Chris Chiu

A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.

Slim Fourati, Aarthi Talla, Mehrad Mahmoudian, Joshua G Burkhart, Riku Klén, Ricardo Henao, Thomas Yu, Zafer Aydın, Ka Yee Yeung, Mehmet Eren Ahsen, Reem Almugbel, Samad Jahandideh, Xiao Liang, Torbjörn EM Nordling, Motoki Shiga, Ana Stanescu, Robert Vogel, undefined Respiratory Viral DREAM Challenge Consortium, Gaurav Pandey, Christopher Chiu, et al.

Journal article  |  2018  |  Nature Communications

The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictor..

Mechanisms of naturally acquired immunity to P-falciparum and approaches to identify merozoite antigen targets

Julie Healer, Chris Y Chiu, Diana S Hansen

Journal article  |  2018  |  Parasitology

Induction and subversion of human protective immunity: Contrasting influenza and respiratory syncytial virus

S Ascough, S Paterson, C Chiu

Journal article  |  2018  |  Frontiers in Immunology

Tuberculosis Infectiousness and Host Susceptibility.

Richard D Turner, Christopher Chiu, Gavin J Churchyard, Hanif Esmail, David M Lewinsohn, Neel R Gandhi, Kevin P Fennelly

Journal article  |  2017  |  The Journal of Infectious Diseases

The transmission of tuberculosis is complex. Necessary factors include a source case with respiratory disease that has developed s..

Metabolic Phenotypes of Response to Vaccination in Humans.

Shuzhao Li, Nicole L Sullivan, Nadine Rouphael, Tianwei Yu, Sophia Banton, Mohan S Maddur, Megan McCausland, Christopher Chiu, Jennifer Canniff, Sheri Dubey, Ken Liu, ViLinh Tran, Thomas Hagan, Sai Duraisingham, Andreas Wieland, Aneesh K Mehta, Jennifer A Whitaker, Shankar Subramaniam, Dean P Jones, Alessandro Sette, et al.

Journal article  |  2017  |  Cell

Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available..

Protective and Harmful Immunity to RSV Infection.

Peter JM Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson

Book  |  2017  |  Annual Review of Immunology

Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epit..

Controlled human infection with RSV: The opportunities of experimental challenge.

Maximillian S Habibi, Christopher Chiu

Journal article  |  2017  |  Vaccine

Despite the recent explosion in RSV vaccine development, there remain substantial hurdles to overcome before licensing of effectiv..

Novel immunological insights in accelerating RSV vaccine development.

Christopher Chiu

Journal article  |  2017  |  Vaccine

Seasonal influenza vaccines and hurdles to mutual protection.

C Chiu

Journal article  |  2016  |  Clinical Microbiology and Infection

While vaccines against seasonal influenza are available, major hurdles still exist that prevent their use having any impact on epi..

Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy

Chris Y Chiu, Michael T White, Julie Healer, Jenny K Thompson, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2016  |  Journal of Infectious Diseases

Limited Degradation of the Plasmodium falciparum Gametocyte Marker pfs25 mRNA Exposed to Tropical Temperatures: Considerations for Malaria Transmission Field Studies

Andreea Waltmann, Stephan Karl, Chris Chiu, Ivo Mueller

Journal article  |  2016  |  The American Journal of Tropical Medicine and Hygiene

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans.

Silke M Currie, Emily Gwyer Findlay, Amanda J McFarlane, Paul M Fitch, Bettina Böttcher, Nick Colegrave, Allan Paras, Agnieszka Jozwik, Christopher Chiu, Jürgen Schwarze, Donald J Davidson

Journal article  |  2016  |  The Journal of Immunology

Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection in infants, causing significant morbidity and ..

Erratum: RSV-specific airway resident memory CD8 T cells and differential disease severity after experimental human infection (Nature Communications (2015) 6 (10224) DOI: 10.1038/ncomms10224)

A Jozwik, MS Habibi, A Paras, J Zhu, A Guvenel, J Dhariwal, M Almond, EHC Wong, A Sykes, M Maybeno, J Del Rosario, MB Trujillo-Torralbo, P Mallia, J Sidney, B Peters, OM Kon, A Sette, SL Johnston, PJ Openshaw, C Chiu

Journal article  |  2016  |  Nature Communications

Monocyte- and Neutrophil-Derived CXCL10 Impairs Efficient Control of Blood-Stage Malaria Infection and Promotes Severe Disease

Lisa J Ioannidis, Catherine Q Nie, Ann Ly, Victoria Ryg-Cornejo, Chris Y Chiu, Diana S Hansen

Journal article  |  2016  |  The Journal of Immunology

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

Victoria Ryg-Cornejo, Lisa Julia Ioannidis, Ann Ly, Chris Yu Chiu, Julie Tellier, Danika Lea Hill, Simon Peter Preston, Marc Pellegrini, Di Yu, Stephen Laurence Nutt, Axel Kallies, Diana Silvia Hansen

Journal article  |  2016  |  Cell Reports

RSV-specific airway resident memory CD8 T cells and differential disease severity after experimental human infection.

Agnieszka Jozwik, Maximillian S Habibi, Allan Paras, Jie Zhu, Aleks Guvenel, Jaideep Dhariwal, Mark Almond, Ernie HC Wong, Annemarie Sykes, Matthew Maybeno, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L Johnston, Peter J Openshaw, Christopher Chiu

Journal article  |  2015  |  Nat Commun

In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination but their importance in man has not b..

Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria

Chris YH Chiu, Anthony N Hodder, Clara S Lin, Danika L Hill, Connie SN Li Wai Suen, Louis Schofield, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2015  |  Journal of Infectious Diseases

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.

