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Mechanisms of naturally acquired immunity to P-falciparum and approaches to identify meroz..
Induction and subversion of human protective immunity: Contrasting influenza and respirato..
Displaying the 35 most recent scholarly works by Chris Chiu.
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
Slim Fourati, Aarthi Talla, Mehrad Mahmoudian, Joshua G Burkhart, Riku Klén, Ricardo Henao, Thomas Yu, Zafer Aydın, Ka Yee Yeung, Mehmet Eren Ahsen, Reem Almugbel, Samad Jahandideh, Xiao Liang, Torbjörn EM Nordling, Motoki Shiga, Ana Stanescu, Robert Vogel, undefined Respiratory Viral DREAM Challenge Consortium, Gaurav Pandey, Christopher Chiu, et al.
Journal article | 2018 | Nature Communications
The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictor..
Tuberculosis Infectiousness and Host Susceptibility.
Richard D Turner, Christopher Chiu, Gavin J Churchyard, Hanif Esmail, David M Lewinsohn, Neel R Gandhi, Kevin P Fennelly
Journal article | 2017 | The Journal of Infectious Diseases
The transmission of tuberculosis is complex. Necessary factors include a source case with respiratory disease that has developed s..
Metabolic Phenotypes of Response to Vaccination in Humans.
Shuzhao Li, Nicole L Sullivan, Nadine Rouphael, Tianwei Yu, Sophia Banton, Mohan S Maddur, Megan McCausland, Christopher Chiu, Jennifer Canniff, Sheri Dubey, Ken Liu, ViLinh Tran, Thomas Hagan, Sai Duraisingham, Andreas Wieland, Aneesh K Mehta, Jennifer A Whitaker, Shankar Subramaniam, Dean P Jones, Alessandro Sette, et al.
Journal article | 2017 | Cell
Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available..
Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy
Chris Y Chiu, Michael T White, Julie Healer, Jenny K Thompson, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen
Journal article | 2016 | Journal of Infectious Diseases
Limited Degradation of the Plasmodium falciparum Gametocyte Marker pfs25 mRNA Exposed to Tropical Temperatures: Considerations for Malaria Transmission Field Studies
Andreea Waltmann, Stephan Karl, Chris Chiu, Ivo Mueller
Journal article | 2016 | The American Journal of Tropical Medicine and Hygiene
Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans.
Silke M Currie, Emily Gwyer Findlay, Amanda J McFarlane, Paul M Fitch, Bettina Böttcher, Nick Colegrave, Allan Paras, Agnieszka Jozwik, Christopher Chiu, Jürgen Schwarze, Donald J Davidson
Journal article | 2016 | The Journal of Immunology
Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection in infants, causing significant morbidity and ..
Erratum: RSV-specific airway resident memory CD8 T cells and differential disease severity after experimental human infection (Nature Communications (2015) 6 (10224) DOI: 10.1038/ncomms10224)
A Jozwik, MS Habibi, A Paras, J Zhu, A Guvenel, J Dhariwal, M Almond, EHC Wong, A Sykes, M Maybeno, J Del Rosario, MB Trujillo-Torralbo, P Mallia, J Sidney, B Peters, OM Kon, A Sette, SL Johnston, PJ Openshaw, C Chiu
Journal article | 2016 | Nature Communications
Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation
Victoria Ryg-Cornejo, Lisa Julia Ioannidis, Ann Ly, Chris Yu Chiu, Julie Tellier, Danika Lea Hill, Simon Peter Preston, Marc Pellegrini, Di Yu, Stephen Laurence Nutt, Axel Kallies, Diana Silvia Hansen
Journal article | 2016 | Cell Reports
RSV-specific airway resident memory CD8 T cells and differential disease severity after experimental human infection.
Agnieszka Jozwik, Maximillian S Habibi, Allan Paras, Jie Zhu, Aleks Guvenel, Jaideep Dhariwal, Mark Almond, Ernie HC Wong, Annemarie Sykes, Matthew Maybeno, Jerico Del Rosario, Maria-Belen Trujillo-Torralbo, Patrick Mallia, John Sidney, Bjoern Peters, Onn Min Kon, Alessandro Sette, Sebastian L Johnston, Peter J Openshaw, Christopher Chiu
Journal article | 2015 | Nat Commun
In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination but their importance in man has not b..
