Hong He

Cannabinoids Inhibited Pancreatic Cancer via P-21 Activated Kinase 1 Mediated Pathway

Yang Yang, Huynh Nhi, Chelsea Dumesny, Kai Wang, Hong He, Mehrdad Nikfarjam

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The anti-cancer effects of cannabinoids including CBD (Cannabidiol) and THC ((-)-trans-∆9-tetrahydrocannabinol) have been reported..

Pancreatic Tumor Microenvironment

Kai Wang, Hong He

Book Chapter  |  2020  |  Advances in Experimental Medicine and Biology

The pancreatic ductal adenocarcinoma (PDAC) microenvironment is a diverse and complex milieu of immune, stromal, and tumor cells a..

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

Kai Wang, Yifan Zhan, Huynh Nhi, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2020  |  CANCER LETTERS

Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence..

Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies worldwide. All-trans retinoic acid (ATRA) has been u..

Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer

Golnaz Sharafi, Hong He, Mehrdad Nikfarjam

Journal article  |  2019  |  JOURNAL OF PANCREATIC CANCER

Background: Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes. The aim of this revi..

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

Kai Wang, Huynh Nhi, Xiao Wang, Marina Pajic, Ashleigh Parkin, Jennifer Man, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

BACKGROUND/OBJECTIVE: Pancreatic ductal adenocarcinoma (PDA) remains the most lethal malignancy due to lack of an effective treatm..

Functions of the CXC ligand family in the pancreatic tumor microenvironment

Nien-Hung Lee, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  PANCREATOLOGY

Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer prog..

p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  WORLD JOURNAL OF GASTROENTEROLOGY

Pancreatic cancer is one of the most aggressive and lethal malignancies worldwide, with a very poor prognosis and a five-year surv..

Inhibition of p21 activated kinase enhances tumour immune response and sensitizes pancreatic cancer to gemcitabine

Kai Wang, Huynh Nhi, Xiao Wang, Graham Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF ONCOLOGY

Pancreatic ductal adenocarcinoma (PDA) is one of the major types of cancer that exhibit high mortality worldwide because of the la..

Depletion of p21-activated kinase 1 up-regulates the immune system of APC(Delta 14/ ) mice and inhibits intestinal tumorigenesis

Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J Dumesny, Mauro S Sandrin, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2017  |  BMC CANCER

BACKGROUND: P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multip..