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Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associ..
PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagent..
Displaying the 2 most recent projects by Hong He.
Displaying the 47 most recent scholarly works by Hong He.
Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1.
Kai Wang, Yifan Zhan, Nhi Huynh, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Journal article | 2020 | Cancer Letters
Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence..
Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer
Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Journal article | 2019 | American Journal of Physiology-Gastrointestinal and Liver Physiology
PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines
Kai Wang, Huynh Nhi, Xiao Wang, Marina Pajic, Ashleigh Parkin, Jennifer Man, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Journal article | 2019 | American Journal of Translational Research
Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1 alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway
Huynh Nhi, John A Beutler, Arthur Shulkes, Graham S Baldwin, Hong He
Journal article | 2015 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways
Huynh Nhi, Mildred Yim, Jonathan Chernoff, Arthur Shulkes, Graham S Baldwin, Hong He
Journal article | 2013 | American Journal of Physiology - Gastrointestinal and Liver Physiology
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
H He, Y Hirokawa, A Gazit, Y Yamashita, H Mano, Y Kawakami, undefined Kawakami, CY Hsieh, HJ Kung, G Lessene, J Baell, A Levitzki, H Maruta
Journal article | 2004 | Cancer Biology & Therapy
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.
Kiyohito Mizutani, Hiroaki Miki, Hong He, Hiroshi Maruta, Tadaomi Takenawa
Journal article | 2002 | Cancer Research
Transformation of cells by the src oncogene causes dramatic changes in adhesive structures. In v-src-transformed 3Y1 rat fibroblas..
Efficient syntheses of novel C2'-alkylated ( /-)-K252a analogues.
K Tamaki, JB Shotwell, RD White, I Drutu, DT Petsch, TV Nheu, H He, Y Hirokawa, H Maruta, JL Wood
Journal article | 2001 | Organic Letters
Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K..
Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.
H He, Y Hirokawa, E Manser, L Lim, A Levitzki, H Maruta
Journal article | 2001 | Cancer Journal from Scientific American (English Edition)
BACKGROUND: Both EGF family ligands and ErbB family receptor kinases act upstream of RAS to induce mitogenesis of normal cells, su..
An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies.
H He, Y Hirokawa, A Levitzki, H Maruta
Journal article | 2000 | Cancer Journal
BACKGROUND: We previously found that both PAK, a Rac/CDC42-activated Ser/Thr kinase, and its binding partner PIX are required for ..
G proteins, phosphoinositides, and actin-cytoskeleton in the control of cancer growth.
H Maruta, H He, A Tikoo, T Vuong, M Nur-E-Kamal
Journal article | 1999 | Microscopy Research and Technique
Almost three decades have passed since actin-cytoskeleton (acto-myosin complex) was first discovered in non-muscle cells. A combin..
Cytoskeletal tumor suppressors that block oncogenic RAS signaling.
H Maruta, H He, A Tikoo, M Nur-e-Kamal
Conference Proceedings | 1999 | Annals of the New York Academy of Sciences
Several distinct peptides or drugs that block the Rho family GTPases-mediated pathways were found to suppress RAS-induced malignan..
Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.
H He, T Watanabe, X Zhan, C Huang, E Schuuring, K Fukami, T Takenawa, CC Kumar, RJ Simpson, H Maruta
Journal article | 1998 | Molecular and Cellular Biology
Oncogenic Ras mutants such as v-Ha-Ras cause a rapid rearrangement of actin cytoskeleton during malignant transformation of fibrob..
Senior Research Fellow
Surgery - Austin Health
Member Of Acabs
Australia Chinese Associations for Biomedical Sciences
Doctor of Philosophy
University of Melbourne
Master of Medicine (Cardiology)
Beijing Medical University
Bachelor of Medicine
Beijing Medical University