Antibodies to the Plasmodium falciparum Proteins MSPDBL1 and MSPDBL2 Opsonize Merozoites, Inhibit Parasite Growth, and Predict Protection From Clinical Malaria
Chris YH Chiu, Anthony N Hodder, Clara S Lin, Danika L Hill, Connie SN Li Wai Suen, Louis Schofield, Peter M Siba, Ivo Mueller, Alan F Cowman, Diana S Hansen
Journal article | 2015 | Journal of Infectious Diseases
Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.
Maximillian S Habibi, Agnieszka Jozwik, Spyridon Makris, Jake Dunning, Allan Paras, John P DeVincenzo, Cornelis AM de Haan, Jens Wrammert, Peter JM Openshaw, Christopher Chiu, undefined Mechanisms of Severe Acute Influenza Consortium Investigators
Journal article | 2015 | American Journal of Respiratory and Critical Care Medicine
RATIONALE: Despite relative antigenic stability, respiratory syncytial virus (RSV) reinfects throughout life. After more than 40 y..
B cell responses to influenza infection and vaccination.
Christopher Chiu, Ali H Ellebedy, Jens Wrammert, Rafi Ahmed
Journal article | 2015 | Current Topics in Microbiology and Immunology
Although vaccines against influenza are widely available, control of the disease remains elusive. In part, this is due to the inab..
Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans.
Ali H Ellebedy, Florian Krammer, Gui-Mei Li, Matthew S Miller, Christopher Chiu, Jens Wrammert, Cathy Y Chang, Carl W Davis, Megan McCausland, Rivka Elbein, Srilatha Edupuganti, Paul Spearman, Sarah F Andrews, Patrick C Wilson, Adolfo García-Sastre, Mark J Mulligan, Aneesh K Mehta, Peter Palese, Rafi Ahmed
Journal article | 2014 | Proceedings of the National Academy of Sciences
The emergence of pandemic influenza viruses poses a major public health threat. Therefore, there is a need for a vaccine that can ..
Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria
Chris YH Chiu, Julie Healer, Jennifer K Thompson, Lin Chen, Aiki Kaul, Laxman Savergave, Arjun Raghuwanshi, Connie SN Li Wai Suen, Peter M Siba, Louis Schofield, Ivo Mueller, Alan F Cowman, Diana S Hansen
Journal article | 2014 | Frontiers in Microbiology
Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV.
Christopher Chiu, Megan McCausland, John Sidney, Fuh-Mei Duh, Nadine Rouphael, Aneesh Mehta, Mark Mulligan, Mary Carrington, Andreas Wieland, Nicole L Sullivan, Adriana Weinberg, Myron J Levin, Bali Pulendran, Bjoern Peters, Alessandro Sette, Rafi Ahmed
Journal article | 2014 | PLoS Pathogens
Human herpesviruses are important causes of potentially severe chronic infections for which T cells are believed to be necessary f..
Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum
Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman
Journal article | 2013 | PLoS One
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells.
Gui-Mei Li, Christopher Chiu, Jens Wrammert, Megan McCausland, Sarah F Andrews, Nai-Ying Zheng, Jane-Hwei Lee, Min Huang, Xinyan Qu, Srilatha Edupuganti, Mark Mulligan, Suman R Das, Jonathan W Yewdell, Aneesh K Mehta, Patrick C Wilson, Rafi Ahmed
Journal article | 2012 | Proceedings of the National Academy of Sciences
We have previously shown that broadly neutralizing antibodies reactive to the conserved stem region of the influenza virus hemaggl..
A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8 T cell responses in vivo.
Michael J Palmowski, Mathew Parker, Kaushik Choudhuri, Christopher Chiu, Margaret FC Callan, P Anton van der Merwe, Vincenzo Cerundolo, Keith G Gould
Journal article | 2009 | The Journal of Immunology
We have generated a construct encoding a single-chain H-2D(b) mouse MHC class I molecule in which an influenza virus nucleoprotein..
Early acquisition of cytolytic function and transcriptional changes in a primary CD8 T-cell response in vivo.
Christopher Chiu, Adrian G Heaps, Vincenzo Cerundolo, Andrew J McMichael, Charles R Bangham, Margaret FC Callan
Journal article | 2007 | Blood
Functional studies show that programming of CD8+ T cells occurs early after initial antigen encounter within as little as 2 hours...
Research Fellow, Hiv Latency
Bachelor of Science (Honours)
Bachelor of Science (Biomedical Science)