthony M Dart

Journal article  |  2015  |  Inflammatory Bowel Diseases

The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics

Martha Lappas, Piyushkumar A Mundra, Gerard Wong, Kevin Huynh, Debra Jinks, Harry M Georgiou, Michael Permezel, Peter J Meikle

Journal article  |  2015  |  Diabetologia

Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment

Peter J Meikle, Piyushkumar A Mundra, Gerard Wong, Khairunnessa Rahman, Kevin Huynh, Christopher K Barlow, Alastair MP Duly, Paul S Haber, John B Whitfield, Devanshi Seth

Journal article  |  2015  |  PLOS ONE

Association of Plasma Ceramides and Sphingomyelin With VLDL apoB-100 Fractional Catabolic Rate Before and After Rosuvastatin Treatment

Theodore WK Ng, Esther MM Ooi, Gerald F Watts, Dick C Chan, Peter J Meikle, P Hugh R Barrett

Journal article  |  2015  |  The Journal of Clinical Endocrinology & Metabolism

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity

Ahrathy Selathurai, Greg M Kowalski, Micah L Burch, Patricio Sepulveda, Steve Risis, Robert S Lee-Young, Severine Lamon, Peter J Meikle, Amanda J Genders, Sean L McGee, Matthew J Watt, Aaron P Russell, Matthew Frank, Suzanne Jackowski, Mark A Febbraio, Clinton R Bruce

Journal article  |  2015  |  Cell Metabolism

Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance

Darren C Henstridge, E Estevez, TL Allen, SE Heywood, T Gardner, C Yang, NA Mellett, BA Kingwell, PJ Meikle, MA Febbraio

Journal article  |  2015  |  Cell Stress and Chaperones

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

Andreas B Jordy, Michael J Kraakman, Tim Gardner, Emma Estevez, Helene L Kammoun, Jacqui M Weir, Bente Kiens, Peter J Meikle, Mark A Febbraio, Darren C Henstridge

Journal article  |  2015  |  American Journal of Physiology-Endocrinology and Metabolism

Acetylation of Trehalose Mycolates Is Required for Efficient MmpL-Mediated Membrane Transport in Corynebacterineae

Yoshiki Yamaryo-Botte, Arek K Rainczuk, David J Lea-Smith, Rajini Brammananth, Phillip L van der Peet, Peter Meikle, Julie E Ralton, Thusita WT Rupasinghe, Spencer J Williams, Ross L Coppel, Paul K Crellin, Malcolm J McConville

Journal article  |  2015  |  ACS Chemical Biology

Dietary predictors of arterial stiffness in a cohort with type 1 and type 2 diabetes

KS Petersen, JB Keogh, PJ Meikle, ML Garg, PM Clifton

Journal article  |  2015  |  Atherosclerosis

Absence of alpha-galactosidase cross-correction in Fabry heterozygote cultured skin fibroblasts

Maria Fuller, Natalie Mellett, Leanne K Hein, Doug A Brooks, Peter J Meikle

Journal article  |  2015  |  Molecular Genetics and Metabolism

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis

Denny L Cottle, Gloria MA Ursino, Sally Chi Leng Ip, Lynelle K Jones, Tia Ditommaso, Douglas F Hacking, Niamh E Mangan, Natalie A Mellett, Katya J Henley, Dmitri Sviridov, Claudia A Nold-Petry, Marcel F Nold, Peter J Meikle, Benjamin T Kile, Ian M Smyth

Journal article  |  2015  |  Human Molecular Genetics

Distribution of heparan sulfate oligosaccharides in murine mucopolysaccharidosis type IIIA

K Mason, P Meikle, J Hopwood, M Fuller

Journal article  |  2014  |  Metabolites

Short term fat feeding rapidly increases plasma insulin but does not result in dyslipidaemia

Benjamin Barzel, Jacquelyn M Weir, Peter J Meikle, Sandra L Burke, James A Armitage, Geoffrey A Head

Journal article  |  2014  |  Frontiers in Physiology

Human Plasma Lipidome Is Pleiotropically Associated With Cardiovascular Risk Factors and Death

Claire Bellis, Hemant Kulkarni, Manju Mamtani, Jack W Kent, Gerard Wong, Jacquelyn M Weir, Christopher K Barlow, Vincent Diego, Marcio Almeida, Thomas D Dyer, Harald HH Goering, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, Sarah Williams-Blangero, Peter J Meikle, John Blangero, Joanne E Curran

Journal article  |  2014  |  Circulation: Cardiovascular Genetics

Sphingomyelin Phosphodiesterase Acid-like 3A (SMPDL3A) Is a Novel Nucleotide Phosphodiesterase Regulated by Cholesterol in Human Macrophages

Mathew Traini, Carmel M Quinn, Cecilia Sandoval, Erik Johansson, Kate Schroder, Maaike Kockx, Peter J Meikle, Wendy Jessup, Leonard Kritharides

Journal article  |  2014  |  Journal of Biological Chemistry

Dose-Dependent Effects of Rosuvastatin on the Plasma Sphingolipidome and Phospholipidome in the Metabolic Syndrome

Theodore WK Ng, Esther MM Ooi, Gerald F Watts, Dick C Chan, Jacquelyn M Weir, Peter J Meikle, P Hugh R Barrett

Journal article  |  2014  |  The Journal of Clinical Endocrinology & Metabolism

LICRE: unsupervised feature correlation reduction for lipidomics

Gerard Wong, Jeffrey Chan, Bronwyn A Kingwell, Christopher Leckie, Peter J Meikle

Journal article  |  2014  |  Bioinformatics

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle

Rachael R Mason, Ruzaidi Mokhtar, Maria Matzaris, Ahrathy Selathurai, Greg M Kowalski, Nancy Mokbel, Peter J Meikle, Clinton R Bruce, Matthew J Watt

Journal article  |  2014  |  Molecular Metabolism

Plasma lipidomic analysis predicts non-calcified coronary artery plaque in asymptomatic patients at intermediate risk of coronary artery disease

