Chin Tan

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Mayur Garg, Simon G Royce, Chris Tikellis, Claire Shallue, Duygu Batu, Elena Velkoska, Louise M Burrell, Sheila K Patel, Lauren Beswick, Anvesh Jackson, Kaushali Britto, Matthew Lukies, Pavel Sluka, Hady Wardan, Yumiko Hirokawa, Chin Wee Tan, Maree Faux, Antony W Burgess, Patrick Hosking, Shaun Monagle, et al.

Journal article  |  2020  |  Gut

OBJECTIVE: We evaluated the influence of the renin-angiotensin system (RAS) on intestinal inflammation and fibrosis. DESIGN: Cultu..

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Paul M Nguyen, Laura F Dagley, Adele Preaudet, Nga Lam, Maybelline Giam, Ka Yee Fung, Kaheina Aizel, Gemma van Duijneveldt, Chin Wee Tan, Yumiko Hirokawa, Hon Yan K Yip, Christopher G Love, Ashleigh R Poh, Akshay D' Cruz, Charlotte Burstroem, Rebecca Feltham, Suad M Abdirahman, Kristy Meiselbach, Ronnie Ren Jie Low, Michelle Palmieri, et al.

Journal article  |  2020  |  Cell Death and Differentiation

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, ..

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Pathum Thilakasiri, Jennifer Huynh, Ashleigh R Poh, Chin Wee Tan, Tracy L Nero, Kelly Tran, Adam C Parslow, Shoukat Afshar-Sterle, David Baloyan, Natalie J Hannan, Michael Buchert, Andrew Mark Scott, Michael Dw Griffin, Frederic Hollande, Michael W Parker, Tracy L Putoczki, Matthias Ernst, Ashwini L Chand

Journal article  |  2019  |  EMBO Molecular Medicine

Excessive signaling through gp130, the shared receptor for the interleukin (IL)6 family of cytokines, is a common hallmark in soli..

Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts

Hon Yan Kelvin Yip, Chin Wee Tan, Yumiko Hirokawa, Antony Wilks Burgess

Journal article  |  2018  |  PLoS One

Mathematical model of TGF-beta signalling: feedback coupling is consistent with signal switching

Shabnam Khatibi, Hong-Jian Zhu, John Wagner, Chin Wee Tan, Jonathan H Manton, Antony W Burgess

Journal article  |  2017  |  BMC SYSTEMS BIOLOGY

TGF-beta and IL-6 family signalling crosstalk: an integrated model

Shabnam Khatibi, Jeff Babon, John Wagner, Jonathan H Manton, Chin Wee Tan, Hong-Jian Zhu, Sam Wormald, Antony W Burgess

Journal article  |  2017  |  Growth Factors

Controlling seepage in discrete particle simulations of biological systems

Bruce S Gardiner, Grand R Joldes, Kelvin KL Wong, Chin Wee Tan, David W Smith

Journal article  |  2016  |  Computer Methods in Biomechanics and Biomedical Engineering

A hypermorphic epithelial beta-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations

Michael Buchert, Franziska Rohde, Moritz Eissmann, Niall Tebbutt, Ben Williams, Chin Wee Tan, Alexander Owen, Yumiko Hirokawa, Alexandra Gnann, Gertraud Orend, Gayle Orner, Rod H Dashwood, Joan K Heath, Matthias Ernst, Klaus-Peter Janssen

Journal article  |  2015  |  Disease Models & Mechanisms

Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components

Bruce S Gardiner, Kelvin KL Wong, Grand R Joldes, Addison J Rich, Chin Wee Tan, Antony W Burgess, David W Smith

Journal article  |  2015  |  PLOS COMPUTATIONAL BIOLOGY

Analysis of Wnt signalling dynamics during colon crypt development in 3D culture

Chin Wee Tan, Yumiko Hirokawa, Antony W Burgess

Journal article  |  2015  |  Scientific Reports