John Wentworth

Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes.

P Augustine, R Gent, J Louise, M Taranto, M Penno, R Linke, JJ Couper, undefined ENDIA Study Group

Journal article  |  2020  |  Diabetic Medicine

AIMS: To measure pancreatic area and exocrine function in young children with recent-onset Type 1 diabetes to determine whether th..

Changes in pancreatic exocrine function in young at-risk children followed to islet autoimmunity and type 1 diabetes in the ENDIA study

Megan AS Penno, Helena Oakey, Priya Augustine, Mario Taranto, Simon C Barry, Peter G Colman, Maria E Craig, Elizabeth A Davis, Lynne C Giles, Mark Harris, Aveni Haynes, Kelly McGorm, Grant Morahan, Claire Morbey, William D Rawlinson, Richard O Sinnott, Georgia Soldatos, Rebecca L Thomson, Peter J Vuillermin, John M Wentworth, et al.

Journal article  |  2020  |  Pediatric Diabetes

AIM: We aimed to monitor pancreatic exocrine function longitudinally in relation to the development of islet autoimmunity and type..

Clinical trial data validate the C-peptide estimate model in type 1 diabetes

John M Wentworth, Naiara G Bediaga, Stephen E Gitelman, Carmela Evans-Molina, Peter A Gottlieb, Peter G Colman, Michael J Haller, Leonard C Harrison

Journal article  |  2020  |  Diabetologia

The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial

John M Wentworth, Peter G Colman

Journal article  |  2020  |  Diabetes, Obesity and Metabolism

The methionine aminopeptidase 2 (MetAP2) inhibitor ZGN-1061 lowered weight and improved glucose in preclinical studies. We sought ..

The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

Laura M Jacobsen, Laura Bocchino, Carmella Evans-Molina, Linda DiMeglio, Robin Goland, Darrell M Wilson, Mark A Atkinson, Tandy Aye, William E Russell, John M Wentworth, David Boulware, Susan Geyer, Jay M Sosenko

Journal article  |  2020  |  Diabetologia

AIMS/HYPOTHESIS: Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed ..

Factors that predict glycaemic response to sodium-glucose linked transporter (SGLT) inhibitors.

Amy L Harding, Naiara Bediaga, Anna Galligan, Peter G Colman, Spiros Fourlanos, John M Wentworth

Journal article  |  2020  |  Internal Medicine Journal

AIM: This study aimed to determine the clinical and biochemical variables associated with change in HbA1c in patients with type 2 ..

Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter I Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang, et al.

Journal article  |  2020  |  Pediatric Diabetes

Background: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compar..

Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm

Leonard C Harrison, John M Wentworth

Book Chapter  |  2020

Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: A prospective cohort study

Jessica E Harbison, Alexandra J Roth-Schulze, Lynne C Giles, Cuong D Tran, Katrina M Ngui, Megan A Penno, Rebecca L Thomson, John M Wentworth, Peter G Colman, Maria E Craig, Grant Morahan, Anthony T Papenfuss, Simon C Barry, Leonard C Harrison, Jennifer J Couper

Journal article  |  2019  |  Pediatric Diabetes

Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study

Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter Ian Lipkin, Grant Morahan, Claire Morbey, Ignatius CN Pang, Anthony T Papenfuss, et al.

Journal article  |  2019  |  Open Forum Infectious Diseases

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

John M Wentworth, Naiara G Bediaga, Lynne C Giles, Mario Ehlers, Stephen E Gitelman, Susan Geyer, Carmella Evans-Molina, Leonard C Harrison

Journal article  |  2019  |  Diabetologia

Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.

Maria J Redondo, Andrea K Steck, Jay Sosenko, Mark Anderson, Peter Antinozzi, Aaron Michels, John M Wentworth, Mark A Atkinson, Alberto Pugliese, Susan Geyer, undefined Type 1 Diabetes TrialNet Study Group

Journal article  |  2018  |  Diabetes Care

OBJECTIVE: The type 2 diabetes-associated alleles at the TCF7L2 locus mark a type 1 diabetes phenotype characterized by single isl..

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes

Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Minimal variation of the plasma lipidome after delayed processing of neonatal cord blood

John M Wentworth, Naiara G Bediaga, Megan AS Penno, Esther Bandala-Sanchez, Komal N Kanojia, Konstantinos A Kouremenos, Jennifer J Couper, Leonard C Harrison

Journal article  |  2018  |  Metabolomics

Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.

Federica Vecchio, Nicola Lo Buono, Angela Stabilini, Laura Nigi, Matthew J Dufort, Susan Geyer, Paola Maria Rancoita, Federica Cugnata, Alessandra Mandelli, Andrea Valle, Pia Leete, Francesca Mancarella, Peter S Linsley, Lars Krogvold, Kevan C Herold, Helena Elding Larsson, Sarah J Richardson, Noel G Morgan, Knut Dahl-Jørgensen, Guido Sebastiani, et al.

Journal article  |  2018  |  JCI Insight

BACKGROUND: Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while thei..

A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.

Maria J Redondo, Susan Geyer, Andrea K Steck, Seth Sharp, John M Wentworth, Michael N Weedon, Peter Antinozzi, Jay Sosenko, Mark Atkinson, Alberto Pugliese, Richard A Oram, undefined Type 1 Diabetes TrialNet Study Group

Conference Proceedings  |  2018  |  Diabetes Care

OBJECTIVE: We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity ..

Detailed Description of Change in Serum Cholesterol Profile with Incremental Weight Loss After Restrictive Bariatric Surgery

Geraldine J Ooi, Arul Earnest, Lisa Doyle, Cheryl Laurie, John M Wentworth, Ken Sikaris, Carel W le Roux, Paul R Burton, Paul E O'Brien, Wendy A Brown

Journal article  |  2018  |  Obesity Surgery

Cord Blood CD8( ) T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner

Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison

Journal article  |  2018  |  Frontiers in Immunology

Diabetes Outcomes More than a Decade Following Sustained Weight Loss After Laparoscopic Adjustable Gastric Band Surgery

John M Wentworth, Chloe Cheng, Cheryl Laurie, Stewart Skinner, Paul R Burton, Wendy A Brown, Paul E O'Brien

Journal article  |  2018  |  Obesity Surgery

Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis

Jocelyn Sietsma Penington, Megan AS Penno, Katrina M Ngui, Nadim J Ajami, Alexandra J Roth-Schulze, Stephen A Wilcox, Esther Bandala-Sanchez, John M Wentworth, Simon C Barry, Cheryl Y Brown, Jennifer J Couper, Joseph F Petrosino, Anthony T Papenfuss, Leonard C Harrison

Journal article  |  2018  |  Scientific Reports

TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.

Maria J Redondo, Susan Geyer, Andrea K Steck, Jay Sosenko, Mark Anderson, Peter Antinozzi, Aaron Michels, John Wentworth, Ping Xu, Alberto Pugliese, undefined Type 1 Diabetes TrialNet Study Group

Conference Proceedings  |  2018  |  Diabetes Care

OBJECTIVE: The phenotypic diversity of type 1 diabetes suggests heterogeneous etiopathogenesis. We investigated the relationship o..

CD52 inhibits Toll-like receptor activation of NF-kappa B and triggers apoptosis to suppress inflammation

Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O'Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison

Journal article  |  2018  |  Cell Death & Differentiation

Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release

JM Wentworth, J-G Zhang, E Bandala-Sanchez, G Naselli, R Liu, M Ritchie, GK Smyth, PE O'Brien, LC Harrison

Journal article  |  2017  |  International Journal of Obesity

The Role of Age and Excess Body Mass Index in Progression to Type 1 Diabetes in At-Risk Adults.

Christine T Ferrara, Susan M Geyer, Carmella Evans-Molina, Ingrid M Libman, Dorothy J Becker, John M Wentworth, Antoinette Moran, Stephen E Gitelman, Maria J Redondo, undefined Type 1 Diabetes TrialNet Study Group

Journal article  |  2017  |  The Journal of Clinical Endocrinology & Metabolism

Background: Given the global rise in both type 1 diabetes incidence and obesity, the role of body mass index (BMI) on type 1 diabe..

Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials

Brandon M Nathan, David Boulware, Susan Geyer, Mark A Atkinson, Peter Colman, Robin Goland, William Russell, John M Wentworth, Darrell M Wilson, Carmella Evans-Molina, Diane Wherrett, Jay S Skyler, Antoinette Moran, Jay M Sosenko

Journal article  |  2017  |  Diabetes Care

OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose..

Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?

Andrea K Steck, Ping Xu, Susan Geyer, Maria J Redondo, Peter Antinozzi, John M Wentworth, Jay Sosenko, Suna Onengut-Gumuscu, Wei-Min Chen, Stephen S Rich, Alberto Pugliese

Journal article  |  2017  |  The Journal of Clinical Endocrinology & Metabolism

Cost-effectiveness of gastric band surgery for overweight but not obese adults with type 2 diabetes in the US

John M Wentworth, Kim M Dalziel, Paul E O'Brien, Paul Burton, Frackson Shaba, Philip M Clarke, Neda Laiteerapong, Wendy A Brown

Journal article  |  2017  |  Journal of Diabetes and its Complications

Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components

GJ Ooi, L Doyle, T Tie, JM Wentworth, C Laurie, A Earnest, MA Cowley, K Sikaris, CW le Roux, PR Burton, PE O'Brien, WA Brown

Journal article  |  2017  |  International Journal of Obesity

Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease

Geraldine J Ooi, Paul R Burton, Lisa Doyle, John M Wentworth, Prithi S Bhathal, Ken Sikaris, Michael A Cowley, Stuart K Roberts, William Kemp, Arul Earnest, Paul E O'Brien, Wendy A Brown

Journal article  |  2017  |  Obesity Surgery

Solitary pituitary metastasis from HER2-positive breast cancer

Jeremy Kam, Jeffrey Kam, G Bruce Mann, Claire Phillips, John M Wentworth, James King, Geoffrey J Lindeman

Journal article  |  2017  |  Asia-Pacific Journal of Clinical Oncology

Five-Year Outcomes of a Randomized Trial of Gastric Band Surgery in Overweight but Not Obese People With Type 2 Diabetes

John M Wentworth, Paul Burton, Cheryl Laurie, Wendy A Brown, Paul E O'Brien

Journal article  |  2017  |  Diabetes Care

Modified thresholds for fibrosis risk scores in nonalcoholic fatty liver disease are necessary in the obese

Geraldine J Ooi, Paul R Burton, Lisa Doyle, John M Wentworth, Prithi S Bhathal, Ken Sikaris, Michael A Cowley, Stuart K Roberts, William Kemp, Paul E O'Brien, Wendy A Brown

Journal article  |  2017  |  Obesity Surgery

Factors associated with insulin-induced weight gain in an Australian type 2 diabetes outpatient clinic

R Yadgar-Yalda, PG Colman, S Fourlanos, JM Wentworth

Journal article  |  2016  |  Internal Medicine Journal

G(M3) ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women

JM Wentworth, G Naselli, K Ngui, GK Smyth, R Liu, PE O'Brien, C Bruce, J Weir, M Cinel, PJ Meikle, LC Harrison

Journal article  |  2016  |  International Journal of Obesity

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome

Andrew J Murphy, Michael J Kraakman, Helene L Kammoun, Dragana Dragoljevic, Man KS Lee, Kate E Lawlor, John M Wentworth, Ajithkumar Vasanthakumar, Motti Gerlic, Lachlan W Whitehead, Ladina DiRago, Louise Cengia, Rachael M Lane, Donald Metcalf, James E Vince, Leonard C Harrison, Axel Kallies, Benjamin T Kile, Ben A Croker, Mark A Febbraio, et al.

Journal article  |  2016  |  Cell Metabolism

The Effect of Weight Loss on Indigenous Australians with Diabetes: a study of Feasibility, Acceptability and Effectiveness of Laparoscopic Adjustable Gastric Banding

Paul E O'Brien, Dawn E DeWitt, Cheryl Laurie, Leah Brennan, John M Wentworth, Margaret Anderson, Kerin O'Dea, Felicia Dean, Andrew Smith, David P Dalton

Journal article  |  2016  |  Obesity Surgery

Gastric Band Surgery Leads to Improved Insulin Secretion in Overweight People with Type 2 Diabetes.

John M Wentworth, Julie Playfair, Cheryl Laurie, Wendy A Brown, Paul Burton, Jonathan E Shaw, Paul E O'Brien

Journal article  |  2015  |  Obesity Surgery

BACKGROUND: We aimed to determine the effects of laparoscopic adjustable gastric band (LAGB) on beta-cell function in overweight p..

Recent advances in type 1 diabetes

Mervyn Kyi, John M Wentworth, Alison J Nankervis, Spiros Fourlanos, Peter G Colman

Journal article  |  2015  |  Medical Journal of Australia

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury, Shimpei Kawamoto, Sidonia Fagarasan, Lisa A Mielke, Shoukat Afshar-Sterle, Seth L Masters, Susumu Nakae, Hirohisa Saito, John M Wentworth, Peng Li, Wei Liao, Warren J Leonard, Gordon K Smyth, Wei Shi, Stephen L Nutt, Shigeo Koyasu, et al.

Journal article  |  2015  |  Nature Immunology

A randomised controlled trial of high dose vitamin D in recent-onset type 2 diabetes

Shirley Elkassaby, Leonard C Harrison, Namita Mazzitelli, John M Wentworth, Peter G Colman, Timothy Spelman, Spiros Fourlanos

Journal article  |  2014  |  Diabetes Research and Clinical Practice

Maturity-onset diabetes of the young type 5 in a family with diabetes and mild kidney disease diagnosed by whole exome sequencing

JM Wentworth, V Lukic, M Bahlo, M Finlay, C Nguyen, G Morahan, LC Harrison

Journal article  |  2014  |  Internal Medicine Journal

Effect of Testosterone Treatment on Glucose Metabolism in Men With Type 2 Diabetes: A Randomized Controlled Trial

Emily J Gianatti, Philippe Dupuis, Rudolf Hoermann, Boyd J Strauss, John M Wentworth, Jeffrey D Zajac, Mathis Grossmann

Journal article  |  2014  |  DIABETES CARE

Multidisciplinary diabetes care with and without bariatric surgery in overweight people: a randomised controlled trial

John M Wentworth, Julie Playfair, Cheryl Laurie, Matthew E Ritchie, Wendy A Brown, Paul Burton, Jonathan E Shaw, Paul E O'Brien

Journal article  |  2014  |  The Lancet Diabetes & Endocrinology

Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes

Sarah A Price, Alexandra Gorelik, Spiros Fourlanos, Peter G Colman, John M Wentworth

Journal article  |  2014  |  Obesity Research & Clinical Practice

Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm

LC Harrison, JM Wentworth

Book Chapter  |  2013

Antigen-Based Vaccination and Prevention of Type 1 Diabetes

Leonard C Harrison, John M Wentworth, Yuxia Zhang, Esther Bandala-Sanchez, Ralph M Boehmer, Alana M Neale, Natalie L Stone, Gaetano Naselli, Julian J Bosco, Priscilla Auyeung, Maryam Rashidi, Petra Augstein, Grant Morahan

Journal article  |  2013  |  Current Diabetes Reports

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes

Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, Leonard C Harrison

Journal article  |  2013  |  BMC PEDIATRICS

GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes

LM Cornall, ML Mathai, DH Hryciw, AC Simcocks, PE O'Brien, JM Wentworth, AJ McAinch

Journal article  |  2013  |  Molecular and Cellular Endocrinology

Cross-Platform Urine Metabolomics of Experimental Hyperglycemia in Type 2 Diabetes

Liesbet Temmerman

Journal article  |  2013  |  Journal of Diabetes and Metabolism

Increase in visceral and subcutaneous abdominal fat in men with prostate cancer treated with androgen deprivation therapy

EJ Hamilton, E Gianatti, BJ Strauss, J Wentworth, D Lim-Joon, D Bolton, JD Zajac, M Grossmann

Journal article  |  2011  |  Clinical Endocrinology

Pro-Inflammatory CD11c( )CD206( ) Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

John M Wentworth, Gaetano Naselli, Wendy A Brovvn, Lisa Doyle, Belinda Phipson, Gordon K Smyth, Martin Wabitsch, Paul E O'Brien, Leonard C Harrison

Journal article  |  2010  |  Diabetes

Reappraising the stereotypes of diabetes in the modern diabetogenic environment.

John M Wentworth, Spiros Fourlanos, Leonard C Harrison

Journal article  |  2009  |  Nature Reviews Endocrinology

The prevailing concentration of blood glucose is a result of the integrated regulation of insulin secretion and insulin action. Ne..

Type 1 diabetes: lessons for other autoimmune diseases?

Leonard C Harrison, Margo C Honeyman, Grant Morahan, John M Wentworth, Shirley Elkassaby, Peter G Colman, Spiros Fourlanos

Journal article  |  2008  |  Journal of Autoimmunity

Type 1 diabetes (T1D) satisfies many of the criteria for an autoimmune disease. The impact of the environment to promote the devel..

Reappraising the stereotypes of diabetes

LC Harrison, JM Wentworth, S Elkassaby, S Fourlanos, CJ Greenbaum

Book Chapter  |  2008

Does insulin resistance need resistin?

John M Wentworth, Leonard C Harrison

Journal article  |  2007  |  The Journal of Clinical Endocrinology & Metabolism

Effectiveness and side effects of thiazolidinediones for type 2 diabetes: real-life experience from a tertiary hospital

Z Hussein, JM Wentworth, AJ Nankervis, J Proietto, PG Colman

Journal article  |  2004  |  Medical Journal of Australia