Francesca Mercuri

Abstract 3502: AXA-042 - a novel systemic TLR2/6 agonist for anti-tumor therapy

Anna V Galkin, Francesca Mercuri, Nicholas West, Ping Zhang, Weiguang Zeng, Grant McLachlan, Michael Bettess, Ian Holmes, David Jackson, Chris Smith, Christophe Demaison, Tobias Bald, Phil Kearney

Journal article  |  2022  |  Cancer Research

Abstract Background: Treatment approaches that engage both the innate and adaptive immune response have the potenti..

TLR2/6 Agonist Treatment Enhances Antiviral Innate Immune Responses in a Novel Mouse Coronavirus Respiratory Infection Model

J Girkin, NE Bryant, S-L Loo, C Demaison, F Mercuri, NW Bartlett

Conference Proceedings  |  2022  |  A28. THE HOST DELIVERS

Development of TLR2/6 Agonist (INNA-051) to Protect the Elderly Against Respiratory Virus Infection

GP Anderson, A Jarnicki, S Loo, J Ciccotosto, J Girkin, R O'Donoghue, F Mercuri, NW Bartlett

Conference Proceedings  |  2022  |  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Safety and Tolerability of the Toll-Like Receptor (TLR)2/6 Agonist INNA-051 in Healthy Adults

S White, C Lemech, R Hari, N Kruger, G McLachlan, C Demaison, F Mercuri

Conference Proceedings  |  2022  |  B31. IMMUNE CELLS AND INFLAMMATORY PATHWAYS DRIVING LUNG INJURY AND INFECTION - VIEWS FROM THE BENCH

TLR2-mediated innate immune priming boosts lung anti-viral immunity

Jason Girkin, Su-Ling Loo, Camille Esneau, Steven Maltby, Francesca Mercuri, Brendon Chua, Andrew T Reid, Punnam Chander Veerati, Chris L Grainge, Peter AB Wark, Darryl Knight, David Jackson, Christophe Demaison, Nathan W Bartlett

Journal article  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

BACKGROUND: We assessed whether Toll-like receptor (TLR)2 activation boosts the innate immune response to rhinovirus infection, as..

TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs

Georgia Deliyannis, Chinn Yi Wong, Hayley A McQuilten, Annabell Bachem, Michele Clarke, Xiaoxiao Jia, Kylie Horrocks, Weiguang Zeng, Jason Girkin, Nichollas E Scott, Sarah L Londrigan, Patrick C Reading, Nathan W Bartlett, Katherine Kedzierska, Lorena E Brown, Francesca Mercuri, Christophe Demaison, David C Jackson, Brendon Y Chua

Journal article  |  2021  |  JCI INSIGHT

The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections po..

Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model

Pamela C Proud, Daphne Tsitoura, Robert J Watson, Brendon Y Chua, Marilyn J Aram, Kevin R Bewley, Breeze E Cavell, Rebecca Cobb, Stuart Dowall, Susan A Fotheringham, Catherine MK Ho, Vanessa Lucas, Didier Ngabo, Emma Rayner, Kathryn A Ryan, Gillian S Slack, Stephen Thomas, Nadina Wand, Paul Yeates, Christophe Demaison, et al.

Journal article  |  2021  |  EBIOMEDICINE

BACKGROUND: The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respirator..

Viral burden, inflammatory milieu and CD8( )T-cell responses to influenza virus in a second-generation thiazolide (RM-5061) and oseltamivir combination therapy study

Simone Nuessing, Edin Mifsud, Luca Hensen, Marios Koutsakos, Zhongfang Wang, Lukasz Kedzierski, Francesca Mercuri, Jean-Francois Rossignol, Aeron C Hurt, Katherine Kedzierska

Journal article  |  2020  |  INFLUENZA AND OTHER RESPIRATORY VIRUSES

BACKGROUND: Influenza viruses cause significant morbidity and mortality, especially in young children, elderly, pregnant women and..

Airway Epithelial Cells from Patients with Asthma and COPD Exhibit Improved Resistance to Rhinovirus Infection Following Treatment with TLR2 Immune Modulators

NW Bartlett, S-L Loo, J Girkin, DC Jackson, F Mercuri, C Demaison

Conference Proceedings  |  2019  |  D21. HOST RESPONSE TO LUNG INFECTIONS

Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity

Brendon Y Chua, Chinn Yi Wong, Edin J Mifsud, Kathryn M Edenborough, Toshiki Sekiya, Amabel CL Tan, Francesca Mercuri, Steve Rockman, Weisan Chen, Stephen J Turner, Peter C Doherty, Anne Kelso, Lorena E Brown, David C Jackson

Journal article  |  2015  |  MBIO

UNLABELLED: The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of ..