Clare Oates

Mouse guanylate-binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo.

Melkamu B Tessema, Daniel Enosi Tuipulotu, Clare V Oates, Andrew G Brooks, Si Ming Man, Sarah L Londrigan, Patrick C Reading

Journal article  |  2023  |  Immunol Cell Biol

Many interferon (IFN)-stimulated genes are upregulated within host cells following infection with influenza and other viruses. Whi..

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli.

Georgina L Pollock, Andrey M Grishin, Cristina Giogha, Jiyao Gan, Clare V Oates, Paul J McMillan, Isabella Gaeta, Matthew J Tyska, Jaclyn S Pearson, Nichollas E Scott, Miroslaw Cygler, Elizabeth L Hartland

Journal article  |  2022  |  Proc Natl Acad Sci U S A

Attaching and effacing (AE) lesion formation on enterocytes by enteropathogenic Escherichia coli (EPEC) requires the EPEC type III..

Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression In Vitro and Prevents Lesion Formation in the Mouse Zosteriform Model

Melkamu B Tessema, Rubaiyea Farrukee, Christopher E Andoniou, Mariapia A Degli-Esposti, Clare Oates, James B Barnes, Linda M Wakim, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Myxovirus resistance (Mx) proteins are dynamin-like GTPases that are inducible by interferons (IFNs) following virus infections. M..

The Role of the HLA Class I alpha 2 Helix in Determining Ligand Hierarchy for the Killer Cell Ig-like Receptor 3DL1 Philippa

Philippa M Saunders, Bruce J MacLachlan, Jacqueline Widjaja, Shu Cheng Wong, Clare VL Oates, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

HLA class I molecules that represent ligands for the inhibitory killer cell Ig-like receptor (KIR) 3DL1 found on NK cells are cate..

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Philippa M Saunders, Bruce J MacLachlan, Phillip Pymm, Patricia T Illing, Yuanchen Deng, Shu Cheng Wong, Clare VL Oates, Anthony W Purcell, Jamie Rossjohn, Julian P Vivian, Andrew G Brooks

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft..

Loss of O-Linked Protein Glycosylation in Burkholderia cenocepacia Impairs Biofilm Formation and Siderophore Activity and Alters Transcriptional Regulators

Cameron C Oppy, Leila Jebeli, Miku Kuba, Clare V Oates, Richard Strugnell, Laura E Edgington-Mitchell, Miguel A Valvano, Elizabeth L Hartland, Hayley J Newton, Nichollas E Scott

Journal article  |  2019  |  MSPHERE

O-linked protein glycosylation is a conserved feature of the Burkholderia genus. The addition of the trisaccharide β-Gal-(1,3)-α-G..

Distinct Roles of the Antiapoptotic Effectors NleB and NleF from Enteropathogenic Escherichia coli

Georgina L Pollock, Clare VL Oates, Cristina Giogha, Tania Wong Fok Lung, Sze Ying Ong, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2017  |  INFECTION AND IMMUNITY

During infection, enteropathogenic Escherichia coli (EPEC) translocates effector proteins directly into the cytosol of infected en..

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Jaclyn S Pearson, Cristina Giogha, Sabrina Muhlen, Ueli Nachbur, Chi LL Pham, Ying Zhang, Joanne M Hildebrand, Clare V Oates, Tania Wong Fok Lung, Danielle Ingle, Laura F Dagley, Aleksandra Bankovacki, Emma J Petrie, Gunnar N Schroeder, Valerie F Crepin, Gad Frankel, Seth L Masters, James Vince, James M Murphy, Margaret Sunde, et al.

Journal article  |  2017  |  NATURE MICROBIOLOGY

Cell death signalling pathways contribute to tissue homeostasis and provide innate protection from infection. Adaptor proteins suc..

Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ

Ying Zhang, Sabrina Muehlen, Clare V Oates, Jaclyn S Pearson, Elizabeth L Hartland

Journal article  |  2016  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The type III secretion system effector protein NleE from enteropathogenic Escherichia coli plays a key role in the inhibition of N..

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor

Gunnar N Schroeder, Philipp Aurass, Clare V Oates, Edward W Tate, Elizabeth L Hartland, Antje Flieger, Gad Frankel

Journal article  |  2015  |  INFECTION AND IMMUNITY

Legionella pneumophila is a bacterial pathogen that thrives in alveolar macrophages, causing a severe pneumonia. The virulence of ..