Chin Tan

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2020  |  Cell Death & Differentiation

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2019  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts

Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess

Journal article  |  2018  |  PLOS ONE

Mathematical model of TGF-beta signalling: feedback coupling is consistent with signal switching

Shabnam Khatibi, Hong-Jian Zhu, John Wagner, Chin Wee Tan, Jonathan H Manton, Antony W Burgess

Journal article  |  2017  |  BMC Systems Biology

TGF-beta and IL-6 family signalling crosstalk: an integrated model

Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess

Journal article  |  2017  |  Growth Factors

Controlling seepage in discrete particle simulations of biological systems

Bruce S Gardiner, Grand R Joldes, Kelvin KL Wong, Chin Wee Tan, David W Smith

Journal article  |  2016  |  Computer Methods in Biomechanics and Biomedical Engineering

A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H Dashwood, Joan K Heath, Matthias Ernst, Klaus-Peter Janssen

Journal article  |  2015  |  Disease Models & Mechanisms

Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components

Bruce S Gardiner, Kelvin KL Wong, Grand R Joldes, Addison J Rich, Chin Wee Tan, Antony W Burgess, David W Smith

Journal article  |  2015  |  PLOS Computational Biology

Analysis of Wnt signalling dynamics during colon crypt development in 3D culture

Chin Wee Tan, Yumiko Hirokawa, Antony W Burgess

Journal article  |  2015  |  Scientific Reports

Genomic approach to translational studies in colorectal cancer

Dane Cheasley, Robert N Jorissen, Sheng Liu, Chin Wee Tan, Christopher Love, Michelle Palmieri, Oliver M Sieber

Journal article  |  2015  |  Translational Cancer Research

LRIG1 Extracellular Domain: Structure and Function Analysis

Yibin Xu, Priscilla Soo, Francesca Walker, Hui Hua Zhang, Nicholas Redpath, Chin Wee Tan, Nicos A Nicola, Timothy E Adams, Thomas P Garrett, Jian-Guo Zhang, Antony W Burgess

Journal article  |  2015  |  Journal of Molecular Biology

Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration

Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay, et al.

Journal article  |  2014  |  Science Signaling

Analysis of Wnt signaling beta-catenin spatial dynamics in HEK293T cells

Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, David W Smith, Antony W Burgess

Journal article  |  2014  |  BMC Systems Biology

Colonic myofibroblast cell line stimulates colonoid formation

Yumiko Hirokawa, Kelvin Hon Yan Yip, Chin Wee Tan, Antony W Burgess

Journal article  |  2014  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Colon Cryptogenesis: Asymmetric Budding

Chin Wee Tan, Yumiko Hirokawa, Bruce S Gardiner, David W Smith, Antony W Burgess

Journal article  |  2013  |  PLoS One

Specification, annotation, visualization and simulation of a large rule-based model for ERBB receptor signaling

Matthew S Creamer, Edward C Stites, Meraj Aziz, James A Cahill, Chin Wee Tan, Michael E Berens, Haiyong Han, Kimberley J Bussey, Daniel D Von Hoff, William S Hlavacek, Richard G Posner

Journal article  |  2012  |  BMC Systems Biology