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Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associ..
PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagent..
Displaying the 2 most recent projects by Hong He.
Displaying the 47 most recent scholarly works by Hong He.
Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1
Kai Wang, Yifan Zhan, Huynh Nhi, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Journal article | 2020 | Cancer Letters
Immunotherapies have not yielded significant clinical benefits for pancreatic ductal adenocarcinoma (PDA) because of the existence..
Antitumor effects of all-trans retinoic acid and its synergism with gemcitabine are associated with downregulation of p21-activated kinases in pancreatic cancer
Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Journal article | 2019 | American Journal of Physiology-Gastrointestinal and Liver Physiology
PAK inhibition by PF-3758309 enhanced the sensitivity of multiple chemotherapeutic reagents in patient-derived pancreatic cancer cell lines
Kai Wang, Huynh Nhi, Xiao Wang, Marina Pajic, Ashleigh Parkin, Jennifer Man, Graham S Baldwin, Mehrdad Nikfarjam, Hong He
Journal article | 2019 | American Journal of Translational Research
Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1 alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway
Huynh Nhi, John A Beutler, Arthur Shulkes, Graham S Baldwin, Hong He
Journal article | 2015 | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways
Huynh Nhi, Mildred Yim, Jonathan Chernoff, Arthur Shulkes, Graham S Baldwin, Hong He
Journal article | 2013 | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
H He, Y Hirokawa, A Gazit, Y Yamashita, H Mano, Y Kawakami, undefined Kawakami, CY Hsieh, HJ Kung, G Lessene, J Baell, A Levitzki, H Maruta
Journal article | 2004 | Cancer Biology & Therapy
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.
Kiyohito Mizutani, Hiroaki Miki, Hong He, Hiroshi Maruta, Tadaomi Takenawa
Journal article | 2002 | Cancer Research
Transformation of cells by the src oncogene causes dramatic changes in adhesive structures. In v-src-transformed 3Y1 rat fibroblas..
Efficient syntheses of novel C2'-alkylated ( /-)-K252a analogues.
K Tamaki, JB Shotwell, RD White, I Drutu, DT Petsch, TV Nheu, H He, Y Hirokawa, H Maruta, JL Wood
Journal article | 2001 | Organic Letters
Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K..
Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.
H He, Y Hirokawa, E Manser, L Lim, A Levitzki, H Maruta
Journal article | 2001 | Cancer Journal from Scientific American (English Edition)
BACKGROUND: Both EGF family ligands and ErbB family receptor kinases act upstream of RAS to induce mitogenesis of normal cells, su..
An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies.
H He, Y Hirokawa, A Levitzki, H Maruta
Journal article | 2000 | Cancer Journal
BACKGROUND: We previously found that both PAK, a Rac/CDC42-activated Ser/Thr kinase, and its binding partner PIX are required for ..
G proteins, phosphoinositides, and actin-cytoskeleton in the control of cancer growth.
H Maruta, H He, A Tikoo, T Vuong, M Nur-E-Kamal
Journal article | 1999 | Microscopy Research and Technique
Almost three decades have passed since actin-cytoskeleton (acto-myosin complex) was first discovered in non-muscle cells. A combin..
Cytoskeletal tumor suppressors that block oncogenic RAS signaling.
H Maruta, H He, A Tikoo, M Nur-e-Kamal
Conference Proceedings | 1999 | Annals of the New York Academy of Sciences
Several distinct peptides or drugs that block the Rho family GTPases-mediated pathways were found to suppress RAS-induced malignan..
Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation.
H He, T Watanabe, X Zhan, C Huang, E Schuuring, K Fukami, T Takenawa, CC Kumar, RJ Simpson, H Maruta
Journal article | 1998 | Molecular and Cellular Biology
Oncogenic Ras mutants such as v-Ha-Ras cause a rapid rearrangement of actin cytoskeleton during malignant transformation of fibrob..
Senior Research Fellow
Surgery - Austin Health
Member Of Acabs
Australia Chinese Associations for Biomedical Sciences
Master of Professional Accounting
Doctor of Philosophy
University of Melbourne
Master of Medicine (Cardiology)
Beijing Medical University
Bachelor of Medicine
Beijing Medical University