Hayley Newton

Proteomic Identification of Coxiella burnetii Effector Proteins Targeted to the Host Cell Mitochondria During Infection.

Laura F Fielden, Nichollas E Scott, Catherine S Palmer, Chen Ai Khoo, Hayley J Newton, Diana Stojanovski

Journal article  |  2020  |  Molecular & Cellular Proteomics

Modulation of the host cell is integral to the survival and replication of microbial pathogens. Several intracellular bacterial pa..

Interfering with Autophagy: The Opposing Strategies Deployed by Legionella pneumophila and Coxiella burnetii Effector Proteins

David R Thomas, Patrice Newton, Nicole Lau, Hayley J Newton

Journal article  |  2020  |  Frontiers in Cellular and Infection Microbiology

Autophagy is a fundamental and highly conserved eukaryotic process, responsible for maintaining cellular homeostasis and releasing..

Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria

Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow

Journal article  |  2020  |  Current Opinion in Microbiology

Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells...

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  Infection and Immunity

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

Lysosomal degradation products induce Coxiella burnetii virulence

Patrice Newton, David R Thomas, Shawna CO Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B Madhamshettiwar, Laura E Edgington-Mitchell, Kaylene J Simpson, Craig R Roy, Hayley J Newton

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB..

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton

Journal article  |  2020  |  Infection and Immunity

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..

SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly.

Mebratu A Bitew, Janine Hofmann, David P De Souza, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2019  |  Cellular Microbiology

Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrop..

Meso-tartrate inhibits intracellular replication of Coxiella burnetii, the causative agent of the zoonotic disease Q fever.

Mebratu A Bitew, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2019  |  Pathogens and Disease

The zoonotic disease Q fever, caused by the intracellular bacterium Coxiella burnetii, remains a global health threat due to its h..

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Cameron C Oppy, Leila Jebeli, Miku Kuba, Clare V Oates, Richard Strugnell, Laura E Edgington-Mitchell, Miguel A Valvano, Elizabeth L Hartland, Hayley J Newton, Nichollas E Scott

Journal article  |  2019  |  mSphere

O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-G..

The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium

Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Iain D Hay, Simon A Cobbold, Mark R Davies, Malcolm J McConville, Trevor Lithgow, Richard A Strugnell

Journal article  |  2019  |  Biochemical Journal

Key physiological differences between bacterial and mammalian metabolism provide opportunities for the development of novel antimi..