Andris H Ellims, Gerard Wong, Jacquelyn M Weir, Philip Lew, Peter J Meikle, Andrew J Taylor

Journal article  |  2014  |  European Heart Journal - Cardiovascular Imaging

Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease

Peter J Meikle, Gerard Wong, Christopher K Barlow, Bronwyn A Kingwell

Journal article  |  2014  |  Pharmacology & Therapeutics

Plasma lipidome is independently associated with variability in metabolic syndrome in Mexican American families

Hemant Kulkarni, Peter J Meikle, Manju Mamtani, Jacquelyn M Weir, Marcio Almeida, Vincent Diego, Juan Manuel Peralta, Christopher K Barlow, Claire Bellis, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, Harald HH Goering, Joanne E Curran, John Blangero

Journal article  |  2014  |  Journal of Lipid Research

Plasma Lipidomic Profiling of Treated HIV-Positive Individuals and the Implications for Cardiovascular Risk Prediction

Gerard Wong, Janine M Trevillyan, Benoit Fatou, Michelle Cinel, Jacquelyn M Weir, Jennifer F Hoy, Peter J Meikle

Journal article  |  2014  |  PLoS ONE

Plasma Dihydroceramide Species Associate with Waist Circumference in Mexican American Families

Manju Mamtani, Peter J Meikle, Hemant Kulkarni, Jacquelyn M Weir, Christopher K Barlow, Jeremy B Jowett, Claire Bellis, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, John Blangero, Joanne E Curran

Journal article  |  2014  |  Obesity

Comparison of the Serum Lipidome in Patients With Abdominal Aortic Aneurysm and Peripheral Artery Disease

Joseph V Moxon, Dawei Liu, Gerard Wong, Jacquelyn M Weir, Ratnesh Behl-Gilhotra, Barbara Bradshaw, Bronwyn A Kingwell, Peter J Meikle, Jonathan Golledge

Journal article  |  2014  |  Circulation: Cardiovascular Genetics

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells

Gemma L Pearson, Natalie Mellett, Kwan Yi Chu, James Cantley, Aimee Davenport, Pauline Bourbon, Casey C Cosner, Paul Helquist, Peter J Meikle, Trevor J Biden

Journal article  |  2014  |  Diabetologia

Effects of low-fat or full-fat fermented and non-fermented dairy foods on selected cardiovascular biomarkers in overweight adults

Paul J Nestel, Natalie Mellett, Suzana Pally, Gerard Wong, Chris K Barlow, Kevin Croft, Trevor A Mori, Peter J Meikle

Journal article  |  2013  |  British Journal of Nutrition

The effect of short-term overfeeding on serum lipids in healthy humans

Leonie K Heilbronn, Adelle CF Coster, Lesley V Campbell, Jerry R Greenfield, Kylie Lange, Michael J Christopher, Peter J Meikle, Dorit Samocha-Bonet

Journal article  |  2013  |  Obesity

Inclusion of Plasma Lipid Species Improves Classification of Individuals at Risk of Type 2 Diabetes

Gerard Wong, Christopher K Barlow, Jacquelyn M Weir, Jeremy BM Jowett, Dianna J Magliano, Paul Zimmet, Jonathan Shaw, Peter J Meikle

Journal article  |  2013  |  PLoS ONE

Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic beta-Cells

Ebru Boslem, Jacquelyn M Weir, Gemma MacIntosh, Nancy Sue, James Cantley, Peter J Meikle, Trevor J Biden

Journal article  |  2013  |  Journal of Biological Chemistry

Plasma Lipidomic Profile Signature of Hypertension in Mexican American Families: Specific Role of Diacylglycerols

Hemant Kulkarni, Peter J Meikle, Manju Mamtani, Jacquelyn M Weir, Christopher K Barlow, Jeremy B Jowett, Claire Bellis, Thomas D Dyer, Matthew P Johnson, David L Rainwater, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, John Blangero, Joanne E Curran

Journal article  |  2013  |  Hypertension

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

N Turner, GM Kowalski, SJ Leslie, S Risis, C Yang, RS Lee-Young, JR Babb, PJ Meikle, GI Lancaster, DC Henstridge, PJ White, EW Kraegen, A Marette, GJ Cooney, MA Febbraio, CR Bruce

Journal article  |  2013  |  Diabetologia

Variability in Associations of Phosphatidylcholine Molecular Species with Metabolic Syndrome in Mexican-American Families

Hemant Kulkarni, Peter J Meikle, Manju Mamtani, Jacquelyn M Weir, Christopher K Barlow, Jeremy B Jowett, Claire Bellis, Thomas D Dyer, Matthew P Johnson, David L Rainwater, Laura Almasy, Michael C Mahaney, Anthony G Comuzzie, John Blangero, Joanne E Curran

Journal article  |  2013  |  Lipids

Postprandial metabolism of docosapentaenoic acid (DPA, 22:5n-3) and eicosapentaenoic acid (EPA, 20:5n-3) in humans

Kaisa M Linderborg, Gunveen Kaur, Eliza Miller, Peter J Meikle, Amy E Larsen, Jacquelyn M Weir, Anu Nuora, Christopher K Barlow, Heikki P Kallio, David Cameron-Smith, Andrew J Sinclair

Journal article  |  2013  |  Prostaglandins, Leukotrienes and Essential Fatty Acids

Metabolomics and ischaemic heart disease

Aliki A Rasmiena, Theodore W Ng, Peter J Meikle

Journal article  |  2013  |  Clinical Science

Skeletal Muscle Insulin Resistance Associated with Cholesterol-Induced Activation of Macrophages Is Prevented by High Density Lipoprotein

Andrew L Carey, Andrew L Siebel, Medini Reddy-Luthmoodoo, Alaina K Natoli, Wilissa D'Souza, Peter J Meikle, Dmitri Sviridov, Brian G Drew, Bronwyn A Kingwell

