Hayley Newton

Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria.

Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow

Journal article  |  2020  |  Current Opinion in Microbiology

Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells...

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  Infection and Immunity

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

Lysosomal degradation products induce Coxiella burnetii virulence

Patrice Newton, David R Thomas, Shawna CO Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B Madhamshettiwar, Laura E Edgington-Mitchell, Kaylene J Simpson, Craig R Roy, Hayley J Newton

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB..

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton

Journal article  |  2020  |  Infection and Immunity

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..

SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly.

Mebratu A Bitew, Janine Hofmann, David P De Souza, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2019  |  Cellular Microbiology

Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrop..

Meso-tartrate inhibits intracellular replication of Coxiella burnetii, the causative agent of the zoonotic disease Q fever.

Mebratu A Bitew, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2019  |  Pathogens and Disease

The zoonotic disease Q fever, caused by the intracellular bacterium Coxiella burnetii, remains a global health threat due to its h..

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Cameron C Oppy, Leila Jebeli, Miku Kuba, Clare V Oates, Richard Strugnell, Laura E Edgington-Mitchell, Miguel A Valvano, Elizabeth L Hartland, Hayley J Newton, Nichollas E Scott

Journal article  |  2019  |  mSphere

O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-G..

The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium

Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell

Journal article  |  2019  |  Biochemical Journal

Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..

Coxiella burnetii utilizes both glutamate and glucose during infection with glucose uptake mediated by multiple transporters

Miku Kuba, Nitika Neha, David P De Souza, Saravanan Dayalan, Joshua PM Newson, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2019  |  BIOCHEMICAL JOURNAL

Loss of O-linked protein glycosylation in Burkholderia cenocepacia impairs biofilm formation and siderophore production via alteration of quorum sensing regulation

Cameron Oppy, Leila Jebeli, Miku Kuba, Clare Oates, Richard Strugnell, Laura Edgington-Mitchell, Miguel Valvano, Elizabeth Hartland, Hayley Newton, Nichollas Scott

Journal article  |  2019

Abstract O -linked protein glycosylation is a conserved feature of the Burkholderia genus. For Burkholderia cenocepacia , the addi..

SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole

Nicole Lau, Amanda L Haeberle, Brittany J O'Keeffe, Eleanor A Latomanski, Jean Celli, Hayley J Newton, Leigh A Knodler

Journal article  |  2019  |  PLOS Pathogens

The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), utilizes two type III secretion systems (..

Taming the Triskelion: Bacterial Manipulation of Clathrin

Eleanor A Latomanski, Hayley J Newton

Journal article  |  2019  |  Microbiology and Molecular Biology Reviews

Genetic Manipulation of Non-pneumophila Legionella: Protocols Developed for Legionella longbeachae.

Elizabeth Korevaar, Chen Ai Khoo, Hayley J Newton

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Current biomedical research into Legionnaires' disease is dominated by studies of Legionella pneumophila, largely because this pat..

Coxiella burnetii: Hiding in Plain Sight

Patrice Newton, Miku Kuba, Bhavna Padmanabhan, Eleanor A Latomanski, Hayley J Newton

Book Chapter  |  2019

Biology and Pathogenesis of Legionella

Hayley J Newton, Elizabeth L Hartland, Matthias P Machner

Journal article  |  2018  |  Frontiers in Cellular and Infection Microbiology

Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Salmonella Typhimurium

Asma Ul Husna, Nancy Wang, Simon A Cobbold, Hayley J Newton, Dianna M Hocking, Jonathan J Wilksch, Timothy A Scott, Mark R Davies, Jay C Hinton, Jai J Tree, Trevor Lithgow, Malcolm J McConville, Richard A Strugnell

Journal article  |  2018  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Dot/Icm-Translocated Proteins Important for Biogenesis of the Coxiella burnetii-Containing Vacuole Identified by Screening of an Effector Mutant Sublibrary

Emerson Crabill, Whitman B Schofield, Hayley J Newton, Andrew L Goodman, Craig R Roy

