Chin Tan

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2019  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2019  |  Cell Death & Differentiation

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts

Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess

Journal article  |  2018  |  PLOS ONE

Mathematical model of TGF-beta signalling: feedback coupling is consistent with signal switching

Shabnam Khatibi, Hong-Jian Zhu, John Wagner, Chin Wee Tan, Jonathan H Manton, Antony W Burgess

Journal article  |  2017  |  BMC Systems Biology

TGF-beta and IL-6 family signalling crosstalk: an integrated model

Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess

Journal article  |  2017  |  Growth Factors

Controlling seepage in discrete particle simulations of biological systems

Bruce S Gardiner, Grand R Joldes, Kelvin KL Wong, Chin Wee Tan, David W Smith

Journal article  |  2016  |  Computer Methods in Biomechanics and Biomedical Engineering

A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H Dashwood, Joan K Heath, Matthias Ernst, Klaus-Peter Janssen

Journal article  |  2015  |  Disease Models & Mechanisms

Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components

Bruce S Gardiner, Kelvin KL Wong, Grand R Joldes, Addison J Rich, Chin Wee Tan, Antony W Burgess, David W Smith

Journal article  |  2015  |  PLOS Computational Biology

Analysis of Wnt signalling dynamics during colon crypt development in 3D culture

Chin Wee Tan, Yumiko Hirokawa, Antony W Burgess

Journal article  |  2015  |  Scientific Reports

Genomic approach to translational studies in colorectal cancer

Dane Cheasley, Robert N Jorissen, Sheng Liu, Chin Wee Tan, Christopher Love, Michelle Palmieri, Oliver M Sieber

Journal article  |  2015  |  Translational Cancer Research

LRIG1 Extracellular Domain: Structure and Function Analysis

Yibin Xu, Priscilla Soo, Francesca Walker, Hui Hua Zhang, Nicholas Redpath, Chin Wee Tan, Nicos A Nicola, Timothy E Adams, Thomas P Garrett, Jian-Guo Zhang, Antony W Burgess

Journal article  |  2015  |  Journal of Molecular Biology

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration

Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay, et al.

Journal article  |  2014  |  Science Signaling

Analysis of Wnt signaling beta-catenin spatial dynamics in HEK293T cells

Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, David W Smith, Antony W Burgess

Journal article  |  2014  |  BMC Systems Biology

Colonic myofibroblast cell line stimulates colonoid formation

Yumiko Hirokawa, Kelvin Hon Yan Yip, Chin Wee Tan, Antony W Burgess

Journal article  |  2014  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Colon Cryptogenesis: Asymmetric Budding

Chin Wee Tan, Yumiko Hirokawa, Bruce S Gardiner, David W Smith, Antony W Burgess

Journal article  |  2013  |  PLoS One

Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling

Matthew S Creamer, Edward C Stites, Meraj Aziz, James A Cahill, Chin Wee Tan, Michael E Berens, Haiyong Han, Kimberley J Bussey, Daniel D Von Hoff, William S Hlavacek, Richard G Posner

Journal article  |  2012  |  BMC Systems Biology