Hong He

Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1

Kai Wang, Yifan Zhan, Huynh Nhi, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2020  |  Cancer Letters

Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence..

Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer

Golnaz Sharafi, Hong He, Mehrdad Nikfarjam

Journal article  |  2019  |  Journal of Pancreatic Cancer

Background: Cannabinoid extracts may have anticancer properties, which can improve cancer treatment outcomes. The aim of this revi..

PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines

Kai Wang, Huynh Nhi, Xiao Wang, Marina Pajic, Ashleigh Parkin, Jennifer Man, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2019  |  American Journal of Translational Research

Functions of the CXC ligand family in the pancreatic tumor microenvironment

Nien-Hung Lee, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  Pancreatology

p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation

Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  World Journal of Gastroenterology

Inhibition of p21 activated kinase enhances tumour immune response and sensitizes pancreatic cancer to gemcitabine

Kai Wang, Huynh Nhi, Xiao Wang, Graham Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2018  |  International Journal of Oncology

Depletion of p21-activated kinase 1 up-regulates the immune system of APC(Delta 14/ ) mice and inhibits intestinal tumorigenesis

Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J Dumesny, Mauro S Sandrin, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2017  |  BMC Cancer

Inhibition of Group 1 p21-Activated Kinases Suppresses Pancreatic Stellate Cell Activation and Increases Survival of Mice with Pancreatic Cancer

Dannel Yeo, Phoebe Phillips, Graham S Baldwin, Hong He, Mehrdad Nikfarjam

Journal article  |  2017  |  International Journal of Cancer

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

Dannel Yeo, Hong He, Oneel Patel, Andrew M Lowy, Graham S Baldwin, Mehrdad Nikfarjam

Journal article  |  2016  |  BMC CANCER

Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model

Dannel Yeo, Huynh Nhi, John A Beutler, Graham S Baldwin, Hong He, Mehrdad Nikfarjam

Journal article  |  2016  |  Journal of Investigative Surgery

Up-regulation of stem cell markers by P21-activated kinase 1 contributes to 5-fluorouracil resistance of colorectal cancer

Nhi Huynh, Arthur Shulkes, Graham Baldwin, Hong He

Journal article  |  2016  |  Cancer Biology & Therapy

The Role of p21-Activated Kinases in Pancreatic Cancer

Dannel Yeo, Hong He, Graham S Baldwin, Mehrdad Nikfarjam

Journal article  |  2015  |  Pancreas

Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1 alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway

Huynh Nhi, John A Beutler, Arthur Shulkes, Graham S Baldwin, Hong He

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Total pancreatectomy for the treatment of pancreatic neoplasms

Mehrdad Nikfarjam, Nicholas Low, Laurence Weinberg, Ping Han Chia, Hong He, Christopher Christophi

Journal article  |  2014  |  ANZ Journal of Surgery

Demonstration and biological significance of a gastrin-P21-activated kinase 1 feedback loop in colorectal cancer cells

Nhi Huynh, Kevin H Liu, Mildred Yim, Arthur Shulkes, Graham S Baldwin, Hong He

Journal article  |  2014  |  Physiological Reports

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

Dannel Yeo, Huynh Nhi, John A Beutler, Christopher Christophi, Arthur Shulkes, Graham S Baldwin, Mehrdad Nikfarjam, Hong He

Journal article  |  2014  |  CANCER LETTERS

Comparison of Two Syngeneic Orthotopic Murine Models of Pancreatic Adenocarcinoma

Mehrdad Nikfarjam, Dannel Yeo, Hong He, Graham Baldwin, Theodora Fifis, Patricia Costa, Bryan Tan, Eunice Yang, Shu Wen Wen, Christopher Christophi

Journal article  |  2013  |  Journal of Investigative Surgery

P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1 alpha

Kevin H Liu, Huynh Nhi, Oneel Patel, Arthur Shulkes, Graham Baldwin, Hong He

Journal article  |  2013  |  CANCER LETTERS

p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways

Huynh Nhi, Mildred Yim, Jonathan Chernoff, Arthur Shulkes, Graham S Baldwin, Hong He

Journal article  |  2013  |  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oncogenicity of PAKs and Their Substrates

Hong He, Hiroshi Maruta

Book Chapter  |  2013

p21-activated kinases and gastrointestinal cancer

Hong He, Graham S Baldwin

Journal article  |  2013  |  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth

Hong He, Huynh Nhi, Kevin H Liu, Cathy Malcontenti-Wilson, Jin Zhu, Christopher Christophi, Arthur Shulkes, Graham S Baldwin

Journal article  |  2012  |  Cancer Letters

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways

Nhi Huynh, Kevin H Liu, Graham S Baldwin, Hong He

Journal article  |  2010  |  Biochimica et Biophysica Acta - Molecular Cell Research

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins

Hong He, Arthur Shulkes, Graham S Baldwin

Journal article  |  2008  |  Biochimica et Biophysica Acta - Molecular Cell Research

Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins

H He, GS Baldwin

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Rho GTPases and p21-activated kinase in the regulation of proliferation and apoptosis by gastrins

Hong He, Graham S Baldwin

Journal article  |  2008  |  International Journal of Biochemistry and Cell Biology

Involvement of G proteins of the Rho family in the regulation of Bcl-2-like protein expression and caspase 3 activation by Gastrins

Hong He, Mildred Yim, Kevin H Liu, Stephen C Cody, Arthur Shulkes, Graham S Baldwin

Journal article  |  2008  |  Cellular Signaling

Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway

H He, J Pannequin, JP Tantiongco, A Shulkes, GS Baldwin

Journal article  |  2005  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner

TTI Stacey, ZZ Nie, A Stewart, M Najdovska, NE Hall, H He, PA Randazzo, P Lock

Journal article  |  2004  |  Journal of Cell Science

Biological activity and ferric ion binding of fragments of glycine-extended gastrin

H He, BP Shehan, KJ Barnham, RS Norton, A Shulkes, GS Baldwin

Journal article  |  2004  |  Biochemistry

PAK is essential for RAS-induced upregulation of cyclin D1 during the G(1) to S transition

T Nheu, H He, Y Hirokawa, F Walker, J Wood, H Maruta

Journal article  |  2004  |  Cell Cycle

The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation

H He, Y Hirokawa, A Gazit, Y Yamashita, H Mano, Y Kawakami, undefined Kawakami, CY Hsieh, HJ Kung, G Lessene, J Baell, A Levitzki, H Maruta

Journal article  |  2004  |  Cancer Biology & Therapy

Method of treatment

GS BALDWIN, KJ BARNHAM, J PANNEQUIN, J TANTIONGCO, AA SHULKES, RS NORTON, S KOVAC, H HE, BP SHEHAN

Patent  |  2004

Rho family-associated kinases PAK1 and rock.

Hiroshi Maruta, Thao V Nheu, Hong He, Yumiko Hirokawa

Journal article  |  2003  |  Progress in Cell Cycle Research

Rho family GTPases (Rho, Rac and CDC42) share around 30% sequence identity with RAS family GTPases, and are essential for RAS-indu..

The K252a derivatives, inhibitors for the PAK/MLK kinase family, selectively block the growth of RAS transformants

TV Nheu, H He, Y Hirokawa, K Tamaki, L Florin, ML Schmitz, I Suzuki-Takahashi, RN Jorissen, AW Burgess, S Nishimura, J Wood, H Maruta

Journal article  |  2002  |  Cancer

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

Kiyohito Mizutani, Hiroaki Miki, Hong He, Hiroshi Maruta, Tadaomi Takenawa

Journal article  |  2002  |  Cancer Research

Transformation of cells by the src oncogene causes dramatic changes in adhesive structures. In v-src-transformed 3Y1 rat fibroblas..

Interfering with Ras signaling using membrane-permeable peptides or drugs.

Hiroshi Maruta, Hong He, Thao Nheu

Journal article  |  2002  |  Methods in molecular biology (Clifton, N.J.)

Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases

H He, A Levitzki, HJ Zhu, F Walker, A Burgess, H Maruta

Journal article  |  2001  |  Journal of Biological Chemistry

Efficient syntheses of novel C2'-alkylated ( /-)-K252a analogues.

K Tamaki, JB Shotwell, RD White, I Drutu, DT Petsch, TV Nheu, H He, Y Hirokawa, H Maruta, JL Wood

Journal article  |  2001  |  Organic Letters

Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K..

Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.

H He, Y Hirokawa, E Manser, L Lim, A Levitzki, H Maruta

Journal article  |  2001  |  Cancer Journal from Scientific American (English Edition)

BACKGROUND: Both EGF family ligands and ErbB family receptor kinases act upstream of RAS to induce mitogenesis of normal cells, su..

An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies.

H He, Y Hirokawa, A Levitzki, H Maruta

Journal article  |  2000  |  Cancer Journal

BACKGROUND: We previously found that both PAK, a Rac/CDC42-activated Ser/Thr kinase, and its binding partner PIX are required for ..

G proteins, phosphoinositides, and actin-cytoskeleton in the control of cancer growth.

H Maruta, H He, A Tikoo, T Vuong, M Nur-E-Kamal

Journal article  |  1999  |  Microscopy Research and Technique

Almost three decades have passed since actin-cytoskeleton (acto-myosin complex) was first discovered in non-muscle cells. A combin..

Cytoskeletal tumor suppressors that block oncogenic RAS signaling.

H Maruta, H He, A Tikoo, M Nur-e-Kamal

Conference Proceedings  |  1999  |  Annals of the New York Academy of Sciences

Several distinct peptides or drugs that block the Rho family GTPases-mediated pathways were found to suppress RAS-induced malignan..

Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.

H He, T Watanabe, X Zhan, C Huang, E Schuuring, K Fukami, T Takenawa, CC Kumar, RJ Simpson, H Maruta

Journal article  |  1998  |  Molecular and Cellular Biology

Oncogenic Ras mutants such as v-Ha-Ras cause a rapid rearrangement of actin cytoskeleton during malignant transformation of fibrob..

[HS1 and EMS1].

H He

Journal article  |  1997  |  Japanese Journal of Cancer and Chemotherapy

Both HS1 (hematopoiesis specific) and EMS1/ cortactin belong to a growing family of cytoskeletal SH3 proteins. Most proteins in th..

[Cytoskeletal SH3 proteins].

H Maruta, H He

Journal article  |  1995  |  Seikagaku. The Journal of Japanese Biochemical Society