Journal article  |  2018  |  Infection and Immunity

Interaction between autophagic vesicles and the Coxiella-containing vacuole requires CLTC (clathrin heavy chain)

Eleanor A Latomanski, Hayley J Newton

Journal article  |  2018  |  Autophagy

De novo NAD synthesis is required for intracellular replication of Coxiella burnetii, the causative agent of the neglected zoonotic disease Q fever

MA Bitew, CA Khoo, N Neha, DP De Souza, D Tull, NK Wawegama, HJ Newton, FM Sansom

Journal article  |  2018  |  Journal of Biological Chemistry

© 2018 Bitew et al. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. Coxiell..

Beginning to Understand the Role of the Type IV Secretion System Effector Proteins in Coxiella burnetii Pathogenesis

Anja Luehrmann, Hayley J Newton, Matteo Bonazzi

Journal article  |  2018  |  Current topics in microbiology and immunology

A Farnesylated Coxiella burnetii Effector Forms a Multimeric Complex at the Mitochondrial Outer Membrane during Infection

Laura F Fielden, Jennifer H Moffatt, Yilin Kang, Michael J Baker, Chen Ai Khoo, Craig R Roy, Diana Stojanovski, Hayley J Newton

Journal article  |  2017  |  Infection and Immunity

Targeting mitochondria: how intravacuolar bacterial pathogens manipulate mitochondria

Laura F Fielden, Yilin Kang, Hayley J Newton, Diana Stojanovski

Journal article  |  2017  |  Cell and Tissue Research

The Effector Cig57 Hijacks FCHO-Mediated Vesicular Trafficking to Facilitate Intracellular Replication of Coxiella burnetii

Eleanor A Latomanski, Patrice Newton, Chen Ai Khoo, Hayley J Newton

Journal article  |  2016  |  PLOS PATHOGENS

Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase II In Vitro

Talita D Fernandes, Larissa D Cunha, Juliana M Ribeiro, Liliana M Massis, Djalma S Lima-Junior, Hayley J Newton, Dario S Zamboni

Journal article  |  2016  |  INFECTION AND IMMUNITY

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole (vol 7, e01327, 2016)

Lara J Kohler, Shawna CO Reed, Shireen A Sarraf, David D Arteaga, Hayley J Newton, Craig R Roy

Journal article  |  2016  |  MBIO

Applying Fluorescence Resonance Energy Transfer (FRET) to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing

Patrice Newton, Eleanor A Latomanski, Hayley J Newton

Journal article  |  2016  |  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole

Lara J Kohler, Shawna R Reed, Shireen A Sarraf, David D Arteaga, Hayley J Newton, Craig R Roy

Journal article  |  2016  |  mBio

Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella-Containing Vacuole (vol 7, e01127, 2016)

Lara J Kohler, Shawna CO Reed, Shireen A Sarraf, David D Arteaga, Hayley J Newton, Craig R Roy

Journal article  |  2016  |  mBio

Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA

Larissa D Cunha, Juliana M Ribeiro, Talita D Fernandes, Liliana M Massis, Chen Ai Khoo, Jennifer H Moffatt, Hayley J Newton, Craig R Roy, Dario S Zamboni

Journal article  |  2015  |  NATURE COMMUNICATIONS

Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires

Rebecca E Wood, Patrice Newton, Eleanor A Latomanski, Hayley J Newton

Journal article  |  2015  |  INFECTION AND IMMUNITY

Coxiella burnetii: turning hostility into a home

Jennifer H Moffatt, Patrice Newton, Hayley J Newton

Journal article  |  2015  |  CELLULAR MICROBIOLOGY

Post-modern pathogens: surprising activities of translocated effectors from E-coil and Legionella

Jaclyn S Pearson, Ying Zhang, Hayley J Newton, Elizabeth L Hartland

Journal article  |  2015  |  CURRENT OPINION IN MICROBIOLOGY

Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila

Patrice Riedmaier, Fiona M Sansom, Trifina Sofian, Travis Beddoe, Ralf Schuelein, Hayley J Newton, Elizabeth L Hartland