Journal article  |  2013  |  PLOS ONE

Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance

James Boon, Andrew J Hoy, Romana Stark, Russell D Brown, Ruth C Meex, Darren C Henstridge, Simon Schenk, Peter J Meikle, Jeffrey F Horowitz, Bronwyn A Kingwell, Clinton R Bruce, Matthew J Watt

Journal article  |  2013  |  Diabetes

The association between dairy food intake and the incidence of diabetes in Australia: the Australian Diabetes Obesity and Lifestyle Study (AusDiab)

Narelle M Grantham, Dianna J Magliano, Allison Hodge, Jeremy Jowett, Peter Meikle, Jonathan E Shaw

Journal article  |  2013  |  Public Health Nutrition

Lipidomic Profiling of Chylomicron Triacylglycerols in Response to High Fat Meals

Maxine P Bonham, Kaisa M Linderborg, Aimee Dordevic, Amy E Larsen, Kay Nguo, Jacquelyn M Weir, Petra Gran, Marika K Luotonen, Peter J Meikle, David Cameron-Smith, Heikki PT Kallio, Andrew J Sinclair

Journal article  |  2013  |  Lipids

INTERLEUKIN 10 ANTIOXIDANT EFFECT DECREASES LEUKOCYTES/ENDOTHELIAL INTERACTION INDUCED BY TUMOR NECROSIS FACTOR alpha

Olivier Huet, Elisabette Laemmel, Yi Fu, Laurent Dupic, Andrea Aprico, Karen L Andrews, Shirley L Moore, Anatole Harrois, Peter L Meikle, Eric Vicaut, Jaye PF Chin-Dusting, Jacques Duranteau

Journal article  |  2013  |  Shock

Investigating the pathogenesis and risk of Type 2 diabetes: clinical applications of metabolomics

Theodore W Ng, Anmar A Khan, Peter J Meikle

Journal article  |  2012  |  Clinical Lipidology

Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice

Clinton R Bruce, Steve Risis, Joanne R Babb, Christine Yang, Greg M Kowalski, Ahrathy Selathurai, Robert S Lee-Young, Jacquelyn M Weir, Kazuaki Yoshioka, Yoh Takuwa, Peter J Meikle, Stuart M Pitson, Mark A Febbraio

Journal article  |  2012  |  Diabetes

Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice

DC Henstridge, CR Bruce, CP Pang, GI Lancaster, TL Allen, E Estevez, T Gardner, JM Weir, PJ Meikle, KSL Lam, A Xu, N Fujii, LJ Goodyear, MA Febbraio

Journal article  |  2012  |  Diabetologia

Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction

Jonathon Habersberger, Frederik Strang, Amelie Scheichl, Nay Htun, Nicole Bassler, Ruusu-Maaria Merivirta, Philipp Diehl, Guy Krippner, Peter Meikle, Steffen U Eisenhardt, Ian Meredith, Karlheinz Peter

Journal article  |  2012  |  Cardiovascular Research

Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice

Melissa L Borg, Simin Fallah Omran, Jacquelyn Weir, Peter J Meikle, Matthew J Watt

Journal article  |  2012  |  The Journal of Physiology

Caveolin-1 Plays a Critical Role in the Differentiation of Monocytes into Macrophages

Yi Fu, Xiao-Lei Moore, Man KS Lee, Manuel A Fernandez-Rojo, Marie-Odile Parat, Robert G Parton, Peter J Meikle, Dmitri Sviridov, Jaye PF Chin-Dusting

Journal article  |  2012  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes

Melissa N Barber, Steve Risis, Christine Yang, Peter J Meikle, Margaret Staples, Mark A Febbraio, Clinton R Bruce

Journal article  |  2012  |  PLoS ONE

Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1 alpha in adulthood

Rhianna C Laker, Mary E Wlodek, Glenn D Wadley, Linda A Gallo, Peter J Meikle, Glenn K McConell

Journal article  |  2012  |  AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Roles of ceramide and sphingolipids in pancreatic beta-cell function and dysfunction

Ebru Boslem, Peter J Meikle, Trevor J Biden

Journal article  |  2012  |  Islets

Mass spectrometric quantification of glycogen to assess primary substrate accumulation in the Pompe mouse.

Maria Fuller, Stephen Duplock, Christopher Turner, Philippa Davey, Doug A Brooks, John J Hopwood, Peter J Meikle

Journal article  |  2012  |  Analytical Biochemistry

Glycogen storage in the α-glucosidase knockout((6neo/6neo)) mouse recapitulates the biochemical defect that occurs in the human co..

Circulating inflammatory and atherogenic biomarkers are not increased following single meals of dairy foods

PJ Nestel, S Pally, GL MacIntosh, MA Greeve, S Middleton, J Jowett, PJ Meikle

Journal article  |  2012  |  European Journal of Clinical Nutrition

New approaches for the discovery of lipid-related genes

Joanne E Curran, Peter J Meikle, John Blangero

Journal article  |  2011  |  Clinical Lipidology

Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids

YY Lam, G Hatzinikolas, JM Weir, A Janovska, AJ McAinch, P Game, PJ Meikle, GA Wittert

Journal article  |  2011  |  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Lipidomics is providing new insight into the metabolic syndrome and its sequelae

Peter J Meikle, Michael J Christopher

Journal article  |  2011  |  Current Opinion in Lipidology

Screening patients referred to a metabolic clinic for lysosomal storage disorders

Maria Fuller, Justin N Tucker, Debbie L Lang, Caroline J Dean, Michael J Fietz, Peter J Meikle, John J Hopwood

Journal article  |  2011  |  Journal of Medical Genetics

Pigment Epithelium-Derived Factor Regulates Lipid Metabolism via Adipose Triglyceride Lipase

Melissa L Borg, Zane B Andrews, Ella J Duh, Rudolf Zechner, Peter J Meikle, Matthew J Watt

Journal article  |  2011  |  Diabetes

A lipidomic screen of palmitate-treated MIN6 beta-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking

Ebru Boslem, Gemma MacIntosh, Amanda M Preston, Clarissa Bartley, Anna K Busch, Maria Fuller, D Ross Laybutt, Peter J Meikle, Trevor J Biden

Journal article  |  2011  |  Biochemical Journal

Reconstituted high-density lipoprotein infusion modulates fatty acid metabolism in patients with type 2 diabetes mellitus

Brian G Drew, Andrew L Carey, Alaina K Natoli, Melissa F Formosa, Donna Vizi, Medini Reddy-Luthmoodoo, Jacquelyn M Weir, Christopher K Barlow, Gerrit van Hall, Peter J Meikle, Stephen J Duffy, Bronwyn A Kingwell

Journal article  |  2011  |  Journal of Lipid Research

Effects of prenatal ethanol exposure on the lungs of postnatal lambs

Foula Sozo, Melissa Vela, Victoria Stokes, Kelly Kenna, Peter J Meikle, Robert De Matteo, David Walker, James Brien, Alan Bocking, Richard Harding

Journal article  |  2011  |  American Journal of Physiology-Lung Cellular and Molecular Physiology

Hepatic accumulation of intestinal cholesterol is decreased and fecal cholesterol excretion is increased in mice fed a high-fat diet supplemented with milk phospholipids

A Kamili, E Wat, RW Chung, S Tandy, JM Weir, PJ Meikle, JS Cohn

Journal article  |  2010  |  Nutrition & Metabolism

Hydrogenated phosphatidylcholine supplementation reduces hepatic lipid levels in mice fed a high-fat diet.

Sally Tandy, Rosanna WS Chung, Alvin Kamili, Elaine Wat, Jacquelyn M Weir, Peter J Meikle, Jeffrey S Cohn

Journal article  |  2010  |  Atherosclerosis

The ability of the fatty acid composition of dietary phosphatidylcholine (PC) to affect hepatic lipid levels was investigated in C..

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

VB Matthews, TL Allen, S Risis, MHS Chan, DC Henstridge, N Watson, LA Zaffino, JR Babb, J Boon, PJ Meikle, JB Jowett, MJ Watt, J-O Jansson, CR Bruce, MA Febbraio

Journal article  |  2010  |  Diabetologia

Biochemical profiling to predict disease severity in metachromatic leukodystrophy.

MAF Tan, M Fuller, ZAMH Zabidi-Hussin, JJ Hopwood, PJ Meikle

Journal article  |  2010  |  Molecular Genetics and Metabolism

Metachromatic leukodystrophy is a neurodegenerative disease that is characterized by a deficiency of arylsulfatase A, resulting in..

Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment.

Grant A Ramm, Ross W Shepherd, Anita C Hoskins, Sonia A Greco, Agnieszka D Ney, Tamara N Pereira, Kim R Bridle, James D Doecke, Peter J Meikle, Bruno Turlin, Peter J Lewindon

Journal article  |  2009  |  Hepatology

UNLABELLED: Cholestatic liver diseases, such as cystic fibrosis (CF) liver disease and biliary atresia, predominate as causes of c..

Minimum substrate requirements of endoglycosidase activities toward dermatan sulfate by electrospray ionization-tandem mass spectrometry.

Timothy C Nielsen, Peter J Meikle, John J Hopwood, Maria Fuller

Journal article  |  2008  |  Glycobiology

The catabolism of dermatan sulfate (DS) commences with endohydrolysis of the polysaccharide to oligosaccharides by proposed endo-b..

Diagnosis of metachromatic leukodystrophy by immune quantification of arylsulphatase A protein and activity in dried blood spots.

Mohd AF Tan, Caroline J Dean, John J Hopwood, Peter J Meikle

Journal article  |  2008  |  Clinical Chemistry

A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis

Ian Smyth, Douglas F Hacking, Adrienne A Hilton, Nigora Mukhamedova, Peter J Meikle, Sarah Ellis, Keith Slattery, Janelle E Collinge, Carolyn A de Graaf, Melanie Bahlo, Dmitri Sviridov, Benjamin T Kile, Douglas J Hilton

Journal article  |  2008  |  PLoS Genet.

Plasma lipids are altered in Gaucher disease: biochemical markers to evaluate therapeutic intervention.

Peter J Meikle, Philip D Whitfield, Tina Rozaklis, David Blacklock, Stephen Duplock, Deborah Elstein, Ari Zimran, Eugen Mengel, Paul Cannell, John J Hopwood, Maria Fuller

Journal article  |  2008  |  Blood Cells, Molecules, and Diseases

Enzyme replacement therapy has been in clinical practice for the non-neuronopathic form of Gaucher disease for 15 years. However, ..

Effect of lysosomal storage on bis(monoacylglycero)phosphate.

Peter J Meikle, Stephen Duplock, David Blacklock, Phillip D Whitfield, Gemma Macintosh, John J Hopwood, Maria Fuller

Journal article  |  2008  |  Biochemical Journal

BMP [bis(monoacylglycero)phosphate] is an acidic phospholipid and a structural isomer of PG (phosphatidylglycerol), consisting of ..

Glucosylceramide accumulation is not confined to the lysosome in fibroblasts from patients with Gaucher disease.

Maria Fuller, Tina Rozaklis, Melanie Lovejoy, Krystyna Zarrinkalam, John J Hopwood, Peter J Meikle

Journal article  |  2008  |  Molecular Genetics and Metabolism

Gaucher disease (GD) is an inborn error of glycosphingolipid metabolism resulting from a deficiency of the lysosomal enzyme beta-g..

Secondary sphingolipid accumulation in a macrophage model of Gaucher disease.

Leanne K Hein, Peter J Meikle, John J Hopwood, Maria Fuller

Journal article  |  2007  |  Molecular Genetics and Metabolism

Glucosylceramide (GC) is a metabolic intermediate derived from the cellular turnover of membrane gangliosides and globosides. The ..

