John Wentworth

Glycaemic trajectory and predictors of suboptimal glycaemic control in people with type 2 diabetes

Nipuni P Pathiraja, Peter G Colman, John M Wentworth

Journal article  |  2020  |  Internal Medicine Journal

We aimed to describe the glycaemic trajectory and define characteristics associated with suboptimal glycaemic control in the type ..

Validation in the general population of a C-peptide estimate equation to measure beta cell function in recent-onset type 1 diabetes (Sep, 10.1007/s00592-020-01604-7, 2020)

Joanna Wang, Naiara Bediaga, Roberto Mallone, Etienne Larger, Leonard C Harrison, John M Wentworth

Journal article  |  2020  |  Acta Diabetologica

Authors would like to correct the first name of author Joanne Wang from Joanne to Joanna.

Validation in the general population of a C-peptide estimate equation to measure beta cell function in recent-onset type 1 diabetes

Joanne Wang, Naiara Bediaga, Roberto Mallone, Etienne Larger, Leonard C Harrison, John M Wentworth

Journal article  |  2020  |  Acta Diabetologica

Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes

P Augustine, R Gent, J Louise, M Taranto, M Penno, R Linke, JJ Couper

Journal article  |  2020  |  Diabetic Medicine

AIMS: To measure pancreatic area and exocrine function in young children with recent-onset Type 1 diabetes to determine whether th..

Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study

Megan AS Penno, Helena Oakey, Priya Augustine, Mario Taranto, Simon C Barry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Lynne C Giles, Mark Harris, Aveni Haynes, Kelly McGorm, Grant Morahan, Claire Morbey, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, et al.

Journal article  |  2020  |  Pediatric Diabetes

AIM: We aimed to monitor pancreatic exocrine function longitudinally in relation to the development of islet autoimmunity and type..

OR32-06 Opportunistic Assessment of Pituitary Gland with Routine MRI and PET/CT Can Guide in Earlier and Increased Identification of Hypophysitis in Patients Treated with Combination Checkpoint Inhibitors

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal of the Endocrine Society

Abstract Background: Hypophysitis is one of the commonly reported adverse events related to immune checkpoint inhib..

SUN-127 Diagnostic Challenges Associated with the Rising Incidence of Endocrine Toxicity in the Era of Combination Immunotherapy

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal of the Endocrine Society

Abstract Background: Immune checkpoint blockade is now established as standard of care in several malignancies. Tri..

Clinical trial data validate the C-peptide estimate model in type 1 diabetes

John M Wentworth, Naiara G Bediaga, Stephen E Gitelman, Carmela Evans-Molina, Peter A Gottlieb, Peter G Colman, Michael J Haller, Leonard C Harrison

Journal article  |  2020  |  Diabetologia

The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial

John M Wentworth, Peter G Colman

Journal article  |  2020  |  Diabetes Obesity and Metabolism

The methionine aminopeptidase 2 (MetAP2) inhibitor ZGN-1061 lowered weight and improved glucose in preclinical studies. We sought ..

The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening

Laura M Jacobsen, Laura Bocchino, Carmella Evans-Molina, Linda DiMeglio, Robin Goland, Darrell M Wilson, Mark A Atkinson, Tandy Aye, William E Russell, John M Wentworth, David Boulware, Susan Geyer, Jay M Sosenko

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed ..