Smitha Rose Georgy

Recent insights into the biology of Barrett's esophagus

Henry Badgery, Lynn Chong, Elhadi Iich, Qin Huang, Smitha Rose Georgy, David H Wang, Matthew Read

Journal article  |  2020  |  ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), an aggressive cancer with a poor prognosi..

The Proteasome Inhibitor Ixazomib Inhibits the Formation and Growth of Pulmonary and Abdominal Osteosarcoma Metastases in Mice

Michael A Harris, Mark A Miles, Tanmay M Shekhar, Carmelo Cerra, Smitha R Georgy, Stewart D Ryan, Claire M Cannon, Christine J Hawkins

Journal article  |  2020  |  CANCERS

Osteosarcoma is the most common form of primary bone cancer. Over 20% of osteosarcoma patients present with pulmonary metastases a..

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

Marina R Carpinelli, Michael E de Vries, Alana Auden, Tariq Butt, Zihao Deng, Darren D Partridge, Lee B Miles, Smitha R Georgy, Jody J Haigh, Charbel Darido, Simone Brabletz, Thomas Brabletz, Marc P Stemmler, Sebastian Dworkin, Stephen M Jane

Journal article  |  2020  |  DISEASE MODELS & MECHANISMS

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mamma..

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane

Journal article  |  2018  |  CELL DEATH AND DIFFERENTIATION

Cutaneous squamous cell carcinoma (SCC) is a recurrent cancer that is prevalent in predisposed subjects such as immunosuppressed p..

Grainyhead-like 3 (Grhl3) Deficiency in Brain Leads to Altered Locomotor Activity and Decreased Anxiety-Like Behaviors in Aged Mice

Sebastian Dworkin, Alana Auden, Darren D Partridge, Maria Daglas, Robert L Medcalf, Theo Mantamadiotis, Smitha R Georgy, Charbel Darido, Stephen M Jane, Stephen B Ting

Journal article  |  2017  |  DEVELOPMENTAL NEUROBIOLOGY

The highly conserved Grainyhead-like (Grhl) family of transcription factors, comprising three members in vertebrates (Grhl1-3), pl..

The role of barrier genes in epidermal malignancy

C Darido, SR Georgy, SM Jane

Journal article  |  2016  |  ONCOGENE

The outermost layer of the mammalian skin, the epidermis, forms a protective barrier against pathogenic microbes and tissue dehydr..

Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life

Michael Cangkrama, Charbel Darido, Smitha R Georgy, Darren Partridge, Alana Auden, Seema Srivastava, Tomasz Wilanowski, Stephen M Jane

Journal article  |  2016  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

The skin barrier is critical for mammalian survival in the terrestrial environment, affording protection against fluid loss, micro..

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

Smitha R Georgy, Michael Cangkrama, Seema Srivastava, Darren Partridge, Alana Auden, Sebastian Dworkin, Catriona A McLean, Stephen M Jane, Charbel Darido

Journal article  |  2015  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a critical tumor suppressor role in the mammali..

Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton

Sebastian Dworkin, Johanna Simkin, Charbel Darido, Darren D Partridge, Smitha R Georgy, Jacinta Caddy, Tomasz Wilanowski, Graham J Lieschke, Karen Doggett, Joan K Heath, Stephen M Jane

Journal article  |  2014  |  MECHANISMS OF DEVELOPMENT

Craniofacial development is a highly conserved process that requires complex interactions between neural crest cells (NCCs) and ph..

Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair

SR Georgy, CN Pagel, A Ghasem-Zadeh, RMD Zebaze, RN Pike, NA Sims, EJ Mackie

Journal article  |  2012  |  BONE

Proteinase-activated receptor-2 (PAR(2)) is a G-protein coupled receptor expressed by osteoblasts and monocytes. PAR(2) is activat..