Patrick Reading

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

Keith J Chappell, Francesca L Mordant, Zheyi Li, Danushka K Wijesundara, Paula Ellenberg, Julia A Lackenby, Stacey TM Cheung, Naphak Modhiran, Michael S Avumegah, Christina L Henderson, Kym Hoger, Paul Griffin, Jillian Bennet, Luca Hensen, Wuji Zhang, Thi HO Nguyen, Sara Marrero-Hernandez, Kevin J Selva, Amy W Chung, Mai H Tran, et al.

Journal article  |  2021  |  LANCET INFECTIOUS DISEASES

BACKGROUND: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essentia..

IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication.

Tina Meischel, Svenja Fritzlar, Fernando Villalon-Letelier, Melkamu B Tessema, Andrew G Brooks, Patrick C Reading, Sarah L Londrigan

Journal article  |  2021  |  J Virol

Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We..

MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells.

Fernando Villalón-Letelier, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2021  |  mBio

Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reduci..

A second external quality assessment of isolation and identification of influenza viruses in cell culture in the Asia Pacific region highlights improved performance by participating laboratories

Vivian KY Leung, Yi-Mo Deng, Angela Todd, Heidi Peck, Iwona Buettner, Tasoula Zakis, Kanta Subbarao, Ian G Barr, Karen Nahapetyan, Francis Y Inbanathan, Magdi Samaan, Patrick C Reading

Journal article  |  2021  |  JOURNAL OF CLINICAL VIROLOGY

Influenza viruses must be amplified in cell culture for detailed antigenic analysis and for phenotypic assays assessing susceptibi..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2

Daniel Watterson, Danushka K Wijesundara, Naphak Modhiran, Francesca L Mordant, Zheyi Li, Michael S Avumegah, Christopher Ld McMillan, Julia Lackenby, Kate Guilfoyle, Geert van Amerongen, Koert Stittelaar, Stacey TM Cheung, Summa Bibby, Mallory Daleris, Kym Hoger, Marianne Gillard, Eve Radunz, Martina L Jones, Karen Hughes, Ben Hughes, et al.

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ..

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2020  |  VIRUSES-BASEL

The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in hum..

Airway Exosomes Released During Influenza Virus Infection Serve as a Key Component of the Antiviral Innate Immune Response

James G Bedford, Giuseppe Infusini, Laura F Dagley, Fernando Villalon-Letelier, Ming ZM Zheng, Vicki Bennett-Wood, Patrick C Reading, Linda M Wakim

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Exosomes are extracellular vesicles secreted by cells that have an important biological function in intercellular communication by..

Influenza A virus interactions with macrophages: Lessons from epithelial cells

Tina Meischel, Fernando Villalon-Letelier, Philippa M Saunders, Patrick C Reading, Sarah L Londrigan

Journal article  |  2020  |  CELLULAR MICROBIOLOGY

Influenza viruses are an important cause of respiratory infection worldwide. In humans, infection with seasonal influenza A virus ..