John Wentworth

Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.

William E Russell, Brian N Bundy, Mark S Anderson, Laura A Cooney, Stephen E Gitelman, Robin S Goland, Peter A Gottlieb, Carla J Greenbaum, Michael J Haller, Jeffrey P Krischer, Ingrid M Libman, Peter S Linsley, S Alice Long, Sandra M Lord, Daniel J Moore, Wayne V Moore, Antoinette M Moran, Andrew B Muir, Philip Raskin, Jay S Skyler, et al.

Journal article  |  2023  |  Diabetes Care

OBJECTIVE: Previous studies showed that inhibiting lymphocyte costimulation reduces declining β-cell function in individuals newly..

Decreased occurrence of ketoacidosis and preservation of beta cell function in relatives screened and monitored for type 1 diabetes in Australia and New Zealand

John M Wentworth, Helena Oakey, Maria E Craig, Jennifer J Couper, Fergus J Cameron, Elizabeth A Davis, Antony R Lafferty, Mark Harris, Benjamin J Wheeler, Craig Jefferies, Peter G Colman, Leonard C Harrison

Journal article  |  2022  |  PEDIATRIC DIABETES

AIMS: Islet autoantibody screening of infants and young children in the Northern Hemisphere, together with semi-annual metabolic m..

Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)-study protocol for a phase 2, randomized, placebo controlled trial

M Waibel, HE Thomas, JM Wentworth, JJ Couper, RJ MacIsaac, FJ Cameron, M So, B Krishnamurthy, MC Doyle, TW Kay

Journal article  |  2022  |  TRIALS

BACKGROUND: Type 1 diabetes (T1D) places an extraordinary burden on individuals and their families, as well as on the healthcare s..

Mental Health During Late Pregnancy and Postpartum in Mothers With and Without Type 1 Diabetes: The ENDIA Study

Madeleine Hall, Helena Oakey, Megan AS Penno, Kelly McGorm, Amanda J Anderson, Pat Ashwood, Peter G Colman, Maria E Craig, Elizabeth A Davis, Mark Harris, Leonard C Harrison, Aveni Haynes, Claire Morbey, Richard O Sinnott, Georgia Soldatos, Peter J Vuillermin, John M Wentworth, Rebecca L Thomson, Jennifer J Couper

Journal article  |  2022  |  DIABETES CARE

OBJECTIVE: Pregnancy and type 1 diabetes are each associated with increased anxiety and depression, but the combined impact on wel..

Screening for Type 1 Diabetes in the General Population: A Status Report and Perspective

Emily K Sims, Rachel EJ Besser, Colin Dayan, Cristy Geno Rasmussen, Carla Greenbaum, Kurt J Griffin, William Hagopian, Mikael Knip, Anna E Long, Frank Martin, Chantal Mathieu, Marian Rewers, Andrea K Steck, John M Wentworth, Stephen S Rich, Olga Kordonouri, Anette-Gabriele Ziegler, Kevan C Herold

Journal article  |  2022  |  DIABETES

Most screening programs to identify individuals at risk for type 1 diabetes have targeted relatives of people living with the dise..

Cytotoxicity-Related Gene Expression and Chromatin Accessibility Define a Subset of CD4( ) T Cells That Mark Progression to Type 1 Diabetes

Naiara G Bediaga, Alexandra L Garnham, Gaetano Naselli, Esther Bandala-Sanchez, Natalie L Stone, Joanna Cobb, Jessica E Harbison, John M Wentworth, Annette-G Ziegler, Jennifer J Couper, Gordon K Smyth, Leonard C Harrison

Journal article  |  2022  |  DIABETES

Type 1 diabetes in children is heralded by a preclinical phase defined by circulating autoantibodies to pancreatic islet antigens...

A Long-Term Evaluation of Facebook for Recruitment and Retention in the ENDIA Type 1 Diabetes Pregnancy-Birth Cohort Study.

Kelly J McGorm, James D Brown, Rebecca L Thomson, Helena Oakey, Belinda Moore, Alexandra Hendry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Mark Harris, Leonard C Harrison, Aveni Haynes, Georgia Soldatos, Peter Vuillermin, John M Wentworth, Jennifer J Couper, Megan AS Penno, undefined ENDIA Study Group

Journal article  |  2022  |  J Diabetes Sci Technol

BACKGROUND: The Environmental Determinants of Islet Autoimmunity (ENDIA) study is an Australia-wide pregnancy-birth cohort study f..

Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation

Esther Bandala-Sanchez, Alexandra J Roth-Schulze, Helena Oakey, Megan AS Penno, Naiara G Bediaga, Gaetano Naselli, Katrina M Ngui, Alannah D Smith, Dexing Huang, Enrique Zozaya-Valdes, Rebecca L Thomson, James D Brown, Peter J Vuillermin, Simon C Barry, Maria E Craig, William D Rawlinson, Elizabeth A Davis, Mark Harris, Georgia Soldatos, Peter G Colman, et al.

Journal article  |  2022  |  DIABETES RESEARCH AND CLINICAL PRACTICE

AIMS: Studies of the gut microbiome have focused on its bacterial composition. We aimed to characterize the gut fungal microbiome ..

Characterising the age-dependent effects of risk factors on type 1 diabetes progression

Michelle So, Colin O'Rourke, Alyssa Ylescupidez, Henry T Bahnson, Andrea K Steck, John M Wentworth, Brittany S Bruggeman, Sandra Lord, Carla J Greenbaum, Cate Speake

Journal article  |  2022  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Age is known to be one of the most important stratifiers of disease progression in type 1 diabetes. However, what..

HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants

Jamie L Felton, David Cuthbertson, Megan Warnock, Kuldeep Lohano, Farah Meah, John M Wentworth, Jay Sosenko, Carmella Evans-Molina

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Methods to identify individuals at highest risk for type 1 diabetes are essential for the successful implementati..