I-cell disease

D Brooks, C Turner, V Muller, JJ Hopwood, P Meikle

Book Chapter  |  2007

Enzyme replacement therapy in alpha-mannosidosis guinea-pigs.

Allison C Crawley, Barbara King, Thomas Berg, Peter J Meikle, John J Hopwood

Journal article  |  2006  |  Molecular Genetics and Metabolism

alpha-Mannosidosis is a lysosomal storage disorder caused by deficient activity of lysosomal alpha-mannosidase and is characterise..

Immunochemistry of lysosomal storage disorders.

Emma Parkinson-Lawrence, Maria Fuller, John J Hopwood, Peter J Meikle, Doug A Brooks

Journal article  |  2006  |  Clinical Chemistry

BACKGROUND: Lysosomal storage disorders are a group of genetic diseases, each with a broad spectrum of clinical presentation that ..

Stabilising normal and mis-sense variant alpha-glucosidase.

Revecca Kakavanos, John J Hopwood, Debbie Lang, Peter J Meikle, Doug A Brooks

Journal article  |  2006  |  FEBS Letters

alpha-Glucosidase (EC 3.2.1.3) is a lysosomal enzyme that hydrolyses alpha-1,4- and alpha-1,6-linkages of glycogen to produce free..

Newborn screening for lysosomal storage disorders.

Peter J Meikle, Dallas J Grasby, Caroline J Dean, Debbie L Lang, Michelle Bockmann, Alison M Whittle, Michael J Fietz, Henrik Simonsen, Maria Fuller, Douglas A Brooks, John J Hopwood

Journal article  |  2006  |  Molecular Genetics and Metabolism

Lysosomal storage disorders (LSD) are chronic progressive diseases that have a devastating impact on the patient and family. Most ..

Characterization of sulfated oligosaccharides in mucopolysaccharidosis type IIIA by electrospray ionization mass spectrometry.

Kerryn E Mason, Peter J Meikle, John J Hopwood, Maria Fuller

Journal article  |  2006  |  Analytical Chemistry

Heparan sulfate is a linear glycosaminoglycan with considerable structural diversity that binds a myriad of growth factors and pro..

A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates.

Maria Fuller, Ally Chau, Rachael C Nowak, John J Hopwood, Peter J Meikle

Journal article  |  2006  |  Glycobiology

Within cells, dermatan sulfate (DS) and heparan sulfate (HS) are degraded in two steps. The initial endohydrolysis of these polysa..

Detection of mucopolysaccharidosis type II by measurement of iduronate-2-sulfatase in dried blood spots and plasma samples.

Caroline J Dean, Michelle R Bockmann, John J Hopwood, Doug A Brooks, Peter J Meikle

Journal article  |  2006  |  Clinical Chemistry

BACKGROUND: Mucopolysaccharidosis type II (MPS II) is a lysosomal storage disorder related to a deficiency in the enzyme iduronate..

Common antigenicity for two glycosidases.

Revecca Kakavanos, Pierre Lehn, Isabelle Callebaut, Peter J Meikle, Emma J Parkinson-Lawrence, John J Hopwood, Doug A Brooks

Journal article  |  2006  |  FEBS Letters

Enzyme replacement therapy (ERT) has proven to be an effective therapy for some lysosomal storage disorder (LSD) patients. A poten..

Lysosomal degradation of heparin and heparan sulfate

PJ Meikle, M Fuller, JJ Hopwood

Book Chapter  |  2005

Immunoquantification of beta-glucosidase: diagnosis and prediction of severity in Gaucher disease.

Maria Fuller, Melanie Lovejoy, John J Hopwood, Peter J Meikle

Journal article  |  2005  |  Clinical Chemistry

Correlation of acid alpha-glucosidase and glycogen content in skin fibroblasts with age of onset in Pompe disease.

Kandiah Umapathysivam, John J Hopwood, Peter J Meikle

Journal article  |  2005  |  Clinica Chimica Acta

BACKGROUND: Pompe disease is an autosomal recessive disorder of glycogen metabolism resulting from a deficiency of acid alpha-gluc..

Profiling oligosaccharidurias by electrospray tandem mass spectrometry: quantifying reducing oligosaccharides.

Steven L Ramsay, Peter J Meikle, John J Hopwood, Peter R Clements

Journal article  |  2005  |  Analytical Biochemistry

A method to semiquantify urinary oligosaccharides from patients suffering from oligosaccharidurias is presented. 1-Phenyl-3-methyl..

Immunochemical analysis of CD107a (LAMP-1).

Emma J Parkinson-Lawrence, Caroline J Dean, Melissa Chang, John J Hopwood, Peter J Meikle, Doug A Brooks

Conference Proceedings  |  2005  |  Cellular Immunology

CD107a, also known as the lysosome associated membrane protein-1 (LAMP-1), is expressed largely in the endosome-lysosome membranes..

Urinary lipid profiling for the identification of fabry hemizygotes and heterozygotes.

Maria Fuller, Peter C Sharp, Tina Rozaklis, Phillip D Whitfield, David Blacklock, John J Hopwood, Peter J Meikle

Journal article  |  2005  |  Clinical Chemistry

BACKGROUND: Fabry disease is an X-linked lysosomal storage disorder resulting from a deficiency of the lysosomal hydrolase, alpha-..

Development of an assay for the detection of mucopolysaccharidosis type VI patients using dried blood-spots.

Leanne K Hein, Peter J Meikle, Caroline J Dean, Michelle R Bockmann, Dyane Auclair, John J Hopwood, Doug A Brooks

Journal article  |  2005  |  Clinica Chimica Acta

BACKGROUND: Mucopolysaccharidosis type VI (MPS VI) is a lysosomal storage disorder (LSD), which is caused by a deficiency in the e..

Prediction of neuropathology in mucopolysaccharidosis I patients.

Maria Fuller, Doug A Brooks, Marco Evangelista, Leanne K Hein, John J Hopwood, Peter J Meikle

Journal article  |  2005  |  Molecular Genetics and Metabolism

Mucopolysaccharidosis I is a lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase alpha-l-iduronidase, whi..

Replacing acid alpha-glucosidase in Pompe disease: recombinant and transgenic enzymes are equipotent, but neither completely clears glycogen from type II muscle fibers.

Nina Raben, Tokiko Fukuda, Abigail L Gilbert, Deborah de Jong, Beth L Thurberg, Robert J Mattaliano, Peter Meikle, John J Hopwood, Kunio Nagashima, Kanneboyina Nagaraju, Paul H Plotz

Journal article  |  2005  |  Molecular Therapy

Pompe disease (type II glycogen storage disease) is an autosomal recessive disorder caused by a deficiency of lysosomal acid alpha..

Laronidase treatment of mucopolysaccharidosis I.

Ed J Wraith, John J Hopwood, Maria Fuller, Peter J Meikle, Doug A Brooks

Journal article  |  2005  |  BioDrugs

The lysosomal storage disorder (LSD) mucopolysaccharidosis type I (MPS I, McKusick 25280, Hurler syndrome, Hurler-Scheie syndrome,..

Monitoring enzyme replacement therapy in Fabry disease--role of urine globotriaosylceramide.

PD Whitfield, J Calvin, S Hogg, E O'Driscoll, D Halsall, K Burling, G Maguire, N Wright, TM Cox, PJ Meikle, PB Deegan

Journal article  |  2005  |  Journal of Inherited Metabolic Disease

Anderson-Fabry disease (referred to as Fabry disease) is an X-linked disorder characterized by a deficiency of the lysosomal enzym..

Disease-specific markers for the mucopolysaccharidoses.

Maria Fuller, Tina Rozaklis, Steven L Ramsay, John J Hopwood, Peter J Meikle

Journal article  |  2004  |  Pediatric Research

Unprecedented demands are now placed on clinicians for early diagnosis as we enter into an era of advancing treatment opportunitie..

Determination of oligosaccharides and glycolipids in amniotic fluid by electrospray ionisation tandem mass spectrometry: in utero indicators of lysosomal storage diseases.

Steven L Ramsay, Irene Maire, Colleen Bindloss, Maria Fuller, Phillip D Whitfield, Monique Piraud, John J Hopwood, Peter J Meikle

Journal article  |  2004  |  Molecular Genetics and Metabolism

Prenatal diagnosis is available for many lysosomal storage disorders (LSD) using chorionic villus samples or amniocytes. Such diag..

Immunoquantification of alpha-galactosidase: evaluation for the diagnosis of Fabry disease.

Maria Fuller, Melanie Lovejoy, Doug A Brooks, Miriam L Harkin, John J Hopwood, Peter J Meikle

Journal article  |  2004  |  Clinical Chemistry

BACKGROUND: Fabry disease is an X-linked inborn error of glycosphingolipid catabolism resulting from a deficiency of the lysosomal..

Newborn screening for lysosomal storage disorders: clinical evaluation of a two-tier strategy.

Peter J Meikle, Enzo Ranieri, Henrik Simonsen, Tina Rozaklis, Steve L Ramsay, Phillip D Whitfield, Maria Fuller, Ernst Christensen, Flemming Skovby, John J Hopwood

Journal article  |  2004  |  PEDIATRICS

OBJECTIVE: To evaluate the use of protein markers using immune-quantification assays and of metabolite markers using tandem mass s..

Newborn screening for lysosomal storage disorders: Ethical and technical considerations

PJ Meikle, CJ Dean, DA Brooks, JJ Hopwood

Journal article  |  2004  |  Italian Journal of Pediatrics

Diagnosis of lysosomal storage disorders: current techniques and future directions.

Peter J Meikle, Michael J Fietz, John J Hopwood

Journal article  |  2004  |  Expert Review of Molecular Diagnostics

Lysosomal storage disorders represent a group of over 45 distinct genetic diseases. The broad spectrum of clinical presentation of..

Transthyretin interacts with the lysosome-associated membrane protein (LAMP-1) in circulation.

Melissa HY Chang, Chi T Hua, Elizabeth L Isaac, Tom Litjens, Greg Hodge, Litsa E Karageorgos, Peter J Meikle

Journal article  |  2004  |  Biochemical Journal

LAMP-1 (lysosome-associated membrane protein), a major glycoprotein present in the lysosomal membrane, constitutes up to 50% of to..

Glycosaminoglycan degradation fragments in mucopolysaccharidosis I.

Maria Fuller, Peter J Meikle, John J Hopwood

Journal article  |  2004  |  Glycobiology

The catabolism of glycosaminoglycans begins with endohydrolysis of polysaccharides to oligosaccharides followed by the sequential ..

Monitoring dose response of enzyme replacement therapy in feline mucopolysaccharidosis type VI by tandem mass spectrometry.

Allison Crawley, Steven L Ramsay, Sharon Byers, JohnJ Hopwood, Peter J Meikle

Journal article  |  2004  |  Pediatric Research

Mucopolysaccharidosis type VI is an inherited disorder of glycosaminoglycan metabolism characterized by organomegaly, corneal clou..

Lysosomal storage disorders: emerging therapeutic options require early diagnosis.

Peter J Meikle, John J Hopwood

Conference Proceedings  |  2003  |  European Journal of Pediatrics

Lysosomal storage disorders have been recognised as one of the major groups of genetic disorders affecting children and adults. Wi..

Mass spectrometry in the study of lysosomal storage disorders.

PJ Meikle, M Fuller, JJ Hopwood

Journal article  |  2003  |  Cellular and molecular biology (Noisy-le-Grand, France)

Lysosomal storage disorders represent a group of over 45 distinct genetic diseases, each one resulting from a deficiency of a part..

Determination of monosaccharides and disaccharides in mucopolysaccharidoses patients by electrospray ionisation mass spectrometry.

Steven L Ramsay, Peter J Meikle, John J Hopwood

Journal article  |  2003  |  Molecular Genetics and Metabolism

The mucopolysaccharidoses are a group of lysosomal storage disorders characterised by the storage of glycosaminoglycans. With the ..

Immortalisation of a mucopolysaccharidosis type IIIC fibroblast cell line via expression of SV40 T antigen.

Kathy Nelson, Elizabeth L Melville, Peter J Meikle, Donald S Anson

Journal article  |  2003  |  Cell Biology International

Mucopolysaccharidosis type IIIC is caused by a deficiency of acetyl-CoA: alpha-glucosaminidase-N-acetyltransferase activity. This ..

CD107a (LAMP-1) and CD107b (LAMP-2).

MHY Chang, LE Karageorgos, PJ Meikle

Journal article  |  2002  |  Journal of Biological Regulators and Homeostatic Agents

Correlation among genotype, phenotype, and biochemical markers in Gaucher disease: implications for the prediction of disease severity.

Phillip D Whitfield, Paul Nelson, Peter C Sharp, Colleen A Bindloss, Caroline Dean, Elaine M Ravenscroft, Beverley A Fong, Michael J Fietz, John J Hopwood, Peter J Meikle

Journal article  |  2002  |  Molecular Genetics and Metabolism

Gaucher disease is a lysosomal storage disorder characterized by a deficiency of the enzyme acid beta-glucosidase. The clinical ma..

Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry.

Tina Rozaklis, Steven L Ramsay, Phillip D Whitfield, Enzo Ranieri, John J Hopwood, Peter J Meikle

Journal article  |  2002  |  Clinical Chemistry

BACKGROUND: The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the..

Quantification of galactosylsphingosine in the twitcher mouse using electrospray ionization-tandem mass spectrometry.

PD Whitfield, PC Sharp, R Taylor, P Meikle

Journal article  |  2001  |  Journal of Lipid Research

Globoid cell leukodystrophy (Krabbe disease) is an autosomal recessive inherited neurodegenerative disorder caused by the deficien..

Conditional tissue-specific expression of the acid alpha-glucosidase (GAA) gene in the GAA knockout mice: implications for therapy.

N Raben, N Lu, K Nagaraju, Y Rivera, A Lee, B Yan, B Byrne, PJ Meikle, K Umapathysivam, JJ Hopwood, PH Plotz

Journal article  |  2001  |  Human Molecular Genetics

Both enzyme replacement and gene therapy of lysosomal storage disorders rely on the receptor-mediated uptake of lysosomal enzymes ..

Determination of acid alpha-glucosidase activity in blood spots as a diagnostic test for Pompe disease.

K Umapathysivam, JJ Hopwood, PJ Meikle

Journal article  |  2001  |  Clinical Chemistry

BACKGROUND: Pompe disease is an autosomal recessive disorder of glycogen metabolism that is characterized by a deficiency of the l..

Purification and characterization of recombinant human lysosomal alpha-mannosidase.

T Berg, B King, PJ Meikle, undefined Nilssen Ø, OK Tollersrud, JJ Hopwood

Journal article  |  2001  |  Molecular Genetics and Metabolism

Lysosomal alpha-mannosidase (EC 3.2.1.24) is required in the degradation of the asparagine-linked carbohydrates of glycoproteins. ..

Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry.

PD Whitfield, PC Sharp, DW Johnson, P Nelson, PJ Meikle

Journal article  |  2001  |  Molecular Genetics and Metabolism

Metachromatic leukodystrophy is an inherited disorder characterized by a deficiency of the lysosomal enzyme arylsulfatase A and th..

Determination of acid alpha-glucosidase protein: evaluation as a screening marker for Pompe disease and other lysosomal storage disorders.

K Umapathysivam, AM Whittle, E Ranieri, C Bindloss, EM Ravenscroft, OP van Diggelen, JJ Hopwood, PJ Meikle

Journal article  |  2000  |  Clinical Chemistry

BACKGROUND: In recent years, there have been significant advances in the development of enzyme replacement and other therapies for..

Saposins A, B, C, and D in plasma of patients with lysosomal storage disorders.

MH Chang, CA Bindloss, GA Grabowski, X Qi, B Winchester, JJ Hopwood, PJ Meikle

Journal article  |  2000  |  Clinical Chemistry

BACKGROUND: Early diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathology, will be critical fo..

Regulation of the lysosome-associated membrane protein in a sucrose model of lysosomal storage.

EL Isaac, LE Karageorgos, DA Brooks, JJ Hopwood, PJ Meikle

Journal article  |  2000  |  Experimental Cell Research

Lysosomal biogenesis is a complex process requiring the coordinated expression and colocalization of numerous soluble and membrane..

Altered trafficking and turnover of LAMP-1 in Pompe disease-affected cells.

PJ Meikle, M Yan, EM Ravenscroft, EL Isaac, JJ Hopwood, DA Brooks

Journal article  |  1999  |  Molecular Genetics and Metabolism

The lysosome-associated membrane protein (LAMP-1) is elevated in the cells and plasma from lysosomal storage disorder-affected ind..

Prevalence of lysosomal storage disorders.

PJ Meikle, JJ Hopwood, AE Clague, WF Carey

Journal article  |  1999  |  JAMA

CONTEXT: Lysosomal storage disorders represent a group of at least 41 genetically distinct, biochemically related, inherited disea..

Newborn screening for lysosomal storage disorders.

PJ Meikle, E Ranieri, EM Ravenscroft, CT Hua, DA Brooks, JJ Hopwood

Journal article  |  1999  |  Southeast Asian Journal of Tropical Medicine and Public Health

Lysosomal storage disorders (LSD) represent a group of over 40 distinct genetic diseases with a total incidence of approximately 1..

Pilot neonatal screening program for lysosomal storage disorders, using lamp-1.

E Ranierri, RL Gerace, EM Ravenscroft, JJ Hopwood, PJ Meikle

Journal article  |  1999  |  Southeast Asian Journal of Tropical Medicine and Public Health

We have demonstrated that the lysosome associated membrane protein (LAMP-1) is elevated in plasma from approximately 70% of lysoso..