Journal article  |  2014  |  Biochemical Journal

A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis

Hayley J Newton, Lara J Kohler, Justin A McDonough, Morayma Temoche-Diaz, Emerson Crabill, Elizabeth L Hartland, Craig R Roy

Journal article  |  2014  |  PLoS Pathogens

The Dot/Icm Effector SdhA Is Necessary for Virulence of Legionella pneumophila in Galleria mellonella and A/J Mice

Clare R Harding, Charlotte A Stoneham, Ralf Schuelein, Hayley Newton, Clare V Oates, Elizabeth L Hartland, Gunnar N Schroeder, Gad Frankel

Journal article  |  2013  |  Infection and Immunity

Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.

JA McDonough, HJ Newton, S Klum, R Swiss, H Agaisse, CR Roy

Journal article  |  2013  |  mBio

Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole

Hayley J Newton, Justin A McDonough, Craig R Roy

Journal article  |  2013  |  PLoS One

Host Pathways Important for Coxiella burnetii Infection Revealed by Genome-Wide RNA Interference Screening

Justin A McDonough, Hayley J Newton, Scott Klum, Rachel Swiss, Herve Agaisse, Craig R Roy

Journal article  |  2013  |  MBIO

The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii

Camille A Hardiman, Justin A McDonough, Hayley J Newton, Craig R Roy

Journal article  |  2012  |  Biochemical Society Transactions

Coxiella burnetii Secretion Systems

Justin A McDonough, Hayley J Newton, Craig R Roy

Journal article  |  2012  |  Advances in Experimental Medicine and Biology

The Coxiella burnetii Dot/Icm System Creates a Comfortable Home through Lysosomal Renovation

Hayley J Newton, Craig R Roy

Journal article  |  2011  |  MBIO

The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication

Kimberly L Carey, Hayley J Newton, Anja Luehrmann, Craig R Roy

Journal article  |  2011  |  PLoS Pathogens

Legionella pneumophila Strain 130b Possesses a Unique Combination of Type IV Secretion Systems and Novel Dot/Icm Secretion System Effector Proteins

Gunnar N Schroeder, Nicola K Petty, Aurelie Mousnier, Clare R Harding, Adam J Vogrin, Bryan Wee, Norman K Fry, Timothy G Harrison, Hayley J Newton, Nicholas R Thomson, Scott A Beatson, Gordon Dougan, Elizabeth L Hartland, Gad Frankel

Journal article  |  2010  |  Journal of Bacteriology

The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication

M Lomma, D Dervins-Ravault, M Rolando, T Nora, HJ Newton, FM Sansom, T Sahr, L Gomez-Valero, M Jules, EL Hartland, C Buchrieser

Journal article  |  2010  |  Cellular Microbiology

Two Novel Point Mutations in Clinical Staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent Infection

Wei Gao, Kyra Chua, John K Davies, Hayley J Newton, Torsten Seemann, Paul F Harrison, Natasha E Holmes, Hyun-Woo Rhee, Jong-In Hong, Elizabeth L Hartland, Timothy P Stinear, Benjamin P Howden

Journal article  |  2010  |  PLoS Pathogens

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-kappa B p65

Hayley J Newton, Jaclyn S Pearson, Luminita Badea, Michelle Kelly, Mark Lucas, Gavan Holloway, Kylie M Wagstaff, Michelle A Dunstone, Joan Sloan, James C Whisstock, James B Kaper, Roy M Robins-Browne, David A Jans, Gad Frankel, Alan D Phillips, Barbara S Coulson, Elizabeth L Hartland

Journal article  |  2010  |  PLoS Pathogens

Molecular Pathogenesis of Infections Caused by Legionella pneumophila

Hayley J Newton, Desmond KY Ang, Ian R van Driel, Elizabeth L Hartland

Journal article  |  2010  |  Clinical Microbiology Reviews

Analysis of the Legionella longbeachae Genome and Transcriptome Uncovers Unique Strategies to Cause Legionnaires' Disease

