MBBS (Hon I) 1994, University of Queensland PhD 2000, University of Cambridge FRACP (Endocrinology) 2004 Currently working on prediction and prevention of type 1 diabetes. Heads Type1Screen diabetes antibody screening program and the Australia/New Zealand node of Type 1 Diabetes TrialNet.
Research interests include clinical trials of immune therapy to prevent type 1 diabetes and laboratory research to improve understanding of its pathogenesis and treatment.
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Evaluation Of A Community-Led Nutrition And Lifestyle Program For Weight Loss And Metaboli..
The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in ..
The risk of progression to type 1 diabetes is highly variable in individuals with multiple..
Factors that predict glycaemic response to sodium-glucose linked transporter (SGLT) inhibi..
Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers wit..
Displaying the most recent project by John Wentworth.
Displaying the 55 most recent scholarly works by John Wentworth.
The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial
John M Wentworth, Peter G Colman
Journal article | 2020 | Diabetes, Obesity and Metabolism
The methionine aminopeptidase 2 (MetAP2) inhibitor ZGN-1061 lowered weight and improved glucose in preclinical studies. We sought ..
The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.
Laura M Jacobsen, Laura Bocchino, Carmella Evans-Molina, Linda DiMeglio, Robin Goland, Darrell M Wilson, Mark A Atkinson, Tandy Aye, William E Russell, John M Wentworth, David Boulware, Susan Geyer, Jay M Sosenko
Journal article | 2020 | Diabetologia
AIMS/HYPOTHESIS: Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed ..
Factors that predict glycaemic response to sodium-glucose linked transporter (SGLT) inhibitors.
Amy L Harding, Naiara Bediaga, Anna Galligan, Peter G Colman, Spiros Fourlanos, John M Wentworth
Journal article | 2020 | Internal Medicine Journal
AIM: This study aimed to determine the clinical and biochemical variables associated with change in HbA1c in patients with type 2 ..
Higher frequency of vertebrate-infecting viruses in the gut of infants born to mothers with type 1 diabetes
Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter Lipkin, Kelly McGorm, Grant Morahan, Claire Morbey, Ignatius CN Pang, et al.
Journal article | 2020 | Pediatric Diabetes
BACKGROUND: Microbial exposures in utero and early life shape the infant microbiome, which can profoundly impact on health. Compar..
Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: A prospective cohort study
Jessica E Harbison, Alexandra J Roth-Schulze, Lynne C Giles, Cuong D Tran, Katrina M Ngui, Megan A Penno, Rebecca L Thomson, John M Wentworth, Peter G Colman, Maria E Craig, Grant Morahan, Anthony T Papenfuss, Simon C Barry, Leonard C Harrison, Jennifer J Couper
Journal article | 2019 | Pediatric Diabetes
Pancreas size and exocrine function is decreased in young children with recent-onset Type 1 diabetes.
P Augustine, R Gent, J Louise, M Taranto, M Penno, R Linke, JJ Couper, undefined ENDIA Study Group
Journal article | 2019 | Diabetic Medicine
AIMS: To measure pancreatic area and exocrine function in young children with recent-onset Type 1 diabetes to determine whether th..
Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study
Ki Wook Kim, Digby W Allen, Thomas Briese, Jennifer J Couper, Simon C Barry, Peter G Colman, Andrew M Cotterill, Elizabeth A Davis, Lynne C Giles, Leonard C Harrison, Mark Harris, Aveni Haynes, Jessica L Horton, Sonia R Isaacs, Komal Jain, Walter Ian Lipkin, Grant Morahan, Claire Morbey, Ignatius CN Pang, Anthony T Papenfuss, et al.
Journal article | 2019 | Open Forum Infectious Diseases
Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.
Maria J Redondo, Andrea K Steck, Jay Sosenko, Mark Anderson, Peter Antinozzi, Aaron Michels, John M Wentworth, Mark A Atkinson, Alberto Pugliese, Susan Geyer, undefined Type 1 Diabetes TrialNet Study Group
Journal article | 2018 | Diabetes Care
OBJECTIVE: The type 2 diabetes-associated alleles at the TCF7L2 locus mark a type 1 diabetes phenotype characterized by single isl..
Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Michelle So, Colleen M Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja, John M Wentworth, Leonard C Harrison, Balasubramanian Krishnamurthy, Helen E Thomas, Christine Rodda, Fergus J Cameron, Jacinta McMahon, Thomas WH Kay, Stuart I Mannering
Journal article | 2018 | Proceedings of the National Academy of Sciences
Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes.