Two-dimensional mapping and microsequencing of lysosomal proteins from human placenta.

TK Chataway, AM Whittle, MD Lewis, CA Bindloss, RC Davey, RL Moritz, RJ Simpson, JJ Hopwood, PJ Meikle

Journal article  |  1998  |  Placenta

Lysosomes degrade a wide range of macromolecules to yield monomer products which are exported out of the lysosome by a series of t..

Evaluation of the lysosome-associated membrane protein LAMP-2 as a marker for lysosomal storage disorders.

CT Hua, JJ Hopwood, SR Carlsson, RJ Harris, PJ Meikle

Journal article  |  1998  |  Clinical Chemistry

For many lysosomal storage disorders, presymptomatic detection, before the onset of irreversible pathology, will greatly improve t..

Development of a two-dimensional gel electrophoresis database of human lysosomal proteins.

TK Chataway, AM Whittle, MD Lewis, CA Bindloss, RL Moritz, RJ Simpson, JJ Hopwood, PJ Meikle

Journal article  |  1998  |  Electrophoresis

Two-dimensional gel electrophoresis databases have been generated for a range of tissue cell and fluid types, from a number of spe..

Diagnosis of lysosomal storage disorders: evaluation of lysosome-associated membrane protein LAMP-1 as a diagnostic marker.

PJ Meikle, DA Brooks, EM Ravenscroft, M Yan, RE Williams, AE Jaunzems, TK Chataway, LE Karageorgos, RC Davey, CD Boulter, SR Carlsson, JJ Hopwood

Journal article  |  1997  |  Clinical Chemistry

Early diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathologies, will be a key factor in the d..

Lysosomal biogenesis in lysosomal storage disorders.

LE Karageorgos, EL Isaac, DA Brooks, EM Ravenscroft, R Davey, JJ Hopwood, PJ Meikle

Journal article  |  1997  |  Experimental Cell Research

Lysosomal biogenesis is an orchestration of the structural and functional elements of the lysosome to form an integrated organelle..

A rapid and efficient method for concentration of small volumes of retroviral supernatant.

DL Miller, PJ Meikle, DS Anson

Journal article  |  1996  |  Nucleic Acids Research

Human acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase. Kinetic characterization and mechanistic interpretation.

PJ Meikle, AM Whittle, JJ Hopwood

Journal article  |  1995  |  Biochemical Journal

Acetyl-CoA: alpha-glucosaminide N-acetyltransferase (N-acetyltransferase) is an integral lysosomal membrane protein which catalyse..

A (1-->3,1-->4)-beta-glucan-specific monoclonal antibody and its use in the quantitation and immunocytochemical location of (1-->3,1-->4)-beta-glucans.

PJ Meikle, NJ Hoogenraad, I Bonig, AE Clarke, BA Stone

Journal article  |  1994  |  The Plant Journal

Monoclonal antibodies were raised against a (1-->3,1-->4)-beta-glucan-bovine serum albumin (BSA) conjugate. One antibody (BG1) sel..

Preliminary crystallographic analysis of a Fab specific for the O-antigen of Shigella flexneri cell surface lipopolysaccharide with and without bound saccharides.

MN Vyas, NK Vyas, PJ Meikle, B Sinnott, BM Pinto, DR Bundle, FA Quiocho

Journal article  |  1993  |  Journal of Molecular Biology

The Fab of a monoclonal anti-carbohydrate antibody, SYA/J6 (IgG3, kappa, murine), raised against the O-polysaccharide antigen of t..

THE BETA-GLUCAN SYNTHASE FROM LOLIUM-MULTIFLORUM - DETERGENT SOLUBILIZATION, PURIFICATION USING MONOCLONAL-ANTIBODIES, AND PHOTOAFFINITY-LABELING WITH A NOVEL PHOTOREACTIVE PYRIMIDINE ANALOG OF URIDINE 5'-DIPHOSPHOGLUCOSE

PJ MEIKLE, KF NG, E JOHNSON, NJ HOOGENRAAD, BA STONE

Journal article  |  1991  |  Journal of Biological Chemistry

The location of (1→3)-β-glucans in the walls of pollen tubes of Nicotiana alata using a (1→3)-β-glucan-specific monoclonal antibody

PJ Meikle, I Bonig, NJ Hoogenraad, AE Clarke, BA Stone

Journal article  |  1991  |  Planta

O-antigen biotin conjugates. Preparation and use in direct competitive enzyme immunoassays.

PJ Meikle, NM Young, DR Bundle

Journal article  |  1990  |  Journal of Immunological Methods

Bacterial O-antigens coupled to biotin were shown to function well as labelled antigens in direct enzyme immunoassay. O-polysaccha..

Preparation of polysaccharide-enzyme conjugates for competitive binding assays

PJ Meikle, DR Bundle

Journal article  |  1990  |  Glycoconjugate Journal

Fine structure of A and M antigens from Brucella biovars.

PJ Meikle, MB Perry, JW Cherwonogrodzky, DR Bundle

Journal article  |  1989  |  Infection and Immunity

Brucella A and M epitopes were found on single O-polysaccharide chains of all biotype strains of this species. Lipopolysaccharides..

Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic oligosaccharides.

DR Bundle, JW Cherwonogrodzky, MA Gidney, PJ Meikle, MB Perry, T Peters

Journal article  |  1989  |  Infection and Immunity

The paradigm that Brucella A and M epitopes are simultaneously expressed on single cells and within one antigen molecule was reinv..

Structural investigations on the mucus from six species of coral

P Meikle, GN Richards, D Yellowlees

Journal article  |  1988  |  Marine Biology

Structural determination of the oligosaccharide side chains from a glycoprotein isolated from the mucus of the coral Acropora formosa.

P Meikle, GN Richards, D Yellowlees

Journal article  |  1987  |  The Journal of biological chemistry

An extracellular mucous glycoprotein has been isolated from the hard coral Acropora formosa. The glycoprotein contains sulfated ol..