Christel Cazalet, Laura Gomez-Valero, Christophe Rusniok, Mariella Lomma, Delphine Dervins-Ravault, Hayley J Newton, Fiona M Sansom, Sophie Jarraud, Nora Zidane, Laurence Ma, Christiane Bouchier, Jerome Etienne, Elizabeth L Hartland, Carmen Buchrieser

Journal article  |  2010  |  PLoS Genetics

Molecular detection of Legionella: moving on from mip

Stacey FY Yong, Shin Hwa Tan, Joanne Wee, Jing Jhi Tee, Fiona M Sansom, Hayley J Newton, Elizabeth L Hartland

Journal article  |  2010  |  Frontiers in Microbiology

Shiga Toxin-producing Escherichia coli Strains Negative for Locus of Enterocyte Effacement

Hayley J Newton, Joan Sloan, Dieter M Bulach, Torsten Seemann, Cody C Allison, Marija Tauschek, Roy M Robins-Browne, James C Paton, Thomas S Whittam, Adrienne W Paton, Elizabeth L Hartland

Journal article  |  2009  |  Emerging Infectious Diseases

Infections caused by nonpneumophila species of Legionella

Ivana Gobin, Peter R Newton, Elizabeth L Hartland, Hayley J Newton

Journal article  |  2009  |  Reviews in Medical Microbiology

Significant role for ladC in initiation of Legionella pneumophila infection

Hayley J Newton, Fiona M Sansom, Jenny Dao, Christel Cazalet, Holger Bruggemann, Christiane Albert-Weissenberger, Carmen Buchrieser, Nicholas P Cianciotto, Elizabeth L Hartland

Journal article  |  2008  |  Infection and Immunity

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila - Substrate specificity and requirement for virulence

Fiona M Sansom, Patrice Riedmaier, Hayley J Newton, Michelle A Dunstone, Christa E Mueller, Holger Stephan, Emma Byres, Travis Beddoe, Jamie Rossjohn, Peter J Cowan, Anthony JF d'Apice, Simon C Robson, Elizabeth L Hartland

Journal article  |  2008  |  Journal of Biological Chemistry

Sell repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar trafficking

Hayley J Newton, Fiona M Sansom, Jenny Dao, Adrian D McAlister, Joan Sloan, Nicholas P Cianciotto, Elizabeth L Hartland

Journal article  |  2007  |  Infection and immunity

Sel1 repeat protein LpnE is a Legionella pneumophila virulence determinant that influences vacuolar trafficking

HJ Newton, FM Sansom, J Dao, AD McAlister, J Sloan, NP Cianciotto, EL Hartland

Journal article  |  2007  |  Infection and Immunity

ABSTRACT The environmental pathogen Legionella pneumophila possesses five proteins with Sel1 repeats (SLRs) from th..

A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila

Fiona M Sansom, Hayley J Newton, Sandra Crikis, Nicholas P Cianciotto, Peter J Cowan, Anthony JF d'Apice, Elizabeth L Hartland

Journal article  |  2007  |  Cellular Microbiology

Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry

HJ Newton, FM Sansom, V Bennett-Wood, EL Hartland

Journal article  |  2006  |  Infection and Immunity

Role of Legionella pneumophila-specific genes in pathogenesis

Hayley J Newton, Fiona M Sansom, Vicki Bennett-Wood, Elizabeth L Hartland

Conference Proceedings  |  2006  |  LEGIONELLA: STATE OF THE ART 30 YEARS AFTER ITS RECOGNITION

Eukaryotic-like proteins of Legionella pneumophila as potential virulence factors

Fiona M Sansom, Hayley J Newton, Elizabeth L Hartland

Conference Proceedings  |  2006  |  LEGIONELLA: STATE OF THE ART 30 YEARS AFTER ITS RECOGNITION

Contribution of long polar fimbriae to the virulence of rabbit-specific enteropathogenic Escherichia coli

HJ Newton, J Sloan, V Bennett-Wood, LM Adams, RM Robins-Browne, EL Hartland

Journal article  |  2004  |  Infection and Immunity