Maximillian S Habibi, Agnieszka Jozwik, Spyridon Makris, Jake Dunning, Allan Paras, John P DeVincenzo, Cornelis AM de Haan, Jens Wrammert, Peter JM Openshaw, Christopher Chiu, undefined Mechanisms of Severe Acute Influenza Consortium Investigators

Journal article  |  2015  |  American Journal of Respiratory and Critical Care Medicine

RATIONALE: Despite relative antigenic stability, respiratory syncytial virus (RSV) reinfects throughout life. After more than 40 y..

B cell responses to influenza infection and vaccination.

Christopher Chiu, Ali H Ellebedy, Jens Wrammert, Rafi Ahmed

Journal article  |  2015  |  Current Topics in Microbiology and Immunology

Although vaccines against influenza are widely available, control of the disease remains elusive. In part, this is due to the inab..

Antiviral B cell and T cell immunity in the lungs.

Christopher Chiu, Peter J Openshaw

Journal article  |  2015  |  Nature Immunology

Respiratory viruses are frequent causes of repeated common colds, bronchitis and pneumonia, which often occur unpredictably as epi..

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.

Ali H Ellebedy, Florian Krammer, Gui-Mei Li, Matthew S Miller, Christopher Chiu, Jens Wrammert, Cathy Y Chang, Carl W Davis, Megan McCausland, Rivka Elbein, Srilatha Edupuganti, Paul Spearman, Sarah F Andrews, Patrick C Wilson, Adolfo García-Sastre, Mark J Mulligan, Aneesh K Mehta, Peter Palese, Rafi Ahmed

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

The emergence of pandemic influenza viruses poses a major public health threat. Therefore, there is a need for a vaccine that can ..

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen

Journal article  |  2014  |  Frontiers in Microbiology

The Contribution of Natural Killer Complex Loci to the Development of Experimental Cerebral Malaria

Diana S Hansen, Victoria Ryg-Cornejo, Lisa J Ioannidis, Chris Y Chiu, Ann Ly, Catherine Q Nie, Anthony A Scalzo, Louis Schofield

Journal article  |  2014  |  PLoS One

Current concepts and progress in RSV vaccine development.

Aleks K Guvenel, Christopher Chiu, Peter Jm Openshaw

Journal article  |  2014  |  Expert Review of Vaccines

Respiratory syncytial virus (RSV) disease is an important cause of morbidity and mortality in children and debilitated adults and ..

Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV.

Christopher Chiu, Megan McCausland, John Sidney, Fuh-Mei Duh, Nadine Rouphael, Aneesh Mehta, Mark Mulligan, Mary Carrington, Andreas Wieland, Nicole L Sullivan, Adriana Weinberg, Myron J Levin, Bali Pulendran, Bjoern Peters, Alessandro Sette, Rafi Ahmed

Journal article  |  2014  |  PLoS Pathogens

Human herpesviruses are important causes of potentially severe chronic infections for which T cells are believed to be necessary f..

Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum

Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman

Journal article  |  2013  |  PLoS One

Opsonising Antibodies to P. falciparum Merozoites Associated with Immunity to Clinical Malaria

Danika L Hill, Emily M Eriksson, Connie SN Li Wai Suen, Chris Y Chiu, Victoria Ryg-Cornejo, Leanne J Robinson, Peter M Siba, Ivo Mueller, Diana S Hansen, Louis Schofield

Journal article  |  2013  |  PLoS One

Definitions, classifications, and antibiotics

C Chiu

Book Chapter  |  2013

Protective and dysregulated T cell immunity in RSV infection

PJ Openshaw, C Chiu

Journal article  |  2013  |  Current Opinion in Virology

Cross-reactive humoral responses to influenza and their implications for a universal vaccine

C Chiu, J Wrammert, GM Li, M Mccausland, PC Wilson, R Ahmed

Journal article  |  2013  |  Annals of the New York Academy of Sciences

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells.

Gui-Mei Li, Christopher Chiu, Jens Wrammert, Megan McCausland, Sarah F Andrews, Nai-Ying Zheng, Jane-Hwei Lee, Min Huang, Xinyan Qu, Srilatha Edupuganti, Mark Mulligan, Suman R Das, Jonathan W Yewdell, Aneesh K Mehta, Patrick C Wilson, Rafi Ahmed

Journal article  |  2012  |  Proceedings of the National Academy of Sciences

We have previously shown that broadly neutralizing antibodies reactive to the conserved stem region of the influenza virus hemaggl..

Assessment of the heat stability of seven rapid HIV assays

Kate M Learmonth, Chris Y Chiu, Hazel Galang, Mohammad J Nawang, Elizabeth M Dax

Journal article  |  2011  |  Transactions of the Royal Society of Tropical Medicine and Hygiene

Photographed Rapid HIV Test Results Pilot Novel Quality Assessment and Training Schemes

Yu-Ho C Chiu, Joanna Ong, Sandy Walker, July Kumalawati, Tintin Gartinah, Dale A McPhee, Elizabeth M Dax

Journal article  |  2011  |  PLoS One

A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8 T cell responses in vivo.

Michael J Palmowski, Mathew Parker, Kaushik Choudhuri, Christopher Chiu, Margaret FC Callan, P Anton van der Merwe, Vincenzo Cerundolo, Keith G Gould

Journal article  |  2009  |  The Journal of Immunology

We have generated a construct encoding a single-chain H-2D(b) mouse MHC class I molecule in which an influenza virus nucleoprotein..

Early acquisition of cytolytic function and transcriptional changes in a primary CD8 T-cell response in vivo.

Christopher Chiu, Adrian G Heaps, Vincenzo Cerundolo, Andrew J McMichael, Charles R Bangham, Margaret FC Callan

Journal article  |  2007  |  Blood

Functional studies show that programming of CD8+ T cells occurs early after initial antigen encounter within as little as 2 hours...