Patrick Reading

Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes.

Daniel Enosi Tuipulotu, Shouya Feng, Abhimanu Pandey, Anyang Zhao, Chinh Ngo, Anukriti Mathur, Jiwon Lee, Cheng Shen, Daniel Fox, Yansong Xue, Callum Kay, Max Kirkby, Jordan Lo Pilato, Nadeem O Kaakoush, Daryl Webb, Melanie Rug, Avril Ab Robertson, Melkamu B Tessema, Stanley Pang, Daniel Degrandi, et al.

Journal article  |  2023  |  EMBO J

Moraxella catarrhalis is an important human respiratory pathogen and a major causative agent of otitis media and chronic obstructi..

Mouse guanylate-binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo.

Melkamu B Tessema, Daniel Enosi Tuipulotu, Clare V Oates, Andrew G Brooks, Si Ming Man, Sarah L Londrigan, Patrick C Reading

Journal article  |  2023  |  Immunol Cell Biol

Many interferon (IFN)-stimulated genes are upregulated within host cells following infection with influenza and other viruses. Whi..

Cutting Edge: High-Dose Live Attenuated Influenza Vaccines Elicit Pulmonary Tissue-Resident Memory CD8( ) T Cells in the Face of Pre-Existing Humoral Immunity

Ming ZM Zheng, Svenja Fritzlar, Zhongfang Wang, Tiong Kit Tan, Katherine Kedzierska, Alain Townsend, Patrick C Reading, Linda M Wakim

Journal article  |  2022  |  JOURNAL OF IMMUNOLOGY

In this study, we investigated how pre-existing Ab immunity to influenza virus established from prior immunizations affects the de..

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

Fernando Villalon-Letelier, Rubaiyea Farrukee, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict..

Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets

Lara SU Schwab, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Anshupa Sahu, Yi-Mo Deng, Jean Moselen, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Intracellular RIG-I receptors represent key innate sensors of RNA virus infection, and RIG-I activation results in the induction o..

Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

Shouya Feng, Daniel Enosi Tuipulotu, Abhimanu Pandey, Weidong Jing, Cheng Shen, Chinh Ngo, Melkamu B Tessema, Fei-Ju Li, Daniel Fox, Anukriti Mathur, Anyang Zhao, Runli Wang, Klaus Pfeffer, Daniel Degrandi, Masahiro Yamamoto, Patrick C Reading, Gaetan Burgio, Si Ming Man

Journal article  |  2022  |  Nat Commun

Inflammasomes are cytosolic signaling complexes capable of sensing microbial ligands to trigger inflammation and cell death respon..

Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection

Lara SU Schwab, Rubaiyea Farrukee, Jean Francois Eleouet, Marie Anne Rameix-Welti, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF INFECTIOUS DISEASES

Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Tre..

Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution

Rubaiyea Farrukee, Vithiagaran Gunalan, Sebastian Maurer-Stroh, Patrick C Reading, Aeron C Hurt

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These c..

Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection

Lara SU Schwab, Fernando Villalon-Letelier, Melkamu B Tessema, Sarah L Londrigan, Andrew G Brooks, Aeron Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies u..

Infection with different human influenza A subtypes affects the period of susceptibility to secondary bacterial infections in ferrets

Edin J Mifsud, Rubaiyea Farrukee, Aeron C Hurt, Patrick C Reading, Ian G Barr

Journal article  |  2022  |  FEMS Microbes

Abstract It is well-established that influenza virus infections predispose individuals to secondary bacterial infec..