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Prof

Patrick Reading

Honorary
Microbiology and Immunology
science & technology
life sciences & biomedicine
animals
mice
humans
immunology
virology
orthomyxoviridae infections
mice, inbred c57bl
Patrick Reading's Profile Picture
Prof

Patrick Reading

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Virology
Patrick Reading's Profile Picture
Prof

Patrick Reading

 
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Projects

Displaying the 10 most recent projects by Patrick Reading.

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Developing a new broad spectrum anti-viral target

2020 - 2022
Active
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IDENTIFICATION OF HOST RESTRICTION FACTORS THAT BLOCK RESPIRATORY VIRUS INFECTION

Following inhalation, respiratory viruses can infect and grow in airway epithelial cells. Although immune cells such as macrophages are also..

2018 - 2021
Active
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IDENTIFICATION OF HOST FACTORS THAT RESTRICT INFLUENZA VIRUS REPLICATION IN MACROPHAGES

Influenza virus infects different cells in the airways, including immune cells (macrophages) and non-immune cells (epithelial cells). Epithe..

2015 - 2017
Completed
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Mechanisms of respiratory virus induced pneumococcal infection in the middle ear.

Streptococcus pneumoniae (the pneumococcus) is a common bacterium that temporarily lives in the nose of most young children, usually not cau..

2013 - 2016
Completed
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STEALTH LIPOSOMES AND SIRNA FOR THE TREATMENT OF RESPITORY VIRAL INFECTIONS

Respiratory infections caused by Influenza and Respiratory syncytial virus cause significant hospitalisations and deaths within the communit..

2013 - 2015
Completed
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Antibody-Dependent Cellular Cytotoxicity based immunity to Influenza

Pandemic influenza causes widespread disease, death and panic. Producing vaccines to new strains takes time. There is a need to produce vacc..

2013 - 2015
Completed
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How influenza virus infects immune cells

Influenza virus is a leading cause of respiratory infection and death worldwide. Infection of humans is initiated when the virus contacts ce..

2012 - 2014
Completed
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Natural inhibitors of influenza infection

This study will characterize the ability of soluble proteins in airway secretions to recognize and destroy influenza viruses. As many of our..

2012 - 2014
Completed
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Novel receptors for influenza virus

Innate immune mechanisms are vital components of early host defence against pathogens. In this proposal we will define novel components of t..

2008 - 2010
Completed
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THE ANTIVIRAL ACTIVITY OF THE LONG CHAIN PENTRAXIN PTX3 AGAINST INFLUENZA

2007 - 2007
Completed

13

Projects

Project Types

11

Research Grant

1

Internal Research Grant

1

Research Contracts

Scholarly Works

Displaying the 10 most recent scholarly works by Patrick Reading.

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TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI Insight

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

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Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

Journal article  |  2021  |  Clinical & Translational Immunology

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

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Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2020  |  Viruses

The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in hum..

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Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response

James G Bedford, Giuseppe Infusini, Laura F Dagley, Fernando Villalon-Letelier, Ming ZM Zheng, Vicki Bennett-Wood, Patrick C Reading, Linda M Wakim

Journal article  |  2020  |  Frontiers in Immunology

Exosomes are extracellular vesicles secreted by cells that have an important biological function in intercellular communication by..

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Influenza A virus interactions with macrophages: Lessons from epithelial cells

Tina Meischel, Fernando Villalon-Letelier, Philippa M Saunders, Patrick C Reading, Sarah L Londrigan

Journal article  |  2020  |  Cellular Microbiology

Influenza viruses are an important cause of respiratory infection worldwide. In humans, infection with seasonal influenza A virus ..

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IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages

Sarah L Londrigan, Linda M Wakim, Jeffrey Smith, Anne J Haverkate, Andrew G Brooks, Patrick C Reading

Journal article  |  2020  |  Virology

Abortive infection of macrophages serves as a "dead end" for most seasonal influenza A virus (IAV) strains, and it is likely to co..

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Characterization of substitutions in the neuraminidase of A(H7N9) influenza viruses selected following serial passage in the presence of different neuraminidase inhibitors

R Farrukee, J Butler, PC Reading, AC Hurt

Journal article  |  2019  |  Antiviral Research

Avian A(H7N9) infections in humans have been reported in China since 2013 and are of public health concern due to their severity a..

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Downregulation of MHC Class I Expression by Influenza A and B Viruses

Marios Koutsakos, Hamish EG McWilliam, Turgut E Aktepe, Svenja Fritzlar, Patricia T Illing, Nicole A Mifsud, Anthony W Purcell, Steve Rockman, Patrick C Reading, Julian P Vivian, Jamie Rossjohn, Andrew G Brooks, Jason M Mackenzie, Justine D Mintern, Jose A Villadangos, Thi HO Nguyen, Katherine Kedzierska

Journal article  |  2019  |  Frontiers in Immunology

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Unraveling the role of the MOV10 RNA helicase during influenza A virus infection

Fernando Villalon-Letelier, Patrick C Reading

Journal article  |  2019  |  Biochemical Journal

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Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo

Joel Z Ma, Wy Ching Ng, Luke Zappia, Linden J Gearing, Moshe Olshansky, Kym Pham, Karey Cheong, Arthur Hsu, Stephen J Turner, Odilia Wijburg, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2019  |  Journal of Virology

134

Scholarly Works

Keyword Analysis

Immunology
Clinical Health (organs, Diseases and Abnormal Conditions)
Medical Microbiology
Clinical (organs, Diseases and Abnormal Conditions)
Biochemistry and Cell Biology
Expanding Knowledge
Microbiology
Indigenous Health
Public Health (excl. Specific Population Health)
Cardiovascular Medicine and Haematology

Credentials

Positions

Honorary

Microbiology and Immunology

Member

Australian Society for Immunology

Education

Doctor of Philosophy

University of Melbourne

Links

International Linkages

Istituto Clinico Humanitas

Italy