Hayley Newton

Characterisation of putative lactate synthetic pathways of Coxiella burnetii

Janine Hofmann, Mebratu A Bitew, Miku Kuba, David P De Souza, Hayley J Newton, Fiona M Sansom

Journal article  |  2021  |  PLOS ONE

The zoonotic pathogen Coxiella burnetii, the causative agent of the human disease Q fever, is an ever-present danger to global pub..

Proteomic Identification of Coxiella burnetii Effector Proteins Targeted to the Host Cell Mitochondria During Infection

Laura F Fielden, Nichollas E Scott, Catherine S Palmer, Chen Ai Khoo, Hayley J Newton, Diana Stojanovski

Journal article  |  2021  |  MOLECULAR & CELLULAR PROTEOMICS

Modulation of the host cell is integral to the survival and replication of microbial pathogens. Several intracellular bacterial pa..

Interfering with Autophagy: The Opposing Strategies Deployed by Legionella pneumophila and Coxiella burnetii Effector Proteins

David R Thomas, Patrice Newton, Nicole Lau, Hayley J Newton

Journal article  |  2020  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Autophagy is a fundamental and highly conserved eukaryotic process, responsible for maintaining cellular homeostasis and releasing..

Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria

Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow

Journal article  |  2020  |  CURRENT OPINION IN MICROBIOLOGY

Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells...

Proteomic identification of Coxiella burnetii effector proteins targeted to the host cell mitochondria during infection

Laura Fielden, Nichollas Scott, Catherine Palmer, Chen Ai Khoo, Hayley Newton, Diana Stojanovski

Journal article  |  2020

Modulation of the host cell is integral to the survival and replication of microbial pathogens. Several intracellular bacterial pa..

EirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetii

Miku Kuba, Nitika Neha, Patrice Newton, Yi Wei Lee, Vicki Bennett-Wood, Abderrahman Hachani, David P De Souza, Brunda Nijagal, Saravanan Dayalan, Dedreia Tull, Malcolm J McConville, Fiona M Sansom, Hayley J Newton

Journal article  |  2020  |  INFECTION AND IMMUNITY

The zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious c..

Lysosomal degradation products induce Coxiella burnetii virulence

Patrice Newton, David R Thomas, Shawna CO Reed, Nicole Lau, Bangyan Xu, Sze Ying Ong, Shivani Pasricha, Piyush B Madhamshettiwar, Laura E Edgington-Mitchell, Kaylene J Simpson, Craig R Roy, Hayley J Newton

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-like vacuole through activation of a Dot/Icm-type IVB..

Biogenesis of the Spacious Coxiella-Containing Vacuole Depends on Host Transcription Factors TFEB and TFE3

Bhavna Padmanabhan, Laura F Fielden, Abderrahman Hachani, Patrice Newton, David R Thomas, Hyun-Jung Cho, Chen Ai Khoo, Diana Stojanovski, Craig R Roy, Nichollas E Scott, Hayley J Newton

Journal article  |  2020  |  INFECTION AND IMMUNITY

Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates inside the lysosome-derived Coxiella-containing ..

SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly

Mebratu A Bitew, Janine Hofmann, David P De Souza, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom

Journal article  |  2020  |  CELLULAR MICROBIOLOGY

Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrop..

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Cameron C Oppy, Leila Jebeli, Miku Kuba, Clare V Oates, Richard Strugnell, Laura E Edgington-Mitchell, Miguel A Valvano, Elizabeth L Hartland, Hayley J Newton, Nichollas E Scott

Journal article  |  2019  |  MSPHERE

O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-G..