Dr Freestone’s research is focused on reverse engineering the human brain. He is developing methods to create a mathematical blueprint of the brain, so engineering methods can be used to treat neurological disorders.
His research findings are about to be trialled in a brain implant designed to predict and control epileptic seizures in collaboration with the medical device company Medtronic. He also works closely IBM Australia, where the team is creating specialised computer chips that can interface with the brain and bypass broken neural circuits.
Dr Freestone has a degree in Electronic Engineering from La Trobe University, where he won the Vice-Chancellor's Travelling Scholarship, the Tad Szental Prize for the best engineering final year student and the Hooper Memorial Prize for best final year project. In 2012, Dr Freestone completed his PhD in the Electrical and Electronic Engineering Department at the University of Melbourne (and The University of Edinburgh on exchange), where he won the John Melvin Memorial Scholarship for the best PhD in Engineering and the University wide Chancellor’s Prize for PhD Excellence. Dr Freestone was the 2014-2015 Victorian Fulbright Postdoctoral Fellow, where he worked in the Neural Statistics Lab at Columbia University in New York City, USA. He is now a junior faculty member in the Department of Medicine at St. Vincent’s Hospital Melbourne, since October 2015.
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Determination of the electrical impedance of neural tissue from its microscopic cellular c..
Displaying the 14 most recent projects by Dean Freestone.
Internal Research Grant
Displaying the 53 most recent scholarly works by Dean Freestone.
Ensembling crowdsourced seizure prediction algorithms using long-term human intracranial EEG
Chip Reuben, Philippa Karoly, Dean R Freestone, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, David B Grayden, Mark J Cook, et al.
Journal article | 2020 | Epilepsia
Seizure prediction is feasible, but greater accuracy is needed to make seizure prediction clinically viable across a large group o..
Determination of the electrical impedance of neural tissue from its microscopic cellular constituents.
Omid Monfared, Bahman Tahayori, Dean Freestone, Dragan Nesic, David B Grayden, Hamish Meffin
Journal article | 2019 | Journal of Neural Engineering
The electrical properties of neural tissue are important in a range of dierent applications in biomedical engineering and basic sc..
Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy.
Shannon Clarke, Philippa J Karoly, Ewan Nurse, Udaya Seneviratne, Janelle Taylor, Rory Knight-Sadler, Robert Kerr, Braden Moore, Patrick Hennessy, Dulini Mendis, Claire Lim, Jake Miles, Mark Cook, Dean R Freestone, Wendyl D'Souza
Journal article | 2019 | Epilepsy & Behavior
Epilepsy diagnosis can be costly, time-consuming, and not uncommonly inaccurate. The reference standard diagnostic monitoring is c..
When can we trust responders? Serious concerns when using 50% response rate to assess clinical trials
Philippa J Karoly, Juan Romero, Mark J Cook, Dean R Freestone, Daniel M Goldenholz
Journal article | 2019 | Epilepsia
Individual seizure rates are highly volatile, with large fluctuations from month‐to‐month. Nevertheless, changes in individual mea..
Validation of 'Somnivore', a Machine Learning Algorithm for Automated Scoring and Analysis of Polysomnography Data
Giancarlo Allocca, Sherie Ma, Davide Martelli, Matteo Cerri, Flavia Del Vecchio, Stefano Bastianini, Giovanna Zoccoli, Roberto Amici, Stephen R Morairty, Anne E Aulsebrook, Shaun Blackburn, John A Lesku, Niels C Rattenborg, Alexei L Vyssotski, Emma Wams, Kate Porcherer, Katharina Wulff, Russell Foster, Julia KM Chan, Christian L Nicholas, et al.
Journal article | 2019 | Frontiers in Neuroscience
Manual scoring of polysomnography data is labor-intensive and time-consuming, and most existing software does not account for subj..
Methods for the Detection of Seizure Bursts in Epilepsy
Udaya Seneviratne, Philippa Karoly, Dean R Freestone, Mark J Cook, Ray C Boston
Journal article | 2019 | Frontiers in Neurology
Background: Seizure clusters and “bursts” are of clinical importance. Clusters are reported to be a marker of antiepileptic drug r..
Identification of a Neural Mass Model of Burst Suppression
Jafarian Amirhossein, Dean Robert Freestone, Dragan Nesic, David Grayden
Conference Proceedings | 2019 | 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Burst suppression includes alternating patterns of silent and fast spike activities in neuronal activities observable in micro to ..
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava, Vojtech Kumpost, Andrew D Powell, Radek Janca, Matias I Maturana, Philippa J Karoly, Dean R Freestone, Mark J Cook, Milan Palus, Jakub Otahal, John GR Jefferys, Premysl Jiruska
Journal article | 2018 | Nature Neuroscience
Epilepsyecosystem.org: crowd-sourcing reproducible seizure prediction with long-term human intracranial EEG
Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, et al.
Journal article | 2018 | Brain
Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System
Isabell Kiral-Kornek, Subhrajit Roy, Ewan Nurse, Benjamin Mashford, Philippa Karoly, Thomas Carroll, Daniel Payne, Susmita Saha, Steven Baldassano, Terence O'Brien, David Grayden, Mark Cook, Dean Freestone, Stefan Harrer
Journal article | 2018 | EBioMedicine
Intracranial EEG fluctuates over months after implanting electrodes in human brain
Hoameng Ung, Steven N Baldassano, Hank Bink, Abba M Krieger, Shawniqua Williams, Flavia Vitale, Chengyuan Wu, Dean Freestone, Ewan Nurse, Kent Leyde, Kathryn A Davis, Mark Cook, Brian Litt
Journal article | 2017 | Journal of Neural Engineering
TrueNorth-enabled Real-time Classification of EEG Data for Brain-Computer Interfacing
Isabell Kiral-Kornek, Dulini Mendis, Ewan S Nurse, Benjamin S Mashford, Dean R Freestone, David B Grayden, Stefan Harrer
Conference Proceedings | 2017 | 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Neural mass model-based tracking of anesthetic brain states
L Kuhlmann, DR Freestone, JH Manton, B Heyse, HEM Vereecke, T Lipping, MMRF Struys, DTJ Liley
Journal article | 2016 | NeuroImage
Abstract Neural mass model-based tracking of brain states from electroencephalographic signals holds the promise of simultaneously..
Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle
Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, Dietmar Plenz
Journal article | 2015 | Proceedings of the National Academy of Sciences
Movement related directional tuning from broadband electrocorticography in humans
ES Nurse, DR Freestone, TJ Oxley, DC Ackland, SJ Vogrin, M Murphy, TJ O'Brien, MJ Cook, DB Grayden
Conference Proceedings | 2015 | 2015 7th International IEEE/EMBS Conference on Neural Engineering (NER)
© 2015 IEEE. Directional tuning is the tendency for cortical neurons to exhibit a peak firing rate when a limb is moved in a prefe..
Electrical Stimulation of Neural Tissue Modeled as a Cellular Composite: Point Source Electrode in an Isotropic Tissue
Omid Monfared, Dragan Nesic, Dean R Freestone, David B Grayden, Bahman Tahayori, Hamish Meffin
Conference Proceedings | 2014 | Proceedings of the 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
A Neural Mass Model of Spontaneous Burst Suppression and Epileptic Seizures
Dean R Freestone, Dragan Nesic, Amirhossein Jafarian, Mark J Cook, David B Grayden
Conference Proceedings | 2013 | Proceedings of the 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
A Method for Actively Tracking Excitability of Brain Networks using a Fully Implantable Monitoring System
Dean R Freestone, Sam N Long, Stephen Frey, Paul H Stypulkowski, Jonathon E Giftakis, Mark J Cook
Conference Proceedings | 2013 | Proceedings of the 35th Annual International Conference of the IEEE EMBS
Electrical probing of cortical excitability in patients with epilepsy
Dean R Freestone, Levin Kuhlmann, David B Grayden, Anthony N Burkitt, Alan Lai, Timothy S Nelson, Simon Vogrin, Michael Murphy, Wendyl D'Souza, Radwa Badawy, Dragan Nesic, Mark J Cook
Journal article | 2011 | Epilepsy and Behavior
CLOSED-LOOP SEIZURE CONTROL WITH VERY HIGH FREQUENCY ELECTRICAL STIMULATION AT SEIZURE ONSET IN THE GAERS MODEL OF ABSENCE EPILEPSY
Timothy S Nelson, Courtney L Suhr, Dean R Freestone, Alan Lai, Amy J Halliday, Karen J Mclean, Anthony N Burkitt, Mark J Cook
Journal article | 2011 | International Journal of Neural Systems
A Paradigm for Epileptic Seizure Prediction Using a Coupled Oscillator Model of the Brain
Elma O'Sullivan-Greene, Iven Mareels, Dean Freestone, Levin Kulhmann, Anthony Burkitt
Conference Proceedings | 2009 | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
The Thalamocortical Circuit and the Generation of Epileptic Spikes in Rat Models of Focal Epilepsy
Dean R Freestone, David B Grayden, Alan Lai, Timothy S Nelson, Amy Halliday, Anthony N Burkitt, Mark J Cook
Conference Proceedings | 2009 | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009
Forecasting Cycles of Seizure Likelihood
Philippa J Karoly, Matias I Maturana, Mark J Cook, Ewan S Nurse, Daniel Payne, Benjamin Brinkmann, David B Grayden, Sonya B Dumanis, Mark P Richardson, Greg Worrell, Andreas Schulze-Bonhage, Levin Kuhlmann, Dean R Freestone
Objective: Seizure unpredictability is rated as one of the most challenging aspects of living with epilepsy. Seizure likelihood ca..
Displaying the most recent news article by Dean Freestone.
Honours, Awards and Fellowships
The Chancellor's Prize for Excellence in the PhD Thesis - 2013
John Melvin Memorial Scholarship for Best PhD Thesis in Engineering 2012
NOTINLIST - Not in List
Senior Research Fellow
Medicine - St Vincent'S Hospital
Doctor of Philosphy
University of Melbourne
Bachelor of Engineering (Electronic Engineering)
La Trobe University