John Archer

Paroxysmal fast activity is a biomarker of treatment response in deep brain stimulation for Lennox-Gastaut syndrome

Linda J Dalic, Aaron EL Warren, Chloe Spiegel, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John S Archer

Journal article  |  2022  |  EPILEPSIA

OBJECTIVE: Epilepsy treatment trials typically rely on seizure diaries to determine seizure frequency, but these are time-consumin..

Cognition, adaptive skills and epilepsy disability/severity in patients with Lennox-Gastaut syndrome undergoing deep brain stimulation for epilepsy in the ESTEL trial

Linda J Dalic, Aaron EL Warren, Charles B Malpas, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John S Archer

Journal article  |  2022  |  SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

PURPOSE: We previously reported seizure and EEG outcomes of the ESTEL study (Electrical Stimulation of Thalamus for Epilepsy of Le..

The Optimal Target and Connectivity for Deep Brain Stimulation in Lennox-Gastaut Syndrome

Aaron EL Warren, Linda J Dalic, Kristian J Bulluss, Annie Roten BAppSci, Wesley Thevathasan, John S Archer

Journal article  |  2022  |  ANNALS OF NEUROLOGY

OBJECTIVE: Deep brain stimulation (DBS) can reduce seizures in Lennox-Gastaut syndrome (LGS). However, little is known about the o..

DBS of Thalamic Centromedian Nucleus for Lennox-Gastaut Syndrome (ESTEL Trial)

Linda J Dalic, Aaron EL Warren, Kristian J Bulluss, Wesley Thevathasan, Annie Roten, Leonid Churilov, John S Archer

Journal article  |  2021  |  ANNALS OF NEUROLOGY

OBJECTIVE: Prior uncontrolled studies have reported seizure reductions following deep brain stimulation (DBS) in patients with Len..

Protocol summary and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial

Alistair Nichol, Rinaldo Bellomo, Bridget Ady, Niklas Nielsen, Carol Hodgson, Rachael Parke, Shay McGuinness, Markus Skrifvars, Dion Stub, Stephen Bernard, Fabio Taccone, John Archer, Ary Serpa Neto, Tony Trapani, Kate Ainscough, Anna Hunt, Jim Kutsogiannis, Glenn M Eastwood

Journal article  |  2021  |  CRITICAL CARE AND RESUSCITATION

Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital ..

Expanding the clinical and radiological phenotypes of leukoencephalopathy due to biallelic HMBS mutations

Chloe A Stutterd, Alexa Kidd, Chris Florkowski, Edward Janus, Miriam Fanjul, Anthony Raizis, Teddy Y Wu, John Archer, Richard J Leventer, David J Amor, Vesna Lukic, Melanie Bahlo, Paul Gow, Paul J Lockhart, Marjo S van Der Knaap, Martin B Delatycki

Journal article  |  2021  |  AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Pathogenic heterozygous variants in HMBS encoding the enzyme hydroxymethylbilane synthase (HMBS), also known as porphobilinogen de..

The severe epilepsy syndromes of infancy: A population-based study

Katherine B Howell, Jeremy L Freeman, Mark T Mackay, Michael C Fahey, John Archer, Samuel F Berkovic, Eunice Chan, Gabriel Dabscheck, Stefanie Eggers, Michael Hayman, James Holberton, Rodney W Hunt, Susan E Jacobs, Andrew J Kornberg, Richard J Leventer, Simone Mandelstam, Jacinta M McMahon, Heather C Mefford, Julie Panetta, Jessica Riseley, et al.

Journal article  |  2021  |  EPILEPSIA

OBJECTIVE: To study the epilepsy syndromes among the severe epilepsies of infancy and assess their incidence, etiologies, and outc..

Cortex leads the thalamic centromedian nucleus in generalized epileptic discharges in Lennox-Gastaut syndrome

Linda J Dalic, Aaron EL Warren, James C Young, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John S Archer

Journal article  |  2020  |  EPILEPSIA

Objective We aimed to assess the roles of the cortex and thalamus (centromedian nucleus [CM]) during epileptic activity in Lennox‐..

Combined Isoflurane-Remifentanil Anaesthesia Permits Resting-State fMRI in Children with Severe Epilepsy and Intellectual Disability

Aaron EL Warren, Andrew Davidson, Simon J Vogrin, A Simon Harvey, Catherine Bailey, Linda J Dalic, David F Abbott, John S Archer

Journal article  |  2020  |  BRAIN TOPOGRAPHY

Head motion is a significant barrier to functional MRI (fMRI) in patients who are unable to tolerate awake scanning, including you..

Targeting the centromedian thalamic nucleus for deep brain stimulation

Aaron EL Warren, Linda J Dalic, Wesley Thevathasan, Annie Roten, Kristian J Bulluss, John Archer

Journal article  |  2020  |  JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

OBJECTIVES: Deep brain stimulation (DBS) of the centromedian thalamic nucleus (CM) is an emerging treatment for multiple brain dis..