Federica Vecchio, Nicola Lo Buono, Angela Stabilini, Laura Nigi, Matthew J Dufort, Susan Geyer, Paola Maria Rancoita, Federica Cugnata, Alessandra Mandelli, Andrea Valle, Pia Leete, Francesca Mancarella, Peter S Linsley, Lars Krogvold, Kevan C Herold, Helena Elding Larsson, Sarah J Richardson, Noel G Morgan, Knut Dahl-Jørgensen, Guido Sebastiani, et al.
Journal article | 2018 | JCI Insight
BACKGROUND: Neutrophils and their inflammatory mediators are key pathogenic components in multiple autoimmune diseases, while thei..
A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk.
Maria J Redondo, Susan Geyer, Andrea K Steck, Seth Sharp, John M Wentworth, Michael N Weedon, Peter Antinozzi, Jay Sosenko, Mark Atkinson, Alberto Pugliese, Richard A Oram, undefined Type 1 Diabetes TrialNet Study Group
Conference Proceedings | 2018 | Diabetes Care
OBJECTIVE: We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity ..
Detailed Description of Change in Serum Cholesterol Profile with Incremental Weight Loss After Restrictive Bariatric Surgery
Geraldine J Ooi, Arul Earnest, Lisa Doyle, Cheryl Laurie, John M Wentworth, Ken Sikaris, Carel W le Roux, Paul R Burton, Paul E O'Brien, Wendy A Brown
Journal article | 2018 | Obesity Surgery
Cord Blood CD8( ) T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner
Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison
Journal article | 2018 | Frontiers in Immunology
Influence of fecal collection conditions and 16S rRNA gene sequencing at two centers on human gut microbiota analysis
Jocelyn Sietsma Penington, Megan AS Penno, Katrina M Ngui, Nadim J Ajami, Alexandra J Roth-Schulze, Stephen A Wilcox, Esther Bandala-Sanchez, John M Wentworth, Simon C Barry, Cheryl Y Brown, Jennifer J Couper, Joseph F Petrosino, Anthony T Papenfuss, Leonard C Harrison
Journal article | 2018 | Scientific Reports
TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.
Maria J Redondo, Susan Geyer, Andrea K Steck, Jay Sosenko, Mark Anderson, Peter Antinozzi, Aaron Michels, John Wentworth, Ping Xu, Alberto Pugliese, undefined Type 1 Diabetes TrialNet Study Group
Conference Proceedings | 2018 | Diabetes Care
OBJECTIVE: The phenotypic diversity of type 1 diabetes suggests heterogeneous etiopathogenesis. We investigated the relationship o..
CD52 inhibits Toll-like receptor activation of NF-kappa B and triggers apoptosis to suppress inflammation
Maryam Rashidi, Esther Bandala-Sanchez, Kate E Lawlor, Yuxia Zhang, Alana M Neale, Swarna L Vijayaraj, Robert O'Donoghue, John M Wentworth, Timothy E Adams, James E Vince, Leonard C Harrison
Journal article | 2018 | Cell Death & Differentiation
Interferon-gamma released from omental adipose tissue of insulin-resistant humans alters adipocyte phenotype and impairs response to insulin and adiponectin release
JM Wentworth, J-G Zhang, E Bandala-Sanchez, G Naselli, R Liu, M Ritchie, GK Smyth, PE O'Brien, LC Harrison
Journal article | 2017 | International Journal of Obesity
The Role of Age and Excess Body Mass Index in Progression to Type 1 Diabetes in At-Risk Adults.
Christine T Ferrara, Susan M Geyer, Carmella Evans-Molina, Ingrid M Libman, Dorothy J Becker, John M Wentworth, Antoinette Moran, Stephen E Gitelman, Maria J Redondo, undefined Type 1 Diabetes TrialNet Study Group
Journal article | 2017 | The Journal of clinical endocrinology and metabolism
Background: Given the global rise in both type 1 diabetes incidence and obesity, the role of body mass index (BMI) on type 1 diabe..
Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials
Brandon M Nathan, David Boulware, Susan Geyer, Mark A Atkinson, Peter Colman, Robin Goland, William Russell, John M Wentworth, Darrell M Wilson, Carmella Evans-Molina, Diane Wherrett, Jay S Skyler, Antoinette Moran, Jay M Sosenko
Journal article | 2017 | Diabetes Care
OBJECTIVE: We assessed dysglycemia and a T1D Diagnostic Index60 (Index60) ≥1.00 (on the basis of fasting C-peptide, 60-min glucose..
Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?
Andrea K Steck, Ping Xu, Susan Geyer, Maria J Redondo, Peter Antinozzi, John M Wentworth, Jay Sosenko, Suna Onengut-Gumuscu, Wei-Min Chen, Stephen S Rich, Alberto Pugliese
Journal article | 2017 | The Journal of Clinical Endocrinology & Metabolism
Cost-effectiveness of gastric band surgery for overweight but not obese adults with type 2 diabetes in the US
John M Wentworth, Kim M Dalziel, Paul E O'Brien, Paul Burton, Frackson Shaba, Philip M Clarke, Neda Laiteerapong, Wendy A Brown
Journal article | 2017 | Journal of Diabetes and its Complications
Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease
Geraldine J Ooi, Paul R Burton, Lisa Doyle, John M Wentworth, Prithi S Bhathal, Ken Sikaris, Michael A Cowley, Stuart K Roberts, William Kemp, Arul Earnest, Paul E O'Brien, Wendy A Brown
Journal article | 2017 | Obesity Surgery
Modified thresholds for fibrosis risk scores in nonalcoholic fatty liver disease are necessary in the obese
Geraldine J Ooi, Paul R Burton, Lisa Doyle, John M Wentworth, Prithi S Bhathal, Ken Sikaris, Michael A Cowley, Stuart K Roberts, William Kemp, Paul E O'Brien, Wendy A Brown
Journal article | 2017 | Obesity Surgery
IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome
Andrew J Murphy, Michael J Kraakman, Helene L Kammoun, Dragana Dragoljevic, Man KS Lee, Kate E Lawlor, John M Wentworth, Ajithkumar Vasanthakumar, Motti Gerlic, Lachlan W Whitehead, Ladina DiRago, Louise Cengia, Rachael M Lane, Donald Metcalf, James E Vince, Leonard C Harrison, Axel Kallies, Benjamin T Kile, Ben A Croker, Mark A Febbraio, et al.
Journal article | 2016 | Cell Metabolism
The Effect of Weight Loss on Indigenous Australians with Diabetes: a study of Feasibility, Acceptability and Effectiveness of Laparoscopic Adjustable Gastric Banding
Paul E O'Brien, Dawn E DeWitt, Cheryl Laurie, Leah Brennan, John M Wentworth, Margaret Anderson, Kerin O'Dea, Felicia Dean, Andrew Smith, David P Dalton
Journal article | 2016 | Obesity Surgery
Gastric Band Surgery Leads to Improved Insulin Secretion in Overweight People with Type 2 Diabetes.
John M Wentworth, Julie Playfair, Cheryl Laurie, Wendy A Brown, Paul Burton, Jonathan E Shaw, Paul E O'Brien
Journal article | 2015 | Obesity Surgery
BACKGROUND: We aimed to determine the effects of laparoscopic adjustable gastric band (LAGB) on beta-cell function in overweight p..
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
Ajithkumar Vasanthakumar, Kazuyo Moro, Annie Xin, Yang Liao, Renee Gloury, Shimpei Kawamoto, Sidonia Fagarasan, Lisa A Mielke, Shoukat Afshar-Sterle, Seth L Masters, Susumu Nakae, Hirohisa Saito, John M Wentworth, Peng Li, Wei Liao, Warren J Leonard, Gordon K Smyth, Wei Shi, Stephen L Nutt, Shigeo Koyasu, et al.
Journal article | 2015 | Nature Immunology
Multidisciplinary diabetes care with and without bariatric surgery in overweight people: a randomised controlled trial
John M Wentworth, Julie Playfair, Cheryl Laurie, Matthew E Ritchie, Wendy A Brown, Paul Burton, Jonathan E Shaw, Paul E O'Brien
Journal article | 2014 | The Lancet Diabetes & Endocrinology
Antigen-Based Vaccination and Prevention of Type 1 Diabetes
Leonard C Harrison, John M Wentworth, Yuxia Zhang, Esther Bandala-Sanchez, Ralph M Boehmer, Alana M Neale, Natalie L Stone, Gaetano Naselli, Julian J Bosco, Priscilla Auyeung, Maryam Rashidi, Petra Augstein, Grant Morahan
Journal article | 2013 | Current Diabetes Reports
Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes
Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, Leonard C Harrison
Journal article | 2013 | BMC Pediatrics
Reappraising the stereotypes of diabetes in the modern diabetogenic environment.
John M Wentworth, Spiros Fourlanos, Leonard C Harrison
Journal article | 2009 | Nature Reviews Endocrinology
The prevailing concentration of blood glucose is a result of the integrated regulation of insulin secretion and insulin action. Ne..
Type 1 diabetes: lessons for other autoimmune diseases?
Leonard C Harrison, Margo C Honeyman, Grant Morahan, John M Wentworth, Shirley Elkassaby, Peter G Colman, Spiros Fourlanos
Journal article | 2008 | Journal of Autoimmunity
Type 1 diabetes (T1D) satisfies many of the criteria for an autoimmune disease. The impact of the environment to promote the devel..