Smitha Georgy

Identification of a Novel GRHL3/HOPX/Wnt/β-Catenin Proto-oncogenic Axis in Squamous Cell Carcinoma of the Esophagus.

Smitha Rose Georgy, Diar Riyanti Rudiatmoko, Alana Auden, Darren Partridge, Tariq Butt, Seema Srivastava, Nick Wong, Dijina Swaroop, Marina Rose Carpinelli, Mirjana Bogeski, Stephen M Jane

Journal article  |  2022  |  Cell Mol Gastroenterol Hepatol

BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with a poor long-term prognosis. The mole..

Early Endothelial Activation in a Mouse Model of Graft vs Host Disease Following Chemotherapy

Melrine Pereira, Natasha Ting Lee, Jonathan Noonan, Abbey EH Willcox, Ilaria Calvello, Smitha Rose Georgy, Carly Selan, Joanne S Chia, Wayne Hauw, Xiaowei Wang, Karlheinz Peter, Simon C Robson, Harshal H Nandurkar, Maithili Sashindranath

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Allogenic hematopoietic stem cell transplant (allo-HSCT) can lead to sinusoidal obstruction syndrome (SOS) and graft-versus-host d..

Recent insights into the biology of Barrett's esophagus

Henry Badgery, Lynn Chong, Elhadi Iich, Qin Huang, Smitha Rose Georgy, David H Wang, Matthew Read

Journal article  |  2020  |  ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), an aggressive cancer with a poor prognosi..

The Proteasome Inhibitor Ixazomib Inhibits the Formation and Growth of Pulmonary and Abdominal Osteosarcoma Metastases in Mice

Michael A Harris, Mark A Miles, Tanmay M Shekhar, Carmelo Cerra, Smitha R Georgy, Stewart D Ryan, Claire M Cannon, Christine J Hawkins

Journal article  |  2020  |  CANCERS

Osteosarcoma is the most common form of primary bone cancer. Over 20% of osteosarcoma patients present with pulmonary metastases a..

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

Marina R Carpinelli, Michael E de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D Partridge, Lee B Miles, Smitha R Georgy, Jody J Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P Stemmler, Sebastian Dworkin, Stephen M Jane

Journal article  |  2020  |  DISEASE MODELS & MECHANISMS

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mamma..

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane

Journal article  |  2018  |  CELL DEATH AND DIFFERENTIATION

Cutaneous squamous cell carcinoma (SCC) is a recurrent cancer that is prevalent in predisposed subjects such as immunosuppressed p..

Grainyhead-like 3 (Grhl3) Deficiency in Brain Leads to Altered Locomotor Activity and Decreased Anxiety-Like Behaviors in Aged Mice

Sebastian Dworkin, Alana Auden, Darren D Partridge, Maria Daglas, Robert L Medcalf, Theo Mantamadiotis, Smitha R Georgy, Charbel Darido, Stephen M Jane, Stephen B Ting

Journal article  |  2017  |  DEVELOPMENTAL NEUROBIOLOGY

The highly conserved Grainyhead-like (Grhl) family of transcription factors, comprising three members in vertebrates (Grhl1-3), pl..

The role of barrier genes in epidermal malignancy

C Darido, SR Georgy, SM Jane

Journal article  |  2016  |  ONCOGENE

The outermost layer of the mammalian skin, the epidermis, forms a protective barrier against pathogenic microbes and tissue dehydr..

Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life

Michael Cangkrama, Charbel Darido, Smitha R Georgy, Darren Partridge, Alana Auden, Seema Srivastava, Tomasz Wilanowski, Stephen M Jane

Journal article  |  2016  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

The skin barrier is critical for mammalian survival in the terrestrial environment, affording protection against fluid loss, micro..

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

Smitha R Georgy, Michael Cangkrama, Seema Srivastava, Darren Partridge, Alana Auden, Sebastian Dworkin, Catriona A McLean, Stephen M Jane, Charbel Darido

Journal article  |  2015  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a critical tumor suppressor